A Promoter Polymorphism of Neurotrophin 3 Gene Is Associated With Curve Severity and Bracing Effectiveness in Adolescent Idiopathic Scoliosis

Spine ◽  
2012 ◽  
Vol 37 (2) ◽  
pp. 127-133 ◽  
Author(s):  
Yong Qiu ◽  
Sai-hu Mao ◽  
Bang-ping Qian ◽  
Jun Jiang ◽  
Xu-sheng Qiu ◽  
...  
Keyword(s):  
Adolescent Idiopathic Scoliosis ◽  
Idiopathic Scoliosis ◽  
Promoter Polymorphism ◽  
Neurotrophin 3 ◽  
Curve Severity

scholarly journals Role of the IL-6 Gene in the Etiopathogenesis of Idiopathic Scoliosis

2015 ◽  
Vol 2015 ◽  
pp. 1-5 ◽  
Author(s):  
Svetla Nikolova ◽  
Milka Dikova ◽  
Dobrin Dikov ◽  
Assen Djerov ◽  
Gyulnas Dzhebir ◽  
...  
Keyword(s):  
Idiopathic Scoliosis ◽  
Case Control Study ◽  
Early Stage ◽  
Promoter Polymorphism ◽  
Case Control ◽  
Chi Squared ◽  
Bulgarian Population ◽  
Deformity Progression ◽  
Curve Severity ◽  
Control Study

Scoliotic human nuclei pulposi can respond to exogenous proinflammatory stimuli by secreting increased amounts of interleukin-6 (IL-6). The G/C polymorphism of the promoter region ofIL-6gene influences levels and functional activity of the IL-6 protein. We conducted a case-control study of eighty patients with idiopathic scoliosis (IS) and one hundred sixty healthy unrelated gender-matched controls trying to investigate the association between IS and theIL-6promoter polymorphism at -174 position (rs1800795 G/C) in Bulgarian population. Molecular detection of theIL-6genotypes was performed by amplification followed by restriction technology. The statistical analysis was performed by Pearson’s chi-squared test. Our case-control study revealed a statistically significant association between theIL-6(-174 G/C) functional polymorphism and susceptibility to IS. In addition, a significant association between theIL-6(-174 G/C) polymorphism and curve severity was detected.IL-6gene could be considered as susceptibility and modifying factor of idiopathic scoliosis. The identification of molecular markers with diagnostic and prognostic value could be useful for early detection of children at risk for the development of scoliosis and for prognosis of the risk for a rapid deformity progression. That would facilitate the therapy decisions and early stage treatment of the patient with the least invasive procedures.

scholarly journals Association Study between Promoter Polymorphism of TPH1 and Progression of Idiopathic Scoliosis

2016 ◽  
Vol 2016 ◽  
pp. 1-5 ◽  
Author(s):  
Vasil Yablanski ◽  
Svetla Nikolova ◽  
Evgeni Vlaev ◽  
Alexey Savov ◽  
Ivo Kremensky
Keyword(s):  
Idiopathic Scoliosis ◽  
Early Stage ◽  
Population Sample ◽  
Promoter Polymorphism ◽  
European Population ◽  
Rapid Progression ◽  
Eastern European ◽  
Exact Test ◽  
Disease Modifier ◽  
Curve Severity

The concept of disease-modifier genes as an element of genetic heterogeneity has been widely accepted and reported. The aim of the current study is to investigate the association between the promoter polymorphism TPH1 (rs10488682) and progression of idiopathic scoliosis (IS) in Eastern European population sample. A total of 105 patients and 210 healthy gender-matched controls were enrolled in this study. The TPH1 promoter polymorphism was genotyped by amplification followed by restriction. The statistical analysis was performed by Fisher’s Exact Test. The results indicated that the genotypes and alleles of TPH1 (rs10488682) are not correlated with curve severity, curve pattern, or bracing. Therefore, the examined polymorphic variant could not be considered as a genetic factor with modifying effect of IS. In conclusion, this case-control study revealed no statistically significant association between TPH1 (rs10488682) and progression of IS in Eastern European population sample. These preliminary results should be replicated in extended population studies including larger sample sizes. The identification of molecular markers for IS could be useful for a more accurate prognosis of the risk for a rapid progression of the curve. That would permit early stage treatment of the patient with the least invasive procedures.

How Does the Supine MRI Correlate With Standing Radiographs of Different Curve Severity in Adolescent Idiopathic Scoliosis?

Spine ◽  
2015 ◽  
Vol 40 (15) ◽  
pp. 1206-1212 ◽  
Author(s):  
Benlong Shi ◽  
Saihu Mao ◽  
Zhiwei Wang ◽  
Tsz Ping Lam ◽  
Fiona Wai Ping Yu ◽  
...  
Keyword(s):  
Adolescent Idiopathic Scoliosis ◽  
Idiopathic Scoliosis ◽  
Curve Severity

scholarly journals The importance of curve severity, type and instrumentation strategy in the surgical correction of adolescent idiopathic scoliosis: an in silico clinical trial on 64 cases

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Fabio Galbusera ◽  
Andrea Cina ◽  
Matteo Panico ◽  
Tito Bassani
Keyword(s):  
Clinical Trial ◽  
Adolescent Idiopathic Scoliosis ◽  
Idiopathic Scoliosis ◽  
In Silico ◽  
Three Dimensional ◽  
Clinical Results ◽  
Implant Loosening ◽  
Surgical Decision ◽  
Curve Severity

AbstractAdolescent idiopathic scoliosis is a three-dimensional deformity of the spine which is frequently corrected with the implantation of instrumentation with generally good or excellent clinical results; mechanical post-operative complications such as implant loosening and breakage are however relatively frequent. The rate of complications is associated with a lack of consensus about the surgical decision-making process; choices about the instrumentation length, the anchoring implants and the degree of correction are indeed mostly based on personal views and previous experience of the surgeon. In this work, we performed an in silico clinical trial on a large number of subjects in order to clarify which factors have the highest importance in determining the risk of complications by quantitatively analysing the mechanical stresses and loads in the instrumentation after the correction maneuvers. The results of the simulations highlighted the fundamental role of the curve severity, also in its three-dimensional aspect, and of the instrumentation strategy, whereas the length of the fixation had a lower importance.

A Replication Study for the Association of rs11190870 With Curve Severity in Adolescent Idiopathic Scoliosis in Japanese

Spine ◽  
2018 ◽  
Vol 43 (10) ◽  
pp. 688-692 ◽  
Author(s):  
Yohei Takahashi ◽  
Ikuyo Kou ◽  
Yoji Ogura ◽  
Atsushi Miyake ◽  
Kazuki Takeda ◽  
...  
Keyword(s):  
Adolescent Idiopathic Scoliosis ◽  
Idiopathic Scoliosis ◽  
Replication Study ◽  
Curve Severity

The influence of 3D curve severity on paraspinal muscle fatty infiltration in patients with adolescent idiopathic scoliosis

2021 ◽  
Author(s):  
David B. Berry ◽  
Connor D. Grant ◽  
Christine L. Farnsworth ◽  
Erin K. Englund ◽  
Peter O. Newton ◽  
...  
Keyword(s):  
Adolescent Idiopathic Scoliosis ◽  
Idiopathic Scoliosis ◽  
Fatty Infiltration ◽  
Paraspinal Muscle ◽  
Curve Severity
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