Lung Cancer Incidence After Exposure of Rats to Low Doses of Radon: Influence of Dose Rate

1994 ◽  
Vol 56 (1-4) ◽  
pp. 93-97 ◽  
Author(s):  
J.P. Morlier ◽  
M. Morin ◽  
G. Monchaux ◽  
P. Fritsch ◽  
J.F. Pineau ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Dose Rate ◽  
Cancer Incidence ◽  
Lung Cancer Incidence ◽  
Sprague Dawley ◽  
Survival Times ◽  
Radon Exposure ◽  
Sprague Dawley Rats ◽  
Low Levels ◽  
And Control

Abstract To study the effect on lung cancer incidence of a long exposure to low levels of radon, 500 male 3-month-old Sprague-Dawley rats, were exposed to a cumulative dose of 25 WLM of radon and its daughters, 6 hours a day, 5 days a week, during 18 months. Exposure conditions were controlled in order to maintain a defined PAEC: 42 x 10-6 J.m-3 (2 WL), in the range of domestic and environmental exposures. Animals were kept until they died or given euthanasia when moribund. Mean survival times were similar in both irradiated and control groups: 828 days (SD = 169) and 830 days (SD = 137), as well as lung cancer incidence, 0.60% at 25 WLM and 0.63% for controls. The incidence of lung lesions was compared statistically with controls and those previously obtained at cumulative exposures of 25 and 50 WLM delivered over a 4-6 month period, inducing a significant increase of lung cancer, 2.2% and 3.8% respectively. Such a comparison showed a decreased lung cancer incidence related to a decrease in the dose rate for low levels of radon exposure.

scholarly journals A statewide investigation of geographic lung cancer incidence patterns and radon exposure in a low-smoking population

BMC Cancer ◽  
2018 ◽  
Vol 18 (1) ◽  
Author(s):  
Judy Y. Ou ◽  
Brynn Fowler ◽  
Qian Ding ◽  
Anne C. Kirchhoff ◽  
Lisa Pappas ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Incidence ◽  
Lung Cancer Incidence ◽  
Radon Exposure

scholarly journals Lung cancer incidence attributable to residential radon exposure in Alberta in 2012

CMAJ Open ◽  
2017 ◽  
Vol 5 (2) ◽  
pp. E529-E534 ◽  
Author(s):  
Anne Grundy ◽  
Kevin Brand ◽  
Farah Khandwala ◽  
Abbey Poirier ◽  
Sierra Tamminen ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Incidence ◽  
Lung Cancer Incidence ◽  
Radon Exposure ◽  
Residential Radon

Lung Cancer Incidence After Exposure of Rats to Low Doses of Radon: Influence of Dose Rate

1994 ◽  
Vol 56 (1-4) ◽  
pp. 93-97 ◽  
Author(s):  
J.P. Morlier ◽  
M. Morin ◽  
G. Monchaux ◽  
P. Fritsch ◽  
J.F. Pineau ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Dose Rate ◽  
Cancer Incidence ◽  
Low Doses ◽  
Lung Cancer Incidence

EFFECT OF EXPERIMENTALLY INDUCED THYROIDITIS ON BIOSYNTHESIS OF THYROXINE IN RATS

1969 ◽  
Vol 62 (1) ◽  
pp. 11-20 ◽  
Author(s):  
Colum A. Gorman ◽  
James W. Anderson ◽  
Eunice V. Flock ◽  
Charles A. Owen ◽  
Khalil G. Wakim
Keyword(s):  
Intravenous Administration ◽  
Hashimoto's Thyroiditis ◽  
Sprague Dawley ◽  
Thyroid Extract ◽  
Histologic Appearance ◽  
Gland Weight ◽  
Sprague Dawley Rats ◽  
Thyroid Glands ◽  
And Control ◽  
Experimentally Induced

ABSTRACT Thyroiditis was induced in Sprague-Dawley rats by repeated immunization with thyroid extract and Freund's adjuvant. Immunized and control animals were killed at intervals up to 6 hours after intravenous administration of 131I as iodide at 5, 8 and 10 weeks after the first injection. Radioiodinated compounds in the thyroid glands were identified chromatographically. Evidence of moderate thyroiditis was present (histologic appearance, gland weight, and protein-bound iodine-butanol-extractable iodine difference) but the rate of incorporation of radioiodide into thyroxine, the percentage of radioactivity in the gland as iodide, and the MIT/DIT ratio were not significantly different in immunized and control animals. The MIT/DIT ratio was found to vary with time after 131I administration in both immunized and control animals. These studies did not uncover a defect in organification of iodide in experimental thyroiditis similar to that described by others in humans with Hashimoto's thyroiditis.

scholarly journals Multiple air pollutant exposure and lung cancer in Tehran, Iran

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Zahra Khorrami ◽  
Mohsen Pourkhosravani ◽  
Maysam Rezapour ◽  
Koorosh Etemad ◽  
Seyed Mahmood Taghavi-Shahri ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Air Pollution ◽  
Cancer Incidence ◽  
Latent Profile Analysis ◽  
Negative Binomial ◽  
Profile Analysis ◽  
Positive Association ◽  
Air Pollutant ◽  
World Health ◽  
Lung Cancer Incidence

AbstractLung cancer is the most rapidly increasing malignancy worldwide with an estimated 2.1 million cancer cases in the latest, 2018 World Health Organization (WHO) report. The objective of this study was to investigate the association of air pollution and lung cancer, in Tehran, Iran. Residential area information of the latest registered lung cancer cases that were diagnosed between 2014 and 2016 (N = 1,850) were inquired from the population-based cancer registry of Tehran. Long-term average exposure to PM10, SO2, NO, NO2, NOX, benzene, toluene, ethylbenzene, m-xylene, p-xylene, o-xylene (BTEX), and BTEX in 22 districts of Tehran were estimated using land use regression models. Latent profile analysis (LPA) was used to generate multi-pollutant exposure profiles. Negative binomial regression analysis was used to examine the association between air pollutants and lung cancer incidence. The districts with higher concentrations for all pollutants were mostly in downtown and around the railway station. Districts with a higher concentration for NOx (IRR = 1.05, for each 10 unit increase in air pollutant), benzene (IRR = 3.86), toluene (IRR = 1.50), ethylbenzene (IRR = 5.16), p-xylene (IRR = 9.41), o-xylene (IRR = 7.93), m-xylene (IRR = 2.63) and TBTEX (IRR = 1.21) were significantly associated with higher lung cancer incidence. Districts with a higher multiple air-pollution profile were also associated with more lung cancer incidence (IRR = 1.01). Our study shows a positive association between air pollution and lung cancer incidence. This association was stronger for, respectively, p-xylene, o-xylene, ethylbenzene, benzene, m-xylene and toluene.

Do socioeconomic factors modify the effects of PM1 and SO2 on lung cancer incidence in China?

2021 ◽  
Vol 756 ◽  
pp. 143998
Author(s):  
Huagui Guo ◽  
Jing Wei ◽  
Xin Li ◽  
Hung Chak Ho ◽  
Yimeng Song ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Socioeconomic Factors ◽  
Cancer Incidence ◽  
Lung Cancer Incidence
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