Effect of retinoic acid and apo‐RBP on serum retinol concentration in acute renal failure 1

1991 ◽  
Vol 5 (1) ◽  
pp. 86-92 ◽  
Author(s):  
Thomas H. Gerlach ◽  
Maija H. Zile
Keyword(s):  
Renal Failure ◽  
Acute Renal Failure ◽  
Retinoic Acid ◽  
Serum Retinol ◽  
Serum Retinol Concentration ◽  
Retinol Concentration

Upregulation of serum retinol in experimental acute renal failure

1990 ◽  
Vol 4 (8) ◽  
pp. 2511-2517 ◽  
Author(s):  
Thomas H. Gerlach ◽  
Maija H. Zile
Keyword(s):  
Renal Failure ◽  
Acute Renal Failure ◽  
Serum Retinol

Vitamin a megadoses during early infancy on serum retinol concentration and acute side effects and residual effects on 6 month follow-up

1997 ◽  
Vol 17 (4) ◽  
pp. 649-659 ◽  
Author(s):  
Dilip Mahalanabis ◽  
Mohammed M. Rahman ◽  
Mohammed A. Wahed ◽  
Mohammed A. Islam ◽  
Demissie Habte
Keyword(s):  
Side Effects ◽  
Vitamin A ◽  
Early Infancy ◽  
Residual Effects ◽  
Serum Retinol ◽  
Acute Side Effects ◽  
Serum Retinol Concentration ◽  
Retinol Concentration

scholarly journals Vitamin A absorption in children with ascariasis

1993 ◽  
Vol 69 (3) ◽  
pp. 817-825 ◽  
Author(s):  
F. Ahmed ◽  
M. Mohiduzzaman ◽  
A. A. Jackson
Keyword(s):  
Vitamin A ◽  
Oral Dose ◽  
Ascaris Lumbricoides ◽  
Social Background ◽  
Dhaka City ◽  
Slum Area ◽  
Serum Retinol ◽  
Serum Retinol Concentration ◽  
Average Serum ◽  
Retinol Concentration

The effect of Ascaris lumbricoides infection on retinol absorption was investigated in young children from a slum area of Dhaka City, Bangladesh. Twenty-four children aged 4–10 years were screened and in every case eggs of either Ascaris, Trichuris or hookworm were isolated from the stool. The average serum retinol was 0.91 (sd 0.35) μmol/l and sixteen children had levels below 1.05 μmol/l. This compared with a serum retinol concentration of 1.70 (sd 0.52) μmol/l in five reference children from a more privileged social background. An oral dose of retinol (41.8 μmol) was given, to ten children in whom the concentration of Ascaris eggs in the stool varied. Less than 1% of the supplement could be recovered in the stools collected over the following 48 h. Ascaris worms were isolated from the stool and assayed for retinol content. In no case was retinol detected in the worms. These findings do not support the contention that infection with Ascaris predisposes to malabsorption of vitamin A.

Serum Vitamin A and E Concentrations in Acute Falciparum Malaria: Modulators or Markers of Severity?

1994 ◽  
Vol 87 (5) ◽  
pp. 505-511 ◽  
Author(s):  
Timothy M. E. Davis ◽  
Tran Quang Binh ◽  
Phan Thi Danh ◽  
John R. Dyer ◽  
Andrew St John ◽  
...  
Keyword(s):  
Vitamin E ◽  
Vitamin A ◽  
Serum Creatinine ◽  
Serum Vitamin ◽  
Serum Creatinine Concentration ◽  
Serum Retinol ◽  
Creatinine Concentration ◽  
Control Subjects ◽  
Serum Retinol Concentration ◽  
Retinol Concentration

1. To assess the association between vitamin A, vitamin E and the clinical course of severe malaria, serial morning blood samples were taken from 24 Vietnamese patients, aged 18–62 years, receiving intensive treatment for complicated Plasmodium falciparum infections. A single fasting blood sample was also taken from 10 control subjects aged 22–45 years. Serum retinol, carotene and vitamin E concentrations were measured by h.p.l.c. 2. Admission serum retinol concentration was depressed relative to that of the control subjects (0.69 ± 0.35 versus 1.86 ± 0.41μmol/l mean ± SD, P < 0.001) and correlated inversely with indices of hepatic function, but positively with the simultaneous serum creatinine concentration (P < 0.05). During the first week of treatment, serum retinol concentration increased in parallel with improving liver function, whereas serum creatinine concentration remained elevated in the majority of patients. Serum α- and β-carotene concentrations remained depressed throughout. 3. Serum vitamin E concentration, corrected for total serum cholesterol concentration in the form of a ratio, was also depressed at presentation (3.1 ± 1.8×103 versus 4.2 ± 0.8×103 in control subjects; P < 0.05), but tended to be higher than the control value at the time of discharge (0.1 > P > 0.05); there was a significant correlation between admission ratio and parasite clearance time (P = 0.04). 4. On the basis of this and previous studies, vitamin A replacement could be considered in selected severely ill patients without renal impairment. As found previously in animal models, depressed vitamin E levels may have a beneficial effect on the course of malarial infection.

scholarly journals Impact of promotion of mango and liver as sources of vitamin A for young children: a pilot study in Burkina Faso

2006 ◽  
Vol 9 (6) ◽  
pp. 808-813 ◽  
Author(s):  
CP Nana ◽  
ID Brouwer ◽  
NM Zagré ◽  
FJ Kok ◽  
AS Traoré
Keyword(s):  
Pilot Study ◽  
Vitamin A ◽  
Burkina Faso ◽  
Financial Support ◽  
Control Area ◽  
Serum Retinol ◽  
Treatment Groups ◽  
Parallel Design ◽  
Serum Retinol Concentration ◽  
Retinol Concentration

AbstractObjectiveTo assess the effectiveness of a behaviour change approach, with or without financial support, in improving vitamin A (VA) intake and serum retinol concentration through mango and liver consumption by children.DesignA parallel design (no control area) was used to assess changes in VA intake and serum retinol over a 15-week period.Setting and subjectsA pilot study was implemented in the Department of Kokologho, a rural area in central west Burkina Faso. One hundred and fifty children aged 2–3 years were randomly selected and assigned to two treatment groups: PA$$ (promotional activities and financial support) and PA (promotional activities).ResultsThe intervention significantly increased (P<0.001) total VA intake by 56% in PA$$ and by 50% in PA. VA intake from liver increased significantly (P<0.001) from 12.7±23.5 to 155.3±56.3 μg retinol activity equivalents (RAE) in PA$$ and from 21.6±29.7 to 135.3±44.9 μg RAE in PA. Changes in VA intake from liver were significantly higher (P=0.004) in PA$$ compared with PA. Mean serum retinol concentration increased significantly by 26% (P<0.001) in PA$$ and 30% (P<0.001) in PA. Changes in serum retinol concentration (0.13 μmol l−1 in PA$$ vs. 0.17 μmol l−1 and in PA) did not differ significantly (P=0.455) between groups over the intervention.ConclusionPromotional activities on mango and liver intake effectively increased VA intake and serum retinol concentrations. Although an additional beneficial effect of financial support on liver intake was observed, this did not translate into a further increase in serum retinol concentration.

Acute renal failure associated with the retinoic acid syndrome in acute promyelocytic leukemia

1996 ◽  
Vol 27 (1) ◽  
pp. 134-137 ◽  
Author(s):  
Carlos D. Flombaum ◽  
Marian Isaacs ◽  
Lillian Reich ◽  
Ellin Berman ◽  
Raymond P. Warrell
Keyword(s):  
Renal Failure ◽  
Acute Renal Failure ◽  
Retinoic Acid ◽  
Acute Promyelocytic Leukemia ◽  
Promyelocytic Leukemia ◽  
Retinoic Acid Syndrome

scholarly journals Vitamin A Status in Neonatal and Weanling Rats Reared by Mothers Consuming Normal and High Fat Diets with or Without Vitamin A Supplementation

2020 ◽  
Vol 4 (Supplement_2) ◽  
pp. 134-134
Author(s):  
Yanqi Zhang ◽  
Kristi Crowe-White ◽  
Lingyan Kong ◽  
Libo Tan
Keyword(s):  
Vitamin A ◽  
Normal Serum ◽  
Sprague Dawley ◽  
Serum Retinol ◽  
High Fat ◽  
Time Points ◽  
Significant Difference ◽  
Storage Organs ◽  
Serum Retinol Concentration ◽  
Retinol Concentration

Abstract Objectives Although the circulating level of vitamin A (VA) is reported to be significantly lower in obese adults, it is unknown if maternal adiposity would influence the VA status of the offspring. The aim of this study was to investigate the status and distribution of VA in the offspring of rats consuming a normal fat diet (NFD) or a high fat diet (HFD), with or without VA supplementation. Methods Sprague-Dawley rats arrived on their second day of gestation and were randomized to either a NFD (25% fat) or a HFD (50% fat) both with an adequate level of VA at 2.6 mg/kg. Upon the delivery of pups, half of rat mothers from the NFD or HFD cohort were switched to a NFD or a HFD both with supplemented VA at 129 mg/kg (NFD + VA and HFD + VA group), respectively. The other half remained on their diets with adequate VA (NFD and HFD group). At postnatal day 14 (P14) and P25, 4 pups/group were euthanized. At P25, the remaining weanling pups (n = 3/group) were fed diets of their respective mothers until being euthanized at P35. Concentrations of total retinol in serum, liver, visceral white AT (WAT), and brown AT (BAT) were measured by UPLC. Results Through the study, pups in non-supplemented groups showed a normal serum retinol concentration but a marginal liver VA status. At all the time points, serum retinol concentration was significantly (P &lt; 0.05) increased in VA-supplemented groups as compared to non-supplemented ones; no significant difference was noted between the NFD and the HFD group. At P14, serum retinol concentration was significantly lower in the HFD + VA group than in the NFD + VA group. In liver, WAT, and BAT, both the concentration and the mass of total retinol was significantly higher in HFD + VA and NFD + VA group than in their respective control at all the time points, with no significant difference noted between the two control groups. At P25, both the concentration and the mass of total retinol in liver and in WAT was significantly higher in HFD + VA than in NFD + VA group. Conclusions Maternal VA supplementation added to both NFD and HFD raised VA status of the offspring. A lower VA concentration in serum but higher concentration in liver and WAT was observed in the HFD + VA group as compared to the NFD + VA group at given time points, indicating that maternal HFD consumption potentially compromised the availability of functional VA in circulation by increasing its deposition in storage organs. Funding Sources NIH.

scholarly journals Placenta: a possible predictor of vitamin A deficiency

2009 ◽  
Vol 103 (9) ◽  
pp. 1340-1344 ◽  
Author(s):  
Mirian Martins Gomes ◽  
Claudia Saunders ◽  
Andrea Ramalho
Keyword(s):  
Vitamin A ◽  
Spectrophotometric Method ◽  
Roc Curve ◽  
Operating Characteristic ◽  
Vitamin A Deficiency ◽  
Curve Analysis ◽  
Serum Retinol ◽  
Roc Curve Analysis ◽  
Serum Retinol Concentration ◽  
Retinol Concentration

The objective of the present study is to assess the association between vitamin A deficiency (VAD) evaluated by serum retinol concentration from the mother and umbilical cord and placental concentration of retinol and carotenoids to propose placental values representative of deficiency. Two hundred and sixty-two puerperal women and their newborns were assessed. Concentration of serum and placental retinol and carotenoids was determined by the spectrophotometric method. Receiver operating characteristic (ROC) curve analysis was performed according to two cut-off points (0·70 and 1·05 μmol/l) to represent deficiency in the placental concentration. No difference between averages of placental retinol and carotenoids was observed in the puerperal women regardless of the cut-off point used to define VAD. In relation to the newborns, a decrease (P = 0·012) in placental retinol averages in individuals with VAD was observed when the 1·05 μmol/l cut-off point was adopted. In respect to the placental carotenoid averages, a decrease is observed for both the cut-off points (P = 0·013 and 0·019 for 1·05 and 0·7 μmol/l, respectively). The ROC curve results point to the value of 0·80 μmol/l as representing deficiency with greater values found for sensitivity (66·7 %), specificity (41·7 %) and accuracy (65 %) when the 0·70 μmol/l cut-off point was adopted. The results of the present study show an association between the placental concentration of retinol and carotenoids with clinical VAD, suggesting the need for further studies on more severe cases of deficiency.

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