58 ROLE OF THYROID HORMONE IN THE REGULATION OF COLONIC Na+ TRANSPORT DURING EARLY POSTNATAL DEVELOPMENT

1995 ◽  
Vol 20 (4) ◽  
pp. 459
Author(s):  
J. Pácha ◽  
I. Pohlová
Keyword(s):  
Thyroid Hormone ◽  
Postnatal Development ◽  
Na Transport ◽  
Early Postnatal Development

Early postnatal development of electrophysiological and histological properties of sensory sural nerves in male rats that were maternally deprived and artificially reared: Role of tactile stimulation

2017 ◽  
Vol 78 (4) ◽  
pp. 351-362 ◽  
Author(s):  
Rene Zempoalteca ◽  
Mercedes G. Porras ◽  
Suelem Moreno-Pérez ◽  
Gabriela Ramirez-Funez ◽  
Elsa L. Aguirre-Benítez ◽  
...  
Keyword(s):  
Postnatal Development ◽  
Tactile Stimulation ◽  
Male Rats ◽  
Early Postnatal Development ◽  
Sural Nerves

Role of thyroxine on postnatal development of ileal active bile salt transport

1986 ◽  
Vol 251 (2) ◽  
pp. G237-G242 ◽  
Author(s):  
J. E. Heubi
Keyword(s):  
Thyroid Hormone ◽  
Postnatal Development ◽  
Active Transport ◽  
Salt Transport ◽  
Maximal Velocity ◽  
Sprague Dawley ◽  
Sprague Dawley Rats ◽  
Taurocholate Transport

The role of thyroid hormone on the postnatal development of ileal active taurocholate transport uptake was measured by an in vitro incubation technique in Sprague-Dawley rats. In 16-day-old rats treated with pharmacological doses of L-thyroxine (50 micrograms X 100 g body wt-1 X day-1 on days 10-13), ileal active transport appeared precociously whose Km was 1.60 +/- 0.48 mM and Vapp (apparent maximal velocity) was 8.09 +/- 1.14 nmol X min-1 X mg dry wt-1, while age-matched shams had only passive diffusion of taurocholate. To determine whether enhanced endogenous secretion of thyroxine was capable of stimulating development of ileal active taurocholate transport, thyrotrophic stimulating hormone (TSH) (0.5 U/100 g body wt twice daily) was given on days 10-13, with uptake measured on day 16. Following TSH treatment, only passive transport for taurocholate was observed in the ileum; uptake rates were consistently higher than those for untreated controls at each study concentration. Thyroidectomy performed at age 14 days with uptake measured at age 21 days did not ablate development of ileal active transport but resulted in a significant reduction (P less than 0.001) in the Vapp (7.39 +/- 1.10 nmol X min-1 X mg dry wt-1) and a significant increase (P less than 0.014) in Km (1.72 +/- 0.53 mM) compared with age-matched controls. Thyroid hormone does not appear to be obligatory for the postnatal development of ileal active taurocholate transport.

scholarly journals Autophagy precedes apoptosis during degeneration of the Kölliker’s organ in the development of rat cochlea

2019 ◽  
Vol 63 (2) ◽  
Author(s):  
Shule Hou ◽  
Jiarui Chen ◽  
Jun Yang
Keyword(s):  
Postnatal Development ◽  
Supporting Cells ◽  
Autophagy Flux ◽  
Early Postnatal Development ◽  
Sequestosome 1 ◽  
Transmission Electron ◽  
Cellular Apoptosis ◽  
Epithelial Structure ◽  
Apoptosis Markers

The Kölliker’s organ is a transient epithelial structure during cochlea development that gradually degenerates and disappears at postnatal 12-14 days (P12-14). While apoptosis has been shown to play an essential role in the degeneration of the Kölliker’s organ, the role of another programmed cell death, autophagy, remains unclear. In our study, autophagy markers including microtubule associated protein light chain 3-II (LC3-II), sequestosome 1 (SQSTM1/p62) and Beclin1 were detected in the supporting cells of the Kölliker’s organ through immunohistochemistry staining. In addition, Western blot and real-time PCR revealed a gradually decreased expression of LC3-II and an increased expression of p62 during early postnatal development. Compared to apoptosis markers that peaks between P7 and P10, autophagy flux peaked earlier at P1 and decreased from P1 to P14. By transmission electron microscopy, we observed representative autophagosome and autolysosome that packaged various organelles in the supporting cells of the Kölliker’s organ. During the degeneration, these organelles were digested via autophagy well ahead of the cellular apoptosis. These results suggest that autophagy plays an important role in transition and degeneration of the Kölliker’s organ prior to apoptosis during the early postnatal development.

scholarly journals The role of Matriptase-2 during the early postnatal development in humans

Haematologica ◽  
2016 ◽  
Vol 101 (4) ◽  
pp. e126-e128 ◽  
Author(s):  
Luigia De Falco ◽  
Mariasole Bruno ◽  
Ebru Yilmaz-Keskin ◽  
Ertan Sal ◽  
Mustafa Büyükavci ◽  
...  
Keyword(s):  
Postnatal Development ◽  
Early Postnatal Development

scholarly journals CRISPR/Cas9-mediated knockout of Mct8 reveals a functional involvement of Mct8 in testis and sperm development in a rat

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Hee Sook Bae ◽  
Yun-Kyeong Jin ◽  
Sangwoo Ham ◽  
Hee Kyoung Kim ◽  
Hyejung Shin ◽  
...  
Keyword(s):  
Postnatal Development ◽  
Male Reproduction ◽  
Monocarboxylate Transporter ◽  
Male Rats ◽  
Growth Delay ◽  
Minor Role ◽  
Wild Type ◽  
Early Postnatal Development ◽  
Functional Involvement

AbstractThyroid hormone (TH) has long been believed to play a minor role in male reproduction. However, evidences from experimental model of thyrotoxicosis or hypothyroidism suggests its role in spermatogenesis. Cellular action of TH requires membrane transport via specific transporters such as monocarboxylate transporter 8 (MCT8). SLC16A2 (encodes for MCT8) inactivating mutation in humans can lead to Allan-Herndon Dudley-syndrome, a X-linked psychomotor and growth retardation. These patients present cryptorchidism which suggests a role of MCT8 during spermatogenesis. In this study, we found that Mct8 is highly expressed during early postnatal development and decreases its expression in the adulthood of testis of wild-type male rats. Histological analysis revealed that spermatogonia largely lacks MCT8 expression while spermatocytes and maturing spermatids highly express MCT8. To further understand the role of Mct8 during spermatogenesis, we generated Slc16a2 (encodes MCT8) knockout rats using CRISPR/Cas9. Serum THs (T3 and T4) level were significantly altered in Slc16a2 knockout rats when compared to wild-type littermates during early to late postnatal development. Unlike Slc16a2 knockout mice, Slc16a2 knockout rats showed growth delay during early to late postnatal development. In adult Slc16a2 knockout rats, we observed reduced sperm motility and viability. Collectively, our data unveil a functional involvement of MCT8 in spermatogenesis, underscoring the importance of TH signaling and action during spermatogenesis.

Thyroid hormone-catecholamine interrelationships during exposure to cold

1981 ◽  
Vol 97 (1) ◽  
pp. 91-97 ◽  
Author(s):  
H. Storm ◽  
C. van Hardeveld ◽  
A. A. H. Kassenaar
Keyword(s):  
Nervous System ◽  
Plasma Concentration ◽  
Thyroid Hormone ◽  
Sympathetic Nervous System ◽  
Plasma Levels ◽  
Surgical Procedure ◽  
Exposure To Cold ◽  
Basal Plasma ◽  
Sympathetic Nervous

Abstract. Basal plasma levels for adrenalin (A), noradrenalin (NA), l-triiodothyronine (T3), and l-thyroxine (T4) were determined in rats with a chronically inserted catheter. The experiments described in this report were started 3 days after the surgical procedure when T3 and T4 levels had returned to normal. Basal levels for the catecholamines were reached already 4 h after the operation. The T3/T4 ratio in plasma was significantly increased after 3, 7, and 14 days in rats kept at 4°C and the same holds for the iodide in the 24-h urine after 7 and 14 days at 4°C. The venous NA plasma concentration was increased 6- to 12-fold during the same period of exposure to cold, whereas the A concentration remained at the basal level. During infusion of NA at 23°C the T3/T4 ratio in plasma was significantly increased after 7 days compared to pair-fed controls, and the same holds for the iodide excretion in the 24-h urine. This paper presents further evidence for a role of the sympathetic nervous system on T4 metabolism in rats at resting conditions.

Biological activity of novel thyroid hormone analogues: role of Na+ taurocholate cotransporting polypeptide in liver selectivity

2015 ◽  
Author(s):  
Giulia Brigante ◽  
Bo Carlsson ◽  
Simone Kersseboom ◽  
Robin P Peeters ◽  
Theo J Visser
Keyword(s):  
Biological Activity ◽  
Thyroid Hormone
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