scholarly journals Role of N‐acetylglucosaminyltransferase‐V and galectin‐3 binding protein in anoikis stress of cancer cells (788.1)

2014 ◽  
Vol 28 (S1) ◽  
Author(s):  
Kyoungjin Song ◽  
Jeong‐Heon Ko ◽  
Yong‐Sam Kim
Keyword(s):  
Cancer Cells ◽  
Binding Protein ◽  
Galectin 3

scholarly journals Estrogen regulation of X-box binding protein-1 and its role in estrogen induced growth of breast and endometrial cancer cells

2010 ◽  
Vol 2 (2) ◽  
Author(s):  
Surojeet Sengupta ◽  
Catherine G.N. Sharma ◽  
V. Craig Jordan
Keyword(s):  
Endometrial Cancer ◽  
Cancer Cells ◽  
Rna Polymerase Ii ◽  
Binding Protein ◽  
Therapeutic Interventions ◽  
Luciferase Reporter ◽  
Mcf7 Cells ◽  
Estrogen Regulation ◽  
Enhancer Region

Abstract: X-box binding protein 1 (XBP1), a transcription factor involved in unfolded protein response, is also an estrogen-regulated gene and strongly correlates with estrogen receptor alpha (ERα) expression in breast cancers. We investigated the functional role of XBP1 in estrogen responsive breast and endometrial cancer cells as its functions are not fully understood.: ERα positive breast (MCF7) and endometrial (ECC1) cancer cells were used to study XBP1 gene regulation by 17-β-estradiol (E2) and to investigate the role of XBP1 in E2-mediated growth using short interfering RNA. Quantitative real-time PCR and Western blot were used to assess RNA and protein levels. Recruitment of ERα and other cofactors at the promoter and enhancer region of the XBP1 gene was investigated by chromatin immunoprecipitation. Estrogen responsive element (ERE)-mediated transcriptional activity was evaluated by a luciferase reporter assay.: E2 induced the transcription of XBP1 in both MCF7 and ECC1 cells. E2-dependent recruitment of ERα, steroid receptor coactivator (SRC)-1 and SRC-3, and RNA polymerase II were observed at the promoter and/or enhancer region of the XBP1 gene. Depletion of XBP1 markedly inhibited the E2-induced growth in MCF7 and ECC1 cells. However, ERE-mediated transcription was not altered in XBP1-overexpressing or XBP1-depleted MCF7 cells.: Our results confirm E2-induced transcription of XBP1 and demonstrate the crucial role of XBP1 in E2-induced growth of ERα positive breast and endometrial cancer cells without modulating the classical ERE-mediated transcription by ER. This knowledge creates new opportunities for therapeutic interventions.

scholarly journals The role of galectin-3 and galectin-3–binding protein in venous thrombosis

Blood ◽  
2015 ◽  
Vol 125 (11) ◽  
pp. 1813-1821 ◽  
Author(s):  
Elise P. DeRoo ◽  
Shirley K. Wrobleski ◽  
Evelyn M. Shea ◽  
Ramsey K. Al-Khalil ◽  
Angela E. Hawley ◽  
...  
Keyword(s):  
Endothelial Cell ◽  
Venous Thrombosis ◽  
Binding Protein ◽  
Cell Interactions ◽  
Key Points ◽  
Galectin 3 ◽  
First Time

Key Points We determined the location of gal3bp and gal3 and their role in promoting VT and leukocyte/endothelial cell interactions for the first time. Gal3bp and gal3 have the potential to be used as targets for future VT therapies.

Role of the eIF4E binding protein 4E-BP1 in regulation of the sensitivity of human pancreatic cancer cells to TRAIL and celastrol-induced apoptosis

2013 ◽  
Vol 105 (9) ◽  
pp. 414-429 ◽  
Author(s):  
Reka Chakravarthy ◽  
Michael J. Clemens ◽  
Grisha Pirianov ◽  
Nectarios Perdios ◽  
Satvinder Mudan ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cancer Cells ◽  
Binding Protein ◽  
Human Pancreatic Cancer ◽  
Pancreatic Cancer Cells ◽  
Induced Apoptosis

scholarly journals Galectin-3 Binding Protein Secreted by Breast Cancer Cells Inhibits Monocyte-Derived Fibrocyte Differentiation

2015 ◽  
Vol 195 (4) ◽  
pp. 1858-1867 ◽  
Author(s):  
Michael J. V. White ◽  
David Roife ◽  
Richard H. Gomer
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Binding Protein ◽  
Galectin 3

Expression of human intestinal mucin (MUC2) is modulated by the b-galactoside binding protein galectin-3 in human colon cancer cells

2000 ◽  
Vol 118 (4) ◽  
pp. A273 ◽  
Author(s):  
Steven P. Dudas ◽  
Christopher K. Yunker ◽  
Lawrence R. Sternberg ◽  
Robert S. Bresalier
Keyword(s):  
Colon Cancer ◽  
Cancer Cells ◽  
Binding Protein ◽  
Human Colon ◽  
Colon Cancer Cells ◽  
Human Colon Cancer ◽  
Intestinal Mucin ◽  
Galectin 3 ◽  
Human Colon Cancer Cells

IRSp53 is a novel interactor of SHIP2: A role of the actin binding protein Mena in their cellular localization in breast cancer cells

2020 ◽  
Vol 73 ◽  
pp. 109692
Author(s):  
Mathieu Antoine ◽  
Isabelle Vandenbroere ◽  
Somadri Ghosh ◽  
Christophe Erneux ◽  
Isabelle Pirson
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Cellular Localization ◽  
Binding Protein ◽  
Actin Binding ◽  
Actin Binding Protein

Modifying expression of the β-galactoside binding protein galectin-3 significantly alters the metastatic ability of human colon cancer cells

1998 ◽  
Vol 114 ◽  
pp. A570 ◽  
Author(s):  
R.S. Bresalier ◽  
N. Mazurek ◽  
L. Sternberg ◽  
C. Yunker ◽  
J.C. Byrd ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cancer Cells ◽  
Binding Protein ◽  
Human Colon ◽  
Colon Cancer Cells ◽  
Human Colon Cancer ◽  
Galectin 3 ◽  
Human Colon Cancer Cells
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