scholarly journals Cancer Risk in Individuals With Major Birth Defects: Large Nordic Population Based Case-Control Study Among Children, Adolescents, and Adults

2021 ◽  
Vol 76 (4) ◽  
pp. 191-193
Author(s):  
Dagrun Slettebø Daltveit ◽  
Kari Klungsøyr ◽  
Anders Engeland ◽  
Anders Ekbom ◽  
Mika Gissler ◽  
...  
Keyword(s):  
Cancer Risk ◽  
Birth Defects ◽  
Case Control Study ◽  
Population Based ◽  
Case Control ◽  
Adolescents And Adults ◽  
Control Study

scholarly journals Cancer risk in individuals with major birth defects: large Nordic population based case-control study among children, adolescents, and adults

BMJ ◽  
2020 ◽  
pp. m4060
Author(s):  
Dagrun Slettebø Daltveit ◽  
Kari Klungsøyr ◽  
Anders Engeland ◽  
Anders Ekbom ◽  
Mika Gissler ◽  
...  
Keyword(s):  
Nervous System ◽  
Cancer Risk ◽  
Birth Defects ◽  
Odds Ratio ◽  
Case Control Study ◽  
Population Based ◽  
Case Control ◽  
Chromosomal Anomalies ◽  
Risk Of Cancer ◽  
Control Study

AbstractObjectiveTo examine associations between birth defects and cancer from birth into adulthood.DesignPopulation based nested case-control study.SettingNationwide health registries in Denmark, Finland, Norway, and Sweden.Participants62 295 cancer cases (0-46 years) and 724 542 frequency matched controls (matched on country and birth year), born between 1967 and 2014.Main outcome measuresRelative risk of cancer in relation to major birth defects, estimated as odds ratios with 99% confidence intervals from logistic regression models.ResultsAltogether, 3.5% (2160/62 295) of cases and 2.2% (15 826/724 542) of controls were born with major birth defects. The odds ratio of cancer for people with major birth defects compared with those without was 1.74 (99% confidence interval 1.63 to 1.84). For individuals with non-chromosomal birth defects, the odds ratio of cancer was 1.54 (1.44 to 1.64); for those with chromosomal anomalies, the odds ratio was 5.53 (4.67 to 6.54). Many structural birth defects were associated with later cancer in the same organ system or anatomical location, such as defects of the eye, nervous system, and urinary organs. The odds ratio of cancer increased with number of defects and decreased with age, for both non-chromosomal and chromosomal anomalies. The odds ratio of cancer in people with any non-chromosomal birth defect was lower in adults (≥20 years: 1.21, 1.09 to 1.33) than in adolescents (15-19 years: 1.58, 1.31 to 1.90) and children (0-14 years: 2.03, 1.85 to 2.23). The relative overall cancer risk among adults with chromosomal anomalies was markedly reduced from 11.3 (9.35 to 13.8) in children to 1.50 (1.01 to 2.24). Among adults, skeletal dysplasia (odds ratio 3.54, 1.54 to 8.15), nervous system defects (1.76, 1.16 to 2.65), chromosomal anomalies (1.50, 1.01 to 2.24), genital organs defects (1.43, 1.14 to 1.78), and congenital heart defects (1.28, 1.02 to 1.59) were associated with overall cancer risk.ConclusionsThe increased risk of cancer in individuals with birth defects persisted into adulthood, both for non-chromosomal and chromosomal anomalies. Further studies on the molecular mechanisms involved are warranted.

scholarly journals Trajectories of physical activity, from young adulthood to older adulthood, and pancreatic cancer risk; a population-based case-control study in Ontario, Canada

BMC Cancer ◽  
2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Jaspreet Sandhu ◽  
Vanessa De Rubeis ◽  
Michelle Cotterchio ◽  
Brendan T. Smith ◽  
Lauren E. Griffith ◽  
...  
Keyword(s):  
Physical Activity ◽  
Pancreatic Cancer ◽  
Cancer Risk ◽  
Young Adulthood ◽  
Case Control Study ◽  
Population Based ◽  
Case Control ◽  
Older Adulthood ◽  
Pancreatic Cancer Risk ◽  
Control Study

Adherence to Mediterranean diet and prostate cancer risk in Sicily: population-based case–control study

2018 ◽  
Vol 31 (4) ◽  
pp. 269-275 ◽  
Author(s):  
Giorgio Ivan Russo ◽  
Tatiana Solinas ◽  
Daniele Urzì ◽  
Salvatore Privitera ◽  
Daniele Campisi ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Risk ◽  
Mediterranean Diet ◽  
Case Control Study ◽  
Prostate Cancer Risk ◽  
Population Based ◽  
Case Control ◽  
Control Study

Prostate cancer risk among users of finasteride and alpha-blockers – A population based case–control study

2007 ◽  
Vol 43 (4) ◽  
pp. 775-781 ◽  
Author(s):  
Teemu J. Murtola ◽  
Teuvo L.J. Tammela ◽  
Liisa Määttänen ◽  
Matti Hakama ◽  
Anssi Auvinen
Keyword(s):  
Prostate Cancer ◽  
Cancer Risk ◽  
Case Control Study ◽  
Prostate Cancer Risk ◽  
Population Based ◽  
Case Control ◽  
Alpha Blockers ◽  
Control Study

P1.15: Exposure to cement dust, related occupational groups and laryngeal cancer risk: Results of a population based case-control study

2004 ◽  
Vol 46 (S1) ◽  
pp. 103-103
Author(s):  
Andreas Dietz ◽  
Heribert Ramroth ◽  
Tobias Urban ◽  
Wolfgang Ahrens ◽  
Heiko Becher
Keyword(s):  
Cancer Risk ◽  
Laryngeal Cancer ◽  
Case Control Study ◽  
Population Based ◽  
Case Control ◽  
Cement Dust ◽  
Occupational Groups ◽  
Control Study

scholarly journals 0058 Colorectal cancer risk and shift work in a population-based case-control study in Spain (MCC-Spain)

2014 ◽  
Vol 71 (Suppl 1) ◽  
pp. A5.3-A6 ◽  
Author(s):  
Kyriaki Papantoniou ◽  
Manolis Kogevinas ◽  
Vicente Martin Sanchez ◽  
Victor Moreno ◽  
Marina Pollan ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Risk ◽  
Shift Work ◽  
Case Control Study ◽  
Population Based ◽  
Case Control ◽  
Colorectal Cancer Risk ◽  
Control Study

Population-based, case-control study of HER2 genetic polymorphism and breast cancer risk.

2001 ◽  
Vol 19 (2) ◽  
pp. 27
Author(s):  
D Xie ◽  
XO Shu ◽  
Z Deng ◽  
WQ Wen ◽  
KE Creek ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Genetic Polymorphism ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Case Control Study ◽  
Population Based ◽  
Case Control ◽  
Control Study

scholarly journals Trajectories of body mass index, from adolescence to older adulthood, and pancreatic cancer risk; a population-based case–control study in Ontario, Canada

2019 ◽  
Vol 30 (9) ◽  
pp. 955-966 ◽  
Author(s):  
Vanessa De Rubeis ◽  
Michelle Cotterchio ◽  
Brendan T. Smith ◽  
Lauren E. Griffith ◽  
Ayelet Borgida ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Body Mass Index ◽  
Cancer Risk ◽  
Body Mass ◽  
Case Control Study ◽  
Population Based ◽  
Case Control ◽  
Older Adulthood ◽  
Pancreatic Cancer Risk ◽  
Control Study
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