scholarly journals Dietary Isoflavone-Dependent and Estradiol Replacement Effects on Body Weight in the Ovariectomized (OVX) Rat

2017 ◽  
Vol 49 (06) ◽  
pp. 457-465 ◽  
Author(s):  
Ashley Russell ◽  
Jamie Grimes ◽  
Danette Cruthirds ◽  
Joanna Westerfield ◽  
Lawren Wooten ◽  
...  
Keyword(s):  
Body Weight ◽  
Weight Gain ◽  
Energy Metabolism ◽  
Body Weight Gain ◽  
Abdominal Fat ◽  
Weight Regulation ◽  
Body Weight Regulation ◽  
Estradiol Treatment ◽  
Serum Leptin ◽  
Cytokines And Chemokines

Abstract17β-Estradiol is known to regulate energy metabolism and body weight. Ovariectomy results in body weight gain while estradiol administration results in a reversal of weight gain. Isoflavones, found in rodent chow, can mimic estrogenic effects making it crucial to understand the role of these compounds on metabolic regulation. The goal of this study is to examine the effect of dietary isoflavones on body weight regulation in the ovariectomized rat. This study will examine how dietary isoflavones can interact with estradiol treatment to affect body weight. Consistent with previous findings, animals fed an isoflavone-rich diet had decreased body weight (p<0.05), abdominal fat (p<0.05), and serum leptin levels (p<0.05) compared to animals fed an isoflavone-free diet. Estradiol replacement resulted in decreased body weight (p<0.05), abdominal fat (p<0.05), and serum leptin (p<0.05). Current literature suggests the involvement of cytokines in the inflammatory response of body weight gain. We screened a host of cytokines and chemokines that may be altered by dietary isoflavones or estradiol replacement. Serum cytokine analysis revealed significant (p<0.05) diet-dependent increases in inflammatory cytokines (keratinocyte-derived chemokine). The isoflavone-free diet in OVX rats resulted in the regulation of the following cytokines and chemokines: interleukin-10, interleukin-18, serum regulated on activation, normal T cell expressed and secreted, and monocyte chemoattractant protein-1 (p<0.05). Overall, these results reveal that estradiol treatment can have differential effects on energy metabolism and body weight regulation depending on the presence of isoflavones in rodent chow.

Nutritional and metabolic adaptations to prolonged sleep deprivation in the rat

1993 ◽  
Vol 264 (2) ◽  
pp. R376-R387 ◽  
Author(s):  
C. A. Everson ◽  
T. A. Wehr
Keyword(s):  
Body Weight ◽  
Sleep Deprivation ◽  
Food Consumption ◽  
Time Course ◽  
Body Weight Gain ◽  
Clinical Chemistry ◽  
Plasma Cholesterol ◽  
Skin Lesions ◽  
Weight Regulation ◽  
Body Weight Regulation

To understand how and why sleep deprivation is physically harmful, we explored the possible causal relationship between its two main effects, 1) negative energy balance and 2) a composite of symptoms that resemble protein malnutrition, both of which occur despite increased food consumption. We provided balanced diets augmented with either protein or calories (by increased fat content) to freely moving rats. Interactions between sleep deprivation symptoms and energy and protein supplies were assessed from measurements of body weight regulation, consumption of macronutrients, clinical chemistry and hematology profiles, and physical appearance. The results indicate that sleep deprivation causes malnutrition, which is secondary to increased energy expenditure. Even though food consumption remained normal in sleep-deprived rats fed a diet of high protein-to-calorie ratio, body weight loss was more than 16% of baseline, development of skin lesions was hastened, and longevity was shortened by 40% compared with sleep-deprived rats fed the calorie-augmented diet. Food consumption of the calorie-fed rats was lower during baseline than that of the protein-fed group but during sleep deprivation increased to amounts 250% of normal without net body weight gain. Despite a fat-laden diet the calorie-fed hyperphagic group did not have abnormal levels of plasma cholesterol, triglycerides, or glucose, indicating accelerated turnover of nutrients. As would be consistent with calorie malnutrition, pronounced clinical chemistry or hematological abnormalities were not found in any group. Beneficial effects of the calorie-augmented diet are attributed to 1) caloric density of fat, 2) induction of hyperphagia, and 3) efficiency of utilization of fat. We conclude that diet composition interacts strongly with sleep deprivation, affecting the time course and development of pathologies, whereas it exerted negligible influence on body weight regulation under normal conditions.

scholarly journals Role of Physical Activity and Exercise in Treating Patients with Overweight and Obesity

2018 ◽  
Vol 64 (1) ◽  
pp. 99-107 ◽  
Author(s):  
John M Jakicic ◽  
Renee J Rogers ◽  
Kelliann K Davis ◽  
Katherine A Collins
Keyword(s):  
Physical Activity ◽  
Weight Loss ◽  
Body Weight ◽  
Weight Gain ◽  
Overweight And Obesity ◽  
Current Evidence ◽  
Dietary Modification ◽  
Weight Regulation ◽  
Body Weight Regulation ◽  
Lifestyle Behavior

Abstract BACKGROUND Overweight and obesity are significant public health concerns that are linked to numerous negative health consequences. Physical activity is an important lifestyle behavior that contributes to body weight regulation. CONTENT Physical activity is inversely associated with weight gain and the incidence of obesity. Physical activity also contributes to additional weight loss when coupled with dietary modification, and it can result in modest weight loss when not coupled with dietary modification. Moreover, physical activity is associated with improved long-term weight loss and prevention of weight gain following initial weight loss. Current evidence supports that physical activity should be moderate to vigorous in intensity to influence body weight regulation. There is also a growing body of evidence that physical activity can be accumulated throughout the day in shorter periods of time rather than being performed during a structured and longer period, and that physical activity performed in this manner can be important for body weight regulation. SUMMARY The literature supports the inclusion of physical activity as an important lifestyle behavior for regulating body weight. There are multiple intervention approaches that may be effective for enhancing physical activity engagement within the context of weight control.

scholarly journals Effect of nicotine on body composition in mice

2011 ◽  
Vol 212 (3) ◽  
pp. 317-326 ◽  
Author(s):  
Michael Mangubat ◽  
Kabirullah Lutfy ◽  
Martin L Lee ◽  
Laura Pulido ◽  
David Stout ◽  
...  
Keyword(s):  
Weight Loss ◽  
Body Weight ◽  
Weight Gain ◽  
Partial Agonist ◽  
Body Weight Gain ◽  
Caloric Intake ◽  
Fat Distribution ◽  
Abdominal Fat ◽  
Chow Diet ◽  
Fat Composition

Nicotine induces weight loss in both humans and rodents consuming a regular diet; however, the effect of nicotine on body weight and fat composition in rodents consuming a high-fat diet (HFD) has not been well studied. Thus, this study examined the effect of nicotine vs saline on body weight and fat composition in mice fed with either an HFD (62% of kcal from fat) or a standard normal chow diet (NCD) for 7 weeks. Nicotine dose dependently reduced body weight gain in mice that consumed both diets, but this effect was significantly greater in mice on the HFD. Caloric intake was decreased in nicotine-treated mice. Estimates of energy intake suggested that decreased caloric intake accounted for all the reduced weight gain in mice on an NCD and 66% of the reduced weight gain on an HFD. Computed tomography analysis for fat distribution demonstrated that nicotine was effective in reducing abdominal fat in mice that consumed the HFD, with nicotine treatment leading to lower visceral fat. The effect of nicotine on weight loss in mice on an HFD was completely blocked by mecamylamine, a nonselective nicotinic acetylcholine receptor (nAChR) antagonist, but only partially blocked by the α4β2 nAChR partial agonist/antagonist, varenicline. We conclude that nicotine is effective in preventing HFD-induced weight gain and abdominal fat accumulation.

scholarly journals Pengaruh Tepung Daun Kipait (Tithonia diversifolia) dalam Pakan terhadap Performa, Persentase Karkas, Lemak Abdominal, dan Giblet Broiler

2020 ◽  
Vol 20 (2) ◽  
Author(s):  
Pajri Anwar ◽  
Jiyanto Jiyanto ◽  
Nariman Hadi ◽  
Melia Afnida Santi
Keyword(s):  
Body Weight ◽  
Weight Gain ◽  
Body Weight Gain ◽  
Relative Weight ◽  
Abdominal Fat ◽  
Feed Consumption ◽  
Tithonia Diversifolia ◽  
Feed Conversion ◽  
Leaf Meal ◽  
Dietary Treatments

ABSTRAK. Tujuan penelitian ini untuk melihat pengaruh penggunaan tepung daun kipait (Tithonia diversifolia) (TDTD) terhadap performa, persentase karkas, persentase lemak abdominal, dan bobot relatif giblet. Penelitian menggunakan 200 ekor Day Old Chick (DOC) Strain CP 707 dengan rata-rata bobot badan adalah 106,03±11,99 g/ekor. Pakan perlakuan disusun berdasarkan standar kebutuhan nutrisi broiler periode starter dan grower dan diberikan mulai umur 7 hari sampai 35 hari. Penelitian menggunakan rancangan acak lengkap dengan lima perlakuan dan empat ulangan, setiap ulangan terdiri atas 10 ekor broiler. Perlakuan dalam penelitian adalah sebagai berikut: P1: Pakan kontrol (0% TDTD); P2: Pakan mengandung 4% TDTD; P3: Pakan mengandung 6% TDTD; P4: pakan mengandung 8% TDTD; dan P5: pakan mengandung 10% TDTD. Peubah yang diukur adalah performa broiler (konsumsi pakan (g/ekor); pertambahan bobot badan (g/ekor); konversi pakan); persentase karkas, persentase lemak abdominal, bobot relatif giblet. Hasil analisis sidik ragam menunjukkan bahwa penggunaan TDTD dalam pakan signifikan (P0,05) memengaruhi konsumsi pakan namun tidak signifikan (P0,05) memengaruhi pertambahan bobot badan, konversi, persentase karkas, persentase lemak abdominal dan giblet. Kesimpulan penelitian adalah TDTD dapat digunakan di dalam pakan sebanyak 4% tanpa memengaruhi performa broiler (konsumsi pakan, pertambahan bobot badan dan konversi pakan). Kemudian penggunaan sampai 10% dapat menurunkan persentase lemak abdominal dan peningkatan persentase karkas. (Effect of feeding Mexican sunflower (Tithonia diversifolia) leaf meal on performance, carcass percentage, abdominal fat, and giblet of broilers) ABSTRACT. The research aimed to see the influence of the used of Mexican sunflower (Tithonia diversifolia) leaf meal (TDLM) on the performance, the percentage of carcasses, the percentage of abdominal fat and the relative weight of giblets. The experiment used 200 day old chick (CP 707) with an average body weight of 106.03 ± 11.99 g/bird.. The treatment diet were arranged according to the standard requirements for the starter and grower period broiler nutrition. The experimental chicken were provided dietary treatments when they were 7-day old and terminated on day 35A completely randomized design (CRD) with 5 treatments and 4 replications and 10 birds in each replication was used in this experiment. Dietary treatments were: P1= control diet (0% of TDLM); P2= diet containing 4% TDLM ; P3= diet containing 6% TDLM ; P4= diet containing 8% TDLM; and P5: diet containing 10% TDLM. Variables measured were performances (feed consumption; body weight gain and feed conversion); Percentage of carcasses, percentage of abdominal fat, relative weight giblet. The results of analysis of variance showed that the used of TDLM in the diets significant effect (P0,05) on the feed consumption, but not significantly (P0,05) affect body weight gain, feed conversion, percentage of carcasses, the percentage of abdominal fat and the relative weight of giblet.. The conclusion of this study was TDLM can be used as 4% in diets without affecting the performance, the percentage of carcasses, the percentage of abdominal fat and the relative weight of giblet. Then the use of up to 10% can reduced the percentage of abdominal fat and increase the percentage of carcasses.

Body Weight Regulation, Uncoupling Proteins, and Energy Metabolism

2001 ◽  
pp. 261-281 ◽  
Author(s):  
Kiefer Daniel ◽  
Tonya Dixon ◽  
Hiroki Onuma ◽  
Wenhong Cao ◽  
Alexander Medvedev ◽  
...  
Keyword(s):  
Body Weight ◽  
Energy Metabolism ◽  
Uncoupling Proteins ◽  
Weight Regulation ◽  
Body Weight Regulation
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