Correlation Between Gut Microbiome Composition and Acute Pain Perception in Young Healthy Male Subjects

Pain Medicine ◽  
2020 ◽  
Author(s):  
Yukiko Shiro ◽  
Young-Chang Arai ◽  
Tatsunori Ikemoto ◽  
Wasa Ueda ◽  
Takahiro Ushida
Keyword(s):  
Negative Correlation ◽  
Pain Threshold ◽  
Pain Perception ◽  
Pressure Pain Threshold ◽  
Healthy Male ◽  
Perception Threshold ◽  
Psychological States ◽  
Current Perception Threshold ◽  
Male Subjects ◽  
Firmicutes Phylum

Abstract Objective Recently, there has been growing interest in the gut–brain axis because it is emerging as a player influencing the health status of the host human. It is a known fact that the gut microbiome (GM) through the gut–brain axis has been implicated in numerous diseases. We previously reported that stool condition was associated with pain perception. Stool consistency and constipation are known to be associated with GM composition. Thus, we imagine that GM composition could influence pain perception. The aim of this study was to investigate the correlations between GM composition and pain perception and psychological states in young healthy male subjects. Subjects A total of 42 healthy young male volunteers completed the present study. Methods The volunteers’ pain perceptions were assessed by pressure pain threshold, current perception threshold, temporal summation of pain, and conditioned pain modulation, and a questionnaire on psychological state was obtained. During the current perception threshold examination, we used 5, 250, and 2,000 Hz to stimulate C, Aδ, and Aβ fibers. In addition, GM composition was evaluated by using 16S rRNA analysis. Results Pressure pain threshold showed a significant and negative correlation with Bacteroidetes phylum, in contrast to a significant and positive correlation with Firmicutes phylum. Current perception threshold of Aδ and Firmicutes phylum showed a significant correlation. There was a negative correlation between anxiety state and Bifidobacterium genus. In contrast, there was no significant correlation between psychological states and pain perceptions. Conclusion The present study showed that acute pain perception was associated with GM composition in young healthy males.

scholarly journals Effect of Progressive Muscle Relaxation on Pain Threshold and Effectiveness of Footballers’ Training

2015 ◽  
Vol 16 (4) ◽  
Author(s):  
Lilianna Jaworska ◽  
Arletta Hawrylak ◽  
Bartosz Burzyński ◽  
Joanna Szczepańska-Gieracha
Keyword(s):  
Pain Threshold ◽  
Pain Perception ◽  
Muscle Relaxation ◽  
Pressure Pain Threshold ◽  
Progressive Muscle Relaxation ◽  
Relaxation Techniques ◽  
Training Methods ◽  
Lumbar Region ◽  
Perception Threshold ◽  
Pressure Therapy

AbstractPurpose. Relaxing in the athlete’s training process is underutilized. Relaxation techniques, however, should be taught from the very beginning of the footballer’s training career. The main aim of this study was to present the effect of progressive muscle relaxation on pressure pain threshold levels and the effectiveness of the footballer’s training. Methods. A sample of 32 football players participated in the therapeutic program consisting of 8 PMR sessions. Before and after applying a pressure therapy, the pain threshold in the lumbar region was measured by a dolorimeter and the Cooper test was carried out to determine the footballers’ level of endurance. Results. PMR training did not increase significantly the pain threshold level in the experimental group (p > 0.05), but it increased significantly the distance covered in the Cooper test (p = 0.04). Analysis of the Spearman rank correlation was also carried out (p = 0.81). Conclusions. PMR does not lower pain perception threshold. PMR therapy increases the distance measured by the Cooper test. In order to determine the role of PMR in injury prevention, further research is necessary.

scholarly journals Can Injuries Have a Lasting Effect on the Perception of Pain in Young, Healthy Women and Men?

2020 ◽  
pp. 194173812095316
Author(s):  
Agnieszka Maciejewska-Skrendo ◽  
Maciej Pawlak ◽  
Agata Leońska-Duniec ◽  
Alina Jurewicz ◽  
Mariusz Kaczmarczyk ◽  
...  
Keyword(s):  
Physical Activity ◽  
Pain Threshold ◽  
Pain Perception ◽  
Emotional Experience ◽  
Pressure Pain Threshold ◽  
Pain Tolerance ◽  
Female Group ◽  
Pressure Pain ◽  
Left Hand ◽  
Healthy Women

Background: Pain is a characteristic, unpleasant sensory and emotional experience associated with actual or potential tissue damage. Pain is a subjective sensation, modulated by many factors such as age, sex, emotional state, national origin, or physical activity. Moreover, it is closely associated with intense physical activity, injuries, and traumas, which can significantly modulate pain tolerance. Hypothesis: We postulate that there are correlations between past injuries, physical activity, and intensity of pain perception (pain threshold and pain tolerance) in a population of healthy men and women. Study Design: Retrospective cohort study. Level of Evidence: Level 4. Methods: A total of 302 participants aged 18 to 32 years were included. The participants were divided into 2 groups (active and inactive individuals), in accordance with the scope of physical activity they had indicated. The test of pressure pain threshold and pressure pain tolerance was performed using an algometer. Results: Active women achieved significantly higher pain threshold and pain tolerance values in all measurements on the upper limb (except for the pain threshold on the left hand) compared with inactive women. In mediation analysis, the effect of injury remained significant only for the pressure pain tolerance in the dominant arm and the left hand in the female group. In the case of men, there were no significant differences in all measurements in view of the threshold and tolerance for pain between the groups of active and inactive and between men with injuries and without injuries. Conclusion: Intense, regular physical activity is a factor modulating the perception of pain. This was demonstrated as lowered sensitivity to pain stimuli in a population of healthy women. Clinical Relevance: Injuries should be treated as an important factor modulating the perception of pain. We recommend detailed monitoring of injuries during treatment and control of pain sensation.

scholarly journals Measurement reliability of current perception threshold and pain threshold in parallel with blood sampling

2017 ◽  
Vol 3 (4) ◽  
pp. 154-159 ◽  
Author(s):  
Takahiro Ogawa ◽  
Suguru Kimoto ◽  
Yoshio Nakashima ◽  
Nobuhiko Furuse ◽  
Masanori Ono ◽  
...  
Keyword(s):  
Pain Threshold ◽  
Blood Sampling ◽  
Measurement Reliability ◽  
Perception Threshold ◽  
Current Perception Threshold

scholarly journals Pressure pain threshold and pain perception in temporomandibular disorder patients: is there any correlation?

Revista Dor ◽  
2015 ◽  
Vol 16 (1) ◽  
Author(s):  
Juliana Stuginski-Barbosa ◽  
Rafael Santos Silva ◽  
Carolina Ortigosa Cunha ◽  
Leonardo Rigoldi Bonjardim ◽  
Ana Cláudia de Castro Ferreira Conti ◽  
...  
Keyword(s):  
Pain Threshold ◽  
Pain Perception ◽  
Temporomandibular Disorder ◽  
Pressure Pain Threshold ◽  
Pressure Pain

Negative correlation between pressure-pain threshold and serum S100β levels in pre-and postmenopausal women: a cross-sectional study

Maturitas ◽  
2019 ◽  
Vol 124 ◽  
pp. 170
Author(s):  
Fernanda Vargas Ferreira ◽  
Charles Francisco Ferreira ◽  
Mona Lúcia Dall’Agno ◽  
Jéssica Zandoná ◽  
Joana Zanotti ◽  
...  
Keyword(s):  
Postmenopausal Women ◽  
Negative Correlation ◽  
Pain Threshold ◽  
Pressure Pain Threshold ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Pressure Pain

Differences in Pain Perception in Children Reporting Joint and Orofacial Muscle Pain

2013 ◽  
Vol 37 (3) ◽  
pp. 321-328 ◽  
Author(s):  
TC Chaves ◽  
H Martins Nagamine ◽  
L Mêlo de Sousa ◽  
A Siriani de Oliveira ◽  
SC Hallak Regalo ◽  
...  
Keyword(s):  
Pain Intensity ◽  
Muscle Pain ◽  
Pain Threshold ◽  
Pain Perception ◽  
Pressure Pain Threshold ◽  
Temporalis Muscle ◽  
Community Based ◽  
Orofacial Region ◽  
Manual Palpation ◽  
Mixed Pain

Purpose: To determine changes in orofacial pain perception in community-based children by assessing the pressure pain threshold (PPT) with an algometer and pain intensity by manual palpation (MP). Methods: A total of 100 children from the community aged 7 to 12 years were assessed. Thirty-eight children reported pain in the orofacial region. Of these children,10 reported joint pain (GJ), 12 reported joint and muscle pain(GJMM), 5 reported muscle pain (GMM), 11 reported pain during mastication(GMAST), and 62 reported no pain. An ANOVA (p<0.05) was used to determine the differences in pain intensity and PPT among groups. Results: Significantly higher pain intensity upon MP was observed for the temporalis muscle in the GJMM, GMAST and GJ groups compared to the remaining groups. The PPT values were significantly lower in the masseter, temporalis muscles, TMJ and thenar region in the GJMM group compared to the other groups. Conclusion: MP more accurately differentiated symptomatic subjects from symptom-free TMD subjects, and PPT values were more sensitive to the discrimination of pain in the orofacial sites assessed. In addition, the changes in perception at a larger number of sites among children reporting mixed pain may suggest the presence of a possible mechanism of central sensitization.

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