Hypertensive Disorders and Birth Weight in Pregnant Women With Sickle Cell Trait [9H]

2016 ◽  
Vol 127 ◽  
pp. 68S
Author(s):  
Shannon Sullivan ◽  
Jeanne Darbinian ◽  
Mara B. Greenberg
Keyword(s):  
Birth Weight ◽  
Pregnant Women ◽  
Sickle Cell ◽  
Sickle Cell Trait ◽  
Hypertensive Disorders

scholarly journals PfEMP1-specific IgG reactivity among Beninese pregnant women with sickle cell trait

2021 ◽  
Author(s):  
Mary Lopez-Perez ◽  
Firmine Viwami ◽  
Zakaria Seidu ◽  
Anja T R Jensen ◽  
Justin Doritchamou ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Sickle Cell ◽  
Infected Erythrocyte ◽  
Sickle Cell Trait ◽  
Placental Malaria ◽  
Plasmodium Falciparum Malaria ◽  
Risk Of Infection ◽  
Native Proteins ◽  
Malaria Exposure ◽  
Specific Igg

Abstract Background Sickle cell trait (HbAS) protects against severe Plasmodium falciparum malaria, but not against placental malaria (PM). In this study, PfEMP1-specific antibodies were measured in HbAA and HbAS Beninese pregnant women as a proxy of exposure to specific PfEMP1 variants. Methods Plasma samples collected at delivery from 338 HbAA and 63 HbAS women were used to measure IgG levels to six recombinant PfEMP1 proteins and three corresponding native proteins expressed on the infected erythrocyte (IE) surface. IgG-mediated inhibition of VAR2CSA + IEs adhesion to CSA was also tested. Results Levels of PfEMP1-specific IgG were similar in the two groups, except for native IT4VAR09 on IEs, where IgG levels were significantly higher in HbAS women. Adjusted odds ratios for women with positive IgG to HB3VAR06 and PFD1235w suggest a lower risk of infection with these virulent variants among HbAS individuals. The percentage of IEs binding to CSA did not differ between HbAA and HbAS women, but correlated positively with levels of anti-VAR2CSA and parity. Women with PM had lower levels of anti-VAR2CSA-specific IgG and lower IgG-mediated inhibition of IE adhesion to CSA. Conclusions The findings support similar malaria exposure in HbAA and HbAS women and a lack of HbAS-dependent protection against placental infection among pregnant women.

scholarly journals Maternal and perinatal outcomes of hypertensive disorders of pregnancy in Ethiopia: systematic review and meta-analysis

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Amanual Getnet Mersha ◽  
Tadesse Melaku Abegaz ◽  
Mohammed Assen Seid
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Pregnant Women ◽  
Maternal Death ◽  
Hellp Syndrome ◽  
Perinatal Death ◽  
Hypertensive Disorder ◽  
Hypertensive Disorders Of Pregnancy ◽  
Hypertensive Disorders ◽  
Pooled Prevalence

Abstract Background Hypertensive disorders of pregnancy complicate around 6% of pregnancies and accounts for 19% of maternal death in Ethiopia. The current review aimed to assess maternal and perinatal outcomes of pregnancies complicated by hypertension in Ethiopia. Methods A systematic review and meta-analysis was done on the outcome of hypertensive disorder among pregnant women in Ethiopia. Literature search was made in five databases and Statistical analyses were carried out by using Stata 14 software. The pooled prevalence of maternal death, HELLP syndrome, perinatal death, and low birth weight was calculated using a random-effects model. Egger’s test and funnel plot were used to evaluate publication bias. The Cochran Q test and I2 test statistics were used to test the heterogeneity of studies. Result Thirteen studies included in the review, with an overall sample size of 5894 women diagnosed to have hypertensive disorder of pregnancy. The pooled prevalence of maternal death was estimated to be 4% (95% CI: 2, 6%). The pooled prevalence of HELLP syndrome was 13% (95% CI: 10, 16%). Other complications such as pulmonary edema, kidney injury, hepatic injury, placental abruption, and aspiration pneumonia were also reported. Perinatal death was observed in one-fourth of women with HDP 25% (95% CI: 18, 32%). The pooled prevalence of low birth weight neonate in a woman with HDP is 37% (95% CI, 27, 48%). Conclusions In Ethiopia, the prevalence of perinatal and maternal mortality among pregnant women with one of the hypertensive disorders were found to be higher than rates reported from high income as well as most of the low and middle income countries. For instance, one in four of pregnancies complicated by hypertensive disorder end up in perinatal death in Ethiopia. HELLP syndrome, placental abruption, pulmonary edema, renal damage, prematurity, perinatal asphyxia, and low birth weight were also commonly reported. To improve the health outcomes of hypertensive disorders of pregnancy, it is recommended to improve utilization of maternal health service; early detection and early referral of pregnant women with hypertensive disorder; advocating policies and strategies that improves the quality of health care that a pregnant woman and her newborn receive.

P357 Perinatal and maternal outcomes in pregnant women with sickle cell disease and sickle cell trait

2009 ◽  
Vol 107 ◽  
pp. S516-S516
Author(s):  
K. Tosta ◽  
R. Nomura ◽  
A. Igai ◽  
G. Fonseca ◽  
S. Gualandro ◽  
...  
Keyword(s):  
Sickle Cell Disease ◽  
Pregnant Women ◽  
Sickle Cell ◽  
Sickle Cell Trait ◽  
Maternal Outcomes ◽  
Cell Disease

scholarly journals Screening on prenatal infections in the South and Southwest macro-regions in the State of Bahia, Brazil: detected on paper filter

2019 ◽  
Vol 19 (3) ◽  
pp. 681-690
Author(s):  
Simone Andrade Porto São Pedro ◽  
Carlos Alberto Lima da Silva ◽  
Mônica Cardozo Rebouças ◽  
Maria de Fátima Dias Costa
Keyword(s):  
Pregnant Women ◽  
Sickle Cell ◽  
Sickle Cell Trait ◽  
The State ◽  
Screening Tests ◽  
The South ◽  
Prenatal Infections ◽  
Paper Filter ◽  
The Mean ◽  
Epidemiological Profile

Abstract Objectives: to estimate the detection rate on prenatal screening pathologies on paper filter in the South and Southwest in the State of Bahia, as well as to delineate the epidemiological profile of these pregnant women, calculate and estimate the rate of adherence and the coverage of the Program. Methods: a descriptive study was carried out from August 2013 to August 2015, and the data were obtained from the Labimuno/ICS/UFBA. Results: 64,743 pregnant women were included; the mean ages were 25 years for the Southwest macro-region and 23 for the South. The results on the screening tests showed positivity of 0.13% and 0.29% for HBsAg, 0.17% and 0.22% for cytomegalovirus, 0.07% and 0.09% for HCV, 0.13% and 0.38% for HTLV, 0.04% and 0.19% for HIV, 1.2% and 2.84% for syphilis, and 0.54% and 0.73% for toxoplasmosis in the Southwest and South macro-regions, respectively. The estimates on coverage were considered satisfactory. Sickle cell anemia showed positivity of 0.02% and of 0.04% and 5% and 6.3% presented sickle cell trait in the Southwest and South macro-regions, respectively. Conclusions: the frequencies of infections in maternal-fetal health were considered low, highlighting on syphilis and the presence for sickle cell trait.

scholarly journals Perinatal outcome in hypertensive disorder of pregnancy in a rural community of Haryana

2019 ◽  
Vol 6 (10) ◽  
pp. 4267
Author(s):  
Bharti . ◽  
Sumit Chawla
Keyword(s):  
Birth Weight ◽  
Pregnant Women ◽  
Perinatal Outcome ◽  
Statistical Tests ◽  
Mode Of Delivery ◽  
Hypertensive Disorder ◽  
Hypertension In Pregnancy ◽  
Hypertensive Disorders ◽  
Increased Risk ◽  
In Pregnancy

Background: Pregnancy in hypertension may complicate pregnancies with variable incidence among different settings. Pregnancies complicated with hypertensive disorders are associated with increased risk of adverse fetal, neonatal and maternal outcome including preterm birth, intrauterine growth retardation (IUGR), perinatal death etc. The present study was undertaken to study the perinatal outcome of hypertension in pregnancy in a rural block of Haryana.Methods: This cross-sectional study was carried out in the all the 20 subcenters under Community Health Center (CHC) Chiri, Block Lakhanmajra. All the pregnant women registered at the particular subcenter at a point of time of visit were included in the study. Pregnancy outcome was followed-up by contacting the health worker of respective sub-center or mother. Information regarding stillbirth, abortion, maturity, birth weight, mode of delivery and early neonatal death was collected. Appropriate statistical tests were used for analysis.Results: A total of 931 pregnant women were included in the present study. Prevalence of hypertension in pregnancy was found to be 6.9%. Hypertension in pregnancy is significantly associated with premature births still births (6.7% vs 1.4%; p=0.003), low birth weight (26.7% vs 4.9%; p=0.000) and early neonatal deaths (8.3% vs 2.8%; p=0.017).Conclusions: Perinatal mortality is significantly high in mothers with hypertensive disorders. Early diagnosis and treatment through regular antenatal checkup is a key factor to prevent hypertensive disorders of pregnancy and its complications.

scholarly journals Heated tobacco product use and hypertensive disorders of pregnancy and low birth weight: analysis of a cross-sectional, web-based survey in Japan

BMJ Open ◽  
2021 ◽  
Vol 11 (9) ◽  
pp. e052976
Author(s):  
Masayoshi Zaitsu ◽  
Yoshihiko Hosokawa ◽  
Sumiyo Okawa ◽  
Ai Hori ◽  
Gen Kobashi ◽  
...  
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Pregnant Women ◽  
Tobacco Product ◽  
Secondary Outcome ◽  
Hypertensive Disorders Of Pregnancy ◽  
Cross Sectional ◽  
Web Based ◽  
Hypertensive Disorders ◽  
The Impact

ObjectivesKnowledge on the impact of heated tobacco product (HTP) use in pregnant women with associated maternal and neonatal risks for hypertensive disorders of pregnancy (HDP) and low birth weight (LBW) is limited. We aimed to assess the status of HTP use among pregnant women in Japan and explore the association of HTP use with HDP and LBW.DesignCross-sectional study.SettingData from the Japan ‘COVID-19 and Society’ Internet Survey study, a web-based nationwide survey.ParticipantsWe investigated 558 postdelivery and 365 currently pregnant women in October 2020.Primary and secondary outcome measuresInformation on HDP and LBW was collected from the postdelivery women’s Maternal and Child Health Handbooks (maternal and newborn records). We estimated the age-adjusted ORs and 95% CIs of ever HTP smokers for HDP and LBW and compared them with those of never HTP smokers in a logistic regression analysis.ResultsThe prevalence of ever and current HTP use were 11.7% and 2.7% in postdelivery women and 12.6% and 1.1% in currently pregnant women, respectively. Among currently pregnant women who were former combustible cigarette smokers, 4.4% (4/91) were current HTP smokers. Among postdelivery women, ever HTP smokers had a higher HDP incidence (13.8% vs 6.5%, p=0.03; age-adjusted OR=2.48, 95% CI 1.11 to 5.53) and higher LBW incidence (18.5% vs 8.9%, p=0.02; age-adjusted OR=2.36, 95% CI 1.16 to 4.87).ConclusionsIn Japan, the incidence of ever HTP use exceeded 10% among pregnant women, and HTP smoking may be associated with maternal and neonatal risks.

scholarly journals Use of heated tobacco products may be associated with hypertensive disorders of pregnancy and low birth weight in Japan: An analysis of the JACSIS study

2021 ◽  
Author(s):  
Masayoshi Zaitsu ◽  
Yoshihiko Hosokawa ◽  
Sumiyo Okawa ◽  
Ai Hori ◽  
Gen Kobashi ◽  
...  
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Pregnant Women ◽  
Nationwide Survey ◽  
Tobacco Product ◽  
Internet Survey ◽  
Tobacco Prevention ◽  
Hypertensive Disorders Of Pregnancy ◽  
Perinatal Complications ◽  
Hypertensive Disorders

Background: Little is known about heated tobacco product (HTP) use in pregnant women and associated maternal and neonatal risks for hypertensive disorders of pregnancy (HDP) and low birth weight (LBW). Thus, this study aimed to assess the status of HTP use among pregnant women in Japan and explore the risk of HDP and LBW associated with HTP use. Methods: Using data from the Japan "COVID-19 and Society" Internet Survey (JACSIS) study, a web-based nationwide survey, we investigated 558 post-delivery and 365 currently pregnant women in October 2020. We assessed the prevalence of ever HTP smokers (defined as ever experiencing HTP use) in post-delivery and currently pregnant women. Among post-delivery women, we collected the information regarding HDP and LBW based on their Maternal and Child Health Handbooks (maternal and newborn records). In the multivariable regression analysis, we estimated the adjusted odds ratios (ORs) and 95% confidence intervals (CIs) of ever HTP smokers for HDP and LBW compared with those of never HTP smokers using logistic regression. A stratified analysis with respect to combustible cigarette smoking (never/ever) was also performed. Results: The prevalence of ever HTP use were 11.7% and 12.6% in post-delivery and currently pregnant women, respectively. Among post-delivery women, ever HTP smokers had higher HDP incidence (13.8% vs. 6.5%, P=0.03), with an OR of 2.78 (95% CI 0.84—9.15) and higher LBW incidence (18.5% versus 8.9%, P=0.02), with an elevated OR of 2.08 (95% CI 0.80—5.39). A similar tendency was observed among never and ever combustible cigarette smokers. Conclusion: In Japan, the incidence of HTP use has exceeded 10% among pregnant women, and HTP smoking may be associated with increased maternal and neonatal risks. School-based tobacco prevention and cessation programs should be conducted regardless of product types to prevent life-threatening perinatal complications and deaths.

Correlation Between Maternal Plasma Thrombomodulin and Infant Birth Weight in Hypertensive Disorders of Pregnancy

2008 ◽  
Vol 15 (2) ◽  
pp. 166-170 ◽  
Author(s):  
Füsun G. Varol ◽  
Levent Ozgen ◽  
N. Cenk Sayin ◽  
Muzaffer Demir
Keyword(s):  
Birth Weight ◽  
Pregnant Women ◽  
Hellp Syndrome ◽  
Maternal Plasma ◽  
Severe Preeclampsia ◽  
Assay Method ◽  
Hypertensive Disorders Of Pregnancy ◽  
Hypertensive Disorders ◽  
Infant Birth ◽  
In Pregnancy

Objective: To evaluate the association between maternal plasma thrombomodulin levels and infant birth weights in pregnancy-induced hypertension. Study design: Plasma thrombomodulin levels were measured in 80 pregnant women living in the Trakya region of Turkey. Of these patients, 30 were with severe preeclampsia, 10 with HELLP syndrome, 10 with eclampsia, and 30 were normotensive healthy pregnant women. Plasma thrombomodulin levels were determined by the enzyme-linked immunosorbent assay method. The correlation analysis between thrombomodulin and birth weight and placental weights was done using analysis of variance and Bonferroni test (significance at P < .05). Kruskal-Wallis statistical analysis was performed in comparison of the descriptive and laboratory data (significance at P < .05). Results: The plasma thrombomodulin values in hypertensive disorders in pregnancy were found to be highly correlated with the infant birth weights (P < .001). In HELLP syndrome, the highest thrombomodulin levels (94.69 + 10.41 ng/mL) were associated with the lowest infant birth weight (1509.70 + 187.55 g) in the study population. Thrombomodulin in eclampsia (81.37 + 3.59 ng/mL) showed an association with infant birth weight (2078 + 132.65 g). Although thrombomodulin levels in severe preeclampsia (67.15 + 3.72 ng/mL) were associated with the values (1748.20 + 132.62 g) in infant birth weight, thrombomodulin levels of the control group demonstrated the mean (48.06 + 2.45) with the highest infant birth weight (3228.85 + 84.83) in the total group. Conclusion: Elevated plasma thrombomodulin levels in hypertensive disorders of pregnancy were well correlated with related infant birth weights of these pathologies. Plasma thrombomodulin levels might point out placental vascular endothelial damage reflecting on infant birth weights.

Pregnant Women with the Sickle Cell Trait Are Not at Increased Risk for Developing Preeclampsia

2003 ◽  
Vol 20 (1) ◽  
pp. 041-048 ◽  
Author(s):  
David M. Stamilio ◽  
Harish M. Sehdev ◽  
George A. Macones
Keyword(s):  
Pregnant Women ◽  
Sickle Cell ◽  
Sickle Cell Trait ◽  
Increased Risk
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