Expression of T-Follicular Helper Markers in Sequential Biopsies of Progressive Mycosis Fungoides and Other Primary Cutaneous T-Cell Lymphomas

2015 ◽  
Vol 37 (2) ◽  
pp. 115-121 ◽  
Author(s):  
Francesca M. Bosisio ◽  
Lorenzo Cerroni
Keyword(s):  
T Cell ◽  
Mycosis Fungoides ◽  
Follicular Helper ◽  
T Cell Lymphomas

Duvelisib as bridge to allotransplantation in refractory peripheral T-cell lymphoma with T-follicular helper phenotype: case report

2021 ◽  
pp. 030089162110272
Author(s):  
Ginevra Lolli ◽  
Beatrice Casadei ◽  
Cinzia Pellegrini ◽  
Lisa Argnani ◽  
Federica Cocito ◽  
...  
Keyword(s):  
Case Report ◽  
T Cell ◽  
Human Leukocyte ◽  
Complete Response ◽  
Unrelated Donor ◽  
Phosphatidylinositol 3 Kinase ◽  
Leukocyte Antigen ◽  
Follicular Helper ◽  
T Cell Lymphomas ◽  
T Cell Malignancies

Objective: Peripheral T-cell lymphomas (PTCLs) are a group of heterogeneous T-cell malignancies representing 5%–10% of aggressive lymphomas. The prognosis is poor for patients with relapsed/refractory (R/R) disease, with a median overall survival of less than 6 months and no standardized treatments. We discuss the role of the phosphatidylinositol 3-kinase (PI3K) γδ inhibitor duvelisib as bridge to allotransplantation in a patient with R/R PTCL. Methods: Case report. Results: A 55-year-old woman diagnosed with relapsed nodal PTCL with T-follicular helper phenotype received PI3K γδ inhibitor duvelisib in the context of the phase II PRIMO clinical trial. After two cycles at a dose of 75 mg twice daily, the patient achieved complete response (CR), which was subsequently consolidated with human leukocyte antigen fully matched unrelated donor allotransplantation. No major toxicities were recorded during the duvelisib treatment period or during hospitalization for allotransplantation. At the latest follow-up, the patient was alive and still in CR 10 months posttransplant. Conclusions: Duvelisib should be further explored as a bridge to allotransplantation in patients with R/R PTCL, given the success and low toxicity in our patient.

scholarly journals Expression and activity of IL-17 in cutaneous T-cell lymphomas(mycosis fungoides and sezary syndrome)

2004 ◽  
Vol 112 (1) ◽  
pp. 113-120 ◽  
Author(s):  
Arnaud Cirée ◽  
Laurence Michel ◽  
Sophie Camilleri-Bröet ◽  
Francette Jean Louis ◽  
Michèle Oster ◽  
...  
Keyword(s):  
T Cell ◽  
Mycosis Fungoides ◽  
Sézary Syndrome ◽  
Sezary Syndrome ◽  
T Cell Lymphomas ◽  
Expression And Activity

scholarly journals Non–Mycosis Fungoides Cutaneous T-Cell Lymphomas

2013 ◽  
Vol 139 (4) ◽  
pp. 491-514 ◽  
Author(s):  
Leticia Quintanilla-Martinez ◽  
Patty M. Jansen ◽  
Marsha C. Kinney ◽  
Steven H. Swerdlow ◽  
Rein Willemze
Keyword(s):  
T Cell ◽  
Mycosis Fungoides ◽  
T Cell Lymphomas

scholarly journals Clonal hematopoiesis in angioimmunoblastic T-cell lymphoma with divergent evolution to myeloid neoplasms

2020 ◽  
Vol 4 (10) ◽  
pp. 2261-2271 ◽  
Author(s):  
Natasha E. Lewis ◽  
Kseniya Petrova-Drus ◽  
Sarah Huet ◽  
Zachary D. Epstein-Peterson ◽  
Qi Gao ◽  
...  
Keyword(s):  
Bone Marrow ◽  
T Cell ◽  
Genetic Alterations ◽  
Divergent Evolution ◽  
Tissue Samples ◽  
Clonal Hematopoiesis ◽  
Follicular Helper ◽  
Myeloid Neoplasms ◽  
T Cell Lymphomas ◽  
Genomic Studies

Abstract TET2 and DNMT3A mutations are frequently identified in T-cell lymphomas of T follicular helper cell origin (TCL-TFH), clonal hematopoiesis (CH), and myeloid neoplasms (MNs). The relationships among these 3 entities, however, are not well understood. We performed comprehensive genomic studies on paired bone marrow and tissue samples as well as on flow cytometry–sorted bone marrow and peripheral blood subpopulations from a cohort of 22 patients with TCL-TFH to identify shared CH-type mutations in various hematopoietic cell compartments. Identical mutations were detected in the neoplastic T-cell and myeloid compartments of 15 out of 22 patients (68%), including TET2 (14/15) and DNMT3A (10/15). Four patients developed MNs, all of which shared CH-type mutations with their TCL-TFH; additional unique genetic alterations were also detected in each patient’s TCL-TFH and MN. These data demonstrate that CH is prevalent in patients with TCL-TFH and that divergent evolution of a CH clone may give rise to both TCL-TFH and MNs.

IL-15 and IL-16 overexpression in cutaneous T-cell lymphomas: stage-dependent increase in mycosis fungoides progression

2000 ◽  
Vol 9 (4) ◽  
pp. 248-251 ◽  
Author(s):  
K. Asadullah ◽  
A. Haeussler-Quade ◽  
S. Gellrich ◽  
S. Hanneken ◽  
T. E. Hansen-Hagge ◽  
...  
Keyword(s):  
T Cell ◽  
Mycosis Fungoides ◽  
T Cell Lymphomas

Mycosis fungoides and other cutaneous T-cell lymphomas

2013 ◽  
pp. 264-282
Author(s):  
Dario Tomasini ◽  
Marco Lucioni ◽  
Marco Paulli ◽  
Emilio Berti
Keyword(s):  
T Cell ◽  
Mycosis Fungoides ◽  
T Cell Lymphomas

scholarly journals The expression of CD26 and CD40 ligand is mutually exclusive in human T- cell non-Hodgkin's lymphomas/leukemias

Blood ◽  
1995 ◽  
Vol 86 (12) ◽  
pp. 4617-4626 ◽  
Author(s):  
A Carbone ◽  
A Gloghini ◽  
V Zagonel ◽  
D Aldinucci ◽  
V Gattei ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
T Lymphocytes ◽  
Mycosis Fungoides ◽  
Cell Lines ◽  
Critical Role ◽  
Cd40 Ligand ◽  
T Cell Lymphomas ◽  
Human T Cell ◽  
Hodgkin's Lymphomas

CD26 and CD40 ligand (CD40L) are surface molecules on human activated T lymphocytes that play a critical role in the regulation of lymphopoiesis. Both molecules are expressed on a restricted fraction of human T-cell non-Hodgkin's lymphomas (NHL)/leukemias; however, little is known about their functional and/or clinical significance in these disorders. In this study, the pattern of expression of CD40L was compared with that of the CD26 molecule. A series of 67 human T-cell NHL/leukemias and a panel of leukemia/lymphoma T-cell lines were evaluated by immunohistochemistry, flow cytometry, and RNA studies. The overall frequency of CD26+ and CD40L+ samples was rather similar (25/67 [37%] v 18/67 [27%]). However, the majority of CD26-expressing cases clustered in the lymphoblastic lymphomas (LBL)/T-acute lymphoblastic leukemias (ALL; 12/23) and CD30+ anaplastic large-cell (ALC) lymphomas (5/8), whereas CD40L+ lymphomas included a large fraction of mycosis fungoides (11/21 [52%]). CD26 and CD40L coexpression was found only in 2 myocosis fungoides cases and 1 small lymphocytic lymphoma. Thus, the expression of the two antigens was mutually exclusive in almost all T- cell lymphomas/leukemias. Accordingly, lymphoma cell lines expressed either one of the molecules or the relative amounts of CD26 and CD40L were inversely proportional. In contrast, reactive T lymphocytes from patients with non-neoplastic T-cell expansions and in vitro activated CD3+ or CD4+ normal T cells were found to coexpress CD40L and CD26. Results of a multivariate analysis showed that the expression of CD26 in T-cell LBL/ALL patients was associated to a worse outcome in terms of survival, as compared with patients with CD26- tumors (P < or = .0001). Based on our results, it can be concluded that, (1) as opposed to activated or reactive normal T cells, the expression of CD26 and of CD40L is mutually exclusive in human T-cell lymphomas/leukemias; (2) expression of CD26 is restricted to aggressive pathologic entities, such as T-cell LBL/ALL and T-cell CD30+ ALC lymphomas, whereas CD40L is expressed on slow progressing diseases such as mycosis fungoides; and (3) within the T-cell LBL/ALL group of tumors, CD26 may identify a subset of poor prognosis patients.

scholarly journals An overview of cutaneous T cell lymphomas

F1000Research ◽  
2016 ◽  
Vol 5 ◽  
pp. 1882 ◽  
Author(s):  
Nooshin Bagherani ◽  
Bruce R. Smoller
Keyword(s):  
T Cell ◽  
T Lymphocytes ◽  
Mycosis Fungoides ◽  
Annual Incidence ◽  
Heterogeneous Group ◽  
Not Otherwise Specified ◽  
T Cell Lymphomas ◽  
Hodgkin's Lymphomas ◽  
Diagnosis Therapy ◽  
Peripheral T Cell Lymphomas

Cutaneous T cell lymphomas (CTCLs) are a heterogeneous group of extranodal non-Hodgkin’s lymphomas that are characterized by a cutaneous infiltration of malignant monoclonal T lymphocytes. They typically afflict adults with a median age of 55 to 60 years, and the annual incidence is about 0.5 per 100,000. Mycosis fungoides, Sézary syndrome, and primary cutaneous peripheral T cell lymphomas not otherwise specified are the most important subtypes of CTCL. CTCL is a complicated concept in terms of etiopathogenesis, diagnosis, therapy, and prognosis. Herein, we summarize advances which have been achieved in these fields.

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