scholarly journals Effects of high protein diets and leucine supplementation on body weight regulation and energy metabolism in mice

2010 ◽  
Vol 24 (S1) ◽  
Author(s):  
Anne Noatsch ◽  
Klaus J. Petzke ◽  
Susanne Klaus
Keyword(s):  
Body Weight ◽  
Energy Metabolism ◽  
High Protein ◽  
Weight Regulation ◽  
Body Weight Regulation ◽  
Leucine Supplementation ◽  
High Protein Diets ◽  
Protein Diets

scholarly journals Contrarily to whey and high protein diets, dietary free leucine supplementation cannot reverse the lack of recovery of muscle mass after prolonged immobilization during ageing

2012 ◽  
Vol 590 (8) ◽  
pp. 2035-2049 ◽  
Author(s):  
Hugues Magne ◽  
Isabelle Savary-Auzeloux ◽  
Carole Migné ◽  
Marie-Agnès Peyron ◽  
Lydie Combaret ◽  
...  
Keyword(s):  
Muscle Mass ◽  
High Protein ◽  
Leucine Supplementation ◽  
Prolonged Immobilization ◽  
High Protein Diets ◽  
Protein Diets

scholarly journals Dietary Isoflavone-Dependent and Estradiol Replacement Effects on Body Weight in the Ovariectomized (OVX) Rat

2017 ◽  
Vol 49 (06) ◽  
pp. 457-465 ◽  
Author(s):  
Ashley Russell ◽  
Jamie Grimes ◽  
Danette Cruthirds ◽  
Joanna Westerfield ◽  
Lawren Wooten ◽  
...  
Keyword(s):  
Body Weight ◽  
Weight Gain ◽  
Energy Metabolism ◽  
Body Weight Gain ◽  
Abdominal Fat ◽  
Weight Regulation ◽  
Body Weight Regulation ◽  
Estradiol Treatment ◽  
Serum Leptin ◽  
Cytokines And Chemokines

Abstract17β-Estradiol is known to regulate energy metabolism and body weight. Ovariectomy results in body weight gain while estradiol administration results in a reversal of weight gain. Isoflavones, found in rodent chow, can mimic estrogenic effects making it crucial to understand the role of these compounds on metabolic regulation. The goal of this study is to examine the effect of dietary isoflavones on body weight regulation in the ovariectomized rat. This study will examine how dietary isoflavones can interact with estradiol treatment to affect body weight. Consistent with previous findings, animals fed an isoflavone-rich diet had decreased body weight (p<0.05), abdominal fat (p<0.05), and serum leptin levels (p<0.05) compared to animals fed an isoflavone-free diet. Estradiol replacement resulted in decreased body weight (p<0.05), abdominal fat (p<0.05), and serum leptin (p<0.05). Current literature suggests the involvement of cytokines in the inflammatory response of body weight gain. We screened a host of cytokines and chemokines that may be altered by dietary isoflavones or estradiol replacement. Serum cytokine analysis revealed significant (p<0.05) diet-dependent increases in inflammatory cytokines (keratinocyte-derived chemokine). The isoflavone-free diet in OVX rats resulted in the regulation of the following cytokines and chemokines: interleukin-10, interleukin-18, serum regulated on activation, normal T cell expressed and secreted, and monocyte chemoattractant protein-1 (p<0.05). Overall, these results reveal that estradiol treatment can have differential effects on energy metabolism and body weight regulation depending on the presence of isoflavones in rodent chow.

Body Weight Regulation, Uncoupling Proteins, and Energy Metabolism

2001 ◽  
pp. 261-281 ◽  
Author(s):  
Kiefer Daniel ◽  
Tonya Dixon ◽  
Hiroki Onuma ◽  
Wenhong Cao ◽  
Alexander Medvedev ◽  
...  
Keyword(s):  
Body Weight ◽  
Energy Metabolism ◽  
Uncoupling Proteins ◽  
Weight Regulation ◽  
Body Weight Regulation

Body Weight Regulation, Uncoupling Proteins, and Energy Metabolism

2001 ◽  
pp. 261-281
Author(s):  
Sheila Collins ◽  
Wenhong Cao ◽  
Tonya M. Dixon ◽  
Kiefer W. Daniel ◽  
Hiroki Onuma ◽  
...  
Keyword(s):  
Body Weight ◽  
Energy Metabolism ◽  
Uncoupling Proteins ◽  
Weight Regulation ◽  
Body Weight Regulation

scholarly journals Impact of dietary macronutrient profile on feline body weight is not consistent with the protein leverage hypothesis

2018 ◽  
Vol 120 (11) ◽  
pp. 1310-1318
Author(s):  
David Allaway ◽  
Carlos H. de Alvaro ◽  
Adrian Hewson-Hughes ◽  
Ruth Staunton ◽  
Penelope Morris ◽  
...  
Keyword(s):  
Body Composition ◽  
Body Weight ◽  
Energy Content ◽  
High Protein ◽  
Protein Energy ◽  
Average Loss ◽  
Metabolisable Energy ◽  
Adult Cats ◽  
High Protein Diets ◽  
Protein Diets

AbstractThe protein leverage hypothesis proposes that the need to prioritise protein intake drives excess energy intake (EI) when the dietary ratio of protein to fat and carbohydrate is reduced. We hypothesised that cats may become prone to overconsuming energy content when moderate protein diets were offered, and considered the potential influence of fat and carbohydrate on intake. To determine the effect of dietary protein and macronutrient profile (MNP) on EI, weight and body composition, cats (1–4 years) were offered food in excess of energy requirements (ER). A total of six diets were formulated, containing moderate (approximately 7 % w/w; approximately 22 % metabolisable energy (ME)) or high (approximately 10 % w/w; approximately 46 % ME) protein and varying levels of carbohydrate and fat. For 4 weeks, 120 cats were offered 100 % of their individual ER of a diet at the MNP selected by adult cats (50:40:10 protein energy ratio:fat energy ratio:carbohydrate energy ratio). EI, body weight (BW), body composition, activity and palatability were measured. Subsequently, cats were offered one of the six diets at 200 % of their individual ER for 4 weeks when measurements were repeated. Cats offered excess high protein diets had higher EI (kJ/kg) throughout, but at 4 weeks BW was not significantly different to baseline. Cats offered excess moderate protein diets reduced EI and gradually lost weight (average loss of 0·358 (99 % CI 0·388, 0·328) kg), irrespective of fat:carbohydrate and initial palatability. The data do not support the protein leverage hypothesis. Furthermore, cats were able to adapt intake of a wet diet with high protein in an overfeeding environment within 28 d.

scholarly journals Effects of high-protein diets on body weight, glycaemic control, blood lipids and blood pressure in type 2 diabetes: meta-analysis of randomised controlled trials

2013 ◽  
Vol 110 (5) ◽  
pp. 781-789 ◽  
Author(s):  
Jia-Yi Dong ◽  
Zeng-Li Zhang ◽  
Pei-Yu Wang ◽  
Li-Qiang Qin
Keyword(s):  
Blood Pressure ◽  
Type 2 Diabetes ◽  
Weight Loss ◽  
Body Weight ◽  
Meta Analysis ◽  
High Protein ◽  
Cochrane Library ◽  
High Protein Diets ◽  
Protein Diets

High-protein diets are popular for weight management, but the health effects of such diets in diabetic persons are inconclusive. The aim of the present meta-analysis was to examine the effects of high-protein diets on body weight and metabolic risk factors in patients with type 2 diabetes. We searched the PubMed and Cochrane Library databases for relevant randomised trials up to August 2012. Either a fixed- or a random-effects model was used to combine the net changes in each outcome from baseline to the end of the intervention. Overall, nine trials including a total of 418 diabetic patients met our inclusion criteria. The study duration ranged from 4 to 24 weeks. The actual intake of dietary protein ranged from 25 to 32 % of total energy in the intervention groups and from 15 to 20 % in the control groups. Compared with the control diets, high-protein diets resulted in more weight loss (pooled mean difference: − 2·08, 95 % CI − 3·25, − 0·90 kg). High-protein diets significantly decreased glycated Hb A1C (HbA1C) levels by 0·52 (95 % CI − 0·90, − 0·14) %, but did not affect the fasting blood glucose levels. There were no differences in lipid profiles. The pooled net changes in systolic and diastolic blood pressure were − 3·13 (95 % CI − 6·58, 0·32) mmHg and − 1·86 (95 % CI − 4·26, 0·56) mmHg, respectively. However, two studies reported a large influence on weight loss and HbA1C levels, respectively. In summary, high-protein diets (within 6 months) may have some beneficial effects on weight loss, HbA1C levels and blood pressure in patients with type 2 diabetes. However, further investigations are still required to draw a conclusion.

EXAMINATION OF HIGH PROTEIN DİETS EFFECTS ON BODY WEIGHT AND HEALTH

2015 ◽  
pp. 70-70
Author(s):  
Nevin ŞANLIER ◽  
Yazar Adı Yazar Soyadı ◽  
Çiğdem Ceren BAŞALAN
Keyword(s):  
Body Weight ◽  
High Protein ◽  
High Protein Diets ◽  
Protein Diets

scholarly journals High-protein diets containing different milk protein fractions differently influence energy intake and adiposity in the rat

2007 ◽  
Vol 99 (4) ◽  
pp. 739-748 ◽  
Author(s):  
Lisa Pichon ◽  
Mylene Potier ◽  
Daniel Tome ◽  
Takashi Mikogami ◽  
Benoit Laplaize ◽  
...  
Keyword(s):  
Body Weight ◽  
Energy Intake ◽  
Milk Protein ◽  
Body Weight Gain ◽  
High Protein ◽  
Lipid Ratio ◽  
Ad Libitum ◽  
Carbohydrate To Lipid Ratio ◽  
High Protein Diets ◽  
Protein Diets

This study was designed to determine whether (1) protein type and (2) the dietary carbohydrate to lipid content affected daily energy intake, body weight and adiposity in rats receiving high-protein diets ad libitum over a 25 d period. Each of the ten groups (n 8) consumed ad libitum one of the diets described below. A normal protein diet (P14C56L30, containing whole milk protein) and nine high-protein diets were used. The composition of the high-protein diets varied in terms of two parameters: macronutrient composition and protein type. Three macronutrient compositions (P55C35L10, P55C15L30 and P55L45) combined with three protein types (Milk, Whey and βLac) allowed us to test nine diets. The results show that both protein type (βLac > Whey > Milk) and the carbohydrate to lipid ratio (P55L45>P55C35L10 or P55C15L30) modulated reductions in energy intake, body weight and adiposity in rats receiving high-protein diets ad libitum, when compared with rats fed a normal diet under the same conditions. By contrast, blood lipid profiles were mainly influenced by the carbohydrate to lipid ratio (P55C15L30>P55L45 or P55C35L10). Moreover, βLac protein was also the most efficient in tending to preserve lean body mass at the expense of fat mass, and improve blood metabolism hormones (insulin, leptin). Taken together, the present results show that whey-derived protein sources, and particularly β-lactoglobulin-enriched fraction, are of considerable value because of their ability to reduce both body weight gain and the adiposity index.

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