Decision Tree Model of the Treatment-Seeking Behaviors Among Korean Cancer Patients

Abstract Background The aim of this study was to confirm the role of Brachyury in breast cells and to establish and verify whether four types of machine learning models can use Brachyury expression to predict the survival of patients.Methods We conducted a retrospective review of the medical records to obtain patient information, and made the patient's paraffin tissue into tissue chips for staining analysis. We selected a total of 303 patients for research and implemented four machine learning prediction algorithms, including multivariate logistic regression model, decision tree, artificial neural network and random forest, and compared the results of these models with each other. Area under the receiver operating characteristic (ROC) curve (AUC) was used to compare the results.Results The chi-square test results of relevant data suggested that the expression of Brachyury protein in cancer tissues was significantly higher than that in paracancerous tissues (p=0.0335); breast cancer patients with high Brachyury expression had a worse overall survival (OS) compared with patients with low Brachyury expression. We also found that Brachyury expression was associated with ER expression (p=0.0489). Subsequently, we used four machine learning models to verify the relationship between Brachyury expression and the survival of breast cancer patients. The results showed that the decision tree model had the best performance (AUC=0.781).Conclusions Brachyury is highly expressed in breast cancer and indicates that the patient had a poor chance of survival. Compared with conventional statistical methods, decision tree model shows superior performance in predicting the survival status of breast cancer patients. This indicates that machine learning can thus be applied in a wide range of clinical studies.

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Machine learning based tissue analysis reveals Brachyury has a diagnosis value in breast cancer

Bioscience Reports ◽

10.1042/bsr20203391 ◽

2021 ◽

Author(s):

Kaichun Li ◽

Qiaoyun Wang ◽

Yanyan Lu ◽

Xiaorong Pan ◽

Long Liu ◽

...

Keyword(s):

Breast Cancer ◽

Machine Learning ◽

Decision Tree ◽

Cancer Patients ◽

Decision Tree Model ◽

Superior Performance ◽

Breast Cancer Patients ◽

Learning Models ◽

Tree Model ◽

Machine Learning Models

Background The aim of this study was to confirm the role of Brachyury in breast cancer and to verify whether four types of machine learning models can use Brachyury expression to predict the survival of patients.</p>  Methods We conducted a retrospective review of the medical records to obtain patient information, and made the patient's paraffin tissue into tissue chips for staining analysis. We selected 303 patients for research and implemented four machine learning algorithms, including multivariate logistic regression model, decision tree, artificial neural network and random forest, and compared the results of these models with each other. Area under the receiver operating characteristic (ROC) curve (AUC) was used to compare the results.</p>  Results The chi-square test results of relevant data suggested that the expression of Brachyury protein in cancer tissues was significantly higher than that in paracancerous tissues (p=0.0335); breast cancer patients with high Brachyury expression had a worse overall survival (OS) compared with patients with low Brachyury expression. We also found that Brachyury expression was associated with ER expression (p=0.0489). Subsequently, we used four machine learning models to verify the relationship between Brachyury expression and the survival of breast cancer patients. The results showed that the decision tree model had the best performance (AUC=0.781).</p>  Conclusions Brachyury is highly expressed in breast cancer and indicates that patients had a poor prognosis. Compared with conventional statistical methods, decision tree model shows superior performance in predicting the survival status of breast cancer patients.

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Decision-tree Model of Treatment-seeking Behaviors after Detecting Symptoms by Korean Stroke Patients

Journal of Korean Academy of Nursing ◽

10.4040/jkan.2006.36.4.662 ◽

2006 ◽

Vol 36 (4) ◽

pp. 662 ◽

Cited By ~ 1

Author(s):

Hyo Sook Oh ◽

Hyeoun Ae Park

Keyword(s):

Decision Tree ◽

Decision Tree Model ◽

Treatment Seeking ◽

Stroke Patients ◽

Tree Model

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A novel enhanced decision tree model for detecting chronic kidney disease

Network Modeling Analysis in Health Informatics and Bioinformatics ◽

10.1007/s13721-021-00302-w ◽

2021 ◽

Vol 10 (1) ◽

Author(s):

Avijit Kumar Chaudhuri ◽

Deepankar Sinha ◽

Dilip K. Banerjee ◽

Anirban Das

Keyword(s):

Chronic Kidney Disease ◽

Kidney Disease ◽

Decision Tree ◽

Decision Tree Model ◽

Tree Model

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Risk of Pre-Malignancy or Malignancy in Postmenopausal Endometrial Polyps: A CHAID Decision Tree Analysis

Diagnostics ◽

10.3390/diagnostics11061094 ◽

2021 ◽

Vol 11 (6) ◽

pp. 1094

Author(s):

Michael Wong ◽

Nikolaos Thanatsis ◽

Federica Nardelli ◽

Tejal Amin ◽

Davor Jurkovic

Keyword(s):

Decision Tree ◽

Expectant Management ◽

Decision Tree Model ◽

Decision Tree Analysis ◽

Focal Lesions ◽

Tree Model ◽

Normal Endometrium ◽

Endometrial Polyps ◽

Tree Analysis ◽

Interaction Detection

Background and aims: Postmenopausal endometrial polyps are commonly managed by surgical resection; however, expectant management may be considered for some women due to the presence of medical co-morbidities, failed hysteroscopies or patient’s preference. This study aimed to identify patient characteristics and ultrasound morphological features of polyps that could aid in the prediction of underlying pre-malignancy or malignancy in postmenopausal polyps. Methods: Women with consecutive postmenopausal polyps diagnosed on ultrasound and removed surgically were recruited between October 2015 to October 2018 prospectively. Polyps were defined on ultrasound as focal lesions with a regular outline, surrounded by normal endometrium. On Doppler examination, there was either a single feeder vessel or no detectable vascularity. Polyps were classified histologically as benign (including hyperplasia without atypia), pre-malignant (atypical hyperplasia), or malignant. A Chi-squared automatic interaction detection (CHAID) decision tree analysis was performed with a range of demographic, clinical, and ultrasound variables as independent, and the presence of pre-malignancy or malignancy in polyps as dependent variables. A 10-fold cross-validation method was used to estimate the model’s misclassification risk. Results: There were 240 women included, 181 of whom presented with postmenopausal bleeding. Their median age was 60 (range of 45–94); 18/240 (7.5%) women were diagnosed with pre-malignant or malignant polyps. In our decision tree model, the polyp mean diameter (≤13 mm or >13 mm) on ultrasound was the most important predictor of pre-malignancy or malignancy. If the tree was allowed to grow, the patient’s body mass index (BMI) and cystic/solid appearance of the polyp classified women further into low-risk (≤5%), intermediate-risk (>5%–≤20%), or high-risk (>20%) groups. Conclusions: Our decision tree model may serve as a guide to counsel women on the benefits and risks of surgery for postmenopausal endometrial polyps. It may also assist clinicians in prioritizing women for surgery according to their risk of malignancy.

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Reanalysis and External Validation of a Decision Tree Model for Detecting Unrecognized Diabetes in Rural Chinese Individuals

International Journal of Endocrinology ◽

10.1155/2017/3894870 ◽

2017 ◽

Vol 2017 ◽

pp. 1-6 ◽

Cited By ~ 2

Author(s):

Zhong Xin ◽

Lin Hua ◽

Xu-Hong Wang ◽

Dong Zhao ◽

Cai-Guo Yu ◽

...

Keyword(s):

Decision Tree ◽

Predictive Value ◽

Early Stage ◽

Current Model ◽

External Validation ◽

Area Under The Curve ◽

Decision Tree Model ◽

Tree Model ◽

Chinese Adult ◽

Significant Difference

We reanalyzed previous data to develop a more simplified decision tree model as a screening tool for unrecognized diabetes, using basic information in Beijing community health records. Then, the model was validated in another rural town. Only three non-laboratory-based risk factors (age, BMI, and presence of hypertension) with fewer branches were used in the new model. The sensitivity, specificity, positive predictive value, negative predictive value, and area under the curve (AUC) for detecting diabetes were calculated. The AUC values in internal and external validation groups were 0.708 and 0.629, respectively. Subjects with high risk of diabetes had significantly higher HOMA-IR, but no significant difference in HOMA-B was observed. This simple tool will help general practitioners and residents assess the risk of diabetes quickly and easily. This study also validates the strong associations of insulin resistance and early stage of diabetes, suggesting that more attention should be paid to the current model in rural Chinese adult populations.

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