scholarly journals Hydrogen Sulfide Protects Against Sepsis‐Induced Myocardial Dysfunction by Inhibiting inflammation and Endoplasmic Reticulum Stress

2019 ◽  
Vol 33 (S1) ◽  
Author(s):  
Yuming Wu ◽  
Yuhong Chen ◽  
Sheng Jin ◽  
Xu Teng ◽  
Danyang Tian
Keyword(s):  
Endoplasmic Reticulum ◽  
Hydrogen Sulfide ◽  
Endoplasmic Reticulum Stress ◽  
Myocardial Dysfunction

scholarly journals Hydrogen Sulfide Attenuated Sepsis-Induced Myocardial Dysfunction Through TLR4 Pathway and Endoplasmic Reticulum Stress

2021 ◽  
Vol 12 ◽  
Author(s):  
Yu-hong Chen ◽  
Xu Teng ◽  
Zhen-jie Hu ◽  
Dan-yang Tian ◽  
Sheng Jin ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Hydrogen Sulfide ◽  
Endoplasmic Reticulum Stress ◽  
Ventricular Function ◽  
Troponin I ◽  
Myocardial Dysfunction ◽  
Left Ventricular ◽  
Left Ventricular Ejection ◽  
Ventricular Ejection Fraction ◽  
Tnf Α

Aims: We examined the change in endogenous hydrogen sulfide (H2S) production and its role in sepsis-induced myocardial dysfunction (SIMD).Results: Significant elevations in plasma cardiac troponin I (cTnI), creatine kinase (CK), tumor necrosis factor-α (TNF-α), and interleukin-1β (IL-1β) were noted in SIMD patients, whereas left ventricular ejection fraction (LVEF), left ventricular fractional shortening (LVFS), and plasma H2S were significantly decreased relative to those in the controls. Plasma H2S was linearly related to LVEF and LVFS. Subsequently, an SIMD model was developed in mice by injecting lipopolysaccharide (LPS), and NaHS, an H2S donor, was used to elucidate the pathophysiological role of H2S. The mice showed decreased ventricular function and increased levels of TNF-α, IL-1β, cTnI, and CK after LPS injections. Toll-like receptor (TLR) 4 protein and endoplasmic reticulum stress (ERS) proteins were over expressed in the SIMD mice. All of the parameters above showed more noticeable variations in cystathionine γ-lyase knockout mice relative to those in wild type mice. The administration of NaHS could improve ventricular function and attenuate inflammation and ERS in the heart.Conclusion: Overall, these findings indicated that endogenous H2S deficiency contributed to SIMD and exogenous H2S ameliorated sepsis-induced myocardial dysfunction by suppressing inflammation and ERS via inhibition of the TLR4 pathway.

scholarly journals Hydrogen Sulfide Inhibits Cigarette Smoke-Induced Endoplasmic Reticulum Stress and Apoptosis in Bronchial Epithelial Cells

2017 ◽  
Vol 8 ◽  
Author(s):  
Fan Lin ◽  
Chengcheng Liao ◽  
Yun Sun ◽  
Jinsheng Zhang ◽  
Weiwei Lu ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Hydrogen Sulfide ◽  
Epithelial Cells ◽  
Endoplasmic Reticulum Stress ◽  
Cigarette Smoke ◽  
Bronchial Epithelial Cells ◽  
Bronchial Epithelial

Hydrogen Sulfide Attenuates Hyperhomocysteinemia-Induced Cardiomyocytic Endoplasmic Reticulum Stress in Rats

2010 ◽  
Vol 12 (9) ◽  
pp. 1079-1091 ◽  
Author(s):  
Hongling Wei ◽  
Rongyuan Zhang ◽  
Hongfang Jin ◽  
Die Liu ◽  
Xiuying Tang ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Hydrogen Sulfide ◽  
Endoplasmic Reticulum Stress

scholarly journals Hydrogen sulfide inhibits homocysteine-induced endoplasmic reticulum stress and neuronal apoptosis in rat hippocampus via upregulation of the BDNF-TrkB pathway

2014 ◽  
Vol 35 (6) ◽  
pp. 707-715 ◽  
Author(s):  
Hai-jun Wei ◽  
Jin-hua Xu ◽  
Man-hong Li ◽  
Ji-ping Tang ◽  
Wei Zou ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Hydrogen Sulfide ◽  
Endoplasmic Reticulum Stress ◽  
Neuronal Apoptosis ◽  
Rat Hippocampus

scholarly journals Hydrogen sulfide inhibits endoplasmic reticulum stress through the GRP78/mTOR pathway in rat chondrocytes subjected to oxidative stress

2021 ◽  
Vol 47 (4) ◽  
Author(s):  
Jianjun Wu ◽  
Fan Yang ◽  
Xin Zhang ◽  
Guanghua Chen ◽  
Jilong Zou ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Endoplasmic Reticulum ◽  
Hydrogen Sulfide ◽  
Endoplasmic Reticulum Stress ◽  
Mtor Pathway

scholarly journals Hydrogen sulfide treatment alleviated ventilator-induced lung injury through regulation of autophagy and endoplasmic reticulum stress

2019 ◽  
Vol 15 (13) ◽  
pp. 2872-2884 ◽  
Author(s):  
Xiaoli Ge ◽  
Jian Sun ◽  
Aihua Fei ◽  
Chengjin Gao ◽  
Shuming Pan ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Hydrogen Sulfide ◽  
Lung Injury ◽  
Endoplasmic Reticulum Stress ◽  
Ventilator Induced Lung Injury

Hydrogen sulfide suppresses endoplasmic reticulum stress-induced endothelial-to-mesenchymal transition through Src pathway

Life Sciences ◽  
2016 ◽  
Vol 144 ◽  
pp. 208-217 ◽  
Author(s):  
Ru Ying ◽  
Xiao-Qiao Wang ◽  
Ying Yang ◽  
Zhen-Jie Gu ◽  
Jing-Ting Mai ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Hydrogen Sulfide ◽  
Endoplasmic Reticulum Stress ◽  
Mesenchymal Transition ◽  
Endothelial To Mesenchymal Transition ◽  
Src Pathway

P37 Role of endoplasmic reticulum stress in the regulation endogenous hydrogen sulfide for hepatocyte apoptosis induced by LPS

Nitric Oxide ◽  
2014 ◽  
Vol 39 ◽  
pp. S27
Author(s):  
Ying-lei Ji ◽  
Yan-sha Wang ◽  
Yi-Chang Liu ◽  
Zhen-yong Gu
Keyword(s):  
Endoplasmic Reticulum ◽  
Hydrogen Sulfide ◽  
Endoplasmic Reticulum Stress ◽  
Hepatocyte Apoptosis
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