scholarly journals Saturated dietary fat prevented unsaturated fat and alcohol‐mediated alterations in gut microbiota resulting in attenuation of intestinal barrier disruption and liver injury in an animal model of alcoholic liver disease (822.9)

2014 ◽  
Vol 28 (S1) ◽  
Author(s):  
Irina Kirpich ◽  
Wenke Feng ◽  
Yuhua Wang ◽  
Yanlong Liu ◽  
Shirish Barve ◽  
...  
Keyword(s):  
Animal Model ◽  
Liver Disease ◽  
Liver Injury ◽  
Gut Microbiota ◽  
Alcoholic Liver Disease ◽  
Dietary Fat ◽  
Intestinal Barrier ◽  
Barrier Disruption ◽  
Unsaturated Fat

scholarly journals Streptococcus, the Predominant Bacterium to Predict the Severity of Liver Injury in Alcoholic Liver Disease

2021 ◽  
Vol 11 ◽  
Author(s):  
Xiaodan Zhong ◽  
Ping Cui ◽  
Junjun Jiang ◽  
Chuanyi Ning ◽  
Bingyu Liang ◽  
...  
Keyword(s):  
Liver Disease ◽  
Liver Injury ◽  
Gut Microbiota ◽  
Alcoholic Liver Disease ◽  
Early Stage ◽  
Characteristic Curve ◽  
Hepatic Function ◽  
Rrna Gene ◽  
Alcoholic Fatty Liver ◽  
Predominant Bacterium

BackgroundNew evidence implies that the imbalance of gut microbiota is associated with the progression of alcoholic liver disease (ALD) and that the composition of gut microbiota is altered in ALD patients. However, the predominant bacterium in patients involved in the progress of ALD has not been identified. The purpose of this study is to investigate the predominant bacterium in the early and end-stages of ALD as well as the relationship between the bacterium and the degree of liver injury.MethodsWe enrolled 21 alcoholic fatty liver (AFL) patients, 17 alcoholic liver cirrhosis (ALC) patients and 27 healthy controls, and sequenced the 16S rRNA gene of their fecal microbiota. The gut microbiota composition and its relationship with the indicators of clinical hepatic function were assessed using canonical correspondence analysis (CCA), spearman correlation heatmap and multivariate association with linear (MaAsLin) Models.ResultsThe composition and structure of gut microbiota changed greatly in different stages of ALD, and the degree of disorder was aggravated with the progression of ALD, even in the early stage. Moreover, the relative abundance of Streptococcus was highly enriched only in patients with ALC (P <0.001), and positively correlated with AST level (P = 0.029). The abundance of Streptococcus distinguished the liver injury of ALC patients from the controls with an area under the receiver-operating characteristic curve (AUC) of 0.877 (P < 0.001).ConclusionsThese findings indicate that the imbalance of gut microbiota exists at the early and end-stages of ALD, and the degree of disorder is aggravated with the progression of ALD. Streptococcus, as the predominant bacterium, may be a microbiological marker to evaluate the severity of liver injury in ALD patients.

scholarly journals Ethanol and unsaturated fat diet‐induced liver injury is associated with intestinal inflammation in a mouse model of alcoholic liver disease

2012 ◽  
Vol 26 (S1) ◽  
Author(s):  
Irina Kirpich ◽  
Wenke Feng ◽  
Yuhua Wang ◽  
Yanlong Liu ◽  
Shirish Barve ◽  
...  
Keyword(s):  
Liver Disease ◽  
Liver Injury ◽  
Mouse Model ◽  
Alcoholic Liver Disease ◽  
Intestinal Inflammation ◽  
Unsaturated Fat

Gut Microbiota and Alcoholic Liver Disease

2016 ◽  
Vol 11 (3) ◽  
pp. 213-219 ◽  
Author(s):  
Emidio Scarpellini ◽  
Forlino Mariana ◽  
Lupo Marinella ◽  
Rasetti Carlo ◽  
Fava Giammarco ◽  
...  
Keyword(s):  
Liver Disease ◽  
Gut Microbiota ◽  
Alcoholic Liver Disease

scholarly journals Modulation of gut microbiota mediates berberine‐induced expansion of immuno‐suppressive cells to against alcoholic liver disease

2020 ◽  
Vol 10 (4) ◽  
Author(s):  
Sha Li ◽  
Ning Wang ◽  
Hor‐Yue Tan ◽  
Fan Chueng ◽  
Zhang‐Jin Zhang ◽  
...  
Keyword(s):  
Liver Disease ◽  
Gut Microbiota ◽  
Alcoholic Liver Disease

Regulatory effect of volatile compounds in fermented alcoholic beverages on gut microbiota and serum metabolism in mouse model

2021 ◽  
Author(s):  
Mei Ji ◽  
Cheng Fang ◽  
Wei Jia ◽  
Hai Du ◽  
Yan Xu
Keyword(s):  
Risk Factor ◽  
Liver Disease ◽  
Mouse Model ◽  
Gut Microbiota ◽  
Volatile Compounds ◽  
Alcoholic Liver Disease ◽  
Alcoholic Beverages ◽  
Regulatory Effect ◽  
Main Risk Factor

Ethanol (EtOH) is the main risk factor for alcoholic liver disease. However, fermented alcoholic beverages contain not only ethanol but also various volatile compounds. Currently, effects of volatile compounds in...

Protective effects of fucoidan against ethanol-induced liver injury through maintaining mitochondria function and mitophagy balance in rats.

2021 ◽  
Author(s):  
Huichao Zhao ◽  
Shuang Liu ◽  
Hui Zhao ◽  
Meilan Xue ◽  
Huaqi Zhang ◽  
...  
Keyword(s):  
Liver Disease ◽  
Liver Injury ◽  
Alcoholic Liver Disease ◽  
Therapeutic Strategy ◽  
Hepatic Lesion ◽  
Protective Effects ◽  
Regulatory Effects

For alcoholic liver disease (ALD), mitophagy was reported as a promising therapeutic strategy to alleviate the hepatic lesion elicited by ethanol. This study was to investigate the regulatory effects of...

A polysaccharide of PFP-1 from Pleurotus geesteranus attenuates alcoholic liver diseases via Nrf2 and NF-κB signaling pathways

2021 ◽  
Author(s):  
Xinling Song ◽  
Wenxue Sun ◽  
Wenxin Cai ◽  
Le Jia ◽  
Jianjun Zhang
Keyword(s):  
Oxidative Stress ◽  
Liver Disease ◽  
Liver Injury ◽  
Signaling Pathways ◽  
Alcoholic Liver Disease ◽  
Fruiting Body ◽  
Liver Diseases ◽  
Alcoholic Liver Diseases

A polysaccharide named as PFP-1 was isolated from Pleurotus geesteranus fruiting body, and the potential investigations on ameliorating oxidative stress and liver injury against alcoholic liver disease (ALD) were processed...

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