scholarly journals Recurrent giant phyllodes tumour in a 17-year-old female: a rare case report

2020 ◽  
Vol 2020 (10) ◽  
Author(s):  
James J Yahaya
Keyword(s):  
Surgical Excision ◽  
High Rate ◽  
Pathology Report ◽  
Spindle Cells ◽  
Eosinophilic Cytoplasm ◽  
Phyllodes Tumour ◽  
Rare Case Report ◽  
Abundant Eosinophilic Cytoplasm ◽  
Phyllodes Tumours ◽  
High Chance

Abstract Phyllodes tumours (PTs) are rare fibroepithelial tumours of the breast with incidence accounting for <1% in the general population. Availability of reports on PTs with size of 31 cm or more in diameter in the literature are extremely rare. Herein, the case of a 17-year-old female patient with a giant recurrent right breast PT is reported. Histologically, the tumour showed proliferation of stromal tumour cells consisting of spindle cells with uniform nuclear chromatin, inconspicuous nucleoli, abundant eosinophilic cytoplasm and proliferation labelling index for Ki67 of <10%. PTs require meticulous surgical excision due to the fact that they have a high rate of recurrence and status of surgical margins must be included in the pathology report. This is because recurrent cases of PTs tend to grow faster than the primary ones with a high chance of transforming to malignancy.

scholarly journals Malignant Phyllodes Tumour with Rhabdomyosarcomatous Differentiation: A Rare Phenomenon

2021 ◽  
Author(s):  
Kusum Yadav ◽  
Jitendra Singh Nigam ◽  
Anshul Singh ◽  
Vatsala Misra
Keyword(s):  
Rare Tumour ◽  
Complete Excision ◽  
Eosinophilic Cytoplasm ◽  
Phyllodes Tumour ◽  
Abundant Eosinophilic Cytoplasm ◽  
One Year ◽  
Phyllodes Tumours ◽  
The Right ◽  
Pleomorphic Cells ◽  
Malignant Phyllodes Tumour

Phyllodes tumour is a rare tumour of the breast constituting less than 1% of all breast tumours. Malignant Phyllodes Tumour (MPT) accounts for only 10-30% of all phyllodes tumours. Heterologous sarcomatous differentiation in a MPT is an infrequent phenomenon, with the cases reported showing differentiation mostly towards liposarcoma, fibrosarcoma, angiosarcoma, osteosarcoma, or chondrosarcoma. MPTs with rhabdomyosarcomatous differentiation are scarcely seen with only three confirmed cases documented till date to the best of the knowledge after a thorough search of literature. Here, authors present a case of 45-year-old female who presented with a well-defined rapidly growing lump in the right breast for last one year. A core needle biopsy performed showed a sarcomatous picture on histology. Complete excision was subsequently done. On microscopy, most of the areas showed fibrosarcomatous changes with frequent mitoses. Some of the foci showed large pleomorphic cells in diffuse sheets that were polygonal with densely abundant eosinophilic cytoplasm and vesicular nucleus with prominent nucleoli (rhabdomyoblasts). Myogenin was diffusely positive on Immunohistochemistry (IHC). A diagnosis of MPT with rhabdomyosarcomatous differentiation was made. This case is reported here for its unusual presentation and to make pathologists aware of this rare heterologous differentiation of MPT.

scholarly journals High-grade ductal carcinoma in-situ detected by microcalcification within borderline phyllodes tumour: A report of a case and literature review

2021 ◽  
Author(s):  
Wing Nam Yuen ◽  
Joshua Jing Xi Li ◽  
Man Yi Chan ◽  
Gary M Tse
Keyword(s):  
Ductal Carcinoma In Situ ◽  
Carcinoma In Situ ◽  
Ductal Carcinoma ◽  
Surgical Excision ◽  
Management Plan ◽  
High Grade ◽  
Total Mastectomy ◽  
Phyllodes Tumour ◽  
Phyllodes Tumours

Abstract BackgroundPhyllodes tumour is a rare biphasic neoplasm of the breast that mostly affects middle aged women. Ductal carcinoma in-situ and microcalcifications occurring within phyllodes tumours are documented but are rare findings. Primary surgical excision with adjuvant therapies remains the mainstay of treatment.Case presentationWe report a case of a 42-year-old woman with high-grade ductal carcinoma in-situ within a borderline phyllodes tumour. Radiologically, clumps of microcalcification were detected within the lesion. Local excision followed by total mastectomy with axillary dissection was then performed. No tumour recurrence was detected up to a period of 8 years.ConclusionPresence of microcalcifications within a phyllodes tumour should alert clinicians and pathologists of possible coexisting carcinoma components. Stromal and epithelial components of these lesions should be evaluated separately when formulating a management plan.

scholarly journals BORDERLINE PHYLLODES TUMOUR

2015 ◽  
Vol 1 (2) ◽  
Author(s):  
Saima Haider ◽  
Misbah Tasleem
Keyword(s):  
Multidisciplinary Approach ◽  
Breast Tumour ◽  
Left Breast ◽  
Breast Ultrasound ◽  
High Rate ◽  
Excision Biopsy ◽  
Breast Masses ◽  
Key Words Breast ◽  
Phyllodes Tumour ◽  
Phyllodes Tumours

We report a case of 40-year-old woman with a painful lump in the left breast. Mammography revealed a suspicious mass ACR BI-RADS category 4a. Excision biopsy revealed borderline phyllodes tumour. Our case highlights the signi cance of multidisciplinary approach in managing benign breast masses such as phyllodes tumours which have malignant potential and a high rate of recurrence. Key words: Breast ultrasound, mammography, phyllodes breast tumour 

Primary Leiomyosarcoma of the Ovarian Vein: Case Report and Literature Review

2016 ◽  
Vol 25 (4) ◽  
pp. 339-343 ◽  
Author(s):  
María Elena López-Ruiz ◽  
Laura Yébenes ◽  
Alberto Berjón ◽  
David Hardisson
Keyword(s):  
Close Relation ◽  
Abdominal Discomfort ◽  
Ovarian Vein ◽  
Pelvic Ultrasound ◽  
Total Hysterectomy ◽  
Spindle Cells ◽  
Eosinophilic Cytoplasm ◽  
Abundant Eosinophilic Cytoplasm ◽  
Irregular Mass ◽  
Primary Leiomyosarcoma

Primary leiomyosarcoma arising from the ovarian vein is extremely rare, with only 10 cases reported in the literature. We report on a case of leiomyosarcoma of the left ovarian vein in a 67-year-old woman who presented with abdominal discomfort. Pelvic ultrasound revealed a large, solid, irregular mass in close relation to the left ovary. The patient subsequently underwent a total hysterectomy with bilateral salpingo-oophorectomy. Histologically, the tumor was composed of interlacing fascicles of spindle cells with abundant eosinophilic cytoplasm, hyperchromatic nuclei, and prominent nucleoli. Mitotic activity was high, with 24 mitoses in 10 high-power fields. Areas of necrosis and hemorrhage were present within the tumor. Immunohistochemically, the tumor cells showed diffuse immunoreactivity for vimentin, muscle-specific actin, desmin, and caldesmon. The patient received chemotherapy postoperatively but subsequently developed disseminated metastatic disease (lung, liver, iliac lymph nodes, and peritoneum). Primary leiomyosarcomas arising from the ovarian vein are aggressive neoplasms, and the prognosis correlates with stage.

scholarly journals Tall Cell Variant of Papillary Thyroid Carcinoma: Recognizing a Rare Aggressive Variant

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Shweta Agarwal ◽  
Keyword(s):  
Tumor Cells ◽  
High Rate ◽  
Papillary Thyroid ◽  
Tall Cell Variant ◽  
Eosinophilic Cytoplasm ◽  
Abundant Eosinophilic Cytoplasm ◽  
Tall Cell ◽  
Cell Variant ◽  
Pathology Reports ◽  
Thyroid Malignancies

Papillary Thyroid Cancer (PTC) accounts for 80–90% of all thyroid malignancies [1]. The most common morphology is the classical papillary which has an indolent course. Aggressive variants exist, of which Tall Cell Variant (TCV) is the most common. TCV is defined as a PTC in which 30% or more of tumor cells are 2-3 times as long as they are wide [1,2]. The histology image (Figure 1A, magnification 4x) shows tumor cells arranged back to back with abundant eosinophilic cytoplasm, and typical nuclear features of PTC; namely overlapping enlarged nuclei, intranuclear grooves, and occasional pseudoinclusions. Figure 1B (magnification: 20x) shows a high power view of the same case where the tall cell features of individual tumor cells can be better appreciated (arrows). This important feature should be recognized and reported in pathology reports as TCVs exhibit worse clinical course with extensive lymph node metastasis, extra thyroidal extension and high rate of recurrence [1,2].

scholarly journals Axillary Mass Turned Out to be A Phyllodes Tumour in An Ectopic Breast Tissue– A Rare Case Report

2021 ◽  
Vol 02 ◽  
Author(s):  
Mohd Shafiq Rahman ◽  
Norly Salleh
Keyword(s):  
Breast Tissue ◽  
Histopathological Examination ◽  
Axillary Artery ◽  
Treatment Modalities ◽  
Ectopic Breast Tissue ◽  
Phyllodes Tumour ◽  
Rare Case Report ◽  
Axillary Mass ◽  
Phyllodes Tumours ◽  
Ectopic Breast

Background: Phyllodes tumours are rare fibroepithelial lesion, which accounts for less than 1% of all breast neoplasm. However, Phyllodes tumours arising from ectopic breast tissue are even rarer, with less than 15 cases ever reported involving the axilla, vulva, and groin. Case Presentation: A 27-year-old lady presented to the surgical clinic with left axillary swelling measuring 5cm x 6cm. Ultrasound of the axilla revealed heterogenous homogenous mass displacing the left axillary artery and vein medially. Excision was performed, and histopathological examination confirmed the diagnosis of a benign Phyllodes tumour. Conclusion: Phyllodes tumour in ectopic breast tissue over the axilla is a rare occurrence, and our case is the fourth case ever reported. Despite its rarity, diagnosis and treatment modalities are similar to Phyllodes tumour of the breast. Regular follow-up is recommended due to the risk of local recurrence.

scholarly journals Fibroadenoma in an operated case of malignant phyllodes tumour: a rare case report

2017 ◽  
Vol 4 (2) ◽  
pp. 792
Author(s):  
Iresh Shetty ◽  
Tushar Jadhav ◽  
Aditya Lad ◽  
Gaurav Batra ◽  
Ishant Rege ◽  
...  
Keyword(s):  
Frozen Section ◽  
Left Breast ◽  
Low Grade ◽  
Previous Surgery ◽  
Rare Presentation ◽  
Phyllodes Tumour ◽  
Rare Case Report ◽  
Single Disease Entity ◽  
Phyllodes Tumours ◽  
Malignant Phyllodes Tumour

Phyllodes tumours are rare fibroepithelial lesions that account for less than 1% of breast neoplasms. Displaying a broad range of clinical and pathological behaviour, phyllodes tumours should be regarded as a spectrum of fibroepithelial neoplasms rather than a single disease entity. We would like to present a rare presentation of fibroadenoma over site of a previously operated case of malignant phyllodes tumour. A 36 year old female came to OPD with complaints of lump in both breasts since 4 months. She gave history of previous surgery, i.e., left breast lumpectomy for which HPE report was suggestive of malignant phyllodes tumour. On examination, 3x2 cm, solitary, firm to hard, non-tender lump was felt in the junction of the upper outer and inner quadrant just below the scar of previous surgery and was not freely mobile and appeared fixed to the scar. Patient underwent excision of the lump with frozen section and final HPE report turning out to be fibroadenoma. Though diagnosis of malignant phyllodes tumour is not difficult, diagnosis of low grade phyllodes tumour and distinction from fibroadenoma on FNA is difficult due to overlapping features between the two lesions. Surgery remains the mainstay of treatment for patients with cystosarcoma phyllodes, extent of surgery been controversial, and continues to evolve. Incidence of fibroadenoma occurring at the previous operated site of malignant phyllodes tumour is very rare with no known previous documentation of such a case.

Management and outcomes of phyllodes tumours – 10 year experience

2021 ◽  
pp. 1-6
Author(s):  
P.A. Boland ◽  
A. Ali Beegan ◽  
M. Stokes ◽  
M.R. Kell ◽  
J.M. Barry ◽  
...  
Keyword(s):  
Local Recurrence ◽  
Surgical Management ◽  
Surgical Excision ◽  
Breast Conserving Surgery ◽  
Tertiary Referral Centre ◽  
Benign Pathology ◽  
Phyllodes Tumour ◽  
Phyllodes Tumours ◽  
Tumour Characteristics

INTRODUCTION: Phyllodes tumours represent 0.3–1% of breast tumours, typically presenting in women aged 35–55 years. They are classified into benign, borderline and malignant grades and exhibit a spectrum of features. There is significant debate surrounding the optimal management of phyllodes tumour, particularly regarding appropriate margins. METHODS: This is a retrospective review of a prospectively maintained database of patients who underwent surgical management for phyllodes tumours in a single tertiary referral centre from 2007–2017. Patient demographics, tumour characteristics, surgical treatment and follow-up data were analysed. Tumour margins were classified as positive (0 mm), close (≤2 mm) and clear (>2 mm). RESULTS: A total of 57 patients underwent surgical excision of a phyllodes tumour. The Mean age was 37.7 years (range: ages 14–91) with mean follow-up of 38.5 months (range: 0.5–133 months). There were 44 (77%) benign, 4 (7%) borderline and 9 (16%) malignant phyllodes cases. 54 patients had breast conserving surgery (BCS) and 3 underwent mastectomy. 30 (53%) patients underwent re-excision of margins. The final margin status was clear in 32 (56%), close in 13 (23%) and positive in 12 (21%). During follow-up, 4 patients were diagnosed with local recurrence (2 malignant, 1 borderline and 1 benign pathology on recurrence samples). CONCLUSION: There are no clear guidelines for the surgical management and follow-up of phyllodes tumours. This study suggests that patients with malignant phyllodes and positive margins are more likely to develop local recurrence. There is a need for large prospective studies to guide the development of future guidelines.

scholarly journals Angiosarcoma of sigmoid colon with intraperitoneal bleeding: case report and literature review

2011 ◽  
Vol 93 (6) ◽  
pp. e91-e93 ◽  
Author(s):  
Tse-Hua Lo ◽  
Mu-Shiun Tsai ◽  
Tzu-An Chen
Keyword(s):  
Sigmoid Colon ◽  
Alimentary Tract ◽  
Surgical Excision ◽  
Sigmoid Colectomy ◽  
Epithelioid Cells ◽  
Spindle Cells ◽  
Choice Of Treatment ◽  
Intraperitoneal Bleeding ◽  
Immunohistochemical Studies

Primary angiosarcomas arising from the alimentary tract are rare and only a few cases have been reported in the literature. We report a case of an angiosarcoma of the sigmoid colon with intraperitoneal bleeding but not rectal bleeding. A 21-year-old female patient received a laparotomy and a mass lesion over the sigmoid colon was found with active bleeding. A sigmoid colectomy was performed as a curative resection. Grossly, the sigmoid colon contained a kidney shaped, hemorrhagic tumour from the submucosal layer extension to the antimesenteric side. Intraluminally, the mucosa of the colon was intact. Microscopic examination revealed a high grade angiosarcoma composed of fascicles of spindle cells and solid sheets of epithelioid cells. Immunohistochemical stains revealed a positive result for CD31 and the endothelial nature of the malignancy was confirmed. Smooth muscle antigens, desmins, cytokeratins AE1/AE3 and CD117 were all negative. The patient is still alive without evidence of recurrence or metastasis at a three-year follow-up appointment. Owing to the availability of immunohistochemical studies, some atypical sarcomas would now be correctly classified as angiosarcomas. Since no optimal adjuvant treatment is effective, curative surgical excision is still the best choice of treatment.

scholarly journals Successful Homoeopathic Treatment of Phyllodes Tumour: A Case Study

2021 ◽  
Vol 34 (02) ◽  
pp. 130-140
Author(s):  
Purnima Shukla ◽  
Purak Misra ◽  
Risabh Kumar Jain ◽  
Rajiv Kumar Misra
Keyword(s):  
Clinical Course ◽  
Research Centre ◽  
Subjective Improvement ◽  
Gradual Improvement ◽  
Conium Maculatum ◽  
Detailed Case ◽  
Phyllodes Tumour ◽  
Phyllodes Tumours ◽  
Over Time

AbstractPhyllodes tumours (PTs) of the breast are rare biphasic fibroepithelial neoplasm. They have potentiality to recur and metastasise. Majority of them follow a benign clinical course. We have treated one patient suffering from PT at the out-patient department of Sri Ram Medical & Homoeopathic Research Centre, Gorakhpur, India. After detailed case taking and repertorisation, first Conium maculatum and later on Phytolacca decandra and Calcarea fluorica were prescribed on the basis of individualisation to treat the case. Outcomes were assessed clinically every month for subjective improvement and objectively by ultrasonography reports at every 6-month interval. Gradual improvement was noted over time. The case has been assessed with MONARCH Inventory, which shows ‘definite’ association between the medicine and the outcome.

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