ASTHMA SYMPTOMS AND SLOWER LUNG FUNCTION GROWTH OVER TWO YEAR FOLLOW-UP IN PREADOLESCENT CHILDREN. THE CASE COHORT STUDY.

AbstractIntroductionA significant number of patients continue to recover from COVID-19; however, little is known about the lung function capacity among survivors. We aim to determine the long-term impact on lung function capacity in patients who have survived moderate or severe COVID-19 disease in a resource-poor setting.Methods and analysisThis prospective cohort study will include patients aged 15 years and above and have reverse transcriptase-polymerase chain reaction (RT-PCR) positive for COVID 19 (nasopharyngeal or oropharyngeal). Patients with a pre-existing diagnosis of obstructive or interstitial lung disease, lung fibrosis and cancers, connective tissue disorders, autoimmune conditions affecting the lungs, underlying heart disease, history of syncope and refuse to participate will be excluded. Pulmonary function will be assessed using spirometry and diffusion lung capacity for carbon monoxide (DLCO) at three- and six-months interval. A chest X-ray at three and six-month follow-up and CT-chest will be performed if clinically indicated after consultation with the study pulmonologist or Infectious Disease (ID) physician. Echocardiogram (ECHO) to look for pulmonary hypertension at the three months visit and repeated at six months if any abnormality is identified initially. Data analysis will be performed using standard statistical software.Ethics and disseminationThe proposal was reviewed and approved by ethics review committee (ERC) of the institution (ERC reference number 2020-4735-11311). Informed consent will be obtained from each study participant. The results will be disseminated among study participants, institutional, provincial and national level through seminars and presentations. Moreover, the scientific findings will be published in high-impact peer-reviewed medical journals.Strengths and Limitations of this study-The study has the potential to develop context-specific evidence on the long-term impact on lung function among COVID-19 survivors-Findings will play key role in understanding the impact of the disease on vital functions and help devise rehabilitative strategies to best overcome the effects of disease-This is a single-center, study recruiting only a limited number of COVID-19 survivors-The study participants may loss-to-follow up due to uncertain conditions and disease reemergence

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The Association of Dietary Macronutrients with Lung Function in Healthy Adults Using the Ansan-Ansung Cohort Study

Nutrients ◽

10.3390/nu12092688 ◽

2020 ◽

Vol 12 (9) ◽

pp. 2688

Author(s):

Sang-Ah Lee ◽

Pankaj Joshi ◽

Yeonjin Kim ◽

Daehee Kang ◽

Woo Jin Kim

Keyword(s):

Cohort Study ◽

Lung Function ◽

Positive Association ◽

Forced Expiratory Volume ◽

Healthy Adults ◽

Carbohydrate Intake ◽

High Carbohydrate ◽

Percentage Difference ◽

Advanced Analysis

This study is aimed to examine the association between macronutrient intake and lung function in healthy adults (n = 5880) using the Ansan-Ansung cohort study. To identify the index of lung function, we used the percentage difference of predicted Forced Expiratory Volume (%FEV1_diff) between baseline and follow-up. Based on the median %FEV1_diff, subjects were classified by two groups as “decreased vs. unchanged/improved”. The dietary macronutrients were estimated and validated using the food-frequency questionnaire. Multiple logistic regression models were used to evaluate the association after adjusting for confounders. Advanced analysis examined the association after stratifying by age and obesity. The average of %FEV1 is 114.1 and 112.5 at baseline and follow-up, respectively. The positive association of protein and fiber intake with lung function was observed in men. Low fat and high carbohydrate intake decreased the lung function in women only. After stratification by age, the association of protein, fat, and carbohydrate intake with lung function was observed in young men and old women only. Otherwise, the association of protein and fiber with lung function was influenced by abdominal obesity. In conclusion, the lung function was positively associated with high protein and fat intake, but was negatively associated with high carbohydrate intake, which could be influenced by age and obesity.

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Of smoking habit on respiratory function in young asthmatics: Follow-up study from 16-30 years of age

Srpski arhiv za celokupno lekarstvo ◽

10.2298/sarh06s2100r ◽

2006 ◽

Vol 134 (Suppl. 2) ◽

pp. 100-103

Author(s):

Snezana Radic ◽

Zorica Zivkovic ◽

Nada Erdeljan ◽

Spomenka Smiljanic ◽

Goran Lakovic

Keyword(s):

Lung Function ◽

Smoking Habit ◽

First Year ◽

Lung Function Tests ◽

Asthma Symptoms ◽

Function Tests ◽

Skin Prick Tests ◽

First Year Of Life ◽

Adolescent Period

INTRODUCTION. Smoking habit of 54 asthmatics was followed for 15 years. OBJECTIVE. To examine if there was any difference of lung function tests between smoking and nonsmoking young asthmatics METHOD. Based on questionnaires, clinical examinations, lung function tests and skin prick tests, 54 adolescents with asthma were separated out of 1134 pupils of one Belgrade high school. They were followed-up till the age of 30. RESULTS. 62.9% of subjects were females and 37.1% were males. Average age at the beginning was 16.3 and 29.6 at the end of study. In 13.0% of subjects, the asthma manifested in the first year of life, in 72.2% between 2-6 years of age and in 14.8% of our subjects, the asthma developed after 7th year. The symptoms of asthma in last 12 months were present in 54.8% of our subjects at the age of 16, compared to 77.8% of asthmatics with asthma symptoms at the age of 30. Percent of smokers increased cumulatively from 16.7% at the beginning of study up to 57.5% upon its completion. Number of cigarettes increased from 7.5% to 16.5% cig/day in a smoker from the adolescent period until the end of study, with no difference in relation to sex. Average duration of smoking experience was 11.5 years, no difference in relation to gender. Values of VC, FVC, FEV1, PEF and MEF75 were always lower in asthmatics-smokers, but with no statistical difference. Tiffeneau index, MEF25 and MEF50 were statistically lower in the smoking group at the age of 30 compared to their values at the age of 21. CONCLUSION. Smoking does affect lung function of asthmatics that started to smoke and Tiffeneu index, MEF25 and MEF50 were statistically lower as early as at the age of 30.

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