scholarly journals Reply to Letter to the Editor regarding the article “Bone metabolism in the healing process of lumbar interbody fusion-Temporal changes of bone turnover markers”

Spine ◽  
2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Ryota Hyakkan ◽  
Masahiro Kanayama ◽  
Masahiko Takahata
Keyword(s):  
Bone Turnover ◽  
Bone Metabolism ◽  
Bone Turnover Markers ◽  
Interbody Fusion ◽  
Healing Process ◽  
Temporal Changes ◽  
Lumbar Interbody Fusion ◽  
Letter To The Editor ◽  
Turnover Markers

Bone Metabolism in the Healing Process of Lumbar Interbody Fusion-Temporal changes of bone turnover markers-

Spine ◽  
2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Ryota Hyakkan ◽  
Masahiro Kanayama ◽  
Masahiko Takahata ◽  
Fumihiro Oha ◽  
Tomoyuki Hashimoto ◽  
...  
Keyword(s):  
Bone Turnover ◽  
Bone Metabolism ◽  
Bone Turnover Markers ◽  
Interbody Fusion ◽  
Healing Process ◽  
Temporal Changes ◽  
Lumbar Interbody Fusion ◽  
Turnover Markers

The changes in bone turnover markers of female systemic lupus erythematousus patients without glucocorticoid

Lupus ◽  
2021 ◽  
Vol 30 (6) ◽  
pp. 965-971
Author(s):  
Wang Tianle ◽  
Zhang Yingying ◽  
Hong Baojian ◽  
Gu Juanfang ◽  
Wang Hongzhi ◽  
...  
Keyword(s):  
Bone Resorption ◽  
Bone Formation ◽  
Bone Turnover ◽  
Bone Metabolism ◽  
Bone Turnover Markers ◽  
Control Group ◽  
Bone Resorption Marker ◽  
Amino Terminal ◽  
Normal People ◽  
Turnover Markers

Objectives SLE is a chronic autoimmune disease, which can affect the level of bone metabolism and increase the risk of osteoporosis and fracture. The purpose of this research is to study the effect of SLE on bone turnover markers without the influence of glucocorticoids. Methods A total of 865 female subjects were recruited from Zhejiang Provincial People’s Hospital and the First Hospital of Jiaxing, including 391 SLE patients without the influence of glucocorticoids and 474 non-SLE people. We detected Bone turnover markers including amino-terminal propeptide of type 1 procollagen (P1NP), C-terminal turnover of β - I collagen (β-CTX), N-terminal midfragment of osteocalcin (NMID) and 25(OH)D, and analyzed the difference in Bone turnover markers between the SLE group and the control group, as well as the influence of age and season on bone metabolism in female SLE patients. Results In the SLE group, the average age was 43.93±13.95 years old. In the control group, the average age was 44.84±11.42 years old. There was no difference between the two groups (t = 1.03, P = 0.30). P1NP, NMID and 25(OH)D in the SLE group were significantly lower than those in the control group (Z = 8.44, p < 0.001; Z = 14.41, p < 0.001; Z = 2.19, p = 0.029), and β-CTX in the SLE group was significantly higher than that in the control group (Z = 2.61, p = 0.009). In addition, the levers of β-CTX, NMID, P1NP and 25(OH)D in older SLE female patients were statistically significantly higher than those in younger (ρ = 0.104, p = 0.041; ρ = 0.223, p < 0.001; ρ = 0.105, p = 0.038; ρ = 0.289, p < 0.001). Moreover, β-CTX reached a high value in summer and PINP reached a low value in winter. Conclusion The bone formation markers of female SLE patients without glucocorticoid were lower than those of normal people and the bone resorption marker was higher than that of normal people. The 25 (OH) D of female SLE patients without glucocorticoid was lower than that of normal people. The risk of osteoporosis and fracture may be higher in elderly women with SLE. The bone resorption level of female SLE patients is high in summer and the bone formation level is low in winter.

scholarly journals Diurnal Rhythms of Bone Turnover Markers in Three Ethnic Groups

2016 ◽  
Vol 101 (8) ◽  
pp. 3222-3230 ◽  
Author(s):  
Jean Redmond ◽  
Anthony J. Fulford ◽  
Landing Jarjou ◽  
Bo Zhou ◽  
Ann Prentice ◽  
...  
Keyword(s):  
Bone Turnover ◽  
Bone Metabolism ◽  
Ethnic Groups ◽  
Bone Turnover Markers ◽  
Type I Collagen ◽  
Diurnal Rhythms ◽  
Type I ◽  
Dihydroxyvitamin D ◽  
1,25 Dihydroxyvitamin D ◽  
Turnover Markers

Context: Ethnic groups differ in fragility fracture risk and bone metabolism. Differences in diurnal rhythms (DRs) of bone turnover and PTH may play a role. Objective: We investigated the DRs of plasma bone turnover markers (BTMs), PTH, and 1,25(OH)2D in three groups with pronounced differences in bone metabolism and plasma PTH. Participants: Healthy Gambian, Chinese, and white British adults (ages 60–75 years; 30 per country). Interventions: Observational study with sample collection every 4 hours for 24 hours. Main Outcomes: Levels of plasma C-terminal telopeptide of type I collagen, procollagen type-1 N-propeptide, N-mid osteocalcin, bone alkaline phosphatase, PTH, and 1,25-dihydroxyvitamin D were measured. DRs were analyzed with random-effects Fourier regression and cross-correlation and regression analyses to assess associations between DRs and fasting and 24-hour means of BTMs and PTH. Results: Concentrations of BTMs, PTH, and 1,25-dihydroxyvitamin D were higher in Gambians compared to other groups (P &lt; .05). The DRs were significant for all variables and groups (P &lt; .03) and were unimodal, with a nocturnal peak and a daytime nadir for BTMs, whereas PTH had two peaks. The DRs of BTMs and PTH were significantly cross-correlated for all groups (P &lt; .05). There was a significant positive association between C-terminal telopeptide of type I collagen and PTH in the British and Gambian groups (P = .03), but not the Chinese group. Conclusions: Despite ethnic differences in plasma BTMs and PTH, DRs were similar. This indicates that alteration of rhythmicity and loss of coupling of bone resorption and formation associated with an elevated PTH in other studies may not uniformly occur across different populations and needs to be considered in the interpretation of PTH as a risk factor of increased bone loss.

Bone Metabolism, Bone Mineral Content, and Density in Elite Late Teen Female Sprinters

2021 ◽  
Author(s):  
Yuka Tsukahara ◽  
Suguru Torii ◽  
Fumihiro Yamasawa ◽  
Jun Iwamoto ◽  
Takanobu Otsuka ◽  
...  
Keyword(s):  
Bone Turnover ◽  
Bone Mineral Content ◽  
Bone Metabolism ◽  
Bone Mineral ◽  
Bone Turnover Markers ◽  
Mineral Content ◽  
Whole Body ◽  
Tartrate Resistant Acid Phosphatase ◽  
Intensive Training ◽  
Turnover Markers

AbstractWith intensive training, bone injuries are a major concern for athletes. To assess bone condition, we often measure bone turnover markers, bone mineral content and density; however, in junior athletes, it is not easy to distinguish changes caused by bone injuries from those caused by growth, because the metabolism is increased in both cases. Moreover, although some studies have examined female endurance athletes, knowledge regarding changes in static and dynamic bone conditions in late teen athletes is limited. In this study, we measured the bone mineral content and density, as well as bone turnover markers, in 40 elite female sprinters in their late teens. Whole body mode dual-energy X-ray absorptiometry was performed to measure bone mineral content and density. Blood samples were collected to determine bone resorption and formation markers at the end of track season in 2016 and during the same period of the following year. Body weight and bone mineral content significantly increased, and tartrate-resistant acid phosphatase type 5b, bone-type alkaline phosphatase, and osteocalcin significantly decreased after a year. Furthermore, the rate of change in bone mineral content was higher in younger athletes, indicating that bone growth approaches completion in the late teen years and that bone metabolism accordingly decreases.

Temporal changes in systemic and local expression of bone turnover markers during six months of sclerostin antibody administration to ovariectomized rats

Bone ◽  
2014 ◽  
Vol 67 ◽  
pp. 305-313 ◽  
Author(s):  
Marina Stolina ◽  
Denise Dwyer ◽  
Qing-Tian Niu ◽  
Kelly S. Villasenor ◽  
Pam Kurimoto ◽  
...  
Keyword(s):  
Bone Turnover ◽  
Bone Turnover Markers ◽  
Temporal Changes ◽  
Ovariectomized Rats ◽  
Turnover Markers ◽  
Sclerostin Antibody ◽  
Local Expression

Bone Mineral Density and Biochemical Markers of Bone Metabolism in Women Engaging in Recreational Horseback Riding

2016 ◽  
Vol 13 (5) ◽  
pp. 520-524 ◽  
Author(s):  
Agnieszka Kaczmarek ◽  
Alicja Nowak ◽  
Piotr Leszczynski
Keyword(s):  
Physical Activity ◽  
Bone Mineral Density ◽  
Bone Mass ◽  
Bone Turnover ◽  
Bone Metabolism ◽  
Bone Mineral ◽  
Bone Turnover Markers ◽  
Horseback Riding ◽  
Mineral Density ◽  
Turnover Markers

Background:An increased occurrence of lifestyle-related diseases such as osteoporosis indicates the necessity for taking preventive action, including regularly engaging in physical activity. The aim of the study was to assess the areal bone mineral density (aBMD) and bone turnover markers levels in young adult women engaging in recreational horseback riding and to determine the relationship between training characteristics and bone metabolism indices.Methods:The study involved 43 women: 23 equestrians and 20 age- and body mass index–matched controls. The hip and spine aBMD and serum levels of the bone turnover markers: osteocalcin and collagen type I cross-linked C-telopeptide were measured.Results:No significant differences were found in somatic features, concentrations of bone turnover markers, or bone mass variables. Correlation analysis of the equestrian participants showed significant relationship between body mass and BMDL1–L4 (P < .05) as well as between BMI and BMDL1–L4 (P ≤ .01) and z-score L1–L4 (P < .05).Conclusions:The study showed no differences in bone mass and levels of bone metabolic indices between groups of women practicing horseback riding at the recreational level and subjects who do not participate in frequent systematic physical activity. No relationship between training characteristics and bone turnover markers were found.

scholarly journals THE IMPACT OF REGULAR FOOTBALL TRAINING ON BONE TURNOVER MARKERS

2020 ◽  
Vol 33 (33) ◽  
pp. 31-40
Author(s):  
Kacper Pajor ◽  
Justyna Szpyt ◽  
Agnieszka Turoń-Skrzypińska ◽  
Iwona Rotter
Keyword(s):  
Physical Activity ◽  
Bone Turnover ◽  
Bone Metabolism ◽  
Bone Turnover Markers ◽  
The Body ◽  
Type I ◽  
Physical Activity Monitoring ◽  
Turnover Markers ◽  
Football Training ◽  
The Impact

Introduction The condition of the skeleton is important not only in the perspective of osteoporosis prevention, but also as a factor affecting the frequency of injuries excluding physical activity. Monitoring the impact of specific sports on osteoclasts and osteoblasts acitivity allows optimization of programming of physical activity limiting the risk of bone mineralization disorders. The review analyzes available papers on the impact of regular football training on skeletal physiology changes analyzed by measuring bone turnover markers in the body. Aim Determining the impact of regular football training on bone mass regulation by analyzing bone turnover markers. Material and methods PubMed and SPORTDiscus with Full Text databases were searched using the keyword combination “the name of team sport” + bone turnover. There is no clinical trials about bone turnover markers among handball, hockey, basketball and volleyball players in the available literature that meet the inclusion criteria, so the topic of the review was narrowed down to football (soccer). After applying the exclusion criteria, five studies were qualified. Results In the analyzed papers, the concentration of osteocalcin, N-terminal procollagen type I extension propeptide and C-terminal telopeptide of type I collagen in blood increased as a result of regular football training. In 3 papers statistically significant (p < 0.05) increases were noted. Conclusions Football training can stimulate bone metabolism, being an effective and attractive form of bone fracture prevention, regardless of your level of sport. Due to the limited availability of studies, there is a high need for further studies describing the impact of physical activity on bone metabolism.

scholarly journals Low serum levels of bone turnover markers are associated with perirenal fat thickness in patients with type 2 diabetes mellitus

2021 ◽  
Vol 10 (10) ◽  
pp. 1337-1343
Author(s):  
Xiaoxia Jia ◽  
Yaxin An ◽  
Yuechao Xu ◽  
Yuxian Yang ◽  
Chang Liu ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Bone Turnover ◽  
Bone Metabolism ◽  
Bone Turnover Markers ◽  
Fat Thickness ◽  
Turnover Markers ◽  
Perirenal Fat

Background Obesity is known as a common risk factor for osteoporosis and type 2 diabetes mellitus (T2DM). Perirenal fat, surrounding the kidneys, has been reported to be unique in anatomy and biological functions. This study aimed to explore the relationship between perirenal fat and bone metabolism in patients with T2DM. Methods A total of 234 patients with T2DM were recruited from September 2019 to December 2019 in the cross-sectional study. The biochemical parameters and bone turnover markers (BTMs) were determined in all participants. Perirenal fat thickness (PrFT) was performed by ultrasounds via a duplex Doppler apparatus. Associations between PrFT and bone metabolism index were determined via correlation analysis and regression models. Results The PrFT was significantly correlated with β-C-terminal telopeptides of type I collagen (β-CTX) (r = −0.14, P < 0.036), parathyroid hormone (iPTH) (r = −0.18, P ≤ 0.006), and 25 hydroxyvitamin D (25-OH-D) (r = −0.14, P = 0.001). Multivariate analysis confirmed that the association of PrFT and β-CTX (β = −0.136, P = 0.042) was independent of other variables. Conclusion This study showed a negative and independent association between PrFT and β-CTX in subjects with T2DM, suggesting a possible role of PrFT in bone metabolism. Follow-up studies and further research are necessary to validate the associations and to elucidate the underlying mechanisms.

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