Neural Adaptation of the Electrically Stimulated Auditory Nerve Is Not Affected by Advanced Age in Postlingually Deafened, Middle-aged, and Elderly Adult Cochlear Implant Users

Electrical stimulation of the auditory nerve in the profoundly deaf population through implanted cochlear prostheses has increased the need for reliable electrophysiologic assessment tools. We have recorded electrically evoked brainstem responses (EABRs) in 21 subjects who have received a 3M/House cochlear implant. Recordings have been made, both intraoperatively and postoperatively, in the laboratory setting. The recording technique, methods of stimulus artifact suppression, and results of our measurements are described. Clinical applications of this technology are suggested.

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Assessing auditory nerve condition by tone decay in deaf subjects with a cochlear implant

International Journal of Audiology ◽

10.1080/14992027.2018.1498598 ◽

2018 ◽

Vol 57 (11) ◽

pp. 864-871

Author(s):

Jan-Willem A. Wasmann ◽

Ruben H. M. van Eijl ◽

Huib Versnel ◽

Gijsbert A. van Zanten

Keyword(s):

Cochlear Implant ◽

Auditory Nerve ◽

Tone Decay

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THE IMPACT OF AUDITORY NERVE EXPERIMENTS ON COCHLEAR IMPLANT DESIGN

Annals of the New York Academy of Sciences ◽

10.1111/j.1749-6632.1983.tb31623.x ◽

1983 ◽

Vol 405 (1 Cochlear Pros) ◽

pp. 114-121 ◽

Cited By ~ 11

Author(s):

N. Y. S. Kiang ◽

E. M. Keithley ◽

M. C. Liberman

Keyword(s):

Cochlear Implant ◽

Auditory Nerve ◽

Implant Design ◽

The Impact

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Neural Tissue Degeneration in Rosenthal’s Canal and Its Impact on Electrical Stimulation of the Auditory Nerve by Cochlear Implants: An Image-Based Modeling Study

International Journal of Molecular Sciences ◽

10.3390/ijms21228511 ◽

2020 ◽

Vol 21 (22) ◽

pp. 8511

Author(s):

Kiran Kumar Sriperumbudur ◽

Revathi Appali ◽

Anthony W. Gummer ◽

Ursula van Rienen

Keyword(s):

Cochlear Implant ◽

Cochlear Implants ◽

Auditory Nerve ◽

Ganglion Cells ◽

Spiral Ganglion ◽

Sensorineural Deafness ◽

Neural Tissue ◽

Neural Degeneration ◽

Tissue Degeneration ◽

Ganglion Neurons

Sensorineural deafness is caused by the loss of peripheral neural input to the auditory nerve, which may result from peripheral neural degeneration and/or a loss of inner hair cells. Provided spiral ganglion cells and their central processes are patent, cochlear implants can be used to electrically stimulate the auditory nerve to facilitate hearing in the deaf or severely hard-of-hearing. Neural degeneration is a crucial impediment to the functional success of a cochlear implant. The present, first-of-its-kind two-dimensional finite-element model investigates how the depletion of neural tissues might alter the electrically induced transmembrane potential of spiral ganglion neurons. The study suggests that even as little as 10% of neural tissue degeneration could lead to a disproportionate change in the stimulation profile of the auditory nerve. This result implies that apart from encapsulation layer formation around the cochlear implant electrode, tissue degeneration could also be an essential reason for the apparent inconsistencies in the functionality of cochlear implants.

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