Oxidative stress and inflammatory mediators contribute to endothelial dysfunction in high-fat diet-induced obesity in mice

2010 ◽  
Vol 28 (10) ◽  
pp. 2111-2119 ◽  
Author(s):  
Renata Kobayasi ◽  
Eliana H Akamine ◽  
Ana P Davel ◽  
Maria AM Rodrigues ◽  
Carla RO Carvalho ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Endothelial Dysfunction ◽  
Inflammatory Mediators ◽  
High Fat Diet ◽  
High Fat ◽  
Diet Induced Obesity ◽  
Obesity In Mice

An ursolic acid-enriched Cynomorium songarium extract attenuates high fat diet-induced obesity in mice possibly through mitochondrial uncoupling

2014 ◽  
Vol 9 ◽  
pp. 211-224 ◽  
Author(s):  
Jihang Chen ◽  
Hoi Shan Wong ◽  
Hoi Yan Leung ◽  
Pou Kuan Leong ◽  
Wing Man Chan ◽  
...  
Keyword(s):  
Ursolic Acid ◽  
High Fat Diet ◽  
High Fat ◽  
Mitochondrial Uncoupling ◽  
Diet Induced Obesity ◽  
Obesity In Mice

scholarly journals CD40L controls obesity-associated vascular inflammation, oxidative stress, and endothelial dysfunction in high fat diet-treated and db/db mice

2017 ◽  
Vol 114 (2) ◽  
pp. 312-323 ◽  
Author(s):  
Sebastian Steven ◽  
Mobin Dib ◽  
Michael Hausding ◽  
Fatemeh Kashani ◽  
Matthias Oelze ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Endothelial Dysfunction ◽  
High Fat Diet ◽  
Immune Cell ◽  
Vascular Inflammation ◽  
Human Study ◽  
Isometric Tension ◽  
Wild Type ◽  
High Fat ◽  
Aorta Ascendens

Abstract Aims CD40 ligand (CD40L) signaling controls vascular oxidative stress and related dysfunction in angiotensin-II-induced arterial hypertension by regulating vascular immune cell recruitment and platelet activation. Here we investigated the role of CD40L in experimental hyperlipidemia. Methods and results Male wild type and CD40L−/− mice (C57BL/6 background) were subjected to high fat diet for sixteen weeks. Weight, cholesterol, HDL, and LDL levels, endothelial function (isometric tension recording), oxidative stress (NADPH oxidase expression, dihydroethidium fluorescence) and inflammatory parameters (inducible nitric oxide synthase, interleukin-6 expression) were assessed. CD40L expression, weight, leptin and lipids were increased, and endothelial dysfunction, oxidative stress and inflammation were more pronounced in wild type mice on a high fat diet, all of which was almost normalized by CD40L deficiency. Similar results were obtained in diabetic db/db mice with CD40/TRAF6 inhibitor (6877002) therapy. In a small human study higher serum sCD40L levels and an inflammatory phenotype were detected in the blood and Aorta ascendens of obese patients (body mass index > 35) that underwent by-pass surgery. Conclusion CD40L controls obesity-associated vascular inflammation, oxidative stress and endothelial dysfunction in mice and potentially humans. Thus, CD40L represents a therapeutic target in lipid metabolic disorders which is a leading cause in cardiovascular disease.

scholarly journals Magnesium deficiency prevents high-fat-diet-induced obesity in mice

Diabetologia ◽  
2018 ◽  
Vol 61 (9) ◽  
pp. 2030-2042 ◽  
Author(s):  
Steef Kurstjens ◽  
Janna A. van Diepen ◽  
Caro Overmars-Bos ◽  
Wynand Alkema ◽  
René J. M. Bindels ◽  
...  
Keyword(s):  
High Fat Diet ◽  
Magnesium Deficiency ◽  
High Fat ◽  
Diet Induced Obesity ◽  
Obesity In Mice

scholarly journals Euphorbia supina extract results in inhibition of high‑fat‑diet‑induced obesity in mice

2018 ◽  
Author(s):  
Sarmila Nepali ◽  
Do‑Kuk Kim ◽  
Hoon‑Yeon Lee ◽  
Hyeon‑Hui Ki ◽  
Bo‑Ram Kim ◽  
...  
Keyword(s):  
High Fat Diet ◽  
High Fat ◽  
Diet Induced Obesity ◽  
Obesity In Mice

scholarly journals Combined effects of Diospyros lotus leaf and grape stalk extract in high-fat-diet-induced obesity in mice

2019 ◽  
Vol 28 (4) ◽  
pp. 1207-1215 ◽  
Author(s):  
Denis Nchang Che ◽  
Hyun Ju Kang ◽  
Byoung Ok Cho ◽  
Jae Young Shin ◽  
Seon Il Jang
Keyword(s):  
High Fat Diet ◽  
Combined Effects ◽  
High Fat ◽  
Lotus Leaf ◽  
Diet Induced Obesity ◽  
Diospyros Lotus ◽  
Obesity In Mice
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