scholarly journals 0232 Heart Rate is Differentially Altered by Total Sleep Deprivation and Psychological Stress in Resistant vs. Vulnerable Individuals and Predicts Cognitive Performance

SLEEP ◽  
2019 ◽  
Vol 42 (Supplement_1) ◽  
pp. A95-A95
Author(s):  
Namni Goel ◽  
Laura E Dennis ◽  
Adrian J Ecker
Keyword(s):  
Heart Rate ◽  
Sleep Deprivation ◽  
Cognitive Performance ◽  
Psychological Stress ◽  
Total Sleep Deprivation

scholarly journals 0041 Heart Rate Variability Differs in Resilient vs. Vulnerable Adults from Total Sleep Deprivation and Psychological Stress and Predicts Cognitive Performance

SLEEP ◽  
2020 ◽  
Vol 43 (Supplement_1) ◽  
pp. A16-A17
Author(s):  
E M Yamazaki ◽  
K M Rosendahl-Garcia ◽  
L E MacMullen ◽  
A J Ecker ◽  
J N Kirkpatrick ◽  
...  
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Individual Differences ◽  
Sleep Deprivation ◽  
Cognitive Performance ◽  
Psychological Stress ◽  
Total Sleep Deprivation ◽  
Time Points ◽  
Significant Time ◽  
Recovery Sleep

Abstract Introduction There are substantial individual differences (resilience and vulnerability) in neurobehavioral performance from psychosocial stress and sleep loss. However, the time course of heart rate variability (HRV) across baseline, total sleep deprivation (TSD), the combination of TSD + psychological stress, and recovery has not been investigated; in addition, it remains unknown whether HRV and blood pressure (BP) differ in resilient vs. vulnerable individuals and predict individual differences in cognitive performance. Methods Thirty-one healthy adults (ages 27–53; mean±SD, 35.4±7.1y; 14 females) participated in a five-day experiment consisting of two 8h time-in-bed (TIB) baseline nights, 39h TSD, and two 8h-10h TIB recovery nights. A modified Trier Social Stress Test (TSST) induced psychological stress on the TSD day. Systolic and diastolic BP and HRV (derived from echocardiographic R-R interval) were obtained at six time points (pre-study, baseline, during TSD, during TSD after the TSST, after recovery, and post-study). Cognitively resilient (n=15) and vulnerable (n=16) groups were defined by a median split on 10-minute Psychomotor Vigilance Test (PVT) TSD performance [total lapses (>500ms response time) and errors]. Repeated measures ANOVA and post-hoc comparisons corrected for multiple testing, examined BP and HRV across time points between groups. Results HRV showed a significant time*group interaction: while resilient individuals had significantly lower HRV at pre-study compared to vulnerable individuals, their HRV increased above that of vulnerable individuals with TSD and with TSD + psychological stress. By contrast, systolic and diastolic BP did not show significant time*group interactions and did not predict cognitive vulnerability during TSD. Conclusion HRV differed between resilient and vulnerable individuals across TSD, psychological stress and recovery sleep and predicted individual differences in cognitive performance, whereby lower HRV during full-rested conditions predicted resilience to TSD and TSD + psychological stress. HRV, but not BP, is a reliable biomarker of sleep deprivation, psychological stress, and neurobehavioral vulnerability. Support NASA NNX14AN49G.

scholarly journals 0042 Stroke Volume and Cardiac Index are Differentially Altered by Total Sleep Deprivation and Psychological Stress in Resilient vs. Vulnerable Individuals and Predict Cognitive Performance

SLEEP ◽  
2020 ◽  
Vol 43 (Supplement_1) ◽  
pp. A17-A17
Author(s):  
E M Yamazaki ◽  
K M Rosendahl-Garcia ◽  
L E MacMullen ◽  
A J Ecker ◽  
J N Kirkpatrick ◽  
...  
Keyword(s):  
Cardiac Index ◽  
Stroke Volume ◽  
Sleep Deprivation ◽  
Cognitive Performance ◽  
Psychological Stress ◽  
Group Interaction ◽  
Sleep Loss ◽  
Total Sleep Deprivation ◽  
Time Points ◽  
Significant Time

Abstract Introduction Individuals show robust resilience and vulnerability in neurobehavioral performance to sleep loss and stress. For the first time, we investigated the time course of two cardiovascular measurements, stroke volume (SV) and cardiac index (CI), both derived from echocardiography, across baseline, total sleep deprivation (TSD), the combination of TSD+psychological stress, and recovery. We also determined whether these variables differ in resilient vs. vulnerable individuals and whether they predict differential vulnerability in cognitive performance. Methods Thirty-one healthy adults (ages 27–53; mean±SD, 35.4±7.1y; 14 females) participated in a five-day experiment consisting of two 8h time-in-bed (TIB) baseline nights, 39h TSD, and two 8h-10h TIB recovery nights. A modified Trier Social Stress Test (TSST) was conducted on the TSD day to induce psychological stress. Echocardiographic measures of SV and CI were obtained at six time points (pre-study, baseline, during TSD, during TSD after the TSST, after recovery, and post-study). A median split of TSD performance [total lapses (>500 ms response time) and errors] on the 10-minute Psychomotor Vigilance Test (PVT), defined cognitively resilient (n=15) and vulnerable (n=16) groups. Repeated measures ANOVA and post-hoc comparisons corrected for multiple testing, examined SV and CI across time points between groups. Results There was a significant time*group interaction for SV: cognitively resilient individuals had greater SV during the five-day experiment. In addition, in both resilient and vulnerable individuals, SV increased with TSD and with TSD+psychological stress compared with baseline. Like SV, there was a significant time*group interaction for CI: resilient individuals had greater CI at all points of the experiment. Conclusion SV and CI differed between resilient and vulnerable individuals across TSD, psychological stress and recovery sleep. Greater SV and greater CI at baseline predicted resilience to TSD and TSD+psychological stress. CI and SV are novel physiological biomarkers of sleep loss, stress, and individual differences in cognitive performance. Support NASA NNX14AN49G.

scholarly journals 0012 Peripheral MicroRNAs Are Altered by Total Sleep Deprivation and Psychological Stress and Predict Cognitive Performance in Humans

SLEEP ◽  
2018 ◽  
Vol 41 (suppl_1) ◽  
pp. A5-A6
Author(s):  
M J Zajko ◽  
D M Taylor ◽  
J Pearson-Leary ◽  
S Bhatnagar ◽  
N Goel
Keyword(s):  
Sleep Deprivation ◽  
Cognitive Performance ◽  
Psychological Stress ◽  
Total Sleep Deprivation

Caffeine and Placebo Expectation

2007 ◽  
Vol 21 (2) ◽  
pp. 91-99 ◽  
Author(s):  
Yunfeng Sun ◽  
Yinling Zhang ◽  
Ning He ◽  
Xufeng Liu ◽  
Danmin Miao
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Sleep Deprivation ◽  
Cognitive Performance ◽  
Cognitive Functions ◽  
Cardiovascular Regulation ◽  
Double Blind ◽  
Positive Effects ◽  
Pressure Tests ◽  
Healthy Males

Abstract. Caffeine placebo expectation seems to improve vigilance and cognitive performance. This study investigated the effect of caffeine and placebo expectation on vigilance and cognitive performance during 28 h sleep deprivation. Ten healthy males volunteered to take part in the double-blind, cross-over study, which required participants to complete five treatment periods of 28 h separated by 1-week wash-out intervals. The treatments were no substance (Control); caffeine 200 mg at 00:00 (C200); placebo 200 mg at 00:00 (P200); twice caffeine 200 mg at 00:00 and 04:00 (C200-C200); caffeine 200 mg at 00:00 and placebo 200 mg at 04:00 (C200-P200). Participants were told that all capsules were caffeine and given information about the effects of caffeine to increase expectation. Vigilance was assessed by a three-letter cancellation test, cognitive functions by the continuous addition test and Stroop test, and cardiovascular regulation by heart rate and blood pressure. Tests were performed bihourly from 00:00 to 10:00 of the second day. Results indicated that C200-P200 and C200-C200 were more alert (p < .05) than Control and P200. Their cognitive functions were higher (p < .05) than Control and P200. Also, C200-P200 scored higher than C200 in the letter cancellation task (p < .05). No test showed any significant differences between C200-P200 and C200-C200. The results demonstrated that the combination of caffeine 200 mg and placebo 200 mg expectation exerted prolonged positive effects on vigilance and cognitive performance.

scholarly journals 0265 Cortisol and C-Reactive Protein Fail to Predict Individual Differences in Neurobehavioral Performance Responses to Total Sleep Deprivation and Psychological Stress

SLEEP ◽  
2020 ◽  
Vol 43 (Supplement_1) ◽  
pp. A101-A101
Author(s):  
N Goel ◽  
E M Yamazaki ◽  
L E MacMullen ◽  
A J Ecker
Keyword(s):  
Individual Differences ◽  
Sleep Deprivation ◽  
Psychological Stress ◽  
Salivary Cortisol ◽  
Time Of Day ◽  
C Reactive Protein ◽  
Total Sleep Deprivation ◽  
Time Points ◽  
Reactive Protein ◽  
Recovery Sleep

Abstract Introduction Individuals show marked differential vulnerability in neurobehavioral deficits from psychosocial stress and sleep deprivation. Although changes in salivary cortisol and C-reactive protein (CRP) typically occur across total sleep deprivation (TSD) and recovery sleep, whether these biological markers during fully rested conditions predict individual differences in cognitive performance during TSD and stress remains unknown. Methods Thirty-one healthy adults (ages 27–53; mean ± SD, 35.4 ± 7.1y; 14 females) participated in a five-day experiment consisting of two 8h time-in-bed (TIB) baseline nights, followed by 39h TSD, and two 8h-10h TIB recovery nights. A modified Trier Social Stress Test (TSST) was conducted on the day of TSD to induce psychological stress. Salivary cortisol and CRP from blood were obtained at six time points during the study (pre-study, baseline, during TSD, during TSD after the TSST, after recovery, and post-study). A median split of TSD performance [total lapses (&gt;500 ms response time) and errors] on the 10-minute Psychomotor Vigilance Test (PVT) defined cognitively resilient (n=15) and cognitively vulnerable (n=16) groups. Repeated measures ANOVA and post-hoc comparisons corrected for multiple testing, examined cortisol and CRP across time points between groups. Results In both cognitively resilient and vulnerable individuals, cortisol increased with TSD compared to baseline in the morning and decreased with TSD + psychological stress in the afternoon compared to TSD alone. By contrast, there were no significant changes in CRP levels throughout the experiment. In addition, there were no significant time*group interactions in cortisol or CRP levels. Conclusion Salivary cortisol increased with TSD compared to baseline and showed a time-of-day effect with stress during TSD. Notably, cortisol and CRP did not differ between cognitively resilient and vulnerable individuals across TSD, psychological stress or recovery sleep and thus are not reliable biomarkers for predicting performance under these conditions. Support NASA NNX14AN49G.

Cognitive performance and brain activation recovery after a nap following total sleep deprivation

2019 ◽  
Vol 64 ◽  
pp. S305-S306
Author(s):  
F.B. Pomares ◽  
N. Cross ◽  
A. Jegou ◽  
A. Nguyen ◽  
A.A. Perrault ◽  
...  
Keyword(s):  
Sleep Deprivation ◽  
Cognitive Performance ◽  
Brain Activation ◽  
Total Sleep Deprivation

Prediction of response to total sleep deprivation by autonomic heart rate parameters?

1995 ◽  
Vol 37 (4) ◽  
pp. 280-282 ◽  
Author(s):  
Thomas Rechlin ◽  
Harald Hegmann ◽  
Maria Weis ◽  
Mark Stemmler ◽  
Detlef Claus ◽  
...  
Keyword(s):  
Heart Rate ◽  
Sleep Deprivation ◽  
Prediction Of Response ◽  
Total Sleep Deprivation

Effects of Total Sleep Deprivation on Cardiovascular Parameters: An Absence of Biologically Significant Findings?

2002 ◽  
Vol 16 (2) ◽  
pp. 119-126 ◽  
Author(s):  
Elena Miró ◽  
Carmen Cano ◽  
Gualberto Buela-Casal
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Sleep Deprivation ◽  
Healthy Volunteers ◽  
Repeated Measures ◽  
Clinical Relevance ◽  
Vigilance Task ◽  
Mean Values ◽  
Total Sleep Deprivation ◽  
The Third

Abstract The present study analyzes the variations of heart rate (HR) and systolic and diastolic blood pressure (SBP and DBP) during 60 h of total sleep deprivation (TSD). All variables were evaluated every 2 h in a resting condition, during the performance of a vigilance task. Thirty healthy volunteers (15 men and 15 women) from 18 to 24 years old participated in the experiment. The analyses of variance (ANOVAS) with repeated measures showed some modifications of HR and SBP mean values mainly marked by circadian oscillations. The circadian oscillations had a smaller amplitude for SBP than for HR. HR showed a slight decrease on the second night of TSD and a slight increase on the third day of TSD. SBP decreased during the first 24 h of TSD and after that maintained its values without significant changes. DBP did not show any significant variations during TSD. In addition, there were no differences in function of gender for the TSD effect on the studied variables. All these statistically significant findings, however, seem to have no biological or clinical relevance. These aspects as well as the possible relationships between our results and activation or stress levels during TSD are discussed.

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