scholarly journals Comprehensive Clinical and Laboratory Follow-up of a Female Patient With Ebola Virus Disease: Sierra Leone Ebola Virus Persistence Study

2019 ◽  
Vol 6 (3) ◽  
Author(s):  
William J Liu ◽  
Foday R Sesay ◽  
Antoine Coursier ◽  
Barbara Knust ◽  
Jaclyn E Marrinan ◽  
...  
Keyword(s):  
Ebola Virus ◽  
Virus Disease ◽  
Disease Onset ◽  
Disease Patient ◽  
Ebola Virus Disease ◽  
Vaginal Fluid ◽  
Virus Rna ◽  
Long Term Follow Up

Abstract The clinical, virologic, and immunologic findings in a female Ebola virus disease patient are described. During the long-term follow-up, Ebola virus RNA was detectable in vaginal fluid before 36 days after symptom onset, with nearly an identical genome sequence as in acute phase blood. Ebola-specific T cells retained activation at 56 days after disease onset.

Screening at ports of entry for Ebola Virus Disease in England—a descriptive analysis of screening assessment data, 2014–2015

2020 ◽  
Author(s):  
Nicki L Boddington ◽  
Sophia Steinberger ◽  
Richard G Pebody
Keyword(s):  
Public Health ◽  
High Risk ◽  
Secondary Care ◽  
Ebola Virus ◽  
Virus Disease ◽  
Descriptive Analysis ◽  
Health Assessment ◽  
Ebola Virus Disease ◽  
Screening Assessment

Abstract Background In response to the outbreak of Ebola Virus Disease (EVD) in West Africa in 2014 and evidence of spread to other countries, pre-entry screening was introduced by PHE at five major ports of entry in the England. Methods All passengers that entered the England via the five ports returning from Liberia, Guinea and Sierra Leonne were required to complete a Health Assessment Form and have their temperature taken. The numbers, characteristics and outcomes of these passengers were analysed. Results Between 14 October 2014 and 13 October 2015, a total of 12 648 passengers from affected countries had been screened. The majority of passengers were assessed as having no direct contact with EVD cases or high-risk events (12 069, 95.4%), although 535 (4.2%) passengers were assessed as requiring public health follow-up. In total, 39 passengers were referred directly to secondary care, although none were diagnosed with EVD. One high-risk passenger was later referred to secondary care and diagnosed with EVD. Conclusions Collection of these screening data enabled timely monitoring of the numbers and characteristics of passengers screened for EVD, facilitated resourcing decisions and acted as a mechanism to inform passengers of the necessary public health actions.

scholarly journals PTSD, depression and anxiety in Ebola virus disease survivors in Beni town, Democratic Republic of the Congo

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Célestin Kaputu-Kalala-Malu ◽  
Eric Mafuta Musalu ◽  
Tim Walker ◽  
Olga Ntumba-Tshitenge ◽  
Steve Ahuka-Mundeke
Keyword(s):  
Ebola Virus ◽  
Democratic Republic ◽  
Short Term Memory ◽  
Virus Disease ◽  
Ebola Virus Disease ◽  
Depression And Anxiety ◽  
Short Term ◽  
Republic Of The Congo ◽  
Persistent Headache

Abstract Background Ebola Virus Disease (EVD) is a deadly and feared infectious disease, which can be responsible of debilitating physical and psychological sequelae in survivors including depression and anxiety disorders. Unfortunately, there are scarce data on survivor sequelae in Democratic Republic of the Congo. So this study assessed PTSD, depression and anxiety symptoms among EVD survivors enrolled in the follow-up program of the psychosocial care team of Beni town’s general hospital. Methods A cross-sectional study used consecutive sampling to recruit 144 Ebola virus disease survivors who came for follow up from October 23 to November 13; 2019. Basic socio-demographic data, presence of headache and short-term memory function were assessed. The Post-traumatic Checklist Scale and Hospital Anxiety and Depression Scale were used to assess psychological burden among participants. Descriptive statistics were used to summarized data and Pearson’s or likelihood chi-square were used to test association between psychiatric disorders and associated factors. Results The prevalence of PTSD, depression and anxiety was 24.3, 24.3 and 33.3% respectively. Being male (OR = 0.42, 95% CI: 0.16, 0.95, p = 0.049), suffering from persistent headache (OR = 2.62, 95% CI: 1.12, 6.14, p = 0.014), losing a loved one because of EVD (OR: 2.60, 95% CI: 1.11, 6.15, p = 0. 015) and being young − 18-24 years - (OR: 0. 261, 95% CI: 0. 08, 0.82, p = 0,026) were statistically associated with PTSD diagnosis. Having short-term memory impairment and suffering from persistent headache were statistically associated with depression and anxiety diagnoses (OR = 2.44, 95% CI: 1.03, 5.82, p = 0.026); (OR = 2.24, 95% CI: 1.04, 4.85, p = 0.025); (OR = 2.62, 95% CI: 1.12, 6.14, p = 0.014); (OR = 2.31, 95% CI: 1.06, 5.01, p = 0.020). Conclusion The prevalence of PTSD, depression and anxiety is high among EVD survivors. Development of specialized psychiatric services to sustain psychiatric and psychological health amongst survivors in the cultural context of the Eastern part of the DRC should be considered by the teams fighting against EVD in the DRC.

scholarly journals Correction to ‘Long-term wildlife mortality surveillance in northern Congo: a model for the detection of Ebola virus disease epizootics’

2019 ◽  
Vol 374 (1786) ◽  
pp. 20190658
Author(s):  
Eeva Kuisma ◽  
Sarah H. Olson ◽  
Kenneth N. Cameron ◽  
Patricia E. Reed ◽  
William B. Karesh ◽  
...  
Keyword(s):  
Ebola Virus ◽  
Virus Disease ◽  
Ebola Virus Disease ◽  
Mortality Surveillance ◽  
Wildlife Mortality

scholarly journals Clinical and Pathological Characteristics of Autoimmune Hepatitis with Acute Presentation

2018 ◽  
Vol 2018 ◽  
pp. 1-10 ◽  
Author(s):  
Yi Shen ◽  
Changli Lu ◽  
Ruoting Men ◽  
Jianping Liu ◽  
Tinghong Ye ◽  
...  
Keyword(s):  
Autoimmune Hepatitis ◽  
Disease Onset ◽  
Histological Evaluation ◽  
Central Necrosis ◽  
Acute Presentation ◽  
Significant Difference ◽  
Long Term Follow Up ◽  
Lobular Inflammation

Aim. To study the differences between acute presentation-autoimmune hepatitis (A-AIH) and chronic autoimmune hepatitis (C-AIH). Methods. Through long-term follow-up, 80 patients were included in our study by using the revised international autoimmune hepatitis group (IAIHG) score and were divided into acute and chronic groups for comparison. Results. No significant difference was found in the gender, age, IAIHG score (pretreatment/posttreatment), definite diagnosis rate, extrahepatic autoimmune disease, onset time, or treatment before biopsy between the acute and chronic groups. In terms of clinical symptoms, A-AIH patients were more prone to jaundice, anorexia, yellow urine, and detesting oil than C-AIH patients, but melena only occurred in chronic group (P<0.05). The acute group exhibited more severe injury upon histological evaluation, with lobular inflammation and bile duct injury, especially central necrosis of the lobule, more pronounced in this group (P<0.05). Conclusion. A-AIH had manifestations of acute hepatitis and presented cholestasis. Serum indicators could preliminarily distinguish A-AIH and C-AIH. Histologically, the primary manifestation of A-AIH was lobular inflammation, which was usually accompanied by lobular central necrosis. For the diagnosis of A-AIH, more attention should be paid to long-term follow-up. This study was registered at ClinicalTrials.gov (identifier: NCT02994537).

scholarly journals Use of Peripheral Health Units in Low-Transmission Ebola Virus Disease Surveillance

2016 ◽  
Vol 8 (1) ◽  
Author(s):  
Alyssa J. Young ◽  
Allison Connolly ◽  
Adam Hoar ◽  
Brooke Mancuso ◽  
John Mark Esplana ◽  
...  
Keyword(s):  
Sierra Leone ◽  
Surveillance System ◽  
Disease Surveillance ◽  
Ebola Virus ◽  
Virus Disease ◽  
Malaria Prevalence ◽  
Ebola Virus Disease ◽  
Alert System ◽  
Community Based

Surveillance strategies for Ebola Virus Disease (EVD) in Sierra Leone use a centralized "live alert" system to refer suspect cases from the community to specialized Ebola treatment centers. As EVD case burden declined in Port Loko District, Sierra Leone so did the number of reported alerts. Because EVD presents similarly to malaria, the number of alerts should remain consistent with malaria prevalence in malaria-endemic areas, irrespective of the reduction in true EVD cases. A community-based EVD surveillance system with improved symptom recording and follow-up of malaria-confirmed patients at PHUs was implemented in order to strengthen the sensitivity of EVD reporting.

scholarly journals Persistence and clearance of Ebola virus RNA from seminal fluid of Ebola virus disease survivors: a longitudinal analysis and modelling study

2017 ◽  
Vol 5 (1) ◽  
pp. e80-e88 ◽  
Author(s):  
Daouda Sissoko ◽  
Sophie Duraffour ◽  
Romy Kerber ◽  
Jacques Seraphin Kolie ◽  
Abdoul Habib Beavogui ◽  
...  
Keyword(s):  
Longitudinal Analysis ◽  
Ebola Virus ◽  
Seminal Fluid ◽  
Virus Disease ◽  
Ebola Virus Disease ◽  
Virus Rna ◽  
Modelling Study

Ensuring On-site Ebola Patient Monitoring and Follow-up: Development of a Laboratory Structure Embedded in an Ebola Treatment Center

2019 ◽  
Vol 13 (5-6) ◽  
pp. 1028-1034
Author(s):  
Anita Williams ◽  
Mathieu Amand ◽  
Rafael Van den Bergh ◽  
Hilde De Clerck ◽  
Annick Antierens ◽  
...  
Keyword(s):  
Patient Monitoring ◽  
Ebola Virus ◽  
Virus Disease ◽  
Real Life ◽  
Disease Outbreaks ◽  
Clinical Results ◽  
Ebola Virus Disease ◽  
Treatment Center ◽  
Risk Zones

ABSTRACTThe capacity to rapidly distinguish Ebola virus disease from other infectious diseases and to monitor biochemistry and viremia levels is crucial to the clinical management of suspected Ebola virus disease cases. This article describes the design and practical considerations of a laboratory straddling the high- and low-risk zones of an Ebola treatment center to produce timely diagnostic and clinical results for informed case management of Ebola virus disease in real-life conditions. This innovation may be of relevance for actors requiring flexible laboratory implementation in contexts of high-communicability, high-lethality disease outbreaks.

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