Comparative Effects of Taurine, Vitamin E and
            Nuclea latifolia
            (Stem‐Bark) Extract on Object Regonition and Anxiety on Wistar Rats Subjected to Water Immersion Restraint Stress

Abstract Background Estrogen deficiency in postmenopausal period causes severe neuroendocrine changes in brain which influences memory and other nervous functions. Anthocleista schweinfurthii is used traditionally to treat female infertility and menopause related symptoms. This study was performed to investigate the potential neuroprotective effects of aqueous extract of Anthocleista schweinfurthii on brain in a postmenopause-like model of ovariectomized Wistar rats. Methods Thirty animals were sham-operated or ovariectomized (Ovx) 84 days after surgery, six groups of five rats each were daily treated orally during 28 days with: distilled water for groups 1 (sham-operated) and 2 (Ovx), estradiol valerate (group 3) and the three doses of extracts {groups 4, 5 and 6 (Ovx)}. Biochemical and histological evaluations focused on brain. Results Compared to sham-operated control, ovariectomy decreased total protein levels in brain (p<0.01) which was increased by plant extract at the dose of 300 mg/kg (p<0.05), underlying its anabolic properties. Ovariectomy significantly decreased magnesium levels in brain (p<0.001). Anthocleista schweinfurthii increased significantly magnesium levels (p<0.01), showing its capacity to act on synaptic conduction. Ovariectomy induced oxidative stress by increasing malondialdehyde levels (p<0.05) and decreasing reduced glutathione levels (p<0.05) in brain. The plant extract exhibited antioxidative activity by reducing malondialdehyde levels and increasing glutathione levels in brain. Damage in brain structure which was caused by ovariectomy disappeared following the treatment. Conclusions Results suggest that Anthocleista schweinfurthii may have neuroprotective effects in Ovx Wistar rats by increasing total protein, magnesium levels and reducing oxidative stress in brain.

Download Full-text

Subchronic toxicity studies of aqueous leaf and stem bark extract of Irvingia gabonensis in male albino wistar rats

Comparative Clinical Pathology ◽

10.1007/s00580-017-2417-3 ◽

2017 ◽

Vol 26 (3) ◽

pp. 553-559 ◽

Cited By ~ 1

Author(s):

Chukwunonso K. Ezeasor ◽

Chigozie Chukwuma ◽

Samuel O. Ekere ◽

Patrick Abah

Keyword(s):

Wistar Rats ◽

Stem Bark ◽

Bark Extract ◽

Subchronic Toxicity ◽

Toxicity Studies ◽

Irvingia Gabonensis ◽

Stem Bark Extract

Download Full-text

Antinociceptive and Anti-Inflammatory Activities of Ethanolic Stem Bark Extract of Smilax zeylanica Linn. in Wistar Rats

Journal of Pharmaceutical Research International ◽

10.9734/jpri/2021/v33i33b31801 ◽

2021 ◽

pp. 103-113

Author(s):

Rasheed Ahemad Shaik ◽

Fazil Ahmad ◽

Mohammed Abdul Aleem

Keyword(s):

Acetic Acid ◽

Wistar Rats ◽

Ethanol Extract ◽

Stem Bark ◽

Drug Group ◽

Bark Extract ◽

Hot Plate ◽

Paw Oedema ◽

Stem Bark Extract ◽

Anti Inflammatory

Background: Smilax zeylanica Linn (Smilaceae) is a woody climbing shrub native to Asia's tropical and subtropical highlands. Traditionally, this plant has been widely used to cure a variety of ailments. Smilax zeylanica stem bark was extracted with ethanol to test its antinociceptive and anti-inflammatory properties. Objective: To study the antinociceptive and anti-inflammatory activities of ethanolic stem bark extract of Smilax zeylanica Linn. in Wistar rats. Methods: The antinociceptive activity has been assessed in mice by formalin-induced paw licking, Eddy’s hot-plate, and acetic-acid induced abdominal stretching models. Carrageenan-induced paw oedema in rats has been conducted to explore the anti-inflammatory activity. Tween 80 (10ml/kg, p.o) was given to the control group, test drug group received ethanol extract of Smilax zeylanica (EESZ) orally at doses of 200 and 400 mg/kg, and standard drugs morphine (5 mg/kg, s.c), diclofenac sodium (10 mg/kg, i.p) were injected to the standard drug group. Results: Oral administration of ethanolic extract of Smilax zeylanica (EESZ) at test doses (200 and 400 mg/kg), produced a significant decrease of the paw licking time for 2 phases (neurogenic and inflammatory) in the formalin test, upsurge of the reaction time in Eddy’s hot plate test, and significantly decreased the abdominal stretching in the acetic acid-induced writhes test. Ethanol extract of Smilax zeylanica significantly decreased the carrageenan-induced paw oedema. Conclusion: The ethanol extract of Smilax zeylanica possesses antinociceptive, anti-inflammatory activity, probably involving central and peripheral pathways

Download Full-text