[OP.7B.05] CAFFEINE AND COFFEE, INDEPENDENT OF BLOOD PRESSURE, PREVENT INCIDENT HEART FAILURE IN GENERAL POPULATION. ROLE OF THE CYP1A2 −163C>A POLYMORPHISM

2017 ◽  
Vol 35 ◽  
pp. e68
Author(s):  
V. Tikhonoff ◽  
F. Albertini ◽  
M. Montagnana ◽  
E. Danese ◽  
F. Finatti ◽  
...  
Keyword(s):  
Heart Failure ◽  
Blood Pressure ◽  
General Population ◽  
Incident Heart Failure

scholarly journals Effects of Caffeine and Coffee on Incident Heart Failure in General Population. Role of the CYP1A2 -163C>A Polymorphism

2017 ◽  
Vol 5 (1) ◽  
Author(s):  
Edoardo Casiglia ◽  
Valérie Tikhonoff ◽  
Federica Albertini ◽  
Martina Montagnana ◽  
Elisa Danese ◽  
...  
Keyword(s):  
Heart Failure ◽  
General Population ◽  
Incident Heart Failure

Intestinales Mikrobiom und kardiovaskuläre Erkrankungen

2019 ◽  
Vol 144 (14) ◽  
pp. 957-963
Author(s):  
Hans-Michael Steffen ◽  
Münevver Demir
Keyword(s):  
Physical Activity ◽  
Risk Factors ◽  
Heart Failure ◽  
Blood Pressure ◽  
Cardiovascular Disease ◽  
Vascular Function ◽  
Kardiovaskuläre Erkrankungen ◽  
Intestinal Microbiome ◽  
Current Review

AbstractAging, physical activity, bodyweight and diet are well established risk factors for cardiovascular disease. For all of these factors a great impact on the intestinal microbiome has been described. The current review will discuss available data regarding the role of the gut microbiome in regulating blood pressure, vascular function and its possible contribution to atherosclerosis and heart failure.

The cardiac isovolumetric contraction time is an independent predictor of incident heart failure in the general population

2020 ◽  
Vol 312 ◽  
pp. 81-86
Author(s):  
Alia Saed Alhakak ◽  
Rasmus Møgelvang ◽  
Peter Schnohr ◽  
Daniel Modin ◽  
Philip Brainin ◽  
...  
Keyword(s):  
Heart Failure ◽  
General Population ◽  
Independent Predictor ◽  
Contraction Time ◽  
Incident Heart Failure

scholarly journals 10-Year Risk Equations for Incident Heart Failure in the General Population

2019 ◽  
Vol 73 (19) ◽  
pp. 2388-2397 ◽  
Author(s):  
Sadiya S. Khan ◽  
Hongyan Ning ◽  
Sanjiv J. Shah ◽  
Clyde W. Yancy ◽  
Mercedes Carnethon ◽  
...  
Keyword(s):  
Heart Failure ◽  
General Population ◽  
Incident Heart Failure

scholarly journals THE LEFT ATRIUM EMPTYING FRACTION IS A SUPERIOR PREDICTOR OF INCIDENT HEART FAILURE IN THE GENERAL POPULATION

2016 ◽  
Vol 67 (13) ◽  
pp. 1922
Author(s):  
Tor Biering-Sorensen ◽  
Rasmus Mogelvang ◽  
Peter Jørgensen ◽  
Peter Schnohr ◽  
Jan Jensen
Keyword(s):  
Heart Failure ◽  
General Population ◽  
Left Atrium ◽  
Incident Heart Failure

scholarly journals Using human genetics to understand the causes and consequences of circulating cardiac troponin I in the general population

2020 ◽  
Author(s):  
Marta R Moksnes ◽  
Helge Røsjø ◽  
Anne Richmond ◽  
Magnus N Lyngbakken ◽  
Sarah E Graham ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Heart Failure ◽  
Acute Myocardial Infarction ◽  
General Population ◽  
Cardiac Troponin ◽  
Troponin I ◽  
Mendelian Randomization ◽  
Cardiac Troponin I ◽  
Health Study

AbstractCirculating cardiac troponin proteins are associated with structural heart disease and predict incident cardiovascular disease in the general population. However, the genetic contribution to cardiac troponin I (cTnI) concentrations and its causal effect on cardiovascular phenotypes is unclear. We combine data from two large population-based studies, the Trøndelag Health Study and the Generation Scotland Scottish Family Health Study and perform a genome-wide association study of high-sensitivity cTnI concentrations with 48 115 individuals. We further used two-sample Mendelian randomization to investigate the causal effects of circulating cTnI on acute myocardial infarction and heart failure.We identified 12 genetic loci (8 novel) associated with cTnI concentrations. Associated protein-altering variants highlighted putative functional genes: CAND2, HABP2, ANO5, APOH, FHOD3, TNFAIP2, KLKB1 and LMAN1. Phenome-wide association tests in 1283 phecodes and 274 continuous traits in UK Biobank showed associations between a polygenic risk score for cTnI and cardiac arrhythmias, aspartate aminotransferase 1 and anthropometric measures. Excluding individuals with a known history of comorbidities did not materially change associations with cTnI. Using two-sample Mendelian randomization we confirmed the non-causal role of cTnI in acute myocardial infarction (5 948 cases, 355 246 controls). We found some indications for a causal role of cTnI in heart failure (47 309 cases and 930 014 controls), but this was not supported by secondary analyses using left ventricular mass as outcome (18 257 individuals).Our findings clarify the biology underlying the heritable contribution to circulating cTnI and support cTnI as a non-causal biomarker for acute myocardial infarction and heart failure development in the general population. Using genetically informed methods for causal inference of cTnI helps inform the role and value of measuring cTnI in the general population.

scholarly journals Matrix Gla Protein Levels Are Associated With Arterial Stiffness and Incident Heart Failure With Preserved Ejection Fraction

2021 ◽  
Author(s):  
Rajeev Malhotra ◽  
Christopher J. Nicholson ◽  
Dongyu Wang ◽  
Vijeta Bhambhani ◽  
Samantha Paniagua ◽  
...  
Keyword(s):  
Heart Failure ◽  
Cardiovascular Disease ◽  
Arterial Stiffness ◽  
Ejection Fraction ◽  
Vascular Calcification ◽  
Matrix Gla Protein ◽  
Preserved Ejection Fraction ◽  
Wild Type ◽  
Incident Heart Failure

Objective: Arterial stiffness is a risk factor for cardiovascular disease, including heart failure with preserved ejection fraction. MGP (matrix Gla protein) is implicated in vascular calcification in animal models, and circulating levels of the uncarboxylated, inactive form of MGP (ucMGP) are associated with cardiovascular disease-related and all-cause mortality in human studies. However, the role of MGP in arterial stiffness is uncertain. Approach and Results: We examined the association of ucMGP levels with vascular calcification, arterial stiffness including carotid-femoral pulse wave velocity (PWV), and incident heart failure in community-dwelling adults from the Framingham Heart Study. To further investigate the link between MGP and arterial stiffness, we compared aortic PWV in age- and sex-matched young (4-month-old) and aged (10-month-old) wild-type and Mgp +/− mice. Among 7066 adults, we observed significant associations between higher levels of ucMGP and measures of arterial stiffness, including higher PWV and pulse pressure. Longitudinal analyses demonstrated an association between higher ucMGP levels and future increases in systolic blood pressure and incident heart failure with preserved ejection fraction. Aortic PWV was increased in older, but not young, female Mgp +/− mice compared with wild-type mice, and this augmentation in PWV was associated with increased aortic elastin fiber fragmentation and collagen accumulation. Conclusions: This translational study demonstrates an association between ucMGP levels and arterial stiffness and future heart failure with preserved ejection fraction in a large observational study, findings that are substantiated by experimental studies showing that mice with Mgp heterozygosity develop arterial stiffness. Taken together, these complementary study designs suggest a potential role of therapeutically targeting MGP in heart failure with preserved ejection fraction.

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