Role of NRF2 in immune modulator expression in developing lung

2021 ◽  
Vol 35 (8) ◽  
Author(s):  
Ritu Mishra ◽  
Afshan Fathima Nawas ◽  
Carole R. Mendelson
Keyword(s):  
Immune Modulator

IL-15 as an Immune Modulator in Schistosomiasis

2019 ◽  
Vol 152 (Supplement_1) ◽  
pp. S102-S103
Author(s):  
Mary Reust
Keyword(s):  
Schistosoma Mansoni ◽  
Mucosal Immunity ◽  
Peripheral Blood ◽  
Schistosoma Haematobium ◽  
Sub Saharan Africa ◽  
Immune Modulator ◽  
Sub Saharan ◽  
Negative Controls

Abstract Introduction Schistosomiasis affects approximately 200,000,000 people globally, with 93% of these cases in sub-Saharan Africa. Women who have been infected with Schistosoma haematobium have four times the risk of contracting HIV due to a change in their cervical mucosal immunity. The mechanism for this altered cervical mucosal immunity was not understood until a recent study published by Downs et al, which showed IL-15 levels were significantly lower in cervicovaginal lavage fluid samples of women with Schistosoma haematobium. Schistosoma mansoni, known to cause intestinal schistosomiasis, has also shown the potential to increase the risk of contracting HIV. The objective for this study is to see if IL-15 levels in peripheral blood are significantly different between patients positive for S mansoni and negative controls. Methods Enzyme-linked immunosorbent assays (BD Biosciences, San Jose, CA) for IL-15 were performed on plasma collected from 84 patients in villages in sub-Saharan Africa. These samples were collected at screening, 3-month follow-up, 6-month follow-up, and 9-month follow-up appointments. Results Of 249 plasma samples tested, 20 had detectable IL-15 levels ranging from 8.329 pg/mL to above the upper limit of detection of 500 pg/mL. While the patients that had detectable IL-15 in the peripheral blood were half S mansoni negative and half S mansoni positive, when an S mansoni–positive patient was positive for IL-15, it was across all timepoints. Conclusion The role of IL-15 as an immune modulator can explain the elevated levels in S mansoni–positive patients. All patients in the study were tested for significant comorbidities, with no correlation seen within the negative controls. Further testing is needed to investigate the role of IL-15 in the alteration of localized areas of infection with both Schistosoma mansoni and Schistosoma haematobium. More samples are currently being collected from the patient population in Tanzania, and future studies are planned.

scholarly journals Dopamine as an immune-modulator between dendritic cells and T cells and the role of dopamine in the pathogenesis of Rheumatoid Arthritis

2009 ◽  
Vol 32 (1) ◽  
pp. 1-6 ◽  
Author(s):  
Kazuhisa NAKANO ◽  
Sho MATSUSHITA ◽  
Kazuyoshi SAITO ◽  
Kunihiro YAMAOKA ◽  
Yoshiya TANAKA
Keyword(s):  
Rheumatoid Arthritis ◽  
T Cells ◽  
Dendritic Cells ◽  
Immune Modulator

scholarly journals A A review of role of Rajanyadi Churna as potential immune-modulator in Kaumarabhritya

2021 ◽  
Vol 9 (02) ◽  
Author(s):  
Sreeja Pillai ◽  
Hemant Paradkar ◽  
Anaya Pathrikar ◽  
Sandeep Pillai
Keyword(s):  
Infectious Diseases ◽  
The Body ◽  
Innate Immune ◽  
Defence Mechanisms ◽  
Immune Modulator ◽  
Immune Mechanisms ◽  
Waiting Periods ◽  
Innate Defence

 The present pandemic situation has alarmed mankind to formulate and implement effective and practical tools  to defend and confront any unexpected breakout of infectious diseases. It emphasizes the need to correct and sharpen the innate immune  mechanisms, particularly under the circumstances of long waiting periods and uncertainty with vaccines. Revisiting the Ayurvedic principle of agni and bala to correct and  enhance innate defence mechanisms in ways that can make the body ready to defend any situation of challenge. The paper explores the possibilities  of the use of Rajanyadi Churna in Kaumarabhritya.

scholarly journals Role of the clarithromycin immune modulator activity on abdominal microhemodynamics and mortality in severe sepsis

Critical Care ◽  
2012 ◽  
Vol 16 (S3) ◽  
Author(s):  
FRE Jesus ◽  
CD Snak-Souza ◽  
FM Dulcini ◽  
EC Del-Massa ◽  
LR Gondim ◽  
...  
Keyword(s):  
Severe Sepsis ◽  
Immune Modulator

scholarly journals Circulatory Immune Cells in Cushing Syndrome: Bystanders or Active Contributors to Atherometabolic Injury? A Study of Adhesion and Activation of Cell Surface Markers

2017 ◽  
Vol 2017 ◽  
pp. 1-9 ◽  
Author(s):  
Gloria Aranda ◽  
Cristina Lopez ◽  
Rebeca Fernandez-Ruiz ◽  
Yaiza Esteban ◽  
Guillermo Garcia-Eguren ◽  
...  
Keyword(s):  
Immune Cells ◽  
Cardiometabolic Risk ◽  
Cushing Syndrome ◽  
Surface Markers ◽  
Cell Surface Markers ◽  
Adrenocorticotrophic Hormone ◽  
Immune Modulator ◽  
Surface Cell Markers ◽  
Hs Crp

Glucocorticoids (GC) induce cardiometabolic risk while atherosclerosis is a chronic inflammation involving immunity. GC are immune suppressors, and the adrenocorticotrophic hormone (ACTH) has immune modulator activities. Both may act in atherothrombotic inflammation involving immune cells (IMNC). Aim. To investigate adhesion and activation surface cell markers (CDs) of peripheral IMNC in endogenous Cushing syndrome (CS) and the immune modulator role of ACTH. Material and Methods. 16 ACTH-dependent CS (ACTH-D), 10 ACTH-independent (ACTH-ID) CS, and 16 healthy controls (C) were included. Leukocytes (Leuc), monocytes (MN), lymphocytes (Lym), and neutrophils (N) were analyzed by flow cytometry for atherosclerosis previously associated with CDs. Results. Leuc, N, and MN correlated with CS (p<0.05), WC (p<0.001), WHR (p=0.003), BMI (p<0.001), and hs-CRP (p<0.001). CD14++CD16+ (p=0.047); CD14+CD16++ (p=0.053) MN; CD15+ (p=0.027); CD15+CD16+ (p=0.008) N; and NK-Lym (p=0.019) were higher in CS. CD14+CD16++ MN were higher in ACTH-ID (8.9 ± 3.5%) versus ACTH-D CS (4.2 ± 1.9%) versus C (4.9 ± 2.3%). NK-Lym correlated with c-LDL (r = 0.433, p=0.039) and CD15+ N with hs-CRP (r = 0.446, p=0.037). In multivariate analysis, Leuc, N, and MN depended on BMI (p=0.021), WC (p=0.002), and WHR (p=0.014), while CD15+ and CD15+CD16+ N on hypercortisolism and CS (p=0.035). Conclusion. In CS, IMNC present changes in activation and adhesion CDs implicated in atherothrombotic inflammation. ACTH-IDCS presents a particular IMNC phenotype, possibly due to the absence of the immune modulator effect of ACTH.

Role of dactinomycin in the improved survival of children with Wilms' tumor

JAMA ◽  
1966 ◽  
Vol 195 (12) ◽  
pp. 1005-1009 ◽  
Author(s):  
D. J. Fernbach
Keyword(s):  
Wilms Tumor
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