scholarly journals Analysis of a purely conductance-based stochastic nerve fibre model as applied to compound models of populations of human auditory nerve fibres used in cochlear implant simulations

2017 ◽  
Vol 111 (5-6) ◽  
pp. 439-458 ◽  
Author(s):  
Werner Badenhorst ◽  
Tania Hanekom ◽  
Johan J. Hanekom
Keyword(s):  
Cochlear Implant ◽  
Nerve Fibre ◽  
Auditory Nerve ◽  
Nerve Fibres ◽  
Nerve Fibre Model

scholarly journals Deafness alters auditory nerve fibre responses to cochlear implant stimulation

2007 ◽  
Vol 26 (2) ◽  
pp. 510-522 ◽  
Author(s):  
David J. Sly ◽  
Leon F. Heffer ◽  
Mark W. White ◽  
Robert K. Shepherd ◽  
Michael G. J. Birch ◽  
...  
Keyword(s):  
Cochlear Implant ◽  
Nerve Fibre ◽  
Auditory Nerve ◽  
Auditory Nerve Fibre

Threshold predictions of different pulse shapes using a human auditory nerve fibre model containing persistent sodium and slow potassium currents

2010 ◽  
Vol 269 (1-2) ◽  
pp. 12-22 ◽  
Author(s):  
Jacoba E. Smit ◽  
Tania Hanekom ◽  
Astrid van Wieringen ◽  
Jan Wouters ◽  
Johan J. Hanekom
Keyword(s):  
Nerve Fibre ◽  
Auditory Nerve ◽  
Potassium Currents ◽  
Auditory Nerve Fibre ◽  
Slow Potassium ◽  
Nerve Fibre Model

scholarly journals Early Detection of Diabetic Peripheral Neuropathy: A Focus on Small Nerve Fibres

Diagnostics ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. 165
Author(s):  
Jamie Burgess ◽  
Bernhard Frank ◽  
Andrew Marshall ◽  
Rashaad S. Khalil ◽  
Georgios Ponirakis ◽  
...  
Keyword(s):  
Peripheral Neuropathy ◽  
Nerve Fibre ◽  
Diabetic Peripheral Neuropathy ◽  
Point Of Care ◽  
Unmet Need ◽  
Screening Tools ◽  
Nerve Fibres ◽  
Diagnostic Laboratory ◽  
Corneal Confocal Microscopy ◽  
Small Nerve

Diabetic peripheral neuropathy (DPN) is the most common complication of both type 1 and 2 diabetes. As a result, neuropathic pain, diabetic foot ulcers and lower-limb amputations impact drastically on quality of life, contributing to the individual, societal, financial and healthcare burden of diabetes. DPN is diagnosed at a late, often pre-ulcerative stage due to a lack of early systematic screening and the endorsement of monofilament testing which identifies advanced neuropathy only. Compared to the success of the diabetic eye and kidney screening programmes there is clearly an unmet need for an objective reliable biomarker for the detection of early DPN. This article critically appraises research and clinical methods for the diagnosis or screening of early DPN. In brief, functional measures are subjective and are difficult to implement due to technical complexity. Moreover, skin biopsy is invasive, expensive and lacks diagnostic laboratory capacity. Indeed, point-of-care nerve conduction tests are convenient and easy to implement however questions are raised regarding their suitability for use in screening due to the lack of small nerve fibre evaluation. Corneal confocal microscopy (CCM) is a rapid, non-invasive, and reproducible technique to quantify small nerve fibre damage and repair which can be conducted alongside retinopathy screening. CCM identifies early sub-clinical DPN, predicts the development and allows staging of DPN severity. Automated quantification of CCM with AI has enabled enhanced unbiased quantification of small nerve fibres and potentially early diagnosis of DPN. Improved screening tools will prevent and reduce the burden of foot ulceration and amputations with the primary aim of reducing the prevalence of this common microvascular complication.

scholarly journals The ectopic newly-formed nerve fibres which repopulate the long-time denervated and atrophic chick skeletal muscle

1968 ◽  
Vol 26 (3) ◽  
pp. 187-194 ◽  
Author(s):  
Eros Abrantes Erhart ◽  
Cecil José Rezze ◽  
Walter Biazotto
Keyword(s):  
Skeletal Muscle ◽  
Electrical Stimulation ◽  
Nerve Fibre ◽  
Nerve Trunk ◽  
Direct Electrical Stimulation ◽  
Nerve Fibres ◽  
Motor Endplates ◽  
Proximal Stump ◽  
Long Time ◽  
Contralateral Muscle

1. The whole biventer cervicis muscles of the chick, being innervated by a branch of the dorsal ramus of C, presents structural Deculiarities which recommend it as good skeletal muscle for embryological, anatomical, physiological and pharmacological neuro-muscular investigations. 2. The nerve trunk responsible for the innervation of the distal belly runs completely included within the intermediate tendon; therefore, a tendon transection determines complete denervation and nerve fibre degeneration of the distal belly of the muscle. 3. Long-time experimentally denervated distal bellies (from three up to twelve months) are repopulated by ectopic nerve fibres which must have arisen from a source other than the proximal stump, neighbour nerves or nervi-vasorum. 4. Motor endplates appear in these long-time (eight or more months) denervated biventer cervicis distal bellies. 5. Although atrophic-looking such muscle bellies responded to indirect and to direct electrical stimulation — 1.5 V — by contraction. 6. The long-time denervated distal bellies of the biventer cervicis muscle of the chick, when properly reoperated by cross-grafting suture with the normal contralateral muscle, lost their atrophic appearance and showed to be successfully recovered in about thirty days.

Electrically Evoked Brainstem Responses in Cochlear Implant Recipients

1987 ◽  
Vol 96 (1) ◽  
pp. 34-38 ◽  
Author(s):  
Richard T. Miyamoto ◽  
D. Douglas Brown
Keyword(s):  
Electrical Stimulation ◽  
Cochlear Implant ◽  
Auditory Nerve ◽  
Clinical Applications ◽  
Assessment Tools ◽  
Laboratory Setting ◽  
Recording Technique ◽  
Stimulus Artifact ◽  
Artifact Suppression ◽  
Stimulation Of

Electrical stimulation of the auditory nerve in the profoundly deaf population through implanted cochlear prostheses has increased the need for reliable electrophysiologic assessment tools. We have recorded electrically evoked brainstem responses (EABRs) in 21 subjects who have received a 3M/House cochlear implant. Recordings have been made, both intraoperatively and postoperatively, in the laboratory setting. The recording technique, methods of stimulus artifact suppression, and results of our measurements are described. Clinical applications of this technology are suggested.

scholarly journals Assessing auditory nerve condition by tone decay in deaf subjects with a cochlear implant

2018 ◽  
Vol 57 (11) ◽  
pp. 864-871
Author(s):  
Jan-Willem A. Wasmann ◽  
Ruben H. M. van Eijl ◽  
Huib Versnel ◽  
Gijsbert A. van Zanten
Keyword(s):  
Cochlear Implant ◽  
Auditory Nerve ◽  
Tone Decay

Aberrant Nerve Fibres in Human Development

Development ◽  
1960 ◽  
Vol 8 (2) ◽  
pp. 119-129
Author(s):  
J. D. Boyd ◽  
A. F. W. Hughes
Keyword(s):  
Nervous System ◽  
Human Development ◽  
Nerve Fibre ◽  
Early Years ◽  
Developmental Studies ◽  
Nerve Fibres ◽  
Ground Plan ◽  
Technical Developments ◽  
Previous Decade ◽  
Ramón Y Cajal

In the early years of this century debate concerning the development of nerve fibres became more intense. During the previous decade, following the developmental studies of His (1883, 1886) and the early embryological studies of Ramon y Cajal (1890), the neurone theory as proclaimed by Waldeyer in 1891 seemed assured of victory; but when, with Apáthy and Bethe, new technical developments diverted attention from the whole neurone to its apparent constituents, the neurofibrillae, the simple concept of the outgrowth of the nerve fibre became enmeshed in complexity. Methods for their impregnation with silver were soon elaborated (Bielschowsky, 1904; Ramon y Cajal, 1903), and Held (1907) affirmed that a network of neurofibrillae preceded the appearance of the definitive nerve process. This claim became associated with the much older views of Hensen (1864, 1876) that protoplasmic strands were the forerunners of the nerve fibres and constituted a ground plan for the later development of the peripheral nervous system.

THE IMPACT OF AUDITORY NERVE EXPERIMENTS ON COCHLEAR IMPLANT DESIGN

1983 ◽  
Vol 405 (1 Cochlear Pros) ◽  
pp. 114-121 ◽  
Author(s):  
N. Y. S. Kiang ◽  
E. M. Keithley ◽  
M. C. Liberman
Keyword(s):  
Cochlear Implant ◽  
Auditory Nerve ◽  
Implant Design ◽  
The Impact
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