scholarly journals Bilateral Mondor’s disease in chikungunya virus infection

2020 ◽  
Vol 2020 (8) ◽  
Author(s):  
Sarah Djebara ◽  
Liesbet Henckaerts ◽  
Peter Vanbrabant
Keyword(s):  
Virus Infection ◽  
Venous Thrombosis ◽  
Deep Venous Thrombosis ◽  
Chikungunya Virus ◽  
Thoracic Wall ◽  
Chikv Infection ◽  
Superficial Thrombophlebitis ◽  
Aedes Mosquitoes ◽  
Mondor’S Disease ◽  
Mondor's Disease

ABSTRACT Chikungunya virus (CHIKV) is an arthropod-borne virus that is transmitted by Aedes mosquitoes, and its main features are high fever and (debilitating) arthritis. Infection with CHIKV, as well as other viruses, has been associated with hypercoagulable states and may be linked with the development of venous thrombosis. In fact, the development of deep venous thrombosis has been described in CHIKV infection. We present a case of superficial thrombophlebitis of the thoracic wall, known as Mondor’s disease, associated with CHIKV infection. To our knowledge, this probable association has never been described before.

scholarly journals Chest Wall Pain after Minor Trauma

2020 ◽  
Vol 4 (3) ◽  
pp. 468-469
Author(s):  
Deepak Chandwani ◽  
Jeff Arnold ◽  
John Terrusa
Keyword(s):  
Thoracic Wall ◽  
Minor Trauma ◽  
Lateral Aspect ◽  
Case Presentation ◽  
Superficial Thrombophlebitis ◽  
Mondor’S Disease ◽  
Mondor's Disease ◽  
Underlying Causes ◽  
Austere Environment ◽  
Careful Physical Examination

Case Presentation: A 30-year-old healthy male presented with a complaint of chest pain after mild thoracic trauma sustained while rescuing stranded flood victims during Hurricane Harvey. Careful physical examination revealed a tender palpable cord along the lateral aspect of his chest consistent with a superficial thrombophlebitis. Discussion: Mondor’s disease is a superficial thrombophlebitis with myriad underlying causes that can involve the thoracic wall. Although Mondor’s disease has been well described in the literature, this case describes a unique presentation in an austere environment with blunt trauma as the underlying cause.

Association of IgA Anti-ß2 Glycoprotein I with Clinical and Laboratory Manifestations of Systemic Lupus Erythematosus

2010 ◽  
Vol 38 (1) ◽  
pp. 64-68 ◽  
Author(s):  
TARANEH MEHRANI ◽  
MICHELLE PETRI
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Venous Thrombosis ◽  
Deep Venous Thrombosis ◽  
Lupus Erythematosus ◽  
Classification Criteria ◽  
Systemic Lupus ◽  
Superficial Thrombophlebitis ◽  
Glycoprotein I ◽  
High Prevalence ◽  
Ischemic Attack

Objective.IgA isotypes of anticardiolipin and anti-ß2 glycoprotein I (anti-ß2-GPI) are omitted from the revised antiphospholipid syndrome (APS) classification criteria. Multiple studies have found a high prevalence of IgA anti-ß2-GPI in systemic lupus erythematosus (SLE). We determined the frequency and associations of IgA anti-ß2-GPI in a cohort of patients with SLE.Methods.Anti-ß2-GPI was measured in 796 patients with SLE (93% women, 53% white, 38% African American, mean age 45 yrs). IgA anti-ß2-GPI (> 20 phospholipid units) was found in 20%. Using a cohort database, associations with cumulative thrombotic and other manifestations were determined.Results.Of patients with SLE who demonstrated IgA anti-ß2-GPI positivity, about 6% had transient ischemic attack (p = 0.070), 4% had superficial thrombophlebitis (p = 0.647), 20% had deep venous thrombosis (p = 0.003), 4% had other venous thrombosis (p = 0.827), 12% had stroke (p = 0.050), and 1% had myocardial infarction (p = 0.397).Conclusion.IgG anti-ß2-GPI has the strongest association with thrombosis in SLE. However, IgA anti-ß2-GPI was more strongly associated with deep venous thrombosis and with stroke than was IgM. These results indicate that assessment of IgA anti-ß2-GPI is associated with thrombosis in SLE, and that the classification criteria for APS should be revised to include IgA anti-ß2-GPI in patients with SLE.

Mondor's disease of the penis following a long-haul flight

2005 ◽  
Vol 16 (7) ◽  
pp. 510-511 ◽  
Author(s):  
S Day ◽  
J S Bingham
Keyword(s):  
Varicose Veins ◽  
Predisposing Factor ◽  
Benign Condition ◽  
Vein Thrombosis ◽  
Superficial Thrombophlebitis ◽  
Dorsal Vein ◽  
Mondor’S Disease ◽  
Left Lower Limb ◽  
Mondor's Disease ◽  
History Of

Mondor's disease of the penis, otherwise known as superficial thrombophlebitis (STP) or thrombosis of the dorsal vein, is an under-reported benign condition, the aetiology of which is poorly understood. It is characterized by a sudden, indurated swelling of the vein, often occurring after vigorous sexual activity. We report a case of Mondor's disease occurring 24h following a 15h flight. This gentleman also reported a history of STP of his left lower limb varicose veins following a similar-length flight three years previously. In the absence of any other clear predisposing factor, we propose long-haul flight as an important factor contributing to the development of dorsal vein thrombosis.

scholarly journals First Imported Case of Chikungunya Virus Infection in a Travelling Canadian Returning from the Caribbean

2016 ◽  
Vol 2016 ◽  
pp. 1-5
Author(s):  
Christian Therrien ◽  
Guillaume Jourdan ◽  
Kimberly Holloway ◽  
Cécile Tremblay ◽  
Michael A. Drebot
Keyword(s):  
Virus Infection ◽  
Dengue Virus ◽  
Neutralizing Antibodies ◽  
Chikungunya Virus ◽  
Joint Stiffness ◽  
Clinical Feature ◽  
Chikv Infection ◽  
Imported Case ◽  
The Caribbean ◽  
Hands And Feet

This is the first Canadian case of Chikungunya virus (CHIKV) infection reported in a traveller returning from the Caribbean. Following multiple mosquito bites in Martinique Island in January 2014, the patient presented with high fever, headaches, arthralgia on both hands and feet, and a rash on the trunk upon his return to Canada. Initial serological testing for dengue virus infection was negative. Support therapy with nonsteroidal anti-inflammatory drugs was administered. The symptoms gradually improved 4 weeks after onset with residual arthralgia and morning joint stiffness. This clinical feature prompted the clinician to request CHIKV virus serology which was found to be positive for the presence of IgM and neutralizing antibodies. In 2014, over four hundred confirmed CHIKV infection cases were diagnosed in Canadian travellers returning from the Caribbean and Central America. Clinical suspicion of CHIKV or dengue virus infections should be considered in febrile patients with arthralgia returning from the recently CHIKV endemic countries of the Americas.

scholarly journals Mondor’s disease of the penis due to asymptomatic infective prostatitis provoking episodes of secondary sclerotizing lymphangitis

2021 ◽  
Vol 10 (2) ◽  
Author(s):  
Maddalena Bressan ◽  
Mirko Tessari ◽  
Alessio Mario Cosacco ◽  
Paolo Zamboni
Keyword(s):  
Differential Diagnosis ◽  
Sexual Activity ◽  
Diagnostic Technique ◽  
Superficial Thrombophlebitis ◽  
Dorsal Vein ◽  
Mondor’S Disease ◽  
Mondor's Disease ◽  
Limiting Condition ◽  
Distinct Variety ◽  
Genitourinary Infection

Mondor’s disease of the penis is an under-reported condition caused by superficial thrombophlebitis of the dorsal vein or thrombosis of the deep venous network of the penis. This is a benign, self-limiting condition, characterized by a sudden, indurated swelling of the aforementioned veins. The possible causes comprise traumatism, neoplasms, excessive sexual activity, or coagulation inherited deficit. An accompanied lymphangitis is discussed, eventually as a distinct variety. The differential diagnosis must be established by the means of ultrasound, which is the imaging diagnostic technique of choice. We describe the case of Mondor’s sclerotizing lymphangitis secondary to recurrent episodes of genitourinary infection previously diagnosed as recurrent superficial Mondor thrombophlebitis of the penis.

scholarly journals Felületes vénás thrombosis – ahogy ma látjuk

2017 ◽  
Vol 158 (4) ◽  
pp. 129-138
Author(s):  
Tamás Sándor
Keyword(s):  
Molecular Weight ◽  
Venous Thrombosis ◽  
Deep Venous Thrombosis ◽  
Duplex Ultrasound ◽  
High Ligation ◽  
Low Molecular Weight ◽  
Benign Condition ◽  
Superficial Thrombophlebitis ◽  
Careful Clinical Examination ◽  
Consensus Statements

Abstract: For a long time superficial thrombophlebitis has been thought to be a rather benign condition. Recently, when duplex ultrasound technique is used for the diagnosis more and more often, the disease is proved to be more dangerous than anticipated. Thrombosis propagates to the deep veins in 6–44% and pulmonary embolism was observed on the patients in 1,5–33%. We can calculate venous thromboembolic complications on every fourth patient. Diagnosis is clinical, but duplex ultrasound examination is mandatory, for estimation of the thrombus extent, for exclusion of the deep venous thrombosis and for follow up. Both legs should be checked with ultrasound, because simultaneous deep venous thrombosis can develop on the contralateral limb. Two different forms can be distinguished: superficial venous thrombosis with, or without varicose veins. In cases of spontaneous, non varicous form, especially when the process is migrating or recurrent, a careful clinical examination is necessery for exclusion of malignant diseases and thrombophilia. The treatment options are summarised on the basis of recent international consensus statements. The American and German guidelines are similar. Compression and mobilisation are cornerstones of the therapy. For a short segment thrombosis non steroidal antiinflammatory drugs are effective. For longer segments low molecular-weight heparins are preferred. Information on the effect of the novel oral anticoagulants for the therapy is lacking but they may appear to be effective in the future for this indication. When thrombus is close to the sapheno-femoral or sapheno-popliteal junction crossectomy (high ligation), or low molecular-weight heparin in therapeutic doses are indicated. The term superficial thrombophlebitis should be discouraged, because inflammation and infection is not the primary pathology. It should be called correctly superficial venous thrombosis in order to avoid the unnecessary administration of antibiotics and the misconception, that superficial venous thrombosis is benign disease. Orv. Hetil., 2017, 158(4), 129–138.

scholarly journals Circular Abscess Formation of the Inner Preputial Leaf as a Complication of a Penile Mondor's Disease: The First Case Report

2014 ◽  
Vol 2014 ◽  
pp. 1-3
Author(s):  
Johann Jakob Wendler ◽  
Daniel Schindele ◽  
Daniel Baumunk ◽  
Uwe-Bernd Liehr ◽  
Markus Porsch ◽  
...  
Keyword(s):  
Clinical Course ◽  
Abscess Formation ◽  
Bacterial Colonisation ◽  
Abscess Drainage ◽  
Case Presentation ◽  
Superficial Thrombophlebitis ◽  
First Case ◽  
Mondor’S Disease ◽  
Mondor's Disease ◽  
Uncommon Condition

Introduction.Mondor's disease of the penis is an uncommon condition characterized by thrombosis or thrombophlebitis involving the superficial dorsal veins. An accompanied lymphangitis is discussed. There is typical self-limiting clinical course.Case Presentation.This paper firstly reports a secondary abscess formation of the preputial leaf two weeks after penile Mondor's disease and subcutaneous lymphangitis as complication of excessive sexual intercourse of a 44-year-old man. Sexual transmitted diseases could be excluded. Lesions healed up completely under abscess drainage, antibiotic, and anti-inflammatory medication.Conclusion.Previous reports in the literature include several entities of the penile Mondor's disease. Our patient is very unusual in that he presented with a secondary preputial abscess formation due to superficial thrombophlebitis, subcutaneous lymphangitis, and local bacterial colonisation. Abscess drainage plus antiphlogistic and antibiotic medication is the treatment of choice.

scholarly journals Genome-Wide Screening Uncovers the Significance of N-Sulfation of Heparan Sulfate as a Host Cell Factor for Chikungunya Virus Infection

2017 ◽  
Vol 91 (13) ◽  
Author(s):  
Atsushi Tanaka ◽  
Uranan Tumkosit ◽  
Shota Nakamura ◽  
Daisuke Motooka ◽  
Natsuko Kishishita ◽  
...  
Keyword(s):  
Virus Infection ◽  
Heparan Sulfate ◽  
Chondroitin Sulfate ◽  
Chikungunya Virus ◽  
Yellow Fever Virus ◽  
Host Cells ◽  
Pseudotyped Virus ◽  
Target Cells ◽  
Chikv Infection ◽  
Genome Wide

ABSTRACT The molecular mechanisms underlying chikungunya virus (CHIKV) infection are poorly characterized. In this study, we analyzed the host factors involved in CHIKV infection using genome-wide screening. Human haploid HAP1 cells, into which an exon-trapping vector was introduced, were challenged with a vesicular stomatitis virus pseudotype bearing the CHIKV E3 to E1 envelope proteins. Analysis of genes enriched in the cells resistant to the pseudotyped virus infection unveiled a critical role of N-sulfation of heparan sulfate (HS) for the infectivity of the clinically isolated CHIKV Thai#16856 strain to HAP1 cells. Knockout of NDST1 that catalyzes N-sulfation of HS greatly decreased the binding and infectivity of CHIKV Thai#16856 strain but not infectivity of Japanese encephalitis virus (JEV) and yellow fever virus (YFV). While glycosaminoglycans were commonly required for the efficient infectivity of CHIKV, JEV, and YFV, as shown by using B3GAT3 knockout cells, the tropism for N-sulfate was specific to CHIKV. Expression of chondroitin sulfate (CS) in NDST1-knockout HAP1 cells did not restore the binding of CHIKV Thai#16856 strain and the infectivity of its pseudotype but restored the infectivity of authentic CHIKV Thai#16856, suggesting that CS functions at later steps after CHIKV binding. Among the genes enriched in this screening, we found that TM9SF2 is critical for N-sulfation of HS and therefore for CHIKV infection because it is involved in the proper localization and stability of NDST1. Determination of the significance of and the relevant proteins to N-sulfation of HS may contribute to understanding mechanisms of CHIKV propagation, cell tropism, and pathogenesis. IMPORTANCE Recent outbreaks of chikungunya fever have increased its clinical importance. Chikungunya virus (CHIKV) utilizes host glycosaminoglycans to bind efficiently to its target cells. However, the substructure in glycosaminoglycans required for CHIKV infection have not been characterized. Here, we unveil that N-sulfate in heparan sulfate is essential for the efficient infection of a clinical CHIKV strain to HAP1 cells and that chondroitin sulfate does not help the CHIKV binding but does play roles at the later steps in HAP1 cells. We show, by comparing previous reports using Chinese hamster ovary cells, along with another observation that enhanced infectivity of CHIKV bearing Arg82 in envelope E2 does not depend on glycosaminoglycans in HAP1 cells, that the infection manner of CHIKV varies among host cells. We also show that TM9SF2 is required for CHIKV infection to HAP1 cells because it is involved in the N-sulfation of heparan sulfate through ensuring NDST1 activity.

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