Faculty Opinions recommendation of Decreased serum vitamin D levels in children with asthma are associated with increased corticosteroid use.

Author(s):  
Leonard Bacharier ◽  
Avraham Beigelman
2010 ◽  
Vol 37 (6) ◽  
pp. 1366-1370 ◽  
Author(s):  
I. Chinellato ◽  
M. Piazza ◽  
M. Sandri ◽  
D. G. Peroni ◽  
F. Cardinale ◽  
...  

2010 ◽  
Vol 125 (5) ◽  
pp. 995-1000 ◽  
Author(s):  
Daniel A. Searing ◽  
Yong Zhang ◽  
James R. Murphy ◽  
Pia J. Hauk ◽  
Elena Goleva ◽  
...  

2017 ◽  
Vol 4 (4) ◽  
pp. 1397
Author(s):  
Pragalatha Kumar ◽  
Aruna Gowdra ◽  
Arathi Arathi ◽  
Ananya Sampath

Background: Vitamin D deficiency has been rediscovered as a public health problem worldwide. Few studies have shown that vitamin D deficiency is associated with asthma severity. The objective of present work was to study the serum vitamin D levels and its relationship with asthma severity in children.Methods: A prospective cohort study of 100 children with asthma between the age group of 5 to 15 years and age and sex matched 40 healthy controls who had come to Indira Gandhi Institute of Child Health, Bengaluru was done. These children’s serum vitamin D levels were estimated and correlated with asthma severity.Results: A total of 100 children with asthma and 40 healthy age and sex matched controls were evaluated. The study group had lower vitamin D (34.95 ng/ml) levels as compared to the control group (57.94 ng/ml) which was statistically significant (p<0.05). 68.4% children had significantly low vitamin D levels and severe form of asthma (p value <0.001). There was also a marked rise in absolute eosinophil count in those who had low vitamin D levels (56.6%) (p-value <0.0001).Conclusions: Vitamin D deficiency is an important risk factor for asthma severity. It modifies the immune system and reduces the inflammation. In the present study, low serum vitamin D levels were significantly correlated with severe form of asthma. There was a significant rise in the absolute eosinophil count in those who exhibited deficiency of vitamin D.  


2019 ◽  
Vol 47 (5) ◽  
pp. 411-416 ◽  
Author(s):  
S. Miceli Sopo ◽  
G. Cerchiara ◽  
G. Bersani ◽  
S. Monaco ◽  
A. Romano ◽  
...  

2014 ◽  
Vol 133 (2) ◽  
pp. AB174
Author(s):  
Zeynep Tamay ◽  
Nurhan Ozcan ◽  
Firdevs Bas ◽  
Umit Turkoglu ◽  
Nermin Guler

2018 ◽  
Vol 5 (2) ◽  
pp. 520
Author(s):  
Sandeep Karanam ◽  
Soumya Reddy ◽  
Ramesh H.

Background: Asthma is a common chronic inflammatory disease of the airways, affecting around 330 million individuals worldwide. Factors like genetic predisposition, early allergen exposure, diet and vitamin D status are all proposed to influence the development and severity of asthma. Epidemiologic data suggests that low serum vitamin D (<30 ng/mL) in children with asthma is associated with more symptoms and exacerbations. The objectives of this study were to determine serum levels of vitamin D in asthmatic children (6-15 years) and to establish a relation between serum vitamin D levels and asthma control.Methods: We conducted a cross sectional observational study. A total of 60 children with asthma were studied to know the relationship between serum vitamin D levels and asthma control, assessed according to Global Initiative for Asthma guidelines (GINA).Results: Only 33.33% of children had sufficient vitamin D levels. Mean±SD vitamin D level of study population was 23.38±8.75. 45% children had well controlled asthma, 28.3% were partly controlled and 26.7% were uncontrolled. Significant (p <0.001) inverse association was found between level of asthma control and vitamin D status. Significant positive correlation was found between percent predicted forced expiratory volume in 1 second and forced vital capacity (P <0.01). Subjects with well controlled asthma had higher serum levels of 25 (OH) D than children with partially controlled or uncontrolled asthma.Conclusions: Hypovitaminosis D is frequent in children with asthma and is associated with exacerbations, decreased lung functions and severe disease.


2020 ◽  
Vol 90 (3-4) ◽  
pp. 346-352
Author(s):  
Vincenzo Pilone ◽  
Salvatore Tramontano ◽  
Carmen Cutolo ◽  
Federica Marchese ◽  
Antonio Maria Pagano ◽  
...  

Abstract. We aim to assess the prevalence of vitamin D deficiency (VDD) in patients scheduled for bariatric surgery (BS), and to identify factors that might be associated with VDD. We conducted a cross-sectional observational study involving all consecutive patients scheduled for BS from 2017 to 2019. The exclusion criteria were missing data for vitamin D levels, intake of vitamin D supplements in the 3 months prior to serum vitamin D determination, and renal insufficiency. A total of 206 patients (mean age and body mass index [BMI] of 34.9 ± 10.7 years, and 44.3 ± 6.99 kg/m2, respectively) met the inclusion criteria and were enrolled for data analysis. VDD (<19.9 ng/mL), severe VDD (<10 ng/mL), and vitamin D insufficiency (20–29.9 ng/mL) were present in 68.8 %, 12.5 %, and 31.2 % of patients, respectively. A significant inverse correlation was found between vitamin D levels and initial BMI, parathyroid hormone, and homeostatic model assessment of insulin resistance (r = −0.280, p < 0.05; r = −0.407, p = 0.038; r = −0.445, p = 0.005), respectively. VDD was significantly more prevalent in patients with higher BMI [−0.413 ± 0.12, CI95 % (−0.659; −0.167), p = 0.006], whereas no significant association between hypertension [−1.005 ± 1.65, CI95 % (−4.338; 2.326), p = 0.001], and diabetes type 2 (T2D) [−0.44 ± 2.20, CI95 % (−4.876; 3.986), p = 0.841] was found. We observed significant association between female sex and levels of vitamin D [6.69 ± 2.31, CI95 % (2.06; 11.33), p = 0.006]. The present study shows that in patients scheduled for BS, VDD deficiency is common and was associated with higher BMI, and female sex.


Background: The risk factors for asthma exacerbations are well understood. However, the effect of vitamin D levels on number of asthma exacerbations per year is not clearly studied. The objective of the study was to find out the association of serum vitamin D levels and asthma risk factors on asthma exacerbations. Methods: In this study, ninety-nine subjects from 5 to 15 years of age were recruited at an episode of acute exacerbation. It was a cross sectional study and carried out from 2012 to 2015. Pulmonary function test was done by spirometry. Asthma exacerbation was labeled when forced expiratory volume/ forced vital capacity (FEV1/FVC) ratio was less than 80% (American Thoracic Society). Global Initiative for Asthma (GINA) guidelines were used to classify asthma into mild, moderate and severe persistent asthma. Serum vitamin D levels were measured by chemiluminescence method. Pearson Chi-square test was applied and p value (p<0.05) was considered as statistically significant. Results: Children who had exposure to animal dander had significantly lower asthma exacerbations per year (p-value <0.046). There was no significant association between vitamin D levels and number of exacerbations per years (p-value <0.099). Asthma was prevalent in girls of low socioeconomic status (SES) compared to males. However, there was no significant association between smoke, exercise, home environment, food allergies, weather, pollen and dust with asthma exacerbations. Conclusion: Low levels of vitamin D were not associated with increased number of asthma exacerbations per year. However, children exposed to animal dander had lesser number of exacerbations per year (p-value <0.046). Keywords: Asthma; Vitamin D; Children; Exacerbations, Risk factors.


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