Short-Duration High-Intensity Interval Exercise Training Is More Effective Than Long Duration for Blood Pressure and Arterial Stiffness But Not for Inflammatory Markers and Lipid Profiles in Patients With Stage 1 Hypertension

Background: Increased plasma levels of inflammatory markers and markers of endothelial cell activation have been associated with increased risk for cardiovascular events. Exercise training may lower the risk for coronary heart disease by attenuating inflammation and improving endothelial function. The objective of this study was to evaluate effects of regular high-intensity exercise training on a wide range of markers of inflammation and endothelial cell activation. Materials and methods: Consecutively, 40 patients were prospectively randomized to a 6 months supervised high-intensity interval training programme or to a control group following successful percutaneous coronary intervention (PCI). Blood samples of 36 patients with stable angina, drawn at baseline (before PCI) and at 6 months, were analysed. Late luminal loss was measured at 6 months using quantitative coronary angiography. Results: At 6 months, levels of the inflammatory markers interleukin (IL)-6 and IL-8 were reduced and levels of the anti-inflammatory cytokine IL-10 increased in the training group only. The decrease in IL-6 and C-reactive protein levels were significantly correlated with the decrease in luminal loss following PCI. In contrast to these anti-inflammatory effects, training had no effect on markers of platelet-mediated inflammation, and the effect of training on markers on endothelial cell activation were rather complex showing attenuating (von Willebrand factor) and enhancing (E-selectin and vascular cell adhesion molecule 1) effects. Conclusions: Regular exercise training in stable angina patients following PCI may attenuate some, but not all, inflammatory pathways, potentially contributing to the beneficial effects of exercise training on restenosis.

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A Single Session of Low-Volume High-Intensity Interval Exercise Reduces Ambulatory Blood Pressure in Normotensive Men

The Journal of Strength and Conditioning Research ◽

10.1519/jsc.0000000000001688 ◽

2017 ◽

Vol 31 (8) ◽

pp. 2263-2269 ◽

Cited By ~ 8

Author(s):

Teresa C.B. Dantas ◽

Luiz F. Farias Junior ◽

Danniel T. Frazão ◽

Paulo H.M. Silva ◽

Altieres E. Sousa Junior ◽

...

Keyword(s):

Blood Pressure ◽

Ambulatory Blood Pressure ◽

High Intensity ◽

Single Session ◽

Interval Exercise ◽

Low Volume ◽

High Intensity Interval

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Effect of 4 weeks of aerobic or resistance exercise training on arterial stiffness, blood flow and blood pressure in pre- and stage-1 hypertensives

Journal of Human Hypertension ◽

10.1038/jhh.2008.36 ◽

2008 ◽

Vol 22 (10) ◽

pp. 678-686 ◽

Cited By ~ 147

Author(s):

S R Collier ◽

J A Kanaley ◽

R Carhart ◽

V Frechette ◽

M M Tobin ◽

...

Keyword(s):

Blood Pressure ◽

Blood Flow ◽

Exercise Training ◽

Arterial Stiffness ◽

Resistance Exercise ◽

Resistance Exercise Training ◽

Stage 1

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The effects of short-term high-intensity interval training vs. moderate-intensity continuous training on plasma levels of nesfatin-1 and inflammatory markers

Hormone Molecular Biology and Clinical Investigation ◽

10.1515/hmbci-2014-0038 ◽

2015 ◽

Vol 21 (3) ◽

Cited By ~ 12

Author(s):

Sajad Ahmadizad ◽

Alireza Salimi Avansar ◽

Khosrow Ebrahim ◽

Mohsen Avandi ◽

Mansour Ghasemikaram

Keyword(s):

Insulin Resistance ◽

Exercise Training ◽

Weight Management ◽

High Intensity ◽

Inflammatory Markers ◽

Interval Training ◽

Moderate Intensity ◽

High Intensity Interval Training ◽

Tnf Α ◽

High Intensity Interval

AbstractExercise training is an effective method of weight management, and knowing about its influence on the hormones involved in the regulation of food intake and inflammation could be useful for body weight management. Therefore, the purpose of this study was to compare the effects of 6 weeks of high-intensity interval training (HIIT) and moderate-intensity continuous exercise training (MCT) on nesfatin-1, interleukin (IL)-6, and tumor necrosis factor alpha (TNF-α).Thirty sedentary overweight men (Mean±SD; age, 25±1 years) were divided into three (n=10) body mass index-matched groups. The participants in the training groups performed either HIIT or MCT protocols 3 days per week for 6 weeks followed by a week of detraining.Plasma IL-6 and TNF-α did not significantly change after training, but nesfatin increased significantly only with HIIT compared with the control group (p<0.05). In addition, fasting glucose, insulin, and homeostasis model estimated insulin resistance (HOMA-IR), decreased significantly following both HIIT and MCT training (p<0.05). After a detraining period, the plasma nesfatin-1 did not return to pre-training levels in the HIIT group.Both the HIIT and MCT groups had similar effects on inflammatory markers and insulin resistance in men who are overweight, but the HIIT seems to have better anorectic effects (as indicated by nesfatin) compared with MCT.

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