Role of Body Cast Application for Scoliosis Associated With Prader-Willi Syndrome

2020 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Harold J.P. van Bosse
Keyword(s):  
Prader Willi Syndrome ◽  
Body Cast

Development of a Young Man with Prader-Willi Syndrome and Secondary Functional Encopresis

1989 ◽  
Vol 34 (2) ◽  
pp. 123-127 ◽  
Author(s):  
Susan P.C. Carpenter
Keyword(s):  
Personality Development ◽  
Life Stage ◽  
Behavioural Therapy ◽  
Complex Problem ◽  
Prader Willi Syndrome ◽  
Case Review ◽  
Therapeutic Modalities ◽  
Eclectic Approach ◽  
Physical Abilities

A case review of a twenty-two year old man suffering from Prader-Willi Syndrome, Secondary Functional Encopresis, mental retardation and aggressive behaviour is presented. Emphasis is made in assessing this man from various developmental perspectives. This includes: personality development, cognitive development, physical abilities, sexual development and family life stage. The role of a psychiatrist in treating this complex problem is established. An eclectic approach to treatment is reviewed using many therapeutic modalities found effective with the mentally handicapped. These modalities include: group therapy, play therapy, individual psychotherapy, behavioural therapy, family therapy, and use of medication. A literature review of Prader-Willi Syndrome is included.

The epigenetic regulation of synaptic genes contributes to the etiology of autism

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Annamaria Srancikova ◽  
Zuzana Bacova ◽  
Jan Bakos
Keyword(s):  
Epigenetic Regulation ◽  
Neurodevelopmental Disorders ◽  
Autism Spectrum ◽  
Prader Willi Syndrome ◽  
Epigenetic Mechanisms ◽  
Substantial Evidence ◽  
Autistic Symptoms ◽  
Spectrum Disorders ◽  
The Brain

Abstract Epigenetic mechanisms greatly affect the developing brain, as well as the maturation of synapses with pervasive, long-lasting consequences on behavior in adults. Substantial evidence exists that implicates dysregulation of epigenetic mechanisms in the etiology of neurodevelopmental disorders. Therefore, this review explains the role of enzymes involved in DNA methylation and demethylation in neurodevelopment by emphasizing changes of synaptic genes and proteins. Epigenetic causes of sex-dependent differences in the brain are analyzed in conjunction with the pathophysiology of autism spectrum disorders. Special attention is devoted to the epigenetic regulation of the melanoma-associated antigen-like gene 2 (MAGEL2) found in Prader-Willi syndrome, which is known to be accompanied by autistic symptoms.

scholarly journals Evidence for the Role of PWCR1/HBII-85 C/D Box Small Nucleolar RNAs in Prader-Willi Syndrome

2002 ◽  
Vol 71 (3) ◽  
pp. 669-678 ◽  
Author(s):  
Renata C. Gallagher ◽  
Birgit Pils ◽  
Mohammed Albalwi ◽  
Uta Francke
Keyword(s):  
Prader Willi Syndrome ◽  
Small Nucleolar Rnas ◽  
Nucleolar Rnas

scholarly journals Targeting the Gut Microbiome in Prader-Willi Syndrome

2021 ◽  
Vol 10 (22) ◽  
pp. 5328
Author(s):  
Marta Ramon-Krauel ◽  
Montse Amat-Bou ◽  
Mercedes Serrano ◽  
Antonio F. Martinez-Monseny ◽  
Carles Lerin
Keyword(s):  
Mental Health ◽  
Gut Microbiome ◽  
Therapeutic Strategy ◽  
Prader Willi Syndrome ◽  
Mental Health Symptoms ◽  
Probiotic Supplementation ◽  
Health Symptoms ◽  
Overwhelming Evidence ◽  
Wide Range

Overwhelming evidence demonstrates an important role of the gut microbiome in the development of a wide range of diseases, including obesity, metabolic disorders, and mental health symptoms. Indeed, interventions targeting the gut microbiome are being actively investigated as a therapeutic strategy to tackle these diseases. Given that obesity and mental health symptoms are both hallmarks of Prader-Willi syndrome, targeting the gut microbiome may be a promising therapeutical strategy. Only a few studies have investigated the gut microbiome in the context of Prader-Willi syndrome and assessed the efficacy of probiotic supplementation as a therapeutic strategy for this disease. Here, we review the knowledge obtained to this date regarding the gut microbiome in individuals with Prader-Willi syndrome. The limited evidence available indicate that probiotic supplementation improves some metabolic and mental health aspects, however further studies are warranted to determine whether targeting the gut microbiome may constitute a safe and efficient strategy to treat individuals with Prader-Willi syndrome.

Prader-Willi Syndrome: Role of Bariatric Surgery in Two Adolescents with Obesity

2020 ◽  
Vol 30 (11) ◽  
pp. 4602-4604
Author(s):  
Marina Tripodi ◽  
Alberto Casertano ◽  
Martina Peluso ◽  
Mario Musella ◽  
Giovanna Berardi ◽  
...  
Keyword(s):  
Bariatric Surgery ◽  
Prader Willi Syndrome
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