OS 23-06 CAN LEFT VENTRICULAR TORSIONAL MECHANICS USING SPECKLE TRACKING ECHOCARDIOGRAPHY IN PREGNANCY TO PREDICT THE NEW ONSET HEART FAILURE?

2016 ◽  
Vol 34 (Supplement 1) ◽  
pp. e242
Author(s):  
Krasimira Hristova ◽  
Rumen Marinov ◽  
Georgi Stamenov ◽  
Kristina Chacheva ◽  
Marina Michova ◽  
...  
Keyword(s):  
Heart Failure ◽  
Speckle Tracking ◽  
Speckle Tracking Echocardiography ◽  
Left Ventricular ◽  
In Pregnancy ◽  
New Onset

Predictors of Left Ventricular Remodeling Post Acute Myocardial Infarction. Protocol for a Clinical Study

2019 ◽  
Vol 4 (3) ◽  
pp. 120-123
Author(s):  
Ioana Cîrneală ◽  
Diana Opincariu ◽  
István Kovács ◽  
Monica Chițu ◽  
Imre Benedek
Keyword(s):  
Myocardial Infarction ◽  
Heart Failure ◽  
Acute Myocardial Infarction ◽  
Speckle Tracking ◽  
Ventricular Remodeling ◽  
Speckle Tracking Echocardiography ◽  
Left Ventricular Remodeling ◽  
Left Ventricular ◽  
Serum Biomarkers ◽  
Remodeling Index

Abstract Heart failure is a clinical syndrome that appears as a consequence of a structural disease, and the most common cause of left ventricular systolic dysfunction results from myocardial ischemia. Cardiac remodeling and neuroendocrine activation are the major compensatory mechanisms in heart failure. The main objective of the study is to identify the association between serum biomarkers illustrating the extent of myocardial necrosis (highly sensitive troponin as-says), left ventricular dysfunction (NT-proBNP), and systemic inflammatory response (illustrated via serum levels of hsCRP and interleukins) during the acute phase of a myocardial infarction, and the left ventricular remodeling process at 6 months following the acute event, quantified via speckle tracking echocardiography. The study will include 400 patients diagnosed with acute myocardial infarction without signs and symptoms of heart failure at the time of enrollment that will undergo a complex clinical examination and speckle tracking echocardiography. Serum samples from the peripheral blood will be collected in order to determine the inflammatory serum biomarkers. After 6 months, patients will be divided into 2 groups according to the development of ventricular remodeling, quantified by speckle tracking echocardiography: group 1 will consist of patients with a remodeling index lower than 15%, and group 2 will consist of patients with a remodeling index higher than 15%. All clinical and imaging data obtained at the baseline will be compared between these two groups in order to determine the features associated with a higher risk of deleterious ventricular remodeling and heart failure.

scholarly journals Left Ventricular Torsion in Hypertension and Hypertensive Heart Failure　― 3-Dimensional Speckle Tracking Echocardiography Assessment ―

2019 ◽  
Vol 1 (2) ◽  
pp. 78-86 ◽  
Author(s):  
Shingo Minatoguchi ◽  
Takashi Yoshizane ◽  
Ryuhei Tanaka ◽  
Makoto Iwama ◽  
Takatomo Watanabe ◽  
...  
Keyword(s):  
Heart Failure ◽  
Speckle Tracking ◽  
Speckle Tracking Echocardiography ◽  
Left Ventricular ◽  
3 Dimensional ◽  
Left Ventricular Torsion ◽  
Ventricular Torsion

scholarly journals Diagnostic and Predictive Value of Speckle Tracking Echocardiography in Cardiac Sarcoidosis

2019 ◽  
Author(s):  
Cristina Di Stefano ◽  
Giulia Bruno ◽  
Maria Arciniegas Calle ◽  
Gayatri A. Acharya ◽  
Lynn M. Fussner ◽  
...  
Keyword(s):  
Heart Failure ◽  
Speckle Tracking ◽  
Cardiac Sarcoidosis ◽  
Speckle Tracking Echocardiography ◽  
Early Stage ◽  
Systolic Function ◽  
Left Ventricular ◽  
Left Ventricular Ejection ◽  
Ventricular Ejection Fraction ◽  
Strain And Strain Rate

Abstract Background: Sarcoidosis is a systemic granulomatous disease that may affect the myocardium. This study evaluated the diagnostic and prognostic value of 2-dimensional speckle tracking echocardiography in cardiac sarcoidosis (CS). Methods: Eighty-three patients with extracardiac, biopsy-proven sarcoidosis and definite/probable diagnosis of cardiac involvement diagnosed from January 2005 through December 2016 were included. Strain parameters in early stages of CS, in a subgroup of 23 CS patients with left ventricular ejection fraction (LVEF) within normal limits (LVEF>52% for men: >54% for women, mean value: 57.3%±3.8%) and no wall motion abnormalities was compared with 97 controls (1:4) without cardiac disease. LV and right ventricular (RV) global longitudinal (GLS), circumferential (GCS), and radial (GRS) strain and strain rate (SR) analyses were performed with TomTec software and correlated with cardiac outcomes (including heart failure and arrhythmias). This study was approved by the Mayo Clinic Institutional Review Board, and all patients gave informed written consent to participate. Results: Mean age of CS patients was 53.6±10.8 years, and 34.9% were women. Mean LVEF was 43.2%±12.4%; LV GLS, -12.4%±3.7%; LV GCS, -17.1%±6.5%; LV GRS, 29.3%±12.8%; and RV wall GLS, 14.6%±6.3%. In the 23 patients with early stage CS with normal LVEF and RV systolic function, strain parameters were significantly reduced when compared with controls (respectively: LV GLS, -15.9%±2.5% vs -18.2%±2.7% [ P =.001]; RV GLS, -16.9%±4.5% vs -24.1%±4.0% [ P <.001]). A LV GLS value of -16.3% provided 82.2% sensitivity and 81.2% specificity for the diagnosis of CS (AUC 0.91), while a RV value of -19.9% provided 88.1% sensitivity and 86.7% specificity (AUC 0.93). Hospital admission and heart failure significantly correlated to impaired LV GLS (> -14%). Conclusion: Reduced strain values in the LV GLS and RV GLS can be used in the diagnostic algorithm in patients with suspicion of cardiac sarcoidosis. These values also correlate with adverse cardiovascular events.

Speckle tracking echocardiography in the assessment of mouse models of cardiac dysfunction

2009 ◽  
Vol 297 (2) ◽  
pp. H811-H820 ◽  
Author(s):  
Yu Peng ◽  
Zoran B. Popović ◽  
Nikolai Sopko ◽  
Jeannie Drinko ◽  
Zheng Zhang ◽  
...  
Keyword(s):  
Heart Failure ◽  
Mouse Models ◽  
Speckle Tracking ◽  
Speckle Tracking Echocardiography ◽  
Radial Strain ◽  
Left Ventricular ◽  
Cross Sectional ◽  
Isoflurane Anesthesia ◽  
Lv Dysfunction ◽  
Lv Mass

Two-dimensional (2-D) speckle tracking echocardiography (STE) accurately quantifies circumferential strain ( Scirc) and radial strain ( Srad) in humans and in large and small animals. This study was performed to assess sensitivity of Scirc and Srad to left ventricular (LV) dysfunction in mouse models. We performed 2-D and M-mode echocardiography 1) in 6 mice during superficial and profound isoflurane anesthesia, 2) serially in 12 mice to monitor the development of heart failure induced by transverse aortic constriction (TAC) and in 8 corresponding control mice, and 3) in 26 mice with varying degrees of TAC-induced heart failure and 12 corresponding control mice immediately before euthanasia. Fractional shortening (FS) and LV mass were measured from standard M-mode tracings, whereas Scirc and Srad were derived by STE. Percent fibrosis and myocyte diameters were assessed from whole heart cross-sectional specimens stained by Masson trichrome. Profound isoflurane anesthesia decreased Scirc ( P = 0.027) but not Srad ( P > 0.05). Mice subjected to TAC showed an immediate and sustained decrease in FS ( P = 0.035), Scirc ( P = 0.016), and Srad ( P = 0.012). Scirc showed better correlation with FS ( r = 0.56 and P < 0.0001) and LV mass ( r = 0.42 and P = 0.0003) than Srad ( r = 0.54 and P < 0.0001 for FS and r = 0.37 and P = 0.014 for LV mass, respectively). Percent fibrosis correlated better with Scirc ( r = 0.46 and P = 0.004) than with Srad ( r = −0.32 and P = 0.05), whereas myocyte diameter showed similar correlation with both strains ( r = 0.45 and r = −0.44, respectively, and P = 0.006 for both). STE correctly identifies LV dysfunction and histological changes in mice and can be used for the serial assessment of cardiac remodeling in murine models.

scholarly journals Assessment of left ventricular myocardial deformation according to Speckle-tracking echocardiography in the long-term period in patients with takotsubo syndrome

2021 ◽  
Vol 10 (Supplement_1) ◽  
Author(s):  
DS Evdokimov ◽  
SA Boldueva
Keyword(s):  
Heart Failure ◽  
Left Ventricle ◽  
Speckle Tracking ◽  
Speckle Tracking Echocardiography ◽  
Essential Feature ◽  
Global Longitudinal Strain ◽  
Left Ventricular ◽  
Myocardial Deformation ◽  
Takotsubo Syndrome

Abstract Funding Acknowledgements Type of funding sources: None. Main funding source(s): North-Western State Medical University named after I.I. Mechnikov Complete improvement of left ventricle systolic function is an essential feature of takotsubo syndrome (TTS). Speckle -tracking echocardiography (STE) provides quantitative information about myocardial deformation, more accurately than conventional echocardiography. Objective to assess the global longitudinal strain (GLS) and global circumferential strain (GCS) by speckle-tracking echocardiography in patients with TTS in the long-term period. Materials and methods 14 female with TTS were monitored, average age 57.5 ± 28.5. The diagnosis was verified by ventriculography and echocardiography. 1 year after the attack, complaints of the patients, cardiovascular events (CE) and signs of heart failure were evaluated. All patients underwent echocardiography using a Vivid-4 (General Electric) with a Speckle-tracking function. The ejection fraction (EF) of the left ventricle (LV), the zone of disorders  of local contractility, the level of GLS and GCS were evaluated. Results after an 1 year of observation, all patients had a good clinical condition, there were no CE, and heart failure was absent. The EF level was 56.3 ± 3.45%; no zones of disorders of local contractility were found in any patient. A GLS level below normal was observed in 7 patients (-12.05% ± 5.15%), and was normal in 7 patients (less than -18%), GCS level was reduced in 3 (21.4%) patients (- 9.7 ± 3.4%) at a normal level of -18 and below. Conclusions despite the absence of global and local contractility disorders in echocardiography, GLS was revealed in 50% of patients, GCS in 20% of patients. Thus, speckle-tracking shows that in some patients changes in LV contractility persist in the long term. It can be explained by a change in the orientation of the myocardial fibers due to remodeling, but this requires further evaluation.

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