571 Evaluating Need for Follow up Polysomnograms after Adenotonsillectomy in children

Abstract Introduction Most children with Obstructive sleep apnea (OSA) undergo repeat polysomnogram (PSG) following adenotonsillectomy (T & A). Repeat PSG is often performed regardless of presence of symptoms of sleep disordered breathing after T & A. PSG data performed before and after T & A performed at our institution over past 2 years were reviewed. Data was collected on patient characteristics such as age, sex, BMI, comorbidities and AHI on pre-T & A study. Data was then analyzed looking at patient characteristics that can help predict significant OSA (AHI >5) in post T & A study. Methods Retrospective review of 50 consecutive PSGs before and after T & A performed at our institution over past 2 years was performed. Data was collected on age, sex, Obstructive AHI, BMI, O2 nadir and comorbidities to identify patient characteristics to predict significant OSA (AHI>5) in the post T & A study. Results Age range of our cohort was 2–16 years. Average age and BMI of our cohort was 5.8 years (median 5 years) and 16.6 respectively. 8 patients had significant OSA (AHI>5) in the after T & A study. AHI (>20) and increased BMI z-score at baseline was highly predictive of significant OSA (AHI>5) in the after T & A study. Conclusion Based on our data, follow up PSG is warranted if AHI is >20/hour on baseline diagnostic PSG. Similarly, high BMI z-score at baseline study is also highly predictive of significant OSA (AHI>5) in the post T & A study. Most children with associated comorbidities with mild (AHI 2–5 hour), moderate (AHI 5–10/hour) and lower end of severe OSA (AHI 10–20/hour) do not need repeat PSG after T & A unless symptoms of sleep disordered breathing are present. We are analyzing larger PSG database to identify other patient characteristics that may signal need for follow up PSG. As PSGs are expensive and time consuming, follow up PSGs should be performed only if clinical suspicion for residual OSA is high to optimize resource utilization. Support (if any):

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Rural Barriers to Surgical Care for Children With Sleep-Disordered Breathing

Otolaryngology ◽

10.1177/0194599821993383 ◽

2021 ◽

pp. 019459982199338

Author(s):

Flora Yan ◽

Dylan A. Levy ◽

Chun-Che Wen ◽

Cathy L. Melvin ◽

Marvella E. Ford ◽

...

Keyword(s):

Logistic Regression ◽

Regression Analysis ◽

Sleep Disordered Breathing ◽

Healthy Children ◽

Loss To Follow Up ◽

Cox Regression Analysis ◽

Obstructive Sleep ◽

The Impact ◽

Disordered Breathing

Objective To assess the impact of rural-urban residence on children with obstructive sleep-disordered breathing (SDB) who were candidates for tonsillectomy with or without adenoidectomy (TA). Study Design Retrospective cohort study. Setting Tertiary children’s hospital. Methods A cohort of otherwise healthy children aged 2 to 18 years with a diagnosis of obstructive SDB between April 2016 and December 2018 who were recommended TA were included. Rural-urban designation was defined by ZIP code approximation of rural-urban commuting area codes. The main outcome was association of rurality with time to TA and loss to follow-up using Cox and logistic regression analyses. Results In total, 213 patients were included (mean age 6 ± 2.9 years, 117 [55%] male, 69 [32%] rural dwelling). Rural-dwelling children were more often insured by Medicaid than private insurance ( P < .001) and had a median driving distance of 74.8 vs 16.8 miles ( P < .001) compared to urban-dwelling patients. The majority (94.9%) eventually underwent recommended TA once evaluated by an otolaryngologist. Multivariable logistic regression analysis did not reveal any significant predictors for loss to follow-up in receiving TA. Cox regression analysis that adjusted for age, sex, insurance, and race showed that rural-dwelling patients had a 30% reduction in receipt of TA over time as compared to urban-dwelling patients (hazard ratio, 0.7; 95% CI, 0.50-0.99). Conclusion Rural-dwelling patients experienced longer wait times and driving distance to TA. This study suggests that rurality should be considered a potential barrier to surgical intervention and highlights the need to further investigate geographic access as an important determinant of care in pediatric SDB.

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Quality of life of children with sleep-disordered breathing treated with adenotonsillectomy

The Journal of Laryngology & Otology ◽

10.1017/s0022215110001635 ◽

2010 ◽

Vol 125 (2) ◽

pp. 193-198 ◽

Cited By ~ 10

Author(s):

S M Powell ◽

M Tremlett ◽

D A Bosman

Keyword(s):

Quality Of Life ◽

Obstructive Sleep Apnoea ◽

Sleep Disordered Breathing ◽

Sleep Apnoea ◽

Life Assessment ◽

Effect Sizes ◽

Obstructive Sleep ◽

Disordered Breathing

AbstractObjective:To assess the quality of life of UK children with sleep-disordered breathing undergoing adenotonsillectomy, by using the Obstructive Sleep Apnoea 18 questionnaire and determining score changes and effect sizes.Design:Prospective, longitudinal study.Setting:The otolaryngology department of a university teaching hospital in Northern England.Participants:Twenty-eight children for whom adenotonsillectomy was planned as treatment for sleep-disordered breathing, and who had either a clinical history consistent with obstructive sleep apnoea or a polysomnographic diagnosis.Main outcome measure:The Obstructive Sleep Apnoea 18 questionnaire, a previously validated, disease-specific quality of life assessment tool; changes in questionnaire scores and effect sizes were assessed.Methods:The Obstructive Sleep Apnoea 18 questionnaire was administered to each child's parent pre-operatively, then again at the follow-up appointment. Questionnaire scores ranged from 1 to 7. Score changes were analysed using the paired t-test; effect sizes were calculated using 95 per cent confidence intervals.Results:Complete data were obtained for 22 children (mean age, 61 months). Ten had undergone pre-operative polysomnography. Twenty-one children underwent adenotonsillectomy (one underwent tonsillectomy). Median follow up was eight weeks (interquartile range, six to 11 weeks). Following surgery, the overall mean score improvement was 2.6 (p < 0.0001) and the mean effect size 2.4 (95 per cent confidence interval 1.9 to 2.8). There were significant improvements in each of the individual questionnaire domains, i.e. sleep disturbance (mean score change 3.9, p < 0.0001), physical suffering (2.2, p < 0.0001), emotional distress (2.0, p = 0.0001), daytime problems (1.8, p = 0.0001) and caregiver concerns (2.6, p < 0.0001).Conclusion:In these children with sleep-disordered breathing treated by adenotonsillectomy, Obstructive Sleep Apnoea 18 questionnaire results indicated significantly improved mean score changes and effect sizes across all questionnaire domains, comparing pre- and post-operative data.

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Impact of Tonsillectomy on the Life Quality of Parents to Children With Obstructive Sleep-Disordered Breathing

Otolaryngology ◽

10.1177/01945998211064188 ◽

2021 ◽

pp. 019459982110641

Author(s):

Yair Heskiau Shteinberg ◽

Netanel Eisenbach ◽

Maayan Gruber ◽

Ohad Ronen

Keyword(s):

Sleep Disordered Breathing ◽

Life Quality ◽

Control Group ◽

Healthy Children ◽

Academic Center ◽

Obstructive Sleep ◽

Before And After ◽

Obstructive Sleep Disordered Breathing ◽

Disordered Breathing

Objective Parents of children with any chronic illness may experience increased anxiety and reduced health-related quality of life (QoL). Our objective was to evaluate the change in parental QoL before vs after tonsillectomy. Our hypothesis was that pediatric tonsil surgery with or without adenoidectomy would improve parental QoL. Study Design A prospective cohort study. Setting An otolaryngology department in a tertiary academic center. Methods We enrolled parents of 79 children <5 years old. Adenotonsillectomy due to an obstructive airway indication was performed in 45 children. A group of 34 parents to healthy children served as a control group. Initially, we validated a modified version of the PAR-ENT-QoL questionnaire; then, we analyzed QoL parameters among parents of children with obstructive sleep-disordered breathing before and after surgical treatment. Results We found significant differences between the QoL score before and after surgery ( P = .003). The QoL score after surgery significantly improved and was even lower than that of the control group ( P < .001). Conclusions These results highlight the importance of timely diagnosis and treatment of children with obstructive sleep-disordered breathing, as this condition may affect not only the children themselves but also their caregivers.

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Impact of Adenotonsillectomy on Homework Performance in Children With Obstructive Sleep-Disordered Breathing

Annals of Otology Rhinology & Laryngology ◽

10.1177/00034894211062543 ◽

2021 ◽

pp. 000348942110625

Author(s):

Derek Wu ◽

Vivienne H. Au ◽

Billy Yang ◽

Sylvia J. Horne ◽

Jeremy Weedon ◽

...

Keyword(s):

Sleep Disordered Breathing ◽

Control Group ◽

Clinical Criteria ◽

Control Subjects ◽

Obstructive Sleep ◽

And Control ◽

The Impact ◽

Obstructive Sleep Disordered Breathing ◽

Disordered Breathing

Objective: As a first line treatment for pediatric obstructive sleep-disordered breathing (SDB), adenotonsillectomy (AT) has been shown to confer physiologic and neurocognitive benefits to a child. However, there is a scarcity of data on how homework performance is affected postoperatively. Our objective was to evaluate the impact of AT on homework performance in children with SDB. Methods: Children in grades 1 to 8 undergoing AT for SDB based on clinical criteria with or without preoperative polysomnography along with a control group of children undergoing surgery unrelated to the treatment of SDB were recruited. The primary outcome of interest was the differential change in homework performance between the study group and control at follow-up as measured by the validated Homework Performance Questionnaire (HPQ-P). Adjustments were made for demographics and Pediatric Sleep Questionnaire (PSQ) scores. Results: 116 AT and 47 control subjects were recruited, and follow-up data was obtained in 99 AT and 35 control subjects. There were no significant differences between the general (total) HPQ-P scores and subscale scores between the AT and control subjects at entry and there were no significant differences in the change scores (follow-up minus initial scores) between the groups. Regression modeling also demonstrated that there were no group (AT vs control) by time interactions that predicted differential improvements in the HPQ-P ( P > .10 for each model) although initial PSQ score was a significant predictor of lower HPQ-P scores for all models. Conclusions: Children with SDB experienced improvement in HPQ-P scores postoperatively, but the degree of change was not significant when compared to controls. Further studies incorporating additional educational metrics are encouraged to assess the true scholastic impact of AT in children with SDB.

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Relationship between surface tension of upper airway lining liquid and upper airway collapsibility during sleep in obstructive sleep apnea hypopnea syndrome

Journal of Applied Physiology ◽

10.1152/japplphysiol.00488.2003 ◽

2003 ◽

Vol 95 (5) ◽

pp. 1761-1766 ◽

Cited By ~ 64

Author(s):

Jason P. Kirkness ◽

Melanie Madronio ◽

Rosie Stavrinou ◽

John R. Wheatley ◽

Terence C. Amis

Keyword(s):

Surface Tension ◽

Obstructive Sleep Apnea ◽

Sleep Apnea ◽

Sleep Disordered Breathing ◽

Upper Airway ◽

Obstructive Sleep ◽

Before And After ◽

Posterior Pharynx ◽

Hypopnea Syndrome ◽

Disordered Breathing

Lowering surface tension (γ) of upper airway lining liquid (UAL) reduces upper airway opening (anesthetized humans) and closing (anesthetized rabbits) pressures. We now hypothesize that in sleeping obstructive sleep apnea hypopnea syndrome (OSAHS) patients lowering γ of UAL will enhance upper airway stability and decrease the severity of sleep-disordered breathing. Nine OSAHS patients [respiratory disturbance index (RDI): 49 ± 8 (SE) events/h, diagnostic night] participated in a two-part, one-night, polysomnography study. In the first part, upper airway closing pressures (during non-rapid eye movement sleep, Pcrit) were measured and samples of UAL (awake) were obtained before and after 2.5 ml of surfactant (Exosurf, Glaxo Smith Kline) was instilled into the posterior pharynx. The γ of UAL was determined with the use of the “pull-off” force technique. In the second part, subjects received a second application of 2.5 ml of surfactant and then slept the remainder of the night (205 ± 30 min). Instillation of surfactant decreased the γ of UAL from 60.9 ± 3.1 mN/m (control) to 45.2 ± 2.5 mN/m (surfactant group) ( n = 9, P < 0.001). Pcrit decreased from 1.19 ± 1.14 cmH2O (control) to -0.56 ± 1.15 cmH2O (surfactant group) ( n = 7, P < 0.02). Compared with the second half of diagnostic night, surfactant decreased RDI from 51 ± 8 to 35 ± 8 events/h ( n = 9, P < 0.03). The fall in RDI (ΔRDI) correlated with the fall in γ of UAL (Δγ) (ΔRDI = 1.8 × Δγ, r = 0.68, P = 0.04). Hypopneas decreased ∼50% from 42 ± 8 to 20 ± 5 events/h ( n = 9, P < 0.03, paired t-test). The γ of UAL measured the next morning remained low at 49.5 ± 2.7 mN/m ( n = 9, P < 0.001, ANOVA, compared with control). In conclusion, instillation of surfactant reduced the γ of UAL in OSAHS patients and decreased Pcrit and the occurrence of hypopneas. Therapeutic manipulation of γ of UAL may be beneficial in reducing the severity of sleep-disordered breathing in OSAHS patients.

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Follow-up and Time to Treatment in an Urban Cohort of Children with Sleep-Disordered Breathing

Otolaryngology ◽

10.1177/0194599818772035 ◽

2018 ◽

Vol 159 (2) ◽

pp. 371-378 ◽

Cited By ~ 9

Author(s):

Vandra C. Harris ◽

Anne R. Links ◽

Julia M. Kim ◽

Jonathan Walsh ◽

David E. Tunkel ◽

...

Keyword(s):

Primary Care ◽

Obstructive Sleep Apnea ◽

Sleep Apnea ◽

Sleep Disordered Breathing ◽

Loss To Follow Up ◽

Obstructive Sleep Apnea Severity ◽

Obstructive Sleep ◽

Lost To Follow Up ◽

Disordered Breathing

Objective To evaluate follow-up and timing of sleep-disordered breathing diagnosis and treatment in urban children referred from primary care. Study Design Retrospective longitudinal cohort analysis. Setting Tertiary health system. Subjects and Methods Pediatric outpatients with sleep-disordered breathing, referred from primary care for subspecialty appointment or polysomnography in 2014, followed for 2 years. Timing of polysomnography or subspecialty appointments, loss to follow-up, and sleep-disordered breathing severity were main outcomes. Chi-square and t-test identified differences in children referred for polysomnography, surgery, and loss to follow-up. Logistic regression identified predictors of loss to follow-up. Days to polysomnography or surgery were evaluated using the Kaplan-Meier estimator, with Cox regression comparing estimates by polysomnography receipt and disease severity. Results Of 216 children, 188 (87%) had public insurance. Half (109 [50%]) were lost to follow-up after primary care referral. More children were lost to follow-up when referred for polysomnography (50 [76%]) compared with subspecialty evaluation (35 [32%]; P < .001). Children referred to both polysomnography and subspecialty were more likely to be lost to follow-up (odds ratio = 2.73, 95% confidence interval = 1.29-5.78; P = .009). For children who obtained polysomnography, an asymmetric distribution of obstructive sleep apnea severity was not observed ( P = .152). Median time to polysomnography and surgery was 75 and 226 days, respectively. Obstructive sleep apnea severity did not influence time to surgery ( P = .410). Conclusion In this urban population, half of the children referred for sleep-disordered breathing evaluation are lost to follow-up from primary care. Obstructive sleep apnea severity did not predict follow-up or timeliness of treatment. These findings suggest social determinants may pose barriers to care in addition to the clinical burden of sleep-disordered breathing.

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Abstract 15777: Association Between Sleep Disordered Breathing, Obstructive Sleep Apnea and Incident Cancer: A Systematic Review and Meta-Analysis

Circulation ◽

10.1161/circ.130.suppl_2.15777 ◽

2014 ◽

Vol 130 (suppl_2) ◽

Author(s):

Ghanshyam Palamaner Subash Shantha ◽

Anita A Kumar ◽

Lawrence J Cheskin ◽

Samir B Pancholy

Keyword(s):

Obstructive Sleep Apnea ◽

Sleep Apnea ◽

Head And Neck ◽

Sleep Disordered Breathing ◽

Meta Analysis ◽

Incident Cancer ◽

Obstructive Sleep ◽

Increased Risk ◽

Disordered Breathing

Introduction: Sleep disordered breathing (SDB) and obstructive sleep apnea (OSA) increase risk for multiple morbidities such as cardiovascular events, diabetes mellitus, and hypertension. Association between SDB and incident cancer is unclear and studies that assessed this association have yielded conflicting results. Hypothesis: We systematically reviewed the literature and pooled available evidence that has associated SDP and incident cancer. Methods: Medline, Embase, Cochrane central library, and electronic databases were searched for relevant studies. Studies were included if: 1) they studied patients with SDB, and 2) reported rates of incident cancer. We excluded studies that reported cancers involving head and neck as we suspected reverse causation, since head and neck cancers can lead to SDP. Data were pooled using a random-effects model. Results: From 3522 retrieved citations, 7 observational studies were included in the review. Of these, 4 studies, representing 48,152 patients with SDB and 87,849 patients without SDB, were included in the meta-analysis. In total 6931 incident cancer cases were reported (2813 in SDB group and 4118 in non-SDB group). In the pooled analysis, patients with SDB experienced higher odds of incident cancer (OR: 1.30, 95% CI: 1.06 - 1.60, P = 0.01, I 2 : 75%, 4 included studies) compared to those without SDB. Data from 2 studies that assessed patients with OSA, showed that OSA increased risk for incident cancer at 5 years follow-up (OR: 1.90, 95% CI: 1.46 - 2.45, P < 0.001, I 2 : 0%) and 8 years follow-up (OR: 1.54, 95% CI: 1.25 - 1.88, P < 0.001, I 2 : 0%). Also, cancer risk (OR: 1.28, 95% CI: 1.09 - 1.51, P = 0.003, I 2 : 21%, 2 studies) and cancer mortality (OR: 1.84, 95% CI: 1.32 - 2.56, P = 0.003, I 2 : 0%, 2 studies) was significant only in patients with severe OSA [apnea-hypopnea index (AHI) > 30] and not in patients with mild to moderate OSA (AHI < 30). Factors namely; obesity, type of cancer, age and gender did not account for between study heterogeneity. Conclusions: SDB and OSA are associated with incident cancer. Though our study did not support the role of obesity in this association, strong mechanistic link exists, associating SDB, obesity and cancer. Future studies should assess the association between SDB and organ specific cancers.

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Sleep-disordered breathing in patients with myelomeningocele

Journal of Neurosurgery Pediatrics ◽

10.3171/2014.11.peds14314 ◽

2015 ◽

Vol 16 (1) ◽

pp. 30-35 ◽

Cited By ~ 20

Author(s):

Daxa M. Patel ◽

Brandon G. Rocque ◽

Betsy Hopson ◽

Anastasia Arynchyna ◽

E. Ralee’ Bishop ◽

...

Keyword(s):

Sleep Apnea ◽

Sleep Disordered Breathing ◽

Apnea Hypopnea Index ◽

Oxygen Supplementation ◽

Subset Analysis ◽

Obstructive Sleep ◽

Before And After ◽

Abnormal Sleep ◽

Neurosurgical Intervention ◽

Disordered Breathing

OBJECT A paucity of literature examines sleep apnea in patients with myelomeningocele, Chiari malformation Type II (CM-II), and related hydrocephalus. Even less is known about the effect of hydrocephalus treatment or CM-II decompression on sleep hygiene. This study is an exploratory analysis of sleep-disordered breathing in patients with myelomeningocele and the effects of neurosurgical treatments, in particular CM-II decompression and hydrocephalus management, on sleep organization. METHODS The authors performed a retrospective review of all patients seen in their multidisciplinary spina bifida clinic (approximately 435 patients with myelomeningocele) to evaluate polysomnographs obtained between March 1999 and July 2013. They analyzed symptoms prompting evaluation, results, and recommended interventions by using descriptive statistics. They also conducted a subset analysis of 9 children who had undergone polysomnography both before and after neurosurgical intervention. RESULTS Fifty-two patients had polysomnographs available for review. Sleep apnea was diagnosed in 81% of these patients. The most common presenting symptom was “breathing difficulties” (18 cases [43%]). Mild sleep apnea was present in 26 cases (50%), moderate in 10 (19%), and severe in 6 (12%). Among the 42 patients with abnormal sleep architecture, 30 had predominantly obstructive apneas and 12 had predominantly central apneas. The most common pulmonology-recommended intervention was adjustment of peripheral oxygen supplementation (24 cases [57%]), followed by initiation of peripheral oxygen (10 cases [24%]). In a subset analysis of 9 patients who had sleep studies before and after neurosurgical intervention, there was a trend toward a decrease in the mean number of respiratory events (from 34.8 to 15.9, p = 0.098), obstructive events (from 14.7 to 13.9, p = 0.85), and central events (from 20.1 to 2.25, p = 0.15) and in the apnea-hypopnea index (from 5.05 to 2.03, p = 0.038, not significant when corrected for multiple measures). CONCLUSIONS A large proportion of patients with myelomeningocele who had undergone polysomnography showed evidence of disordered sleep on an initial study. Furthermore, 31% of patients had moderate or severe obstructive sleep apnea. Myelomeningocele patients with an abnormal sleep structure who had undergone nonoperative treatment with peripheral oxygen supplementation showed improvement in the apnea-hypopnea index. Results in this study suggested that polysomnography in patients with myelomeningocele may present an opportunity to detect and classify sleep apnea, identify low-risk interventions, and prevent future implications of sleep-disordered breathing.

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