THE EFFECT OF TOPICAL FLUOCINOLONE ACETONIDE AND NEARLY TOTAL BODY OCCLUSIVE DRESSINGS ON THE URINARY EXCRETION OF NITROGEN, SODIUM, POTASSIUM, 17-KETOSTEROIDS AND 17-HYDROXYSTEROIDS

1964 ◽  
Vol 248 (4) ◽  
pp. 441-444 ◽  
Author(s):  
Ralph M. Myerson
Keyword(s):  
Urinary Excretion ◽  
Fluocinolone Acetonide ◽  
Sodium Potassium ◽  
Occlusive Dressings ◽  
Total Body

RESPONSE OF THE NEWBORN INFANT TO MAJOR SURGERY

PEDIATRICS ◽  
1959 ◽  
Vol 23 (6) ◽  
pp. 1063-1084
Author(s):  
Eleanor Colle ◽  
Elsa Proehl Paulsen
Keyword(s):  
Urinary Excretion ◽  
Potassium Chloride ◽  
Newborn Infant ◽  
Renal Excretion ◽  
Newborn Infants ◽  
Relative Magnitude ◽  
Postoperative Management ◽  
Major Surgery ◽  
Sodium Potassium ◽  
Diminished Capacity

Balance data for sodium, potassium, chloride, nitrogen, and water were obtained postoperatively in 15 newborn infants operated upon in the first 4 days of life and in 5 control newborn infants. The infants showed a response in terms of electrolyte and water balances which is significantly different from that reported in adults: The volumes of urine were equal to or greater than those in normal infants of a comparable age. The data suggest a diminished capacity of the newborn to conserve water postoperatively, but a normal capacity to dilute the urine. No evidence of retention of water was observed. The urinary excretion of sodium and chloride was equal to or larger than that of normal infants. The infants who had losses postoperatively from gastrointestinal suction showed no capacity to reduce renal excretion of these ions while they suffered these large extrarenal losses. The concentrations of sodium and chloride in the serum remained normal or became slightly elevated postoperatively. Losses of potassium and nitrogen in the urine were of the same relative magnitude as those in adults. The observed responses are discussed in terms of the function of antidiuretic and adrenocortical hormones in the newborn infant. The application of these data to practical considerations of fluid and electrolyte therapy in the postoperative management of the newborn infant are discussed briefly.

Electrolytes

2012 ◽  
Author(s):  
Matthew R Rosengart
Keyword(s):  
Systematic Approach ◽  
Cell Function ◽  
Patient Survival ◽  
Regulatory Mechanisms ◽  
Electrolyte Disorders ◽  
Sodium Potassium ◽  
Electrolyte Homeostasis ◽  
Total Body ◽  
Additional Support ◽  
Underlying Pathophysiology

Cell function and thus life depend on the preservation of several electrochemical gradients. Evolutionary pressures have developed several regulatory mechanisms, the penultimate goal of which is to maintain total body and distribution of each electrolyte within the intracellular and extracellular compartments at concentrations compatible with life. Ultimately, patient survival depends on this balance despite the continual changes imposed by both internal physiologic processes and external stressors. During periods of critical illness, however, these mechanisms can be overwhelmed, necessitating additional support. Indeed, disorders of electrolyte homeostasis are highly prevalent among intensive care unit patients, and severe disturbances are associated with elevated mortality. As has been previously learned, merely normalizing laboratory abnormalities without addressing the underlying pathophysiology does little to improve outcome. Thus, for those providing this care, an in-depth understanding of the biochemistry and physiology of electrolyte disorders and a systematic approach to diagnosis and therapy are complementary components essential for patient survival. This chapter discusses the major electrolytes—sodium, potassium, calcium and phosphate, and magnesium—and covers the hyper- and hypodeficiencies and disturbances for each electrolyte. This review contains 7 Figures, 6 Tables, 5 Etiologic Algorithms, and 106 References.

Bone resorption and mineral excretion in rats during spaceflight

1983 ◽  
Vol 244 (3) ◽  
pp. R327-R331 ◽  
Author(s):  
C. E. Cann ◽  
R. R. Adachi
Keyword(s):  
Neutron Activation Analysis ◽  
Bone Resorption ◽  
Time Course ◽  
Large Change ◽  
Sodium Potassium ◽  
Total Body Calcium ◽  
Mineral Excretion ◽  
Synchronous Control ◽  
Total Body ◽  
Sodium And Potassium

Bone resorption was measured directly in flight and synchronous control rats during COSMOS 1129. Continuous tracer administration techniques were used, with replacement of dietary calcium with isotopically enriched 40Ca and measurement by neutron activation analysis of the 48Ca released by the skeleton. There is no large change in bone resorption in rats at the end of 20 days of spaceflight as has been found for bone formation. Based on the time course of changes, the measured 20–25% decrease in resorption is probably secondary to a decrease in total body calcium turnover. The excretion of sodium, potassium, and zinc all increase during flight, sodium and potassium to a level four to five times control values.

EFFECT OF PORCINE, SALMON AND HUMAN CALCITONIN ON URINARY EXCRETION OF SOME ELECTROLYTES IN SHEEP

1972 ◽  
Vol 55 (1) ◽  
pp. 153-161 ◽  
Author(s):  
J. P. BARLET
Keyword(s):  
Urinary Excretion ◽  
Salmon Calcitonin ◽  
Inorganic Phosphorus ◽  
Plasma Calcium ◽  
Performic Acid ◽  
Human Calcitonin ◽  
Intact Male ◽  
Sodium Potassium

SUMMARY Purified porcine and salmon calcitonin and synthetic salmon and human calcitonin were infused at the rate of 20 MRC mu./kg/h over a 96 h period in intact male lambs. Every calcitonin preparation significantly increased the urinary excretion of inorganic phosphorus, sodium, potassium and calcium, while the urinary excretion of magnesium was always significantly inhibited. Similar significant effects were observed with purified porcine calcitonin in thyroparathyroidectomized lambs supplemented with thyroxine. Oxidation of calcitonin with performic acid completely abolished its effects on plasma calcium and on the kidney. It is concluded that, when used at physiological doses, in sheep calcitonin has an important effect on urinary excretion of inorganic phosphorus, sodium and magnesium.

Sodium-, potassium-, chloride-, and bicarbonate-related effects on blood pressure and electrolyte homeostasis in deoxycorticosterone acetate-treated rats

2008 ◽  
Vol 295 (6) ◽  
pp. F1752-F1763 ◽  
Author(s):  
Agata Ziomber ◽  
Agnes Machnik ◽  
Anke Dahlmann ◽  
Peter Dietsch ◽  
Franz-Xaver Beck ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Male Rats ◽  
Sodium Potassium ◽  
Arterial Blood ◽  
Electrolyte Homeostasis ◽  
Water Mass Balance ◽  
Group 2 ◽  
Total Body ◽  
Salt Sensitive Hypertension ◽  
Volume Retention

Na+ loading without Cl− fails to increase blood pressure in the DOCA model. We compared the changes in the total body (TB) effective Na+, K+, Cl−, and water (TBW) content as well as in intracellular (ICV) or extracellular (ECV) volume in rats receiving DOCA-NaCl, DOCA-NaHCO3, or DOCA-KHCO3. We divided 42 male rats into 5 groups. Group 1 was untreated, group 2 received 1% NaCl, and groups 3, 4, and 5 were treated with DOCA and received 1% NaCl, 1.44% NaHCO3, or 1.7% KHCO3 to drink. We measured mean arterial blood pressure (MAP) directly after 3 wk. Tissue electrolyte and water content was measured by chemical analysis. Compared with control rats, DOCA-NaCl increased MAP while DOCA-NaHCO3 and DOCA-KHCO3 did not. DOCA-NaCl increased TBNa+ 26% but only moderately increased TBW. DOCA-NaHCO3 led to similar TBNa+ excess, while TBW and ICV, but not ECV, were increased more than in DOCA-NaCl rats. DOCA-KHCO3 did not affect TBNa+ or volume. At a given TB(Na++K+) and TBW, MAP in DOCA-NaCl rats was higher than in control, DOCA-NaHCO3, and DOCA-KHCO3 rats, indicating that hypertension in DOCA-NaCl rats was not dependent on TB(Na++K+) and water mass balance. Skin volume retention was hypertonic compared with serum and paralleled hypertension in DOCA-NaCl rats. These rats had higher TB(Na++K+)-to-TBW ratio in accumulated fluid than DOCA-NaHCO3 rats. DOCA-NaCl rats also had increased intracellular Cl− concentrations in skeletal muscle. We conclude that excessive cellular electrolyte redistribution and/or intracellular Na+ or Cl− accumulation may play an important role in the pathogenesis of salt-sensitive hypertension.

scholarly journals Associations between Dietary Intake and Urinary Excretion of Sodium, Potassium, Phosphorus, Magnesium, and Calcium

2004 ◽  
Vol 59 (1) ◽  
pp. 23-30 ◽  
Author(s):  
Mitsuru KIMIRA ◽  
Yoko KUDO ◽  
Ribeka TAKACHI ◽  
Ryota HABA ◽  
Shaw WATANABE
Keyword(s):  
Dietary Intake ◽  
Urinary Excretion ◽  
Sodium Potassium

scholarly journals Regulation of Water and Some Ions in Gammarids (Amphipoda)

1971 ◽  
Vol 55 (2) ◽  
pp. 357-369
Author(s):  
D. W. SUTCLIFFE
Keyword(s):  
Sodium Chloride ◽  
Sea Water ◽  
Chloride Concentration ◽  
Sodium Concentration ◽  
Body Water ◽  
The Body ◽  
Salinity Range ◽  
Sodium Potassium ◽  
Body Sodium ◽  
Total Body

1. A comparison was made of the body water contents and the concentrations of sodium, potassium and chloride in the blood and body water of Gammarus zaddachi, G. locusta and Marinogammarus finmarchicus. 2. G. zaddachi had a slightly higher body water content than G. locusta and M. finmarchicus. 3. In all three species the blood chloride concentration was lower than the external chloride concentration in 80-113 % sea water, but the blood sodium concentration was equal to or slightly above the sodium concentration in the external medium. 4. The total body sodium concentration was always greater than the total body chloride concentration. In M.finmarchicus the ratio of body sodium/chloride increased from 1.2 to 1.3 over the salinity range 100-20% sea water. In G. zaddachi the ratio of body sodium/chloride increased from 1.08 at 100% sea water to 1.87 in 0.25 mM/l NaCl. 5. The total body potassium concentration remained constant. The potassium loss rate and the balance concentration were relatively high in G. zaddachi. 6. The porportion of body water in the blood space was calculated from the assumption that a Donnan equilibrium exists between chloride and potassium ions in the extracellular blood space and the intracellular space. In G. zaddachi the blood space was equivalent to 60% body H2O at 100% sea water, and equivalent to 50% body H2O at 40% sea water down to 0.5 mM/l NaCl. In M.finmarchicus the blood space was equivalent to 38-44% body H2O at salinities of 20-100% sea water. 7. The mean intracellular concentrations of sodium, potassium and chloride were also calculated. It was concluded that for each ion its intracellular concentration is much the same in the four euryhaline gammarids. The intracellular chloride concentration is roughly proportional to the blood chloride concentration. The intracellular sodium concentration is regulated in the face of large changes in the blood sodium concentration.

Regulation of Water and Some Ions in Gammarids (Amphipoda)

1971 ◽  
Vol 55 (2) ◽  
pp. 345-355
Author(s):  
D. W. SUTCLIFFE
Keyword(s):  
Water Content ◽  
Sea Water ◽  
Potassium Concentration ◽  
Body Water ◽  
The Body ◽  
Sodium Potassium ◽  
Intracellular Space ◽  
Body Sodium ◽  
The Mean ◽  
Total Body

1. The water content, and the concentrations of sodium potassium and chloride in the blood and body water were determined in Gammarus pulex acclimatized to external salinities ranging from 0.06 mM/l NaCl up to 50 % sea water. 2. The mean body water content remained constant at 79.0-80.3 % body wet weight. The total body sodium and chloride concentrations were lowered in 0.06 mM/l NaCl and increased markedly at salinities above 10% sea water. The normal ratio of body sodium/chloride was 1.45-1.70, decreasing to 1.0 at 50% sea water. 3. The total body potassium concentration remained constant at 47.5-55.2 mM/kg body H2O. The rate of potassium loss across the body surface was relatively fast. Potassium balance was maintained at an external potassium concentration of 0.005 mM/l by starved animals, and at 0.005 mM/l by fed animals. 4. The proportion of body water in the blood space was calculated from the concentrations of potassium and chloride in the blood and in the body water. The blood space contained 38-42% body H2O in animals from fresh water. The blood space decreased to 31 % body H2O in animals from 0.06 mM/l NaCl. The sodium space was equivalent to about 70 % body H2O. 5. The mean intracellular concentrations of sodium, potassium and chloride were estimated and the results were compared with previous analyses made on the tissues of G. pulex and other crustaceans. It was concluded that in G. pulex from fresh water the distribution of potassium and chloride ions between the extracellular blood space and the intracellular space approximately conforms to a Donnan equilibrium. 30-40% of the body sodium is apparently located in the intracellular space.

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