Body mass index and serum vitamin D levels in Cuban, African, and Haitian Americans with type 2 diabetes (1029.7)

Background: The 21st century has seen the rise of diabetes mellitus as one of the major metabolic issues as is vitamin D deficiency which has been found to be pandemic worldwide. The present study is an endeavor to study the status of serum vitamin D levels in relation to the glycemic and insulin resistance status in type 2 diabetes mellitus patients.Methods: The present is a cross-sectional study with a sample size of 100 type 2 diabetic subjects in the age group of 30-60 years. Serum vitamin D and Insulin levels were estimated using the ELISA technique. HbA1c levels were measured using immunoturbidimetric assays and plasma glucose levels were determined using glucose oxidase- peroxidase method.Results: The fasting plasma glucose, HbA1c and serum insulin levels were found to be significantly higher in those with vitamin D levels below the normal cut-off value of less than 30ng/ml (p value <0.01). Also, the insulin resistance calculated using HOMA-IR was found to be higher in those subjects having vitamin D deficiency or insufficiency.Conclusions: Hence, the study suggests that vitamin D deficiency contributes to further insulin resistance and poorer long-term diabetic control in type 2 diabetes mellitus subjects.

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COMBINATORIAL EFFECT OF LEPTIN, TUMOR NECROSIS FACTOR-ΑLPHA, AND VITAMIN D IN PROGRESSION OF TYPE 2 DIABETES IN KASHMIRI POPULATION

Asian Journal of Pharmaceutical and Clinical Research ◽

10.22159/ajpcr.2018.v11i10.28097 ◽

2018 ◽

Vol 11 (10) ◽

pp. 477 ◽

Cited By ~ 1

Author(s):

Sabhiya Majid ◽

Fouzia Rashid ◽

Ishrat Hussain ◽

Rakesh K Koul ◽

Jasiya Qadir ◽

...

Keyword(s):

Type 2 Diabetes ◽

Vitamin D ◽

Tumor Necrosis ◽

Serum Vitamin ◽

Healthy Controls ◽

Serum Vitamin D ◽

Vitamin D Levels ◽

Tnf Α ◽

Necrosis Factor

Objectives: Type 2 diabetes mellitus (T2DM) is a metabolic disorder usually characterized by hyperglycemia. Adipose tissue secretes bioactive substances known as adipocytokines including leptin, tumor necrosis factor-alpha (TNF-α), and adiponectin. These are considered as a bridge connecting obesity and insulin resistance. There is considerable epidemiological evidence to suggest a role of Vitamin D deficiency in the etiology of T2DM. This study was performed to evaluate and compare serum Vitamin D and adipocytokine levels in T2DM patients and healthy controls of Jammu and Kashmir region of India.Methods: A total of 200 T2DM patients and normal 200 healthy controls were considered for the study. Enzyme-linked immunosorbent assay was used to measure serum leptin and TNF-α levels. The Vitamin D levels were measured by chemiluminescent microparticle immunoassay method. Biochemical parameters were measured by the enzymatic method.Results: Our results concluded that basic metabolic parameters, TNF-α and leptin levels were significantly higher in cases than controls. The serum Vitamin D levels were found significantly lower among T2DM patients. No correlation of Vitamin D with leptin was observed in cases and controls. However, a positive correlation between leptin and TNF-α was noted in T2DM subjects as well as in controls with statistical significance being higher in females (r=0.500; p=0.001) as compared to males (r=0.298; p=0.036) in T2DM subjects as well as in controls (r=0.659; p=0.001; r=0.621; p=001).Conclusion: These results concluded that lowering of Vitamin D levels and upregulation of leptin and TNF-α altogether play an important role in the development of T2DM, and from correlation analysis, it could be predicted that leptin and TNF-α act in a synergistic manner toward the development of T2DM.

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Association of serum vitamin D levels and diabetic retinopathy in Asian Indians with type 2 diabetes

Diabetes Research and Clinical Practice ◽

10.1016/j.diabres.2018.02.040 ◽

2018 ◽

Vol 139 ◽

pp. 308-313 ◽

Cited By ~ 5

Author(s):

Beteal Ashinne ◽

Ramachandran Rajalakshmi ◽

Ranjit M. Anjana ◽

K.M. Venkat Narayan ◽

Ramamoorthy Jayashri ◽

...

Keyword(s):

Type 2 Diabetes ◽

Vitamin D ◽

Diabetic Retinopathy ◽

Asian Indians ◽

Serum Vitamin ◽

Serum Vitamin D ◽

Vitamin D Levels

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PR077: The impact of serum vitamin D levels on GCF 25(OH)D and 1,25(OH)2D3 levels in chronic periodontitis patients diagnosed with well-controlled type-2 diabetes mellitus

Journal Of Clinical Periodontology ◽

10.1111/jcpe.76_12915 ◽

2018 ◽

Vol 45 ◽

pp. 145-145

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Vitamin D ◽

Type 2 Diabetes Mellitus ◽

Chronic Periodontitis ◽

Serum Vitamin ◽

Serum Vitamin D ◽

Vitamin D Levels ◽

The Impact

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Serum Vitamin D Levels in Persons with Type 2 Diabetes Mellitus in Lagos, Nigeria

International Journal of Diabetes and Clinical Research ◽

10.23937/2377-3634/1410133 ◽

2020 ◽

Vol 7 (4) ◽

Author(s):

AC Anyanwu ◽

OB Olopade ◽

SI Onung ◽

IA Odeniyi ◽

HAB Coker ◽

...

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Vitamin D ◽

Type 2 Diabetes Mellitus ◽

Serum Vitamin ◽

Serum Vitamin D ◽

Vitamin D Levels

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Body Mass Index, Vitamin D, and Type 2 Diabetes: A Systematic Review and Meta-Analysis

Nutrients ◽

10.3390/nu10091182 ◽

2018 ◽

Vol 10 (9) ◽

pp. 1182 ◽

Cited By ~ 21

Author(s):

Shamaila Rafiq ◽

Per Jeppesen

Keyword(s):

Systematic Review ◽

Body Mass Index ◽

Vitamin D ◽

Body Mass ◽

Observational Studies ◽

Meta Analysis ◽

Serum Vitamin ◽

Vitamin D Supplementation ◽

Serum Vitamin D ◽

Vitamin D Levels

The deficiency of vitamin D is prevalent all over the world. Studies have shown that vitamin D may play an important role in the development of obesity. The current study was conducted to quantitatively evaluate the association between serum 25-(OH) vitamin D levels and the risk of obesity in both diabetic and non-diabetic subjects. A systematic review and meta-analysis of observational studies was carried out for that purpose. We searched the Medline, PubMed, and Embase databases throughout all of March 2018. A total of fifty five observational studies for both diabetic and non-diabetic subjects were finally included in the meta-analysis. The data were analyzed by comprehensive meta-analysis software version 3 and the random effects model was used to analyze the data. The meta-analysis showed an overall inverse relationship between serum vitamin D status and body mass index (BMI) in studies of both diabetic (r = −0.173, 95% = −0.241 to −0.103, p = 0.000) and non-diabetic (r = −0.152, 95% = −0.187 to −0.116, p = 0.000) subjects. The evidence of publication bias was not found in this meta-analysis. In conclusion, the deficiency of vitamin D is associated with an increased level of BMI in the studies of both diabetic and non-diabetic subjects. Reliable evidence from well-designed future randomized controlled trials is required to confirm the findings from observational studies and to find out the potential regulatory effects of vitamin D supplementation to lower BMI.

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