scholarly journals Effects of Dietary Fatty Acids on Hepatic Function and Gene Expression in a Model of Hepatic Steatosis

2008 ◽  
Vol 22 (S1) ◽  
Author(s):  
Maria Monica Gonzalez ◽  
Whitney Sealls ◽  
Julia Brosnan ◽  
Paul N Black ◽  
Concetta C DiRusso
Keyword(s):  
Gene Expression ◽  
Fatty Acids ◽  
Hepatic Steatosis ◽  
Hepatic Function ◽  
Dietary Fatty Acids

scholarly journals Dietary fatty acids alter left ventricular myocardial gene expression in Wistar rats

2014 ◽  
Vol 34 (8) ◽  
pp. 694-706 ◽  
Author(s):  
Kimberly M. Jeckel ◽  
Gerrit J. Bouma ◽  
Ann M. Hess ◽  
Erin B. Petrilli ◽  
Melinda A. Frye
Keyword(s):  
Gene Expression ◽  
Fatty Acids ◽  
Wistar Rats ◽  
Left Ventricular ◽  
Dietary Fatty Acids ◽  
Myocardial Gene Expression

scholarly journals Saturated and monounsaturated fatty acids in membranes are determined by the gene expression of their metabolizing enzymes SCD1 and ELOVL6 regulated by the intake of dietary fat

2019 ◽  
Vol 59 (6) ◽  
pp. 2759-2769 ◽  
Author(s):  
Kathrin Weiss-Hersh ◽  
Ada L. Garcia ◽  
Tamás Marosvölgyi ◽  
Mónika Szklenár ◽  
Tamás Decsi ◽  
...  
Keyword(s):  
Gene Expression ◽  
Fatty Acids ◽  
Fatty Acid ◽  
Fish Oil ◽  
Hormone Receptors ◽  
Dietary Fatty Acids ◽  
Dietary Fats ◽  
Hepatic Gene Expression ◽  
Metabolizing Enzymes ◽  
Plasma Phospholipids

Abstract Purpose We investigated the effect of dietary fats on the incorporation of saturated (SAFAs) and monounsaturated dietary fatty acids (MUFAs) into plasma phospholipids and the regulation of the expression of lipid-metabolizing enzymes in the liver. Methods Mice were fed different diets containing commonly used dietary fats/oils (coconut fat, margarine, fish oil, sunflower oil, or olive oil) for 4 weeks (n = 6 per diet group). In a second experiment, mice (n = 6 per group) were treated for 7 days with synthetic ligands to activate specific nuclear hormone receptors (NHRs) and the hepatic gene expression of CYP26A1 was investigated. Hepatic gene expression of stearoyl-coenzyme A desaturase 1 (SCD1), elongase 6 (ELOVL6), and CYP26A1 was examined using quantitative real-time PCR (QRT-PCR). Fatty acid composition in mouse plasma phospholipids was analyzed by gas chromatography (GC). Results We found significantly reduced hepatic gene expression of SCD1 and ELOVL6 after the fish oil diet compared with the other diets. This resulted in reduced enzyme-specific fatty acid ratios, e.g., 18:1n9/18:0 for SCD1 and 18:0/16:0 and 18:1n7/16:1n7 for ELOVL6 in plasma phospholipids. Furthermore, CYP26A1 a retinoic acid receptor-specific target was revealed as a new player mediating the suppressive effect of fish oil-supplemented diet on SCD1 and ELOVL6 hepatic gene expression. Conclusion Plasma levels of MUFAs and SAFAs strongly reflect an altered hepatic fatty acid-metabolizing enzyme expression after supplementation with different dietary fats/oils.

scholarly journals Fatty acids, epigenetic mechanisms and chronic diseases: a systematic review

2019 ◽  
Vol 18 (1) ◽  
Author(s):  
K. González-Becerra ◽  
O. Ramos-Lopez ◽  
E. Barrón-Cabrera ◽  
J. I. Riezu-Boj ◽  
F. I. Milagro ◽  
...  
Keyword(s):  
Gene Expression ◽  
Systematic Review ◽  
Fatty Acids ◽  
Chronic Diseases ◽  
Gene Expression Regulation ◽  
Saturated Fatty Acids ◽  
Dietary Fatty Acids ◽  
Epigenetic Mechanisms ◽  
Metabolic Alterations

Abstract Background Chronic illnesses like obesity, type 2 diabetes (T2D) and cardiovascular diseases, are worldwide major causes of morbidity and mortality. These pathological conditions involve interactions between environmental, genetic, and epigenetic factors. Recent advances in nutriepigenomics are contributing to clarify the role of some nutritional factors, including dietary fatty acids in gene expression regulation. This systematic review assesses currently available information concerning the role of the different fatty acids on epigenetic mechanisms that affect the development of chronic diseases or induce protective effects on metabolic alterations. Methods A targeted search was conducted in the PubMed/Medline databases using the keywords “fatty acids and epigenetic”. The data were analyzed according to the PRISMA-P guidelines. Results Consumption fatty acids like n-3 PUFA: EPA and DHA, and MUFA: oleic and palmitoleic acid was associated with an improvement of metabolic alterations. On the other hand, fatty acids that have been associated with the presence or development of obesity, T2D, pro-inflammatory profile, atherosclerosis and IR were n-6 PUFA, saturated fatty acids (stearic and palmitic), and trans fatty acids (elaidic), have been also linked with epigenetic changes. Conclusions Fatty acids can regulate gene expression by modifying epigenetic mechanisms and consequently result in positive or negative impacts on metabolic outcomes.

scholarly journals The role of rumen-protected choline in hepatic function and performance of transition dairy cows

2016 ◽  
Vol 116 (1) ◽  
pp. 35-44 ◽  
Author(s):  
Arash Shahsavari ◽  
Michael J. D’Occhio ◽  
Rafat Al Jassim
Keyword(s):  
Gene Expression ◽  
Fatty Acids ◽  
Dairy Cows ◽  
Milk Production ◽  
Transition Period ◽  
Hepatic Function ◽  
Negative Energy ◽  
Liver Fat ◽  
Economic Losses ◽  
Negative Effects

AbstractHigh-producing dairy cows enter a period of negative energy balance during the first weeks of lactation. Energy intake is usually sufficient to cover the increase in energy requirements for fetal growth during the period before calving, but meeting the demand for energy is often difficult during the early stages of lactation. A catabolic state predominates during the transition period, leading to the mobilisation of energy reserves (NEFA and amino acids) that are utilised mainly by the liver and muscle. Increased uptake of mobilised NEFA by the liver, combined with the limited capacity of hepatocytes to either oxidise fatty acids for energy or to incorporate esterified fatty acids into VLDL results in fatty liver syndrome and ketosis. This metabolic disturbance can affect the general health, and it causes economic losses. Different nutritional strategies have been used to restrict negative effects associated with the energy challenge in transition cows. The provision of choline in the form of rumen-protected choline (RPC) can potentially improve liver function by increasing VLDL exportation from the liver. RPC increases gene expression of microsomal TAG transfer protein and APOB100 that are required for VLDL synthesis and secretion. Studies with RPC have looked at gene expression, metabolic hormones, metabolite profiles, milk production and postpartum reproduction. A reduction in liver fat and enhanced milk production has been observed with RPC supplementation. However, the effects of RPC on health and reproduction are equivocal, which could reflect the lack of sufficient dose–response studies.

Nutritional stimuli of gilthead seabream (Sparus aurata) larvae by dietary fatty acids: effects on larval performance, gene expression and neurogenesis

2015 ◽  
Vol 48 (1) ◽  
pp. 202-213 ◽  
Author(s):  
Serhat Turkmen ◽  
Pedro Luis Castro ◽  
María José Caballero ◽  
Carmen María Hernández-Cruz ◽  
Reda Saleh ◽  
...  
Keyword(s):  
Gene Expression ◽  
Fatty Acids ◽  
Sparus Aurata ◽  
Dietary Fatty Acids ◽  
Gilthead Seabream ◽  
Larval Performance

scholarly journals Modulation of hepatic steatosis by dietary fatty acids

2014 ◽  
Vol 20 (7) ◽  
pp. 1746 ◽  
Author(s):  
Alessandra Ferramosca
Keyword(s):  
Fatty Acids ◽  
Hepatic Steatosis ◽  
Dietary Fatty Acids
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