Correlation of Serum Vitamin D Levels to Vascular Access Dysfunction in Prevalent Hemodialysis

QJM ◽  
2021 ◽  
Vol 114 (Supplement_1) ◽  
Author(s):  
Mona Hosny Abdel Salam ◽  
Reem Jan Farid ◽  
Mostafa Abdelnassier Abdelgawad ◽  
Marwa Salim Youssef Ismail
Keyword(s):  
Vitamin D ◽  
Blood Flow ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Vascular Access ◽  
Serum Vitamin ◽  
International Normalized Ratio ◽  
Serum Vitamin D ◽  
Vitamin D Levels ◽  
Aspartate Transferase

Abstract Vascular access dysfunction in hemodialysis patients has been correlated to low serum vitamin D level in previous studies. Vitamin D deficiency and hepatitis C virus infection have been linked to endothelial cell dysfunction, promoting inflammatory cascade.30 negative - & 30 positive - hepatitis C virus patients on prevalent hemodialysis in Ain Shams University Hospitals, were enrolled in the study. All patients had access blood flow < 800 ml/min. For all patients we performed: complete physical examination, complete blood count, serum ferritin, ESR 1st and 2nd hours, CRP, blood urea, serum creatinine, serum albumin, total and direct bilirubin, alanine transferase, aspartate transferase, prothrombin time, International Normalized Ratio, serum calcium and phosphorus, and serum intact parathyroid hormone. Previous laboratory tests were performed using conventional methods within our hospitals laboratories. Serum vitamin Dlevel was measured by Enzyme Linked Immunosorbent Assay. Access blood flow was measured by Duplex Ultrasound. Vitamin D serum level was < 20 ng/ml within negative and positive groups with no significant difference between them. Vascular access flow was significantly lower within positive patients. Parathyroid hormone, Phosphorus, Prothrombin time, International Normalized Ratio, Alanine - and Aspartate - transferase were significantly higher within positive patients. We deduced that Vitamin D level < 20ng/ml was associated with reduced vascular access blood flow < 800 ml/min, with much more reduced access flow within hepatitis C virus positive patients. [Mona Hosny Abdel Salam, Reem Jan Farid, Mostafa Abdelnassier Abdelgawad and Marwa Salim Youssef Ismail. Correlation of Serum Vitamin D Levels to Vascular Access Dysfunction in Prevalent Hemodialysis.

scholarly journals Is there an association between vitamin D and liver fibrosis in patients with chronic hepatitis C?

2017 ◽  
Vol 54 (1) ◽  
pp. 57-59 ◽  
Author(s):  
Kalinca da Silva OLIVEIRA ◽  
Caroline BUSS ◽  
Cristiane Valle TOVO
Keyword(s):  
Vitamin D ◽  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Liver Fibrosis ◽  
Chronic Hepatitis C ◽  
Serum Vitamin ◽  
Inflammatory Activity ◽  
Serum Vitamin D ◽  
Vitamin D Levels ◽  
Study Results

ABSTRACT BACKGROUND Vitamin D is known for its immunomodulatory, anti-inflammatory and antifibrotic properties, which are quite relevant in the pathogenesis and treatment of many causes of chronic liver disease. OBJECTIVE This study aimed to evaluate the association between serum vitamin D levels and the histopathological findings in patients with chronic hepatitis C virus infection. METHODS Cross-sectional study composed of patients with chronic hepatitis C. All patients underwent vitamin D 25 dosage and anthropometric data analysis. Liver biopsy was performed in a maximum 36-month period before inclusion in the study. RESULTS Of the 74 patients included in the study, 45 (60.8%) were women, mean age was 57.03±9.24 years, and 63 (85.1%) were white. No association was observed between the serum levels of vitamin D and inflammatory activity (P=0.699) nor with the degree of liver fibrosis (P=0.269). CONCLUSION In this study, no association was observed between vitamin D and inflammatory activity, as well as the degree of liver fibrosis, in patients with chronic hepatitis C.

scholarly journals Relationship of serum vitamin D with hepatic fibrosis in patients with chronic hepatitis C

2020 ◽  
Vol 8 (10) ◽  
pp. 3618
Author(s):  
Manas Kumar Behera ◽  
Surendra Nath Swain ◽  
V. B. Abhilash ◽  
Sunit Kumar Shukla ◽  
Vinod Kumar Dixit
Keyword(s):  
Vitamin D ◽  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Serum Vitamin ◽  
Serum Vitamin D ◽  
Vitamin D Levels ◽  
Chronic Hcv ◽  
Negative Predictor ◽  
Age And Sex

Background: Serum vitamin D concentration is proposed to have an important role on outcome in patients with chronic hepatitis C virus (HCV) infection. A few studies have shown an inverse association of vitamin D level with stage of fibrosis. The aim of the present study was to verify whether serum vitamin D level is an independent predictor of significant hepatic fibrosis.Methods: Seventy-two treatment naive chronic HCV subjects and 40 healthy age and sex matched controls were included in the study. A serum vitamin D level was assessed in both HCV subjects and controls, and liver biopsy was performed in all HCV subjects to assess for stage of fibrosis.Results: Serum vitamin D levels were significantly lower HCV patients in comparison to age and sex matched controls (18.04±6.92 versus 21.53±8.2, p<0.01). Most common genotype in HCV patients was genotype 3 (62.5%) and blood transfusion was the most common mode of transmission (28%) followed by intravenous drug user (IVDU) (17%). The HCV patients with vitamin D level <20 ng/ml had higher metavir score as compared to vitamin D≥20 ng/ml (1.67±0.66 versus 2.5±0.67, p<0.001). Both univariate and multivariate analysis performed using logistic regression revealed that vitamin D<20 ng/dl is a significant negative predictor of liver fibrosis (p<0.05).Conclusions: Chronic HCV patients had significantly lower vitamin D levels as compared to healthy controls. Serum vitamin D was a negative predictor of stage of fibrosis in patients with chronic hepatitis C.

scholarly journals Correlation of serum vitamin D levels with serum levels of alkaline phosphatase.

2019 ◽  
Vol 26 (10) ◽  
pp. 1651-1654
Author(s):  
Momina Haq ◽  
Farzana Salman ◽  
Seher Obaid ◽  
Mohsina Haq ◽  
Ambreen Gul ◽  
...  
Keyword(s):  
Vitamin D ◽  
Alkaline Phosphatase ◽  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Serum Vitamin ◽  
P Value ◽  
Serum Vitamin D ◽  
Vitamin D Levels ◽  
Chronic Hepatitis C Patients

Objectives: To determine whether serum vitamin D levels are correlated with serum levels of alkaline phosphatase or not? Study Design: Case control cross sectional study. Setting: Gastroenterology unit of private teaching hospital in Peshawar. Period: From November 2015-Januaray 2016. Material and Methods: 100 participants meeting the criteria were included in the study. Fifty clinically normal young adults and fifty were non cirrhotic chronic hepatitis C patients were included in the study. Venous blood samples were taken from all the study participants and serum vitamin D levels were determined by Electro-chemiluminescence binding assay (ECLIA) and serum alkaline phosphatase was determined by Photometric Kinetics. Results: patients were divided into two groups on the basis of gender i.e.25 males and 25 females. A correlation between vitamin D and alkaline phosphatase was determined. Alkaline phosphatase was raised in the non cirrhotic chronic hepatitis C patients. Pearson correlation was applied to find out the relation between vitamin D levels and alkaline phosphatase in the two groups which had a significant relationship with a p-value of 0.01. A positive correlation between alkaline phosphatase and parathyroid hormone was found with a p value of <0.0001. Conclusion: In our study alkaline phosphate was considerably increased in chronic hepatitis C patients who might be due to underlying liver disease. In chronic liver disease the hepatocytes swell up and due to damage to the liver parenchyma the level of alkaline phosphatase increases.

scholarly journals Serum Vitamin D Levels Are Not Predictive of the Progression of Chronic Liver Disease in Hepatitis C Patients with Advanced Fibrosis

PLoS ONE ◽  
2012 ◽  
Vol 7 (2) ◽  
pp. e27144 ◽  
Author(s):  
Kathleen E. Corey ◽  
Hui Zheng ◽  
Jorge Mendez-Navarro ◽  
Aymin Delgado-Borrego ◽  
Jules L. Dienstag ◽  
...  
Keyword(s):  
Vitamin D ◽  
Liver Disease ◽  
Hepatitis C ◽  
Chronic Liver Disease ◽  
Serum Vitamin ◽  
Chronic Liver ◽  
Advanced Fibrosis ◽  
Serum Vitamin D ◽  
Vitamin D Levels

Clinical factors correlated with vitamin D deficiency in patients with obesity scheduled for bariatric surgery: A single center experience

2020 ◽  
Vol 90 (3-4) ◽  
pp. 346-352
Author(s):  
Vincenzo Pilone ◽  
Salvatore Tramontano ◽  
Carmen Cutolo ◽  
Federica Marchese ◽  
Antonio Maria Pagano ◽  
...  
Keyword(s):  
Bariatric Surgery ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Serum Vitamin ◽  
Inverse Correlation ◽  
Model Assessment ◽  
Cross Sectional ◽  
Serum Vitamin D ◽  
Female Sex ◽  
Vitamin D Levels

Abstract. We aim to assess the prevalence of vitamin D deficiency (VDD) in patients scheduled for bariatric surgery (BS), and to identify factors that might be associated with VDD. We conducted a cross-sectional observational study involving all consecutive patients scheduled for BS from 2017 to 2019. The exclusion criteria were missing data for vitamin D levels, intake of vitamin D supplements in the 3 months prior to serum vitamin D determination, and renal insufficiency. A total of 206 patients (mean age and body mass index [BMI] of 34.9 ± 10.7 years, and 44.3 ± 6.99 kg/m2, respectively) met the inclusion criteria and were enrolled for data analysis. VDD (<19.9 ng/mL), severe VDD (<10 ng/mL), and vitamin D insufficiency (20–29.9 ng/mL) were present in 68.8 %, 12.5 %, and 31.2 % of patients, respectively. A significant inverse correlation was found between vitamin D levels and initial BMI, parathyroid hormone, and homeostatic model assessment of insulin resistance (r = −0.280, p < 0.05; r = −0.407, p = 0.038; r = −0.445, p = 0.005), respectively. VDD was significantly more prevalent in patients with higher BMI [−0.413 ± 0.12, CI95 % (−0.659; −0.167), p = 0.006], whereas no significant association between hypertension [−1.005 ± 1.65, CI95 % (−4.338; 2.326), p = 0.001], and diabetes type 2 (T2D) [−0.44 ± 2.20, CI95 % (−4.876; 3.986), p = 0.841] was found. We observed significant association between female sex and levels of vitamin D [6.69 ± 2.31, CI95 % (2.06; 11.33), p = 0.006]. The present study shows that in patients scheduled for BS, VDD deficiency is common and was associated with higher BMI, and female sex.

Association of Vitamin D Levels and Other Risk Factors with Asthma Exacerbations in Children

2020 ◽  
Keyword(s):  
Risk Factors ◽  
Vitamin D ◽  
Serum Vitamin ◽  
Persistent Asthma ◽  
Food Allergies ◽  
P Value ◽  
Serum Vitamin D ◽  
Asthma Exacerbations ◽  
Vitamin D Levels ◽  
Animal Dander

Background: The risk factors for asthma exacerbations are well understood. However, the effect of vitamin D levels on number of asthma exacerbations per year is not clearly studied. The objective of the study was to find out the association of serum vitamin D levels and asthma risk factors on asthma exacerbations. Methods: In this study, ninety-nine subjects from 5 to 15 years of age were recruited at an episode of acute exacerbation. It was a cross sectional study and carried out from 2012 to 2015. Pulmonary function test was done by spirometry. Asthma exacerbation was labeled when forced expiratory volume/ forced vital capacity (FEV1/FVC) ratio was less than 80% (American Thoracic Society). Global Initiative for Asthma (GINA) guidelines were used to classify asthma into mild, moderate and severe persistent asthma. Serum vitamin D levels were measured by chemiluminescence method. Pearson Chi-square test was applied and p value (p<0.05) was considered as statistically significant. Results: Children who had exposure to animal dander had significantly lower asthma exacerbations per year (p-value <0.046). There was no significant association between vitamin D levels and number of exacerbations per years (p-value <0.099). Asthma was prevalent in girls of low socioeconomic status (SES) compared to males. However, there was no significant association between smoke, exercise, home environment, food allergies, weather, pollen and dust with asthma exacerbations. Conclusion: Low levels of vitamin D were not associated with increased number of asthma exacerbations per year. However, children exposed to animal dander had lesser number of exacerbations per year (p-value <0.046). Keywords: Asthma; Vitamin D; Children; Exacerbations, Risk factors.

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