Effect of Gum Arabic on Oxidative Stress Markers in The Liver of High Fat Diet Induced Obesity in Mice

Obesity and high-fat diet (HF) are prevalent causes of oxidative stress (OS). Duodenal-jejunal omega switch (DJOS) is a bariatric procedure used for body mass reduction, extensively tested in animal models. We studied the long-term impact of bariatric surgery and an HF diet on the oxidative stress markers in erythrocytes and heart muscles of rats. We analyzed superoxide dismutase (SOD), catalase (CAT), glutathione transferase (GST), glutathione reductase (GR), glutathione peroxidase (GPx) activity and malondialdehyde (MDA) concentration in DJOS or SHAM (control) operated rats fed with different dietary protocols (control diet (CD) and high-fat diet (HF)), before and after the surgery (CD/CD, HF/HF, CD/HF, and HF/CD). We observed higher erythrocytes CAT, GST and GPx activity in DJOS-operated (vs. SHAM) rats fed with an HF/HF diet. For DJOS-operated rats, erythrocytes CAT and GPx activity and MDA concentration were significantly lower in CD/CD group. We observed increased heart muscle GR activity in SHAM-operated rats (vs. DJOS bariatric surgery) fed with an HF/HF diet. Change from HF to CD diet increased heart muscle GPx activity after DJOS bariatric surgery. Heart muscle SOD activity was lower in HF/HF and CD/CD groups after DJOS bariatric surgery (vs. SHAM). DJOS surgery significantly reduced heart muscle MDA concentration in HF/HF and HF/CD groups (vs. SHAM). We conclude that the selected dietary patterns had a stronger impact on oxidative stress markers in erythrocytes and heart muscle than DJOS bariatric surgery.

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Metabolic and oxidative stress markers in Wistar rats after 2 months on a high-fat diet

Diabetology & Metabolic Syndrome ◽

10.1186/1758-5996-6-130 ◽

2014 ◽

Vol 6 (1) ◽

pp. 130 ◽

Cited By ~ 23

Author(s):

Nathalie Auberval ◽

Stéphanie Dal ◽

William Bietiger ◽

Michel Pinget ◽

Nathalie Jeandidier ◽

...

Keyword(s):

Oxidative Stress ◽

High Fat Diet ◽

Wistar Rats ◽

Oxidative Stress Markers ◽

High Fat ◽

Stress Markers ◽

And Oxidative Stress

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ACE Reduces Metabolic Abnormalities in a High-Fat Diet Mouse Model

Evidence-based Complementary and Alternative Medicine ◽

10.1155/2015/352647 ◽

2015 ◽

Vol 2015 ◽

pp. 1-8 ◽

Cited By ~ 3

Author(s):

Seong-Jong Lee ◽

Jong-Min Han ◽

Jin-Seok Lee ◽

Chang-Gue Son ◽

Hwi-Jin Im ◽

...

Keyword(s):

Oxidative Stress ◽

High Fat Diet ◽

Serum Lipid ◽

Peroxisome Proliferator ◽

Metabolic Abnormalities ◽

Oxidative Stress Markers ◽

High Fat ◽

Peroxisome Proliferator Activated Receptor ◽

Stress Markers ◽

And Oxidative Stress

The medicinal plantsArtemisia iwayomogi(A. iwayomogi) andCurcuma longa(C. longa) radix have been used to treat metabolic abnormalities in traditional Korean medicine and traditional Chinese medicine (TKM and TCM). In this study we evaluated the effect of the water extract of a mixture ofA. iwayomogiandC. longa(ACE) on high-fat diet-induced metabolic syndrome in a mouse model. Four groups of C57BL/6N male mice (except for the naive group) were fed a high-fat diet freely for 10 weeks. Among these, three groups (except the control group) were administered a high-fat diet supplemented with ACE (100 or 200 mg/kg) or curcumin (50 mg/kg). Body weight, accumulation of adipose tissues in abdomen and size of adipocytes, serum lipid profiles, hepatic steatosis, and oxidative stress markers were analyzed. ACE significantly reduced the body and peritoneal adipose tissue weights, serum lipid profiles (total cholesterol and triglycerides), glucose levels, hepatic lipid accumulation, and oxidative stress markers. ACE normalized lipid synthesis-associated gene expressions (peroxisome proliferator-activated receptor gamma, PPARγ; fatty acid synthase, FAS; sterol regulatory element-binding transcription factor-1c, SREBP-1c; and peroxisome proliferator-activated receptor alpha, PPARα). The results from this study suggest that ACE has the pharmaceutical potential reducing the metabolic abnormalities in an animal model.

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High-fat diet-induced metabolic syndrome and oxidative stress in obese rats are ameliorated by yogurt supplementation

Scientific Reports ◽

10.1038/s41598-019-56538-0 ◽

2019 ◽

Vol 9 (1) ◽

Cited By ~ 21

Author(s):

Shoumen Lasker ◽

Md Mizanur Rahman ◽

Faisal Parvez ◽

Mushfera Zamila ◽

Pintu Miah ◽

...

Keyword(s):

Oxidative Stress ◽

Metabolic Syndrome ◽

High Fat Diet ◽

Alternative Therapy ◽

High Fat ◽

Stress Markers ◽

Diet Induced Obesity ◽

Obese Rats ◽

Male Wistar Rats ◽

And Oxidative Stress

AbstractThe main objective of this experiment was to determine the effects of yogurt supplementation on fat deposition, oxidative stress, inflammation and fibrosis in the liver of rats with high-fat (HF) diet-induced obesity. Male Wistar rats were used in this study and were separated into the following four different groups: the control, control + yogurt, high fat and high fat+ yogurt groups. The high fat groups received a HF diet for eight weeks. A 5% yogurt (w/w) supplement was also provided to rats fed the HF diet. Yogurt supplementation prevented glucose intolerance and normalized liver-specific enzyme activities in the HF diet-fed rats. Yogurt supplementation also significantly reduced the levels of oxidative stress markers in the plasma and liver of HF diet-fed rats. Moreover, inflammatory cell infiltration, collagen deposition and fibrosis in the liver of HF diet-fed rats were also prevented by yogurt supplementation. Furthermore, yogurt supplementation normalized the intestinal lining and brush border in HF diet-fed rats. This study suggests that yogurt supplementation potentially represents an alternative therapy for the prevention of metabolic syndrome in HF diet-fed rats.

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