Relationship of epicardial adipose tissue with atrial dimensions and diastolic function in morbidly obese subjects

2007 ◽  
Vol 115 (2) ◽  
pp. 272-273 ◽  
Author(s):  
Gianluca Iacobellis ◽  
Frida Leonetti ◽  
Navneet Singh ◽  
Arya M Sharma
Keyword(s):  
Adipose Tissue ◽  
Diastolic Function ◽  
Epicardial Adipose Tissue ◽  
Morbidly Obese ◽  
Obese Subjects ◽  
Relationship Of

scholarly journals RANTES release by human adipose tissue in vivo and evidence for depot-specific differences

2009 ◽  
Vol 296 (6) ◽  
pp. E1262-E1268 ◽  
Author(s):  
Rana Madani ◽  
Kalypso Karastergiou ◽  
Nicola C. Ogston ◽  
Nazar Miheisi ◽  
Rahul Bhome ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Subcutaneous Adipose Tissue ◽  
Epicardial Adipose Tissue ◽  
Ex Vivo ◽  
Human Adipose Tissue ◽  
Fat Pad ◽  
Obese Subjects ◽  
Subcutaneous Adipose ◽  
Circulating Levels

Obesity is associated with elevated inflammatory signals from various adipose tissue depots. This study aimed to evaluate release of regulated on activation, normal T cell expressed and secreted (RANTES) by human adipose tissue in vivo and ex vivo, in reference to monocyte chemoattractant protein-1 (MCP-1) and interleukin-6 (IL-6) release. Arteriovenous differences of RANTES, MCP-1, and IL-6 were studied in vivo across the abdominal subcutaneous adipose tissue in healthy Caucasian subjects with a wide range of adiposity. Systemic levels and ex vivo RANTES release were studied in abdominal subcutaneous, gastric fat pad, and omental adipose tissue from morbidly obese bariatric surgery patients and in thoracic subcutaneous and epicardial adipose tissue from cardiac surgery patients without coronary artery disease. Arteriovenous studies confirmed in vivo RANTES and IL-6 release in adipose tissue of lean and obese subjects and release of MCP-1 in obesity. However, in vivo release of MCP-1 and RANTES, but not IL-6, was lower than circulating levels. Ex vivo release of RANTES was greater from the gastric fat pad compared with omental ( P = 0.01) and subcutaneous ( P = 0.001) tissue. Epicardial adipose tissue released less RANTES than thoracic subcutaneous adipose tissue in lean ( P = 0.04) but not obese subjects. Indexes of obesity correlated with epicardial RANTES but not with systemic RANTES or its release from other depots. In conclusion, RANTES is released by human subcutaneous adipose tissue in vivo and in varying amounts by other depots ex vivo. While it appears unlikely that the adipose organ contributes significantly to circulating levels, local implications of this chemokine deserve further investigation.

scholarly journals Increase in Brown Adipose Tissue Activity after Weight Loss in Morbidly Obese Subjects

2012 ◽  
Vol 97 (7) ◽  
pp. E1229-E1233 ◽  
Author(s):  
G. H. E. J. Vijgen ◽  
N. D. Bouvy ◽  
G. J. J. Teule ◽  
B. Brans ◽  
J. Hoeks ◽  
...  
Keyword(s):  
Weight Loss ◽  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Morbidly Obese ◽  
Brown Adipose ◽  
Obese Subjects ◽  
Brown Adipose Tissue Activity

scholarly journals Associations between Tissue Visfatin/Nicotinamide, Phosphoribosyltransferase (Nampt), Retinol Binding Protein-4, and Vaspin Concentrations and Insulin Resistance in Morbidly Obese Subjects

2013 ◽  
Vol 2013 ◽  
pp. 1-9 ◽  
Author(s):  
Zeynep Goktas ◽  
Shannon Owens ◽  
Mallory Boylan ◽  
David Syn ◽  
Chwan-Li Shen ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Adipose Tissue ◽  
Binding Protein ◽  
Retinol Binding Protein ◽  
Morbidly Obese ◽  
Tissue Samples ◽  
Blood Concentrations ◽  
Nicotinamide Phosphoribosyltransferase ◽  
Retinol Binding Protein 4 ◽  
Obese Subjects

Visfatin/Nampt, vaspin, and retinol binding protein-4 (RBP-4) play an important role in insulin resistance. The objectives of this study were to measure visfatin/Nampt, vaspin, and RBP-4 concentrations in blood, liver, muscle, subcutaneous, omental, and mesenteric adipose tissues in morbidly obese subjects and investigate their relationship to insulin resistance. Blood and tissue samples were collected from 38 morbidly obese subjects during Roux-en-Y surgery. Insulin resistance biomarkers were measured using standard kits. Visfatin/Nampt, vaspin, and RBP-4 gene expression levels in tissues were measured using real-time PCR. Their protein concentrations in blood and tissues were measured using ELISA kits. Diabetic subjects had significantly higher homeostasis model of assessment-insulin resistance and age and lower blood HDL-cholesterol concentrations than nondiabetic and prediabetic subjects. Diabetic and prediabetic subjects had significantly higher blood concentrations of visfatin/Nampt and vaspin than nondiabetic subjects. Liver RBP-4 concentrations were positively associated with blood glucose concentrations. Blood insulin resistance biomarker levels were positively associated with visfatin/Nampt concentrations in omental adipose tissue and liver, and vaspin concentrations in mesenteric adipose tissue. In conclusion, the correlations of visfatin/Nampt, vaspin, and RBP-4 with insulin resistance are tissue dependent.

Circulating Chemerin, Oxidative Stress, Inflammation and Insulin Resistance in Morbid Obesity

2017 ◽  
Vol 68 (5) ◽  
pp. 1014-1018 ◽  
Author(s):  
Viviana Aursulesei ◽  
Siminela Bulughiana ◽  
Bogdan Alexandru Stoica ◽  
Ecaterina Anisie
Keyword(s):  
Oxidative Stress ◽  
Insulin Resistance ◽  
Morbid Obesity ◽  
Independent Predictor ◽  
Metabolic Phenotype ◽  
Morbidly Obese ◽  
Pathophysiological Role ◽  
Obese Subjects ◽  
Relationship Of ◽  
The Relationship

Chemerin is a relatively novel adipokine with controversial pathophysiological role in obesity. Our study aimed to investigate the relationship of serum chemerin level with inflammation, oxidative stress and insulin resistance in morbidly obese subjects. Circulating chemerin was an independent predictor of TNF-Q level, superoxide dismutase activity and lipid peroxidation, but no relation with insulin resistance could be sustained. Taken together chemerin could be a marker of dysfunctional adipose tissue, but its serum level does not reflect properly the metabolic phenotype in morbid obesity.

Energy Expenditure, Epicardial Adipose Tissue and Cardiorespiratory Fitness in Morbidly Obese Adults

2007 ◽  
Vol 39 (Supplement) ◽  
pp. S385
Author(s):  
Thomas E. Vanhecke ◽  
Peter A. McCullough ◽  
Justin Trivax ◽  
Adam deJong ◽  
Barry A. Franklin
Keyword(s):  
Adipose Tissue ◽  
Energy Expenditure ◽  
Cardiorespiratory Fitness ◽  
Epicardial Adipose Tissue ◽  
Morbidly Obese ◽  
Obese Adults
Sign in / Sign up

Export Citation Format

Share Document