Transcutaneous Bilirubin Screening Program: Nomogram for Term and Near-Term Infants

Abstract Objective We examined whether erythropoietin monotherapy improves neurodevelopmental outcomes in near-term and term infants with neonatal encephalopathy (NE) in low-middle income countries (LMICs). Methods We searched Pubmed, Embase, and Web of Science databases to identify studies that used erythropoietin (1500–12,500 units/kg/dose) or a derivative to treat NE. Results Five studies, with a total of 348 infants in LMICs, were retrieved. However, only three of the five studies met the primary outcome of death or neuro-disability at 18 months of age or later. Erythropoietin reduced the risk of death (during the neonatal period and at follow-up) or neuro-disability at 18 months or later (p < 0.05). Death or neuro-disability occurred in 27.6% of the erythropoietin group and 49.7% of the comparison group (risk ratio 0.56 (95% CI: 0.42–0.75)). Conclusion The pooled data suggest that erythropoietin monotherapy may improve outcomes after NE in LMICs where therapeutic hypothermia is not available.

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Intermodal Enhancement of Stimulus Localisation in Infants Born Prematurely

Perceptual and Motor Skills ◽

10.2466/pms.1989.69.1.43 ◽

1989 ◽

Vol 69 (1) ◽

pp. 43-50 ◽

Cited By ~ 2

Author(s):

Nigel Foreman ◽

Alistair Fielder

Keyword(s):

Visual Fields ◽

Visual Stimuli ◽

Peripheral Stimulus ◽

Term Infants ◽

Visual Enhancement ◽

Sensory Space ◽

Near Term ◽

Gestational Age At Birth ◽

Age At Birth ◽

Prematurely Born Infants

The interaction of auditory and visual modalities in the enhancement of orientation was examined in premature and near-term infants by presenting them auditory or visual stimuli or auditory-visual stimulus combinations at various positions in sensory space. In 4.5–15-mo.-olds, brisk orienting responses could be elicited to very peripheral stimulus positions but only when the stimulus consisted of a spatially coherent auditory-visual combination (i.e., where a sound and a light occurred at the same point in space). This occurred for all infants, irrespective of age or gestational age at birth. First, the result shows that infants can respond to visual stimuli at eccentric positions, beyond the supposed limits of their effective visual fields as measured by standard perimetry. Second, the result extends earlier studies showing that intersensory integration and stimulus localisation develop relatively normally in prematurely born infants. The auditory-visual enhancement test as used here may have a number of further uses and applications in the clinic and laboratory.

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Delivery room resuscitation of near-term infants: Role of the laryngeal mask airway

Resuscitation ◽

10.1016/j.resuscitation.2009.11.005 ◽

2010 ◽

Vol 81 (3) ◽

pp. 327-330 ◽

Cited By ~ 22

Author(s):

Vincenzo Zanardo ◽

Gary Weiner ◽

Massimo Micaglio ◽

Nicoletta Doglioni ◽

Ramona Buzzacchero ◽

...

Keyword(s):

Laryngeal Mask Airway ◽

Laryngeal Mask ◽

Delivery Room ◽

Term Infants ◽

Near Term

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Bovine Milk Oligosaccharides with Sialyllactose for Preterm Piglets

Nutrients ◽

10.3390/nu10101489 ◽

2018 ◽

Vol 10 (10) ◽

pp. 1489 ◽

Cited By ~ 4

Author(s):

Karina Obelitz-Ryom ◽

Amalie Rendboe ◽

Duc Nguyen ◽

Silvia Rudloff ◽

Anne Brandt ◽

...

Keyword(s):

Bacterial Colonization ◽

Bovine Milk ◽

Protective Effects ◽

Gut Development ◽

Artificial Rearing ◽

Milk Oligosaccharides ◽

Term Infants ◽

Brain Functions ◽

Near Term ◽

Dietary Treatments

Oligosaccharides support gut development and bacterial colonization in term infants, but it is unknown if they benefit preterm infants. Using preterm pigs, we investigated effects of bovine milk supplements enriched with oligosaccharides to improve gut development and colonization. Caesarean-delivered preterm pigs (n = 57) were reared for 19 days. The pigs were fed bovine milk supplemented with an oligosaccharide-enriched whey containing sialyllactose, or a heterogeneous oligosaccharide ingredient. To evaluate the influence of artificial rearing, near-term, vaginally born pigs raised by their sow (n = 12) were compared with artificially reared, caesarean-delivered near-term pigs (n = 14). In preterm pigs, the clinical outcome, gut function, gut microbiota, and systemic immunity were similar among dietary treatments. Natural rearing increased growth rates, gut functions, colon short chain fatty acid concentrations and bacterial diversity, relative to artificial rearing. In conclusion, supplements with bovine milk oligosaccharides were well tolerated, but did not improve gut maturation or clinical outcomes in artificially reared preterm piglets. Immaturity at birth, coupled with artificial rearing, may render the neonate unresponsive to the gut-protective effects of milk oligosaccharides. Whether bovine milk oligosaccharides may affect other endpoints (e.g., brain functions) in conditions of immaturity remains to be investigated.

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Predictability of transcutaneous bilirubinometry in late preterm and term infants at risk for pathological hyperbilirubinemia

Journal of Neonatal-Perinatal Medicine ◽

10.3233/npm-200486 ◽

2020 ◽

pp. 1-7

Author(s):

E. Dianova ◽

J. Fogel ◽

R.P. Verma

Keyword(s):

At Risk ◽

Serum Bilirubin Level ◽

Late Preterm ◽

Term Infants ◽

Term Neonates ◽

Transcutaneous Bilirubin ◽

Immune Mediated ◽

Positive Direct ◽

Neonatal Population ◽

Transcutaneous Bilirubinometry

BACKGROUND: The aim was to assess the predictability of transcutaneous bilirubinometry in late preterm and term neonates at risk for pathological hyperbilirubinemia, and to identify the neonatal population in which transcutaneous bilirubin most accurately predicts serum bilirubin level (SB, mg/dl). METHODS: The correlations between transcutaneous bilirubin (TCB, mg/dl) and SB in different neonatal population subsets; and between ΔTSB (TCB-SB) and relevant neonatal variables and clinical groups were analyzed. RESULTS: TCB correlated with SB (r = 0.82, p < 0.05) in the cohort (n = 350) and in population subsets (r = 0.81–0.9, p < 0.001). Black infants with gestational age (GA) >35 weeks and chronological age (CA) >3 days recorded strongest correlation (r = 0.9, p < 0.001) followed by Blacks, and non-Black infants with CA >3 days and GA >35 weeks. ΔTSB was positive in Blacks, and in infants with CA <3 days, or with no phototherapy. ΔTSB was negative in non-Blacks, in infants with positive direct Coombs test (DC+) or those receiving phototherapy. Black race [beta (SE) = 1.3(0.33), p < 0.001] had positive, while CA [beta (SE) =−1.74 (0.36), p < 0.001], DC + status [beta (SE) =−0.72 (0.25), p = 0.004] and receipt of phototherapy [beta (SE) =−0.84 (0.21), p < 0.001] each had negative correlation with ΔTSB. ΔTSB for Blacks was >Whites, Hispanics and Asians. CONCLUSION: SB is best predicted by TCB in Black infants with CA over 3 days and GA over 35 weeks. Variability in SB estimation by TCB is race, CA and immune mediated hemolysis specific.

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1323 Impact of the Near Term Infants on NICU Bed Utilization

Archives of Disease in Childhood ◽

10.1136/archdischild-2012-302724.1323 ◽

2012 ◽

Vol 97 (Suppl 2) ◽

pp. A377-A377

Author(s):

E. Abdulrahman ◽

M. A. Al-Seoud

Keyword(s):

Term Infants ◽

Near Term

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Plotting Transcutaneous Bilirubin Measurements on Specific Transcutaneous Nomogram Results in Better Prediction of Significant Hyperbilirubinemia in Healthy Term and Near-Term Newborns: A Pilot Study

Neonatology ◽

10.1159/000358373 ◽

2014 ◽

Vol 105 (4) ◽

pp. 306-311 ◽

Cited By ~ 8

Author(s):

I. Mohamed ◽

A.C. Blanchard ◽

E. Delvin ◽

J. Cousineau ◽

A. Carceller

Keyword(s):

Pilot Study ◽

Transcutaneous Bilirubin ◽

Term Newborns ◽

Near Term

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Combined effects of body position and sleep status on the cardiorespiratory stability of near-term infants

Scientific Reports ◽

10.1038/s41598-018-27212-8 ◽

2018 ◽

Vol 8 (1) ◽

Cited By ~ 4

Author(s):

Yoshihisa Oishi ◽

Hidenobu Ohta ◽

Takako Hirose ◽

Sachiko Nakaya ◽

Keiji Tsuchiya ◽

...

Keyword(s):

Body Position ◽

Combined Effects ◽

Term Infants ◽

Near Term

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Necrotizing Enterocolitis in the First 24 Hours of Life

PEDIATRICS ◽

10.1542/peds.73.4.476 ◽

1984 ◽

Vol 73 (4) ◽

pp. 476-480 ◽

Cited By ~ 2

Author(s):

Elizabeth H. Thilo ◽

Raul A. Lazarte ◽

Jacinto A. Hernandez

Keyword(s):

Birth Weight ◽

Necrotizing Enterocolitis ◽

Gestational Age ◽

Surgical Intervention ◽

Term Infants ◽

Large Size ◽

Disease Occurrence ◽

Near Term ◽

Degree Of Maturity ◽

Minute Apgar Score

Necrotizing enterocolitis (NEC) is commonly thought of as occuring in the sick premature infant, usually in the first one to two weeks of life. A review of NEC at the Children's Hospital of Denver over a 5-year period, found that 13 of 79 infants (16.1%) had onset of NEC during the first day of life. These infants were larger (mean birth weight 2,624 ± 849 g), more mature (mean gestational age 37.9 ± 2.5 weeks), and less asphyxiated as judged by Apgar scores (mean five-minute score 8.15 ± 1.07) than infants with onset of NEC after the first day of life (mean birth weight 1,519 ± 586 g, mean gestational age 32.0 ± 3.5 weeks, P < .001, and mean five-minute Apgar score 6.81 ± 1.84, P < .05). Despite their large size and degree of maturity, eight of these infants (62%) showed signs of respiratory distress; four (31%) were polycythemic; four (31%) had either a partial or double-volume exchange transfusion performed; and 11 (85%) were fed prior to developing NEC. Presenting signs of disease, occurrence of sepsis (31%), requirement for surgical intervention (62%), and mortality (30%) were similar for the two groups of infants. It is suggested that term and near-term infants who have significant illness after delivery be treated more like their premature counterparts with cautious introduction of feedings after an adequate period of stabilization.

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