Is the function of CCKA-receptors blunted in morbidly obese subjects?

The effect of bariatric surgery on lipid profile and the qualitative characteristics of lipoproteins was analyzed in morbidly obese subjects. Thirteen obese patients underwent bariatric surgery. Plasma samples were obtained before surgery and at 6 and 12 months after the intervention. Thirteen healthy subjects comprised the control group. Lipid profile, hsCRP, and the composition and functional characteristics of VLDL, LDL, and HDL were assessed. At baseline, plasma from subjects with obesity had more triglycerides, VLDLc, and hsCRP, and less HDLc than the control group. These levels progressively normalized after surgery, although triglyceride and hsCRP levels remained higher than those in the controls. The main differences in lipoprotein composition between the obese subjects and the controls were increased apoE in VLDL, and decreased cholesterol and apoJ and increased apoC-III content in HDL. The pro-/anti-atherogenic properties of LDL and HDL were altered in the subjects with obesity at baseline compared with the controls, presenting smaller LDL particles that are more susceptible to modification and smaller HDL particles with decreased antioxidant capacity. Bariatric surgery normalized the composition of lipoproteins and improved the qualitative characteristics of LDL and HDL. In summary, patients with obesity present multiple alterations in the qualitative properties of lipoproteins compared with healthy subjects. Bariatric surgery reverted most of these alterations.

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Accuracy of Near Infrared-Guided Surgery in Morbidly Obese Subjects Undergoing Laparoscopic Cholecystectomy

Obesity Surgery ◽

10.1007/s11695-015-1781-9 ◽

2015 ◽

Vol 26 (3) ◽

pp. 525-530 ◽

Cited By ~ 19

Author(s):

Fernando Dip ◽

David Nguyen ◽

Lisandro Montorfano ◽

María Eugenia Szretter Noste ◽

Emanuele Lo Menzo ◽

...

Keyword(s):

Laparoscopic Cholecystectomy ◽

Near Infrared ◽

Morbidly Obese ◽

Guided Surgery ◽

Obese Subjects

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Relationship of epicardial adipose tissue with atrial dimensions and diastolic function in morbidly obese subjects

International Journal of Cardiology ◽

10.1016/j.ijcard.2006.04.016 ◽

2007 ◽

Vol 115 (2) ◽

pp. 272-273 ◽

Cited By ~ 123

Author(s):

Gianluca Iacobellis ◽

Frida Leonetti ◽

Navneet Singh ◽

Arya M Sharma

Keyword(s):

Adipose Tissue ◽

Diastolic Function ◽

Epicardial Adipose Tissue ◽

Morbidly Obese ◽

Obese Subjects ◽

Relationship Of

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Leptin Production in Adipocytes from Morbidly Obese Subjects: Stimulation by Dexamethasone, Inhibition with Troglitazone, and Influence of Gender1

The Journal of Clinical Endocrinology & Metabolism ◽

10.1210/jcem.85.8.6733 ◽

2000 ◽

Vol 85 (8) ◽

pp. 2678-2684

Author(s):

Lloyd B. Williams ◽

Rachael L. Fawcett ◽

Angela S. Waechter ◽

Peili Zhang ◽

Brian E. Kogon ◽

...

Keyword(s):

Morbidly Obese ◽

Obese Subjects

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Long-Term Effects of Sleeve Gastrectomy and Roux-en-Y Gastric Bypass Surgery on Type 2 Diabetes Mellitus in Morbidly Obese Subjects

Annals of Surgery ◽

10.1097/sla.0b013e318262ee6b ◽

2012 ◽

Vol 256 (6) ◽

pp. 1023-1029 ◽

Cited By ~ 167

Author(s):

Amanda Jiménez ◽

Roser Casamitjana ◽

Lílliam Flores ◽

Judith Viaplana ◽

Ricard Corcelles ◽

...

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Gastric Bypass ◽

Bypass Surgery ◽

Gastric Bypass Surgery ◽

Morbidly Obese ◽

Long Term Effects ◽

Obese Subjects

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Facilitating Airway Surgery in a Morbidly Obese Patient Using Transnasal Humidified Rapid Insufflation Ventilatory Exchange (THRIVE)

Case Reports in Anesthesiology ◽

10.1155/2018/5310342 ◽

2018 ◽

Vol 2018 ◽

pp. 1-3 ◽

Cited By ~ 4

Author(s):

Si-Jia Lee ◽

Kelvin Howyow Quek

Keyword(s):

Obese Patient ◽

Normal Weight ◽

Morbidly Obese ◽

Airway Surgery ◽

Laryngeal Surgery ◽

Morbidly Obese Patient ◽

Obese Population ◽

Obese Subjects ◽

Difficult Airways ◽

Surgical Field

Transnasal Humidified Rapid Insufflation Ventilatory Exchange (THRIVE) is a relatively new noninvasive oxygenation technique with a broad range of applications. It is used in the treatment of type one respiratory failure, as a preoxygenation tool, as a rescue and temporising measure in difficult airways, and as step-down oxygen therapy in patients after extubation. Its use has also been described in laryngeal surgeries, but they mainly involved normal-weight subjects or were used as a bridging oxygenation therapy before definitive airway is secured. The major benefits of using THRIVE in obese subjects undergoing laryngeal surgery include a tubeless and uninterrupted surgical field. This advantage is especially crucial in obese patients as they tend to have limited oropharyngeal space, rendering a shared airway technically challenging for surgeons. However, concerns of potential difficult airway and shorter safe apnoeic time in the obese population limit its use. In this case, we report its use as the sole oxygenation strategy in a morbidly obese patient undergoing airway surgery. Our experience suggests that THRIVE can provide a conducive operating field and adequate oxygenation in short apnoeic laryngeal procedures in the obese population, without causing excessive hypercarbia.

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The association of NOV/CCN3 with obstructive sleep apnea (OSA): preliminary evidence of a novel biomarker in OSA

Hormone Molecular Biology and Clinical Investigation ◽

10.1515/hmbci-2017-0029 ◽

2017 ◽

Vol 31 (2) ◽

Cited By ~ 3

Author(s):

Jeremy A. Weingarten ◽

Lars Bellner ◽

Stephen J. Peterson ◽

Moe Zaw ◽

Puja Chadha ◽

...

Keyword(s):

Obstructive Sleep Apnea ◽

Sleep Apnea ◽

Matrix Protein ◽

Strong Association ◽

Preliminary Evidence ◽

Extracellular Matrix Protein ◽

Morbidly Obese ◽

Potential Marker ◽

Obstructive Sleep ◽

Obese Subjects

AbstractObstructive sleep apnea (OSA) has a strong association with cardiovascular and metabolic abnormalities, although the mechanism driving this association is not well established. NOV/CCN3, a multifunctional extracellular matrix protein, may play a mechanistic and/or prognostic role in these associations. We hypothesized that patients with OSA, which primarily affects obese individuals, will have increased levels of NOV, and that NOV can serve as a biomarker in patients to predict OSA as well as metabolic and cardiac risk. Ten morbidly obese and 10 healthy lean subjects underwent overnight polysomnography (PSG) and clinical evaluation. Blood samples were analyzed for NOV levels, adiponectin and IL-6. OSA was found in nine obese subjects and three lean subjects. NOV levels were significantly higher in the OSA vs. no OSA group (2.1 ± 0.9 vs. 1.3 ± 0.8, p < 0.03). NOV levels were significantly higher in the obese vs. lean group (2.2 ± 0.3 vs. 1.4 ± 0.2-fold change, p < 0.03). Among lean subjects, NOV levels were significantly higher in the OSA vs. no OSA group (2.1 ± 0.9 vs. 1.0 ± 0.4, p < 0.05). NOV and AHI were positively correlated (ρ = 0.49, p = 0.033). IL-6 and adiponectin differences in obese vs. lean and OSA vs. no OSA were consistent with an inflammatory phenotype in obese subjects and OSA subjects. NOV is a novel biomarker of the presence and severity of OSA and a potential marker of future cardiovascular and metabolic disease in OSA patients.

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Liver markers, prevalence of the metabolic syndrome abnormalities and effect of Roux-en-Y gastric bypass in morbidly obese subjects

Einstein (São Paulo) ◽

10.1590/s1679-45082011ao2042 ◽

2011 ◽

Vol 9 (4) ◽

pp. 429-435

Author(s):

Ary Serpa Neto ◽

Felipe Martin Bianco Rossi ◽

Rodrigo Dal Moro Amarante ◽

Marçal Rossi

Keyword(s):

Metabolic Syndrome ◽

Gastric Bypass ◽

Heavy Drinking ◽

University Hospital ◽

Morbidly Obese ◽

Metabolic Abnormalities ◽

Glucose Levels ◽

The Metabolic Syndrome ◽

Obese Subjects ◽

Liver Markers

ABSTRACT Objectives: To evaluate the relations between liver markers (GGT, ALT and AST) and the metabolic syndrome (and its components) in morbidly obese subjects, and to determine the response of these metabolic factors and hepatic enzymes after weight loss induced by Roux-en-Y gastric bypass. Methods: This study was carried out at a university hospital, in Santo André (SP), Brazil. We evaluated 140 morbidly obese subjects aged from 18 to 60 years submitted to a Roux-en-Y gastric bypass, who were followed for a mean period of 8 months. Patients with a history of heavy drinking, type 1 diabetes, and/or liver disease were excluded. Results: Liver markers, most notably GGT, were strongly associated with metabolic abnormalities, mainly hyperglycemia. The prevalence of type 2 diabetes significantly increased with increasing levels of GGT (highest versus lowest quartile GGT: odds ratio 3.89 [95%CI: 1.07-14.17]). Liver markers significantly decreased 8 months after the Roux-en-Y gastric bypass and the reduction of GGT levels were associated with the reduction of glucose levels (Pearson r = 0.286; p = 0.001). Conclusions: Elevated levels of liver markers, principally GGT, in morbidly obese subjects are associated with metabolic abnormalities. In addition to the well-known benefits of bariatric surgery, Roux-en-Y gastric bypass, reduced the levels of liver markers to the normal range.

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