scholarly journals Association between Serum Neopterin and Inflammatory Activation in Chronic Kidney Disease

2012 ◽  
Vol 2012 ◽  
pp. 1-6 ◽  
Author(s):  
Ashok Kumar Yadav ◽  
Vinod Sharma ◽  
Vivekanand Jha
Keyword(s):  
Cardiovascular Disease ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Inverse Correlation ◽  
Serum Levels ◽  
Cell Mediated Immunity ◽  
Serum Neopterin ◽  
Markers Of Inflammation ◽  
Stage 4 ◽  
Highly Sensitive

Background.The serum levels of neopterin, a marker associated with cell-mediated immunity are elevated in chronic kidney disease (CKD). We evaluated serum neopterin levels and investigated its association with markers of inflammation in a cross-section of CKD subjects without known cardiovascular disease.Methods.Serum neopterin levels were measured in 118 patients with stage 3–5 CKD and 41 healthy subjects with normal kidney function (HC). Patients with known cardiovascular disease were excluded. We also estimated highly sensitive CRP (hsCRP) and interluekin-6 (IL-6), tumor necrosis factor-α(TNF-α) and interferon-γ(IFN-γ) in the CKD subjects. All assays were done using commercially available ELISA kits. The correlation between neopterin and markers of inflammation were investigated.Results.Of the CKD population, 82 were in stage 5 (60 stage 5 D), 24 in stage 4, and 12 in stage 3. The mean age was51.04±1.3years and 66% were males. The commonest cause of CKD was diabetes (36%). Serum neopterin levels were 5-fold higher in CKD patients as compared to HC (74.8±3.6versus15.0±2.8 nmol/L,P<0.0001). There was a graded increase of serum neopterin from stages 3 to 4 and 5. CKD 5 D patients exhibited significantly higher levels compared to nondialysis stage 5 patients (P<0.0001). An inverse correlation was noted between serum neopterin and eGFR (r=−0.359,P<0.0001). Serum neopterin correlated with hsCRP (r=0.285,P=0.002), IL-6 (r=0.212,P=0.034), and IFN-γ(r=0.32,P=0.001) but not with TNF-α.Conclusion.Serum neopterin level is elevated and correlates with the severity of CKD. The elevation correlates with elevation of most, but not all, inflammatory markers. Its role in future development of cardiovascular disease and modulation with anti-inflammatory therapies needs further studies.

HIGHLY SENSITIVE TROPONIN AS POSSIBLE PREDICTIVE MARKER FOR CARDIOVASCULAR DISEASE IN MILD CHRONIC KIDNEY DISEASE PATIENTS

2019 ◽  
Vol 37 ◽  
pp. e86
Author(s):  
A.B. M.D. Radzi ◽  
K.S. Ibrahim ◽  
N.Y.C. Chua ◽  
H.A. Zainal Abidin ◽  
R. Najme Khir ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Predictive Marker ◽  
Highly Sensitive ◽  
Highly Sensitive Troponin

scholarly journals The inflammatory profile of chronic kidney disease patients

2021 ◽  
Vol 5 (3) ◽  
pp. 107-111
Author(s):  
Chaker Hanen ◽  
Jarraya Faiçal ◽  
Toumi Salma ◽  
Kammoun Khawla ◽  
Mahfoudh Hichem ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Chronic Kidney Disease ◽  
Renal Failure ◽  
Kidney Disease ◽  
Sedimentation Rate ◽  
Biological Data ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Markers Of Inflammation ◽  
Inflammatory Profile

Background: Chronic kidney disease is a worldwide public health issue which is associated with an increased risk of end-stage renal failure and cardiovascular disease. Systemic inflammation exists during chronic renal failure. Recent researches have highlighted the pivotal role of inflammation between renal and cardiovascular disease. The aim of our study is to determine the inflammatory profile of the patient suffering from chronic kidney disease and the influence of hemodialysis on this profile. Methods: We carried out a cross sectional study on 93 patients in the Nephrology Department at Hedi Chaker University Hospital, Sfax, South of Tunisia. Among those patients, 72 patients underwent hemodialysis and 21 patients had chronic kidney disease at stage 3. Clinical data and antecedents were collected. Biological samples were taken after informing the patients and taking their consent. Biological data consisted in lipid profile, albumin rate, hemoglobin rate, uric acid concentration and the usual markers of inflammation noting sedimentation rate, C - reactive protein and orosomucoid. Results: Hemodialysis group of the 72 patients had mean hemodialysis vintage of 54.6 ± 43 months. The inflammatory profile was worse in hemodialysis patients compared to chronic kidney disease patients. Both sedimentation rate, C - reactive protein and orosomucoid were higher in hemodialysis group than in chronic kidney disease group with 71 ± 35.3 mm vs. 42.1 ± 15.5 mm (p < 0.05); 14.6 ± 28.7 mg/l vs. 6.7 ± 8 mg/l (p = 0.02); 1.3 ± 0.7g/l vs. 0.9 ± 0.4 g/l (p = 0.01), respectively. Conclusion: Inflammation increases in dialysis patient. It deserves the nephrologist’s consideration in order to minimize its harmful effects. The monitoring of inflammation markers must be integrated into the nephrologist’s medical practice.

Elevated serum levels of S-adenosylhomocysteine, but not homocysteine, are associated with cardiovascular disease in stage 5 chronic kidney disease patients

2008 ◽  
Vol 395 (1-2) ◽  
pp. 106-110 ◽  
Author(s):  
Alessandro Valli ◽  
Juan J. Carrero ◽  
Abdul Rashid Qureshi ◽  
Giacomo Garibotto ◽  
Peter Bárány ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Elevated Serum ◽  
Serum Levels

scholarly journals Gambaran Komplikasi Penyakit Ginjal Kronik Non Dialisis di Poliklinik Ginjal-Hipertensi RSUP Prof. Dr. R. D. Kandou Periode Januari 2017 – Desember 2018

e-CliniC ◽  
2019 ◽  
Vol 7 (2) ◽  
Author(s):  
Tasya U. S. Karinda ◽  
Cerelia E. C. Sugeng ◽  
Emma Sy. Moeis
Keyword(s):  
Diabetes Mellitus ◽  
Cardiovascular Disease ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Uncontrolled Hypertension ◽  
Electrolyte Disturbance ◽  
Stage 4 ◽  
Using Data ◽  
Global Health Problem ◽  
Diabetes Melitus

Abstract: Chronic kidney disease (CKD) is still a global health problem with a rising prevalence in many countries. Complications of CKD are inter alia cardiovascular disease, hypertension, anemia, electrolyte disturbance, diabetes mellitus, and metabolic asidosis. This study was aimed to provide an overview of CKD at the Kidney-Hypertension polyclinic of Prof. Dr. R. D. Kandou Hospital. This was a descriptive retrospective study using data of CKD patients at the Kidney-Hypertension Polyclinic from January 2017 to December 2018. The results obtained 63 CKD patients consisting of 47.61% males and 52.38% females. Based on CKD staging, the eprcentages of patients were, as follows: stage 3 CKD (1.58%), stage 4 CKD (22.22%), and stage 5 CKD ND (76.19%). Patients aged 50-59 years had the highest percentage of stage 5 ND CKD numbering 10 males (20.83%) and 12 females (25%). The prevalences of complications in stage 5 ND CKD compared to stage 4 CKD were, as follows: anemia Hb 11-11.9 g/dL (77.5% vs 36.36%), uncontrolled hypertension (37.50% vs 14.28%), dyslipidemia (25% vs 28.57%), hyperurisemia (27.08% in males and 41.67% in females vs 57.15% in males and 28.57% in females), hyponatremia (66.67% vs 64.28%), hypernatremia (31.25% vs 0%), and hypokalemia (16.67% vs 35.72%). In conclusion, CKD complications were anemia, hypertension, dyslipidemia, hyper-urisemia, and electrolite imbalance; most were higher in stadium 5 ND CKD.Keywords: chronic kidney disease, complications Abstrak: Penyakit ginjal kronik (PGK) masih menjadi masalah kesehatan global dan prevalensinya terus meningkat di berbagai negara. Komplikasi PGK antara lain penyakit kardiovaskular, hipertensi, anemia, gangguan elektrolit, diabetes melitus, dan asidosis metabolik. Penelitian ini bertujuan untuk mengetahui gambaran komplikasi PGK di Poliklinik Ginjal-Hipertensi RSUP Prof. Dr. R. D. Kandou. Jenis penelitian ialah deskriptif retrospektif dengan menggunakan data pasien PGK yang dirawat di Poliklinik Ginjal-Hipertensi periode Januari 2017 - Desember 2018. Hasil penelitian mendapatkan 63 pasien PGK, terdiri dari 52,38% perempuan dan 47,61% laki-laki. Berdasarkan stadium PGK, PGK stadium 3 (1,58%) orang, PGK stadium 4 (22,22%), dan PGK stadium 5 ND (76,19%). Kelompok usia tertinggi ialah 50-59 tahun. Prevalensi komplikasi pada PGK stadium 5 ND dibandingkan PGK stadium 4 ialah sebagai berikut: anemia Hb 11-11,9 g/dL (77,5% vs 36,36%), hipertensi tidak terkontrol (37,50% vs 14,28%), dislipidemia (25% vs 28,57%), hiperurisemia (27,08% pada laki-laki dan 41,67% pada perempuan vs 57,15% pada laki-laki dan 28,57% pada perempuan), gangguan elektrolit hiponatremia (66,67% vs 64,28%), hipernatremia (31,25% vs 0%), dan hipokalemia (16,67% vs 35,72%). Simpulan penelitian ini ialah komplikasi PGK ialah anemia, hipertensi, dislipidemia, hiperurisemia, dan gangguan elektrolit; sebagian besar lebih banyak terjadi pada PGK stadium 5 ND.Kata kunci: penyakit ginjal kronik, komplikasi

S100A12 Gene Expression Is Increased in Peripheral Leukocytes in Chronic Kidney Disease Stage 4-5 Patients with Cardiovascular Disease

2013 ◽  
Vol 123 (3-4) ◽  
pp. 202-208 ◽  
Author(s):  
Masaki Hara ◽  
Minoru Ando ◽  
Taku Morito ◽  
Hirohiko Nokiba ◽  
Yuko Iwasa ◽  
...  
Keyword(s):  
Gene Expression ◽  
Cardiovascular Disease ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Chronic Kidney Disease Stage ◽  
Disease Stage ◽  
Stage 4 ◽  
Peripheral Leukocytes

scholarly journals P0271SERUM VASCULAR ENDOTHELIAL GROWTH FACTOR-D LEVEL CORRELATES WITH RENAL FUNCTION AND ALBUMINURIA IN PATIENT WITH DIABETIC CHRONIC KIDNEY DISEASE

2020 ◽  
Vol 35 (Supplement_3) ◽  
Author(s):  
Hyeongwan Kim ◽  
Jong Hwan Chong ◽  
Woong Park ◽  
Sung Kwang Park ◽  
Won Kim
Keyword(s):  
Chronic Kidney Disease ◽  
Vascular Endothelial Growth Factor ◽  
Renal Function ◽  
Kidney Disease ◽  
Serum Levels ◽  
Control Group ◽  
Vascular Endothelial ◽  
Stage 4 ◽  
Ckd Stage ◽  
Endothelial Growth Factor

Abstract Background and Aims Biomarkers associated with chronic kidney disease (CKD) may play a crucial role in patients with diabetic kidney diseases. Vascular endothelial growth factor (VEGF)-C and VEGF-D are lymphangiogenic growth factors. It has been well demonstrated that there is lympnagiogenesis in fibrotic kidney disease in human. Previously, we showed that renal VEGF-C and VEGF-D are involved in lymphangiogensis in renal fibrosis model. Recent studies have shown a relationship between sodium load and serum VEGF-C levels in hypertensive patients. Lymphatic endothelial proliferation has been detected in diabetic nephropathy. Thus, serum VEGF-C level has been introduced as a candidate marker of chronic kidney disease. However, until now, there have been few report about serum VEGF-D in patients with diabetic CKD. Thus, we evaluated the relationships between serum VEGF-D and renal function and albuminuria of diabetic CKD. Method We divided diabetic CKD patients into four groups: CKD stage 3, CKD stage 4, and CKD stage 5 (without dialysis). Total forty two Asian patients with diabetic CKD (14 patients with CKD stage 3, 14 patients with CKD stage 4 and 14 patients with CKD stage 5) and seven healthy controls without diabetes mellitus have been enrolled in this study. In this cross-sectional study, we performed comparative analysis with serum level of VEGF-D in patients with each group. We measured the levels of VEGF-D through the multiplexing using Luminex® technology. Results The serum levels of VEGF-D were higher in the CKD 3, CKD 4 and CKD 5 group compared with the control group (25.9±5.6 pg/ml in control group, 60.3±9.7in stage 3, 62.9±8.5 in stage 4, and 66.5±8.0 in stage 5). However, there was not a significant difference between CKD stage III or IV and CKD stage V in serum levels of VEGF-D. Serum VEGF-D level were negatively correlated with estimated glomerular filtration rate and positively correlated with serum creatinine. At GFR level ≥60 ml/min per 1.73 m2, serum VEGF-D were biomarkers in ROC analysis. There was a positive correlation between serum VEGF-D level and albuminuria in patient with diabetic CKD. We also found that serum VEGF-D level also correlated with urine protein-to-creatinine ratio in patient with diabetic CKD. Conclusion Serum VEGF-D is correlated with renal function in patients with diabetic CKD. VEGF levels in the serum correlate to the severity of proteinuria and albuminuria in diabetic CKD patients. Further large-scale studies are required to confirm these findings.

scholarly journals Gambaran Komplikasi Penyakit Ginjal Kronik Non Dialisis di Poliklinik Ginjal-Hipertensi RSUP Prof. Dr. R. D. Kandou Periode Januari 2017 – Desember 2018

e-CliniC ◽  
2019 ◽  
Vol 7 (2) ◽  
Author(s):  
Tasya U. S. Karinda ◽  
Cerelia E. C. Sugeng ◽  
Emma Sy. Moeis
Keyword(s):  
Diabetes Mellitus ◽  
Cardiovascular Disease ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Uncontrolled Hypertension ◽  
Electrolyte Disturbance ◽  
Stage 4 ◽  
Using Data ◽  
Global Health Problem ◽  
Diabetes Melitus

Abstract: Chronic kidney disease (CKD) is still a global health problem with a rising prevalence in many countries. Complications of CKD are inter alia cardiovascular disease, hypertension, anemia, electrolyte disturbance, diabetes mellitus, and metabolic asidosis. This study was aimed to provide an overview of CKD at the Kidney-Hypertension polyclinic of Prof. Dr. R. D. Kandou Hospital. This was a descriptive retrospective study using data of CKD patients at the Kidney-Hypertension Polyclinic from January 2017 to December 2018. The results obtained 63 CKD patients consisting of 47.61% males and 52.38% females. Based on CKD staging, the eprcentages of patients were, as follows: stage 3 CKD (1.58%), stage 4 CKD (22.22%), and stage 5 CKD ND (76.19%). Patients aged 50-59 years had the highest percentage of stage 5 ND CKD numbering 10 males (20.83%) and 12 females (25%). The prevalences of complications in stage 5 ND CKD compared to stage 4 CKD were, as follows: anemia Hb 11-11.9 g/dL (77.5% vs 36.36%), uncontrolled hypertension (37.50% vs 14.28%), dyslipidemia (25% vs 28.57%), hyperurisemia (27.08% in males and 41.67% in females vs 57.15% in males and 28.57% in females), hyponatremia (66.67% vs 64.28%), hypernatremia (31.25% vs 0%), and hypokalemia (16.67% vs 35.72%). In conclusion, CKD complications were anemia, hypertension, dyslipidemia, hyper-urisemia, and electrolite imbalance; most were higher in stadium 5 ND CKD.Keywords: chronic kidney disease, complications Abstrak: Penyakit ginjal kronik (PGK) masih menjadi masalah kesehatan global dan prevalensinya terus meningkat di berbagai negara. Komplikasi PGK antara lain penyakit kardiovaskular, hipertensi, anemia, gangguan elektrolit, diabetes melitus, dan asidosis metabolik. Penelitian ini bertujuan untuk mengetahui gambaran komplikasi PGK di Poliklinik Ginjal-Hipertensi RSUP Prof. Dr. R. D. Kandou. Jenis penelitian ialah deskriptif retrospektif dengan menggunakan data pasien PGK yang dirawat di Poliklinik Ginjal-Hipertensi periode Januari 2017 - Desember 2018. Hasil penelitian mendapatkan 63 pasien PGK, terdiri dari 52,38% perempuan dan 47,61% laki-laki. Berdasarkan stadium PGK, PGK stadium 3 (1,58%) orang, PGK stadium 4 (22,22%), dan PGK stadium 5 ND (76,19%). Kelompok usia tertinggi ialah 50-59 tahun. Prevalensi komplikasi pada PGK stadium 5 ND dibandingkan PGK stadium 4 ialah sebagai berikut: anemia Hb 11-11,9 g/dL (77,5% vs 36,36%), hipertensi tidak terkontrol (37,50% vs 14,28%), dislipidemia (25% vs 28,57%), hiperurisemia (27,08% pada laki-laki dan 41,67% pada perempuan vs 57,15% pada laki-laki dan 28,57% pada perempuan), gangguan elektrolit hiponatremia (66,67% vs 64,28%), hipernatremia (31,25% vs 0%), dan hipokalemia (16,67% vs 35,72%). Simpulan penelitian ini ialah komplikasi PGK ialah anemia, hipertensi, dislipidemia, hiperurisemia, dan gangguan elektrolit; sebagian besar lebih banyak terjadi pada PGK stadium 5 ND.Kata kunci: penyakit ginjal kronik, komplikasi

scholarly journals MO440KLOTHO AS A BIOMARKER OF SUBCLINICAL CARDIOVASCULAR DISEASE IN CHRONIC KIDNEY DISEASE: A PROOF-OF-CONCEPT STUDY*

2021 ◽  
Vol 36 (Supplement_1) ◽  
Author(s):  
Carla Ferri ◽  
Javier Donate-Correa ◽  
Ernesto Martín-Núñez ◽  
Nayra Pérez-Delgado ◽  
Ainhoa González-Luis ◽  
...  
Keyword(s):  
Gene Expression ◽  
Cardiovascular Disease ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Serum Levels ◽  
Receiver Operating Curve ◽  
Atherosclerotic Cardiovascular Disease ◽  
Proof Of Concept ◽  
Expression Levels ◽  
Concept Study

Abstract Background and Aims Cardiovascular disease (CVD) is the major cause of mortality among chronic kidney disease (CKD) patients. Reductions in serum Klotho levels are related to the prevalence of CVD in CKD patients. However, it is unclear whether circulating Klotho, and its expression in peripheral blood cells (PBCs), are associated with subclinical atherosclerotic cardiovascular disease (sCVD) in these subjects. In this proof-of-concept study, we analyzed in a group of CKD patients the relationship between Klotho and two markers of sCVD: ankle-brachial index (ABI) and carotid intima-media thickness (CIMT). Method Gene expression in PBCs and serum levels of Klotho and inflammatory cytokines (TNF, IL6 and IL10) were measured in 103 CKD patients (stages 3-4), older than 18 years of age, and without known atherosclerotic cardiovascular disease. Biochemical data were obtained following standardized clinical methods. The presence of sCVD was defined as ABI &lt; 0.9 and/or CIMT ≥ 0.9 mm. Patients with ABI values ≥ 1.3 were excluded. Results Patients with sCVD presented lower serum and PBCs expression levels of Klotho (P&lt;0.001 for both). Stratified analysis showed that upper tertiles of both serum and PBCs expression levels of Klotho presented significantly higher ABI (P&lt;0.001 for both Klotho determinations) and lower CIMT (P&lt;0.001 for serum levels and P&lt;0.01 for KL expression in PBCs), which resulted in a lower prevalence of sCVD (P&lt;0.001 for both determinations of Klotho). Correlation analysis showed that both serum and PBCs mRNA Klotho levels were positively correlated with ABI (r=0.556, P&lt;0.0001; and r=0.373, P&lt;0.0001, respectively) and inversely correlated with CIMT (r=-0.541, P&lt;0.0001; and r=-0.437, P&lt;0.0001, respectively). Among inflammatory markers, only serum IL6 levels presented significant associations with sCVD, being inversely related with ABI (r=-0.568, P&lt;0.0001) and positively associated with CIMT (r=0.558, P&lt;0.0001). Multiple regression analysis with ABI and CIMT as dependent variables demonstrated that both Klotho variables, together with serum IL6, were positively and significantly associated with ABI (adjusted R2=0.511, P&lt;0,0001) and CIMT (adjusted R2=0.445, P&lt;0,0001) values, independently of traditional and emergent cardiovascular risk factors. Multivariate logistic regression, using the presence/absence of sCVD as the dependent variable, showed that circulating Klotho, and its expression in PBCs constituted independent protective factors for sCVD [OR (95% CI): 0.993 (P=0.002) and 0.231 (P=0.025), respectively]. Receiver operating curve (ROC) analysis pointed to the prognostic ability for sCVD of serum Klotho (area under the curve [AUC]: 0.817, 95% CI: 0.736–0.898, P&lt;0.001) and its gene expression in PBCs (AUC: 0.742, 95% CI: 0.647–0.836, P&lt;0.001). Conclusion The reductions in serum soluble and PBCs expression levels of Klotho in CKD patients are independently associated with the presence of sCVD. Further research exploring whether therapeutic approaches to maintain or elevate the Klotho level could reduce the impact of CVD in CKD patients is warranted.

scholarly journals The Kidney and COVID-19: Pandemic Effects on the Patients

2020 ◽  
Vol 10 (6) ◽  
pp. X1-X2
Author(s):  
A.S.M. Sarwar ◽  
Divya Jain ◽  
Anika Bushra ◽  
Khandaker Sabit Bin Razzak ◽  
Mohammad Nabil Hossain ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Disease ◽  
Chronic Kidney Disease ◽  
Respiratory Failure ◽  
Kidney Disease ◽  
Chronic Renal Disease ◽  
Diffuse Alveolar Damage ◽  
Serum Levels ◽  
Principal Characteristics ◽  
Patient Health

COVID-19 pathogens were identified as new coronaviruses by the sequencing of sample lower respiratory tracts from patients affected, which share a sequence of 79.6 percent identified as severe acute respiratory syndrome coronavirus. The virus has spread rapidly worldwide and was reported as a pandemic on 11 March 2020 since its detection in Wuhan, China in December 2019. The principal characteristics of COVID-19 were diffuse alveolar damage and acute respiratory failure, involving other organs. Although co-morbidities such as diabetes and cardiovascular disease have reported as risk factors of COVID-19, there is still no proof of an increased vulnerability to chronic renal disease in patients with chronic kidney disease (CKDs), although there are several studies continuing worldwide. CKD is differentiated by kidney structure abnormalities or functions which last > 3 months and have an impact on patient health. The deaths were not specifically caused by COVID-19, but were considered systemic causes. In HD patients with COVID-19 there were decreased lymphopenia, reduced serum levels of inflammatory receptors and more severe clinical disease than patients with HD CKD. Therefore, additional precautions should be taken in CKD patients to minimize risk of the infection. Doctors can also be carefully watched to identify signs of worsening of the disease in CKD patients with confirmed COVID-19.

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