HEALING CHRONIC WOUNDS WITH EPIDERMAL GROWTH FACTOR

Background: Chronic wounds, particularly non-healing wounds, are one of the most prevalent surgical disorders that a surgeon may see. The characteristic of a chronic wound is that it does not heal despite daily dressings and costly local treatments. Aims of the study to investigate the healing effects of recombinant human epidermal growth factor (hEGF) on non-healing ulcers and to assess the effectiveness, acceptability, and safety of a new epidermal growth factor (EGF) wound dressing.Methods: On 60 patients with chronic non-healing ulcers, a randomized, prospective, and comparative research was conducted in the department of general surgery, SVS medical college and hospital, Mahbubnagar. These 60 patients were separated into two groups, each with fifteen patients. The EGF was applied to group A, whereas normal saline was given to group B.Results: The 60 patients who agreed to participate in the trial were separated into two groups (30 each) that were equal and comparable. Patients who received topical EGF 0.01% gel dressings were assigned to the trial, whereas those who received standard antiseptic wound dressing were assigned to the control group. Six of the fifteen patients in the test group were men, whereas eleven were males and four were females in the control group. When the two groups were compared, the test group had a substantial reduction in ulcer area compared to the control group (p<0.001)Conclusions: EGF is a superior alternative for treating chronic non-healing ulcers because of its cost effectiveness, availability, reduced hospital stay, and simplicity of administration.

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Epidermal Growth Factor in Wound Healing: A Model for the Molecular Pathogenesis of Chronic Wounds

Growth Factors and Wound Healing ◽

10.1007/978-1-4612-1876-0_12 ◽

1997 ◽

pp. 206-228 ◽

Cited By ~ 6

Author(s):

Roy W. Tarnuzzer ◽

Shawn P. Macauley ◽

Bruce A. Mast ◽

Jane S. Gibson ◽

Michael C. Stacey ◽

...

Keyword(s):

Wound Healing ◽

Growth Factor ◽

Epidermal Growth Factor ◽

Chronic Wounds ◽

Molecular Pathogenesis ◽

Epidermal Growth

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Growth factor functionalized biomaterial for drug delivery and tissue regeneration

Journal of Bioactive and Compatible Polymers ◽

10.1177/0883911517705403 ◽

2017 ◽

Vol 32 (6) ◽

pp. 568-581 ◽

Cited By ~ 6

Author(s):

Alex Leonard ◽

Piyush Koria

Keyword(s):

Drug Delivery ◽

Wound Healing ◽

Growth Factor ◽

Epidermal Growth Factor ◽

Tissue Regeneration ◽

Chronic Wounds ◽

Biologically Active ◽

Application Site ◽

Epidermal Growth ◽

And Migration

Elastin-like polypeptides are a class of naturally derived and non-immunogenic biomaterials that are widely used in drug delivery and tissue engineering. Elastin-like polypeptides undergo temperature-mediated inverse phase transitioning, which allows them to be purified in a relatively simple manner from bacterial expression hosts. Being able to genetically encode elastin-like polypeptides allows for the incorporation of bioactive peptides, thereby functionalizing them. Here, we report the synthesis of a biologically active epidermal growth factor–elastin-like polypeptide fusion protein that could aid in wound healing. Epidermal growth factor plays a crucial role in wound healing by inducing cell proliferation and migration. The use of exogenous epidermal growth factor has seen success in the treatment of acute wounds, but has seen relatively minimal success in chronic wounds because the method of delivery does not prevent it from diffusing away from the application site. Our data show that epidermal growth factor–elastin-like polypeptide retained the biological activity of epidermal growth factor and the phase transitioning property of elastin-like polypeptide. Furthermore, the ability of the epidermal growth factor–elastin-like polypeptide to self-assemble near physiological temperatures could allow for the formation of drug depots at the wound site and minimize diffusion, increasing the bioavailability of epidermal growth factor and enhancing tissue regeneration.

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Effect of moist dressing, collagen sheet dressing and epidermal growth factor in healing of chronic wounds

International Surgery Journal ◽

10.18203/2349-2902.isj20173395 ◽

2017 ◽

Vol 4 (8) ◽

pp. 2594

Author(s):

Sheelchandra Jain ◽

Darshana S. Tote ◽

Gaurav Kolte ◽

Suhas Jajoo ◽

Sachin Tote

Keyword(s):

Growth Factor ◽

Epidermal Growth Factor ◽

Chronic Wounds ◽

Chronic Wound ◽

Cost Effective ◽

Functional Results ◽

Treated Group ◽

Controlled Study ◽

Collagen Group ◽

Epidermal Growth

Background: Surgical literature is full of innumerable solutions to the problems of wound healing and it speaks of itself that the problem is not so simple and straight forward to tackle with. The aim of the present study was to compare three modalities moist saline dressing, collagen sheet dressing and epidermal growth factor in early epithelization and healing of chronic wounds. to study the effect of various dressing modalities on epithelization of chronic wound in terms of time required for healing and the quality of scar it forms, the functional results both early and late, post-healing morbidity and complications and the practicality and the cost involved in using these modalities.Methods: Prospective randomized controlled study. Study including chronic wound cases admit to AVBRH Sawangi over period of 3 years.Results: Reduction in size of wound by 70-100% was found highest in Epigrof group. In Epigrof treated group 88% of wounds healed within 3 weeks while 80% in collagen group and 56% in moist dressing group it. Collagen dressing is the most cost effective of the three whereas Epigrof was most costly due to the initial cost of purchase. The scar quality was satisfactory in 19 of Epigrof group and 17 of the collagen sheet group and 15 of the moist dressing group.Conclusions: Epidermal growth factor is superior in epithelization, collagen is the next best local applicant, but collagen sheet is more cost effective than Epigrof and non-adherent dressings.

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Stimulation of Healing of Chronic Wounds by Epidermal Growth Factor

Plastic & Reconstructive Surgery ◽

10.1097/00006534-199108000-00001 ◽

1991 ◽

Vol 88 (2) ◽

pp. 189-194 ◽

Cited By ~ 98

Author(s):

Gregory L. Brown ◽

Luke Curtsinger ◽

Maurice J. Jurkiewicz ◽

Foad Nahai ◽

Gregory Schultz

Keyword(s):

Growth Factor ◽

Epidermal Growth Factor ◽

Chronic Wounds ◽

Epidermal Growth ◽

Stimulation Of

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Stimulation of Healing of Chronic Wounds by Epidermal Growth Factor

Plastic & Reconstructive Surgery ◽

10.1097/00006534-199108000-00002 ◽

1991 ◽

Vol 88 (2) ◽

pp. 195-196 ◽

Cited By ~ 1

Author(s):

Gregory L. Brown ◽

Luke Curtsinger ◽

Maurice J. Jurkiewicz ◽

Foad Nahai ◽

Gregory Schultz ◽

...

Keyword(s):

Growth Factor ◽

Epidermal Growth Factor ◽

Chronic Wounds ◽

Epidermal Growth ◽

Stimulation Of

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Diabetic Foot Ulcers and Epidermal Growth Factor: Revisiting the Local Delivery Route for a Successful Outcome

BioMed Research International ◽

10.1155/2017/2923759 ◽

2017 ◽

Vol 2017 ◽

pp. 1-10 ◽

Cited By ~ 13

Author(s):

Jorge Berlanga-Acosta ◽

José Fernández-Montequín ◽

Calixto Valdés-Pérez ◽

William Savigne-Gutiérrez ◽

Yssel Mendoza-Marí ◽

...

Keyword(s):

Growth Factor ◽

Epidermal Growth Factor ◽

Chronic Wounds ◽

Healing Process ◽

Tissue Response ◽

Successful Outcome ◽

Local Infiltration ◽

Epidermal Growth ◽

The Impact

Soon after epidermal growth factor (EGF) discovery, some in vivo models appeared demonstrating its property to enhance cutaneous wound healing. EGF was the first growth factor (GF) introduced in the clinical arena as a healing enhancer, exerting its mitogenic effects on epithelial, fibroblastoid, and endothelial cells via a tyrosine kinase membrane receptor. Compelling evidences from the 90s documented that, for EGF, locally prolonged bioavailability and hourly interaction with the receptor were necessary for a successful tissue response. Eventually, the enthusiasm on the clinical use of EGF to steer the healing process was wiped out as the topical route to deliver proteins started to be questioned. The simultaneous in vivo experiments, emphasizing the impact of the parenterally administered EGF on epithelial and nonepithelial organs in terms of mitogenesis and cytoprotection, rendered the theoretical fundamentals for the injectable use of EGF and shaped the hypothesis that locally infiltrating the diabetic ulcers would lead to an effective healing. Although the diabetic chronic wounds microenvironment is hostile for local GFs bioavailability, EGF local infiltration circumvented the limitations of its topical application, thus expanding its therapeutic prospect. Our clinical pharmacovigilance and basic studies attest the significance of the GF local infiltration for chronic wounds healing.

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Synergistic effects of hyaluronate – epidermal growth factor conjugate patch on chronic wound healing

Biomaterials Science ◽

10.1039/c8bm00079d ◽

2018 ◽

Vol 6 (5) ◽

pp. 1020-1030 ◽

Cited By ~ 9

Author(s):

Yun Seop Kim ◽

Dong Kyung Sung ◽

Won Ho Kong ◽

Hyemin Kim ◽

Sei Kwang Hahn

Keyword(s):

Wound Healing ◽

Growth Factor ◽

Epidermal Growth Factor ◽

Chronic Wounds ◽

Chronic Wound ◽

Synergistic Effects ◽

Topical Delivery ◽

Epidermal Growth

A HA–EGF conjugate patch was developed for the treatment of diabetic chronic wounds with advantages such as facilitating topical delivery and interaction with dual receptors, and alleviating the degradation of EGF.

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