scholarly journals ATP induces proliferation and neuroprotection in Swiss Webster mouse olfactory epithelium

2008 ◽  
Vol 22 (S1) ◽  
Author(s):  
Colleen Hegg ◽  
James Doherty ◽  
Sean Crudgington ◽  
Eric Jones
Keyword(s):  
Olfactory Epithelium ◽  
Swiss Webster Mouse

Methods for making stereoslides and -prints, with freeze-etched olfactory epithelium as example

1984 ◽  
Vol 42 ◽  
pp. 704-705
Author(s):  
Bert Ph. M. Menco ◽  
Ido F. Menco ◽  
Frans L.T. Verdonk
Keyword(s):  
Electron Microscope ◽  
Olfactory Epithelium ◽  
Three Dimensional ◽  
Supporting Cell ◽  
Structural Features ◽  
Extensive Study ◽  
Sprague Dawley ◽  
Freezing Method ◽  
Respiratory Epithelia ◽  
Three Dimensional Presentation

Previously we presented an extensive study of the distributions of intramembranous particles of structures in apical surfaces of nasal olfactory and respiratory epithelia of the Sprague-Dawley rat. For the same structures these distributions were compared in samples which were i) chemically fixed and cryo-protected with glycerol before cryo-fixation, after excision, and ii)ultra-rapidly frozen by means of the slam-freezing method. Since a three-dimensional presentation markedly improves visualization of structural features micrographs were presented as stereopairs. Two exposures were made by tiling the sample stage of the electron microscope 6° in either direction with an eucentric goniometer. The negatives (Agfa Pan 25 Professional) were reversed with Kodak Technical Pan Film 2415 developed in D76 1:1. The prints were made from these reversed negatives. As an example tight-junctional features of an olfactory supporting cell in a region where this cell conjoined with two other cells are presented (Fig. 1).

Bilateral Nasoseptal Rescue Flap with Olfactory Epithelium Preservation: A Prospective Study Analyzing Postoperative Olfaction and Epistaxis

2015 ◽  
Vol 76 (S 01) ◽  
Author(s):  
Chester Griffiths ◽  
Garni Barkhoudarian ◽  
Aaron Cutler ◽  
Huy Duong ◽  
Bjorn Lobo ◽  
...  
Keyword(s):  
Prospective Study ◽  
Olfactory Epithelium ◽  
A Prospective Study

Lineage analysis of the olfactory epithelium using a replication-incompetent retrovirus

1994 ◽  
Vol 19 (6) ◽  
pp. 683-693 ◽  
Author(s):  
Dale D. Hunter ◽  
Mary Caggiano ◽  
John S. Kauer
Keyword(s):  
Olfactory Epithelium ◽  
Lineage Analysis

Olfactory mucosal and neural responses in the frog

1962 ◽  
Vol 203 (2) ◽  
pp. 353-358 ◽  
Author(s):  
Maxwell Mark Mozell
Keyword(s):  
Stimulus Intensity ◽  
Olfactory Epithelium ◽  
Flow Rate ◽  
Olfactory Nerve ◽  
Neural Responses ◽  
Criterion Measure ◽  
Repeated Stimulation ◽  
Two Measures ◽  
Electrophysiological Technique

A comparatively recent electrophysiological technique for studying peripheral olfactory events is to record sustained negative potentials from the olfactory epithelium. This method is rapidly replacing the older technique of recording multifiber discharges from the olfactory nerve or bulb. Therefore, the extent to which the results from the two methods correlate with each other was studied by simultaneously recording from the nerve and from the mucosa under several conditions. Although most often parallel, some differences between the two measures were found. Their response maxima did not always temporally coincide. Their amplitudes did not always correlate. Certain stimuli reduced subsequent mucosal responses but not the neural. Repeated stimulation sometimes produced similar differences. Finally, the two responses were not linearly related as a function of stimulus intensity or flow rate. However, for reasons discussed, it is difficult to conclude that these discrepancies necessarily reflect unfavorably upon the reliability of the mucosal potential as the criterion measure of peripheral olfactory activity. Nevertheless, the mucosal potential should not be accepted unequivocally as such a criterion measure until it is more thoroughly understood.

scholarly journals Zone-specific damage of the olfactory epithelium under protein restriction

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Ayinuer Tuerdi ◽  
Shu Kikuta ◽  
Makoto Kinoshita ◽  
Teru Kamogashira ◽  
Kenji Kondo ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Olfactory Epithelium ◽  
Control Diet ◽  
Intervention Strategy ◽  
Protein Restriction ◽  
Outer Hair Cells ◽  
Basal Cells ◽  
Cell Dynamics ◽  
Age Related ◽  
Positive Effect

AbstractOxidative stress causes tissue damage, affecting age-related pathologies. Protein restriction (PR) provides a powerful intervention strategy for reducing oxidative stress, which may have a positive effect on individual organs. However, it is unknown whether PR intervention influences the olfactory system. Here, we investigated how 10 months of PR could affect the cell dynamics of the olfactory epithelium (OE) in mice. We found that PR reduced age-related loss of outer hair cells in the cochlea, providing preventive effects against age-related hearing loss. In contrast, PR resulted in reduced mature olfactory sensory neurons (OSNs), increased proliferative basal cells, and increased apoptotic OSNs in zone 1 (the only area containing neurons expressing NQO1 [quinone dehydrogenase 1]) of the OE in comparison with animals given a control diet. Substantial oxidative stress occurred in NQO1-positive cells and induced apoptotic OSNs in zone 1. These results indicate that in contrast to the positive effect on the auditory system, PR induces oxidative stress and structurally and functionally negative effects on OSNs in zone 1, which is probably involved in the bioactivation of NQO1.

scholarly journals Biopsy of the olfactory epithelium from the superior nasal septum: is it possible to obtain neurons without damaging olfaction?

2021 ◽  
Author(s):  
Ellen Cristine Duarte Garcia ◽  
Lucas de Almeida Luz ◽  
Lucas Kanieski Anzolin ◽  
José Lucas Barbosa ◽  
Richard L. Doty ◽  
...  
Keyword(s):  
Olfactory Epithelium ◽  
Nasal Septum

scholarly journals Extinction reverses olfactory fear-conditioned increases in neuron number and glomerular size

2015 ◽  
Vol 112 (41) ◽  
pp. 12846-12851 ◽  
Author(s):  
Filomene G. Morrison ◽  
Brian G. Dias ◽  
Kerry J. Ressler
Keyword(s):  
Olfactory Bulb ◽  
Learning And Memory ◽  
Olfactory Epithelium ◽  
Olfactory System ◽  
Structural Changes ◽  
Freezing Behavior ◽  
Extinction Training ◽  
Odor Stimulus ◽  
Main Olfactory Epithelium ◽  
Odor Learning

Although much work has investigated the contribution of brain regions such as the amygdala, hippocampus, and prefrontal cortex to the processing of fear learning and memory, fewer studies have examined the role of sensory systems, in particular the olfactory system, in the detection and perception of cues involved in learning and memory. The primary sensory receptive field maps of the olfactory system are exquisitely organized and respond dynamically to cues in the environment, remaining plastic from development through adulthood. We have previously demonstrated that olfactory fear conditioning leads to increased odorant-specific receptor representation in the main olfactory epithelium and in glomeruli within the olfactory bulb. We now demonstrate that olfactory extinction training specific to the conditioned odor stimulus reverses the conditioning-associated freezing behavior and odor learning-induced structural changes in the olfactory epithelium and olfactory bulb in an odorant ligand-specific manner. These data suggest that learning-induced freezing behavior, structural alterations, and enhanced neural sensory representation can be reversed in adult mice following extinction training.

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