HIGHLY SENSITIVE TROPONIN AS POSSIBLE PREDICTIVE MARKER FOR CARDIOVASCULAR DISEASE IN MILD CHRONIC KIDNEY DISEASE PATIENTS

2019 ◽  
Vol 37 ◽  
pp. e86
Author(s):  
A.B. M.D. Radzi ◽  
K.S. Ibrahim ◽  
N.Y.C. Chua ◽  
H.A. Zainal Abidin ◽  
R. Najme Khir ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Predictive Marker ◽  
Highly Sensitive ◽  
Highly Sensitive Troponin

Elevated highly-sensitive troponin T and pulse wave velocity in mild chronic kidney disease

2021 ◽  
Vol 345 ◽  
pp. 19-20
Author(s):  
A.B. Md Radzi ◽  
R.E.F. Raja Shariff ◽  
M.H. Hamidi ◽  
H. Sani ◽  
K.S. Ibrahim ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Pulse Wave Velocity ◽  
Wave Velocity ◽  
Pulse Wave ◽  
Troponin T ◽  
Highly Sensitive ◽  
Highly Sensitive Troponin

scholarly journals Association between Serum Neopterin and Inflammatory Activation in Chronic Kidney Disease

2012 ◽  
Vol 2012 ◽  
pp. 1-6 ◽  
Author(s):  
Ashok Kumar Yadav ◽  
Vinod Sharma ◽  
Vivekanand Jha
Keyword(s):  
Cardiovascular Disease ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Inverse Correlation ◽  
Serum Levels ◽  
Cell Mediated Immunity ◽  
Serum Neopterin ◽  
Markers Of Inflammation ◽  
Stage 4 ◽  
Highly Sensitive

Background.The serum levels of neopterin, a marker associated with cell-mediated immunity are elevated in chronic kidney disease (CKD). We evaluated serum neopterin levels and investigated its association with markers of inflammation in a cross-section of CKD subjects without known cardiovascular disease.Methods.Serum neopterin levels were measured in 118 patients with stage 3–5 CKD and 41 healthy subjects with normal kidney function (HC). Patients with known cardiovascular disease were excluded. We also estimated highly sensitive CRP (hsCRP) and interluekin-6 (IL-6), tumor necrosis factor-α(TNF-α) and interferon-γ(IFN-γ) in the CKD subjects. All assays were done using commercially available ELISA kits. The correlation between neopterin and markers of inflammation were investigated.Results.Of the CKD population, 82 were in stage 5 (60 stage 5 D), 24 in stage 4, and 12 in stage 3. The mean age was51.04±1.3years and 66% were males. The commonest cause of CKD was diabetes (36%). Serum neopterin levels were 5-fold higher in CKD patients as compared to HC (74.8±3.6versus15.0±2.8 nmol/L,P<0.0001). There was a graded increase of serum neopterin from stages 3 to 4 and 5. CKD 5 D patients exhibited significantly higher levels compared to nondialysis stage 5 patients (P<0.0001). An inverse correlation was noted between serum neopterin and eGFR (r=−0.359,P<0.0001). Serum neopterin correlated with hsCRP (r=0.285,P=0.002), IL-6 (r=0.212,P=0.034), and IFN-γ(r=0.32,P=0.001) but not with TNF-α.Conclusion.Serum neopterin level is elevated and correlates with the severity of CKD. The elevation correlates with elevation of most, but not all, inflammatory markers. Its role in future development of cardiovascular disease and modulation with anti-inflammatory therapies needs further studies.

Prognostic value of highly sensitive troponin T on cardiac events in patients with chronic kidney disease not on dialysis

2012 ◽  
Vol 28 (4) ◽  
pp. 473-479 ◽  
Author(s):  
Midori Hasegawa ◽  
Junichi Ishii ◽  
Fumihiko Kitagawa ◽  
Kyoko Kanayama ◽  
Hiroshi Takahashi ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Prognostic Value ◽  
Troponin T ◽  
Cardiac Events ◽  
Highly Sensitive ◽  
Highly Sensitive Troponin

Value of Highly Sensitive Troponin T for Diagnosis of Acute Coronary Syndrome in Chronic Kidney Disease Patients

2017 ◽  
Vol 1 (7) ◽  
Author(s):  
M. Ashry ◽  
Osama Ibrahim ◽  
Ahmed Obiedallah ◽  
Samir Abdulhamid ◽  
Lobna Tag ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Acute Coronary Syndrome ◽  
Kidney Disease ◽  
Troponin T ◽  
Coronary Syndrome ◽  
Highly Sensitive ◽  
Highly Sensitive Troponin
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