A study in scarlet
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Chapter 2 provides an overview of hemoglobin function and its physiological role in respiratory gas transport. Much of the chapter is devoted to explaining the physiological significance of cooperative oxygen binding by hemoglobin, and why it constitutes a key innovation in vertebrate evolution. The chapter explores the respiratory functions of hemoglobin under in vivo conditions in the red blood cell and its recently discovered role in regulating local blood flow via oxygen-coupled transport of vasoactive nitric oxide. Findings to date demonstrate that vertebrate hemoglobin has evolved physiologically important interactions with nitric oxide in addition to the more familiar interactions with oxygen and carbon dioxide.
2012 ◽
Vol 303
(2)
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pp. H216-H223
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1997 ◽
Vol 272
(5)
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pp. H2107-H2114
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2005 ◽
Vol 289
(2)
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pp. H916-H923
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1997 ◽
Vol 273
(5)
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pp. G1160-G1167
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2001 ◽
Vol 280
(3)
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pp. H1222-H1231
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2005 ◽
Vol 98
(2)
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pp. 151-160
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