scholarly journals MP04-18 IN VITRO BENCH TESTING OF A TELEMETRIC DEVICE USING BLUE TOOTH TECHNOLOGY

2020 ◽  
Vol 203 ◽  
pp. e39
Author(s):  
Angelo Gousse* ◽  
Christopher Gomez ◽  
Christopher Ross ◽  
Peter Sayet
Keyword(s):  
Bench Testing ◽  
Blue Tooth

scholarly journals Sensitivity analysis of FDA´s benchmark nozzle regarding in vitro imperfections - Do we need asymmetric CFD benchmarks?

2020 ◽  
Vol 6 (3) ◽  
pp. 78-81
Author(s):  
Michael Stiehm ◽  
Christoph Brandt-Wunderlich ◽  
Stefan Siewert ◽  
Klaus-Peter Schmitz ◽  
Niels Grabow ◽  
...  
Keyword(s):  
Reynolds Number ◽  
Flow Field ◽  
In Silico ◽  
Nozzle Geometry ◽  
Geometrical Imperfection ◽  
Custom Made ◽  
Inlet Conditions ◽  
Silicone Model ◽  
Bench Testing

AbstractModern technologies and methods such as computer simulation, so-called in silico methods, foster the development of medical devices. For accelerating the uptake of computer simulations and to increase credibility and reliability the U.S. Food and Drug Administration organized an inter-laboratory round robin study of a generic nozzle geometry. In preparation of own bench testing experiment using Particle Image Velocimetry, a custom made silicone nozzle was manufactured. By using in silico computational fluid dynamics method the influence of in vitro imperfections, such as inflow variations and geometrical deviations, on the flow field were evaluated. Based on literature the throat Reynolds number was varied Rethroat = 500 ± 50. It could be shown that the flow field errors resulted from variations of inlet conditions can be largely eliminated by normalizing if the Reynolds number is known. Furthermore, a symmetric imperfection of the silicone model within manufacturing tolerance does not affect the flow as much as an asymmetric failure such as an unintended curvature of the nozzle. In brief, we can conclude that geometrical imperfection of the reference experiment should be considered accordingly to in silico modelling. The question arises, if an asymmetric benchmark for biofluid analysis needs to be established. An eccentric nozzle benchmark could be a suitable case and will be further investigated.

scholarly journals Design, development, testing at ISO standards and in vivo feasibility study of a novel polymeric heart valve prosthesis

2020 ◽  
Vol 8 (16) ◽  
pp. 4467-4480
Author(s):  
Joanna R. Stasiak ◽  
Marta Serrani ◽  
Eugenia Biral ◽  
James V. Taylor ◽  
Azfar G. Zaman ◽  
...  
Keyword(s):  
Heart Valve ◽  
Feasibility Study ◽  
Heart Valve Prosthesis ◽  
Valve Prosthesis ◽  
Design Development ◽  
Iso Standards ◽  
Bench Testing ◽  
Bioprosthetic Valves

A novel polymeric heart valve shows durability equivalent to 25 years in accelerated bench testing, in vitro hydrodynamics equivalent to existing bioprosthetic valves; and good performance in a small acute feasibility study in sheep.

scholarly journals TCT-374 Mitral Prosthetic Fracture to Facilitate Transcatheter Mitral Procedures: Results of In Vitro Bench Testing

2018 ◽  
Vol 72 (13) ◽  
pp. B151-B152
Author(s):  
Dawn Hui ◽  
Anish Thomas ◽  
Katherine Polednik ◽  
Keith Allen ◽  
Richard Lee
Keyword(s):  
Bench Testing

scholarly journals Side-branch expansion capacity of contemporary DES platforms

2021 ◽  
Vol 26 (1) ◽  
Author(s):  
Alper Öner ◽  
Paula Rosam ◽  
Finja Borowski ◽  
Niels Grabow ◽  
Stefan Siewert ◽  
...  
Keyword(s):  
Morphological Characteristics ◽  
In Vitro Study ◽  
Normal Pressure ◽  
Side Branch ◽  
Drug Eluting Stent ◽  
Cell Diameter ◽  
Drug Eluting ◽  
Bench Testing ◽  
Expansion Capacity

Abstract Background Percutaneous coronary interventions (PCI) of bifurcation stenoses are both complex and challenging. Stenting strategies share that the stents’ side cells must be carefully explored and appropriately prepared using balloons or stents. So far, stent manufacturers have not provided any information regarding side-branch expansion capacity of their stent platforms. Aims Given that drug-eluting stent (DES) information regarding their mechanical capacity of side-branch expansion is not available, we aimed to evaluate contemporary DES (Orsiro, BIOTRONIK AG; Xience Sierra, Abbott Vascular; Resolute Integrity, Medtronic; Promus Premier Select, Boston Scientific; Supraflex Cruz, Sahajan and Medical Technologies) by their side-branch expansion behavior using in vitro bench testing. Methods In this in vitro study, we analyzed five commercially available DES (diameter 3.0 mm), measuring their side-branch expansion following inflation of different high-pressure non-compliant (NC) balloons (balloon diameter: 2.00–4.00 mm), thereby revealing the morphological characteristics of their side-branch expansion capacities. Results We demonstrated that all tested contemporary DES platforms could withstand large single-cell deformations, up to 4.0 mm. As seen in our side-branch experiments, DES designs consisting of only two connectors between strut rings did not only result in huge cell areas, but also in larger cell diameters following side-branch expansion compared with DES designs using three or more connectors. Furthermore, the stent cell diameter attained was below the balloon diameter at normal pressure. Conclusions We recommend that the expansion capacity of side-branches should be considered in stent selection for bifurcation interventions.

Improved Understanding of Stent Malapposition Using Virtual Bench Testing

2011 ◽  
Vol 6 (2) ◽  
pp. 106 ◽  
Author(s):  
Peter Mortier ◽  
Heleen MM van Beusekom ◽  
Matthieu De Beule ◽  
Ilona Krabbendam-Peters ◽  
Benjamin Van Der Smissen ◽  
...  
Keyword(s):  
Imaging Techniques ◽  
Average Distance ◽  
Three Dimensional ◽  
Proximal Part ◽  
New Approach ◽  
Incomplete Stent Apposition ◽  
Bifurcation Stenting ◽  
Silicone Model ◽  
Bench Testing

Intravascular imaging techniques such as optical coherence tomography (OCT) and intravascular ultrasound (IVUS) are often used to assess strut apposition, but only provide limited insight into the three-dimensional appositioning behaviour of stents. Recently, a new approach has been introduced to study the phenomenon of incomplete stent apposition (ISA) based on finite element simulations. In this study, we employed this virtual strut apposition assessment technique in the setting of coronary bifurcation stenting and compared simulated strut–artery distances of two stent designs with actual measurements based on OCT imaging using a silicone model. Stenting of the main branch leads to malapposed struts in the proximal part and the average strut–artery distance in that region for the Integrity stent is 126 μm based on the simulation and 117±14 μm based on the OCT analysis. For the Multi-Link 8 stent, this average distance is 150 μm and 174±7 µm for the simulation and thein vitroOCT measurements respectively. In conclusion, the virtual assessment of strut appositioning results in similar strut–artery distances when compared with measurements based on OCT-visualisedin vitrostent deployments and could be used to optimise devices and procedures.

Coronary bifurcation stenting: insights from in vitro and virtual bench testing

2010 ◽  
Vol 6 (J) ◽  
pp. J53-J60 ◽  
Author(s):  
Peter Mortier ◽  
Matthieu De Beule ◽  
Gabriele Dubini ◽  
Yutaka Hikichi ◽  
Yoshinobu Murasato ◽  
...  
Keyword(s):  
Coronary Bifurcation ◽  
Bifurcation Stenting ◽  
Bench Testing

scholarly journals Validation of Air as an Equilibration Medium in Gastric Tonometry: An in Vitro Evaluation of Two Techniques for Measuring Air Pco2

1998 ◽  
Vol 26 (1) ◽  
pp. 46-50 ◽  
Author(s):  
B. Venkatesh ◽  
J. Morgan ◽  
R. D. M. Jones ◽  
A. Clague
Keyword(s):  
Correction Factor ◽  
Gastric Tonometry ◽  
Equilibration Time ◽  
Blood Gas ◽  
Infra Red ◽  
Set Up ◽  
Bench Testing ◽  
Silicone Balloon ◽  
Different Levels

This laboratory-based bench study was undertaken to evaluate the accuracy and equilibration characteristics of air and saline respectively as CO2 equilibrating media in the silicone balloon of a gastric tonometer and to compare two methods of measuring air Pco2. Two gastric tonometers were suspended in a bath containing 0.9% saline maintained at 37°C. Certified calibration gases at three different CO2 concentrations were bubbled into the bath. When the bath Pco2 measurement was stable the tonometers were primed with 5 ml of air and 2.5 ml normal saline respectively and allowed to equilibrate for 30 and 90 minutes. Following equilibration, samples were aspirated and analysed in duplicate in a blood gas analyser. Bias and precision were calculated from the measured and expected Pco2 values. A consistent negative bias (21–23%) was seen with air at all three CO2 concentrations at 30 and 90 minutes with a coefficient of variation between 2.7 and 3.3%. Imprecise data were obtained with saline at different levels of CO2. A similar experimental set-up was used to compare air Pco2 measurement by a blood gas analyser and an infra-red analyser (Tonocap). Similar bias was obtained with the blood gas analyser with respect to air Pco2 measurement as in experiment 1. The infra-red analyser measurement was highly precise with negligible bias. Air appears to be a better CO2 equilibration medium during bench testing of tonometry producing a systematic negative offset and requiring a uniform correction factor of 1.25. This correction factor is independent of equilibration time and equilibrating CO2 concentration. The use of the infra-red analyser eliminates any bias in the measurement of air Pco2 and obviates the need for a correction factor.

Ultrastructural Investigations of the Contractile Filaments of Amoebae

1974 ◽  
Vol 32 ◽  
pp. 188-189
Author(s):  
P.L. Moore
Keyword(s):  
Cytoplasmic Streaming ◽  
Three Dimensional ◽  
Freeze Fracture ◽  
Amoeboid Movement ◽  
Different Types ◽  
Chemical Conditions ◽  
Complete Interpretation

Previous freeze fracture results on the intact giant, amoeba Chaos carolinensis indicated the presence of a fibrillar arrangement of filaments within the cytoplasm. A complete interpretation of the three dimensional ultrastructure of these structures, and their possible role in amoeboid movement was not possible, since comparable results could not be obtained with conventional fixation of intact amoebae. Progress in interpreting the freeze fracture images of amoebae required a more thorough understanding of the different types of filaments present in amoebae, and of the ways in which they could be organized while remaining functional.The recent development of a calcium sensitive, demembranated, amoeboid model of Chaos carolinensis has made it possible to achieve a better understanding of such functional arrangements of amoeboid filaments. In these models the motility of demembranated cytoplasm can be controlled in vitro, and the chemical conditions necessary for contractility, and cytoplasmic streaming can be investigated. It is clear from these studies that “fibrils” exist in amoeboid models, and that they are capable of contracting along their length under conditions similar to those which cause contraction in vertebrate muscles.

Sign in / Sign up

Export Citation Format

Share Document