scholarly journals Copper-Induced Stimulation of Extracellular Signal-Regulated Kinase in Trout Hepatocytes: The Role of Reactive Oxygen Species, Ca2+, and Cell Energetics and the Impact of Extracellular Signal-Regulated Kinase Signaling on Apoptosis and Necrosis

2006 ◽  
Vol 92 (2) ◽  
pp. 464-475 ◽  
Author(s):  
Muhammad Nawaz ◽  
Claudia Manzl ◽  
Veronika Lacher ◽  
Gerhard Krumschnabel
Keyword(s):  
Reactive Oxygen Species ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Kinase Signaling ◽  
Extracellular Signal Regulated Kinase ◽  
Extracellular Signal ◽  
Apoptosis And Necrosis ◽  
The Impact ◽  
Stimulation Of

scholarly journals The Pivotal Role of Reactive Oxygen Species Generation in the Hypoxia-Induced Stimulation of Adipose-Derived Stem Cells

2011 ◽  
Vol 20 (10) ◽  
pp. 1753-1761 ◽  
Author(s):  
Ji Hye Kim ◽  
So-Hyun Park ◽  
Sang Gyu Park ◽  
Joon-Seok Choi ◽  
Ying Xia ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Stem Cells ◽  
Reactive Oxygen Species Generation ◽  
Reactive Oxygen ◽  
Pivotal Role ◽  
Adipose Derived Stem Cells ◽  
Oxygen Species ◽  
Stimulation Of

scholarly journals Reactive Oxygen Species and Extracellular Signal-Regulated Kinase 1/2 Mediate Hexachlorobenzene-Induced Cell Death in FRTL-5 Rat Thyroid Cells

2013 ◽  
Vol 134 (2) ◽  
pp. 276-290 ◽  
Author(s):  
Florencia Chiappini ◽  
Carolina Pontillo ◽  
Andrea S. Randi ◽  
Laura Alvarez ◽  
Diana L. Kleiman de Pisarev
Keyword(s):  
Reactive Oxygen Species ◽  
Cell Death ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Thyroid Cells ◽  
Extracellular Signal Regulated Kinase ◽  
Extracellular Signal ◽  
Rat Thyroid

scholarly journals Genetic Association in the Maintenance of the Mitochondrial Microenvironment and Sperm Capacity

2021 ◽  
Vol 2021 ◽  
pp. 1-12
Author(s):  
Hwang I. S. Thomas ◽  
Ying-Shiuan Chen ◽  
Ching-Han Hung ◽  
Dilip Bhargava Sreerangaraja Urs ◽  
Tien-Ling Liao ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Sperm Motility ◽  
Manganese Superoxide Dismutase ◽  
Uncoupling Protein ◽  
Reactive Oxygen ◽  
Human Sperm ◽  
Oxygen Species ◽  
Genotype Frequencies ◽  
The Impact

Sperm motility is one of the major determinants of male fertility. Since sperm need a great deal of energy to support their fast movement by active metabolism, they are thus extremely vulnerable to oxidative damage by the reactive oxygen species (ROS) and other free radicals generated as byproducts in the electron transport chain. The present study is aimed at understanding the impact of a mitochondrial oxidizing/reducing microenvironment in the etiopathology of male infertility. We detected the mitochondrial DNA (mtDNA) 4,977 bp deletion in human sperm. We examined the gene mutation of ATP synthase 6 (ATPase6 m.T8993G) in ATP generation, the gene polymorphisms of uncoupling protein 2 (UCP2, G-866A) in the uncoupling of oxidative phosphorylation, the role of genes such as manganese superoxide dismutase (MnSOD, C47T) and catalase (CAT, C-262T) in the scavenging system in neutralizing reactive oxygen species, and the role of human 8-oxoguanine DNA glycosylase (hOGG1, C1245G) in 8-hydroxy-2 ′ -deoxyguanosine (8-OHdG) repair. We found that the sperm with higher motility were found to have a higher mitochondrial membrane potential and mitochondrial bioenergetics. The genotype frequencies of UCP2 G-866A, MnSOD C47T, and CAT C-262T were found to be significantly different among the fertile subjects, the infertile subjects with more than 50% motility, and the infertile subjects with less than 50% motility. A higher prevalence of the mtDNA 4,977 bp deletion was found in the subjects with impaired sperm motility and fertility. Furthermore, we found that there were significant differences between the occurrences of the mtDNA 4,977 bp deletion and MnSOD (C47T) and hOGG1 (C1245G). In conclusion, the maintenance of the mitochondrial redox microenvironment and genome integrity is an important issue in sperm motility and fertility.

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