scholarly journals Early‐Life Sickness May Predispose Individuals to Behavioral Changes Following Gut Dysbiosis in Adulthood

2018 ◽  
Vol 32 (S1) ◽  
Author(s):  
Kristyn E. Sylvia ◽  
Jessica E. Deyoe ◽  
Gregory E. Demas
Keyword(s):  
Early Life ◽  
Behavioral Changes ◽  
Gut Dysbiosis

scholarly journals A murine model of pediatric inflammatory bowel disease causes microbiota-gut-brain axis deficits in adulthood

2020 ◽  
Vol 319 (3) ◽  
pp. G361-G374 ◽  
Author(s):  
Eloisa Salvo ◽  
Patricia Stokes ◽  
Ciara E. Keogh ◽  
Ingrid Brust-Mascher ◽  
Carly Hennessey ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Early Life ◽  
Low Dose ◽  
Behavioral Deficits ◽  
Colonic Inflammation ◽  
Gut Dysbiosis ◽  
Pediatric Inflammatory Bowel Disease ◽  
Adult Mice ◽  
Inflammatory Bowel

Here we describe long-lasting impacts on the microbiota-gut-brain (MGB) axis following administration of low-dose dextran sodium sulfate (DSS) to weaning mice (P21), including gut dysbiosis, colonic inflammation, and brain/behavioral deficits in adulthood (P56). Early-life DSS leads to acute colonic inflammation, similar to adult mice; however, it results in long-lasting deficits in the MGB axis in adulthood (P56), in contrast to the transient deficits seen in adult DSS. This model highlights the unique features of pediatric inflammatory bowel disease.

scholarly journals Behavioral changes following a single episode of early-life seizures support the latent development of an autistic phenotype

2015 ◽  
Vol 44 ◽  
pp. 78-85 ◽  
Author(s):  
Paul B. Bernard ◽  
Anna M. Castano ◽  
Christy S. Beitzel ◽  
Vivian B. Carlson ◽  
Tim A. Benke
Keyword(s):  
Early Life ◽  
Behavioral Changes ◽  
Single Episode

EFFECTS OF HIGH URACIL DIET-INDUCED GUT DYSBIOSIS ON COURTSHIP BEHAVIOR IN DROSOPHILA

2020 ◽  
Vol 72 (1) ◽  
Author(s):  
Roger Garcia ◽  
Camila Salcedo ◽  
Richard C. Laughlin ◽  
Maria E. Velez-Hernandez
Keyword(s):  
Courtship Behavior ◽  
Past Research ◽  
Behavioral Changes ◽  
Ros Generation ◽  
Short Term ◽  
Gut Inflammation ◽  
Gut Dysbiosis ◽  
20 Nm ◽  
The Relationship

Abstract Past research has established that Drosophila gut inflammation via the dual oxidase (DUOX) regulatory pathway is induced by exposure to bacterial-derived uracil, which can be secreted by allochthonous and autochthonous bacteria in the midgut. However, the effects of the inflammatory response and resulting gut dysbiosis on the courtship behavior of the Drosophila host have yet to be determined. This work studies the changes in Drosophila courtship behavior resulting from diet-based exposure to uracil, a ligand for DUOX-dependent reactive oxygen species (ROS) generation in the epithelia of the midgut. The effects of a high-uracil diet on courtship behavior were determined by comparing courtship index (CI) values of flies treated with 20 nM of uracil for 16-hr (short-term) or 10-d (long-term) exposure to age-matched control flies. Although short-term uracil treatment caused no change in courtship behavior, long-term uracil treatment resulted in a significant decrease in CI. This result suggests that the underlying association for the behavioral change may be influenced by gut inflammation initiated by long-term exposure to uracil. By measuring the effects of an innate immune response such as exposure to a ligand for DUOX-dependent ROS generation on the courtship index of Drosophila, the current understanding of the relationship between gut inflammation and behavioral changes in animals can be expanded. Given that prior research has also established that the DUOX-dependent response can be found in animals ranging from Drosophila to humans, the behavioral changes observed from induction of the pathway have the potential to expand this connection in the future.

scholarly journals Neonatal hyperoxia induces gut dysbiosis and behavioral changes in adolescent mice

2021 ◽  
Vol 84 (3) ◽  
pp. 290-298
Author(s):  
Yu-Chun Lo ◽  
Kai-Yun Chen ◽  
Hsiu-Chu Chou ◽  
I-Hsuan Lin ◽  
Chung-Ming Chen
Keyword(s):  
Behavioral Changes ◽  
Gut Dysbiosis ◽  
Neonatal Hyperoxia

scholarly journals A single early-life seizure results in long-term behavioral changes in the adult Fmr1 knockout mouse

2019 ◽  
Vol 157 ◽  
pp. 106193 ◽  
Author(s):  
Samantha L. Hodges ◽  
Conner D. Reynolds ◽  
Suzanne O. Nolan ◽  
Jessica L. Huebschman ◽  
James T. Okoh ◽  
...  
Keyword(s):  
Early Life ◽  
Knockout Mouse ◽  
Behavioral Changes ◽  
Fmr1 Knockout Mouse

scholarly journals Impairment of motor coordination and interneuron migration in perinatal exposure to glufosinate-ammonium

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Kyung-Tai Kim ◽  
Ye-Jung Kwak ◽  
Su-Cheol Han ◽  
Jeong Ho Hwang
Keyword(s):  
Early Life ◽  
Motor Coordination ◽  
Cortical Development ◽  
Behavioral Changes ◽  
Perinatal Exposure ◽  
Glufosinate Ammonium ◽  
Functional Behavior ◽  
Early Life Exposure ◽  
Agricultural Weed ◽  
New Evidence

AbstractGlufosinate-ammonium (GLA) is a broad-spectrum herbicide for agricultural weed control and crop desiccation. Due to many GLA-resistant crops being developed to effectively control weeds and increase harvest yields, herbicide usage and the residual GLA in food has increased significantly. Though perinatal exposure by the residual GLA in food might affect brain development, the developmental neurotoxicity of GLA is still unclear. Therefore, this study aimed to investigate the effects of perinatal exposure to GLA on cortical development. The analysis revealed that perinatal GLA exposure altered behavioral changes in offspring, especially motor functional behavior. Moreover, perinatal GLA exposure affected cortical development, particularly by disrupting interneuron migration. These results provide new evidence that early life exposure to GLA alters cortical development.

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