scholarly journals Side-branch expansion capacity of contemporary DES platforms

2021 ◽  
Vol 26 (1) ◽  
Author(s):  
Alper Öner ◽  
Paula Rosam ◽  
Finja Borowski ◽  
Niels Grabow ◽  
Stefan Siewert ◽  
...  
Keyword(s):  
Morphological Characteristics ◽  
In Vitro Study ◽  
Normal Pressure ◽  
Side Branch ◽  
Drug Eluting Stent ◽  
Cell Diameter ◽  
Drug Eluting ◽  
Bench Testing ◽  
Expansion Capacity

Abstract Background Percutaneous coronary interventions (PCI) of bifurcation stenoses are both complex and challenging. Stenting strategies share that the stents’ side cells must be carefully explored and appropriately prepared using balloons or stents. So far, stent manufacturers have not provided any information regarding side-branch expansion capacity of their stent platforms. Aims Given that drug-eluting stent (DES) information regarding their mechanical capacity of side-branch expansion is not available, we aimed to evaluate contemporary DES (Orsiro, BIOTRONIK AG; Xience Sierra, Abbott Vascular; Resolute Integrity, Medtronic; Promus Premier Select, Boston Scientific; Supraflex Cruz, Sahajan and Medical Technologies) by their side-branch expansion behavior using in vitro bench testing. Methods In this in vitro study, we analyzed five commercially available DES (diameter 3.0 mm), measuring their side-branch expansion following inflation of different high-pressure non-compliant (NC) balloons (balloon diameter: 2.00–4.00 mm), thereby revealing the morphological characteristics of their side-branch expansion capacities. Results We demonstrated that all tested contemporary DES platforms could withstand large single-cell deformations, up to 4.0 mm. As seen in our side-branch experiments, DES designs consisting of only two connectors between strut rings did not only result in huge cell areas, but also in larger cell diameters following side-branch expansion compared with DES designs using three or more connectors. Furthermore, the stent cell diameter attained was below the balloon diameter at normal pressure. Conclusions We recommend that the expansion capacity of side-branches should be considered in stent selection for bifurcation interventions.

Development of an in vitro measurement method for improved assessment of the side branch expansion capacity

2020 ◽  
Vol 6 (3) ◽  
pp. 442-445
Author(s):  
Paula Rosam ◽  
Finja Borowski ◽  
Michael Stiehm ◽  
Klaus Peter Schmitz ◽  
Jonas Keiler ◽  
...  
Keyword(s):  
Cell Damage ◽  
Side Branch ◽  
Cell Diameter ◽  
Limited Information ◽  
Elastic Recoil ◽  
Essential Information ◽  
Nominal Diameter ◽  
Large Expansion ◽  
Expansion Capacity

AbstractThe expansion capacity and accessibility of the side branch is essential for the stenting of complex bifurcations. Since previous measurement methods only provide limited information based on geometrical data of stent cells, a new measurement approach was developed which considers the mechanical deformation capacity of the stent design. This approach provides essential information on the stent with regard to the application of bifurcation stenting. Four different commercially available coronary stents (nominal diameter 3.0 mm) were dilated and a central strut cell was over-expanded by means balloon catheters of increasing nominal diameter (2.0 to 5.0 mm). After balloon inflation, the remaining cell size was investigated for maximum cell diameter and strut fractures. Large expansion capacity without cell damage is taken as a measure of the accessibility of the side branch. In none of the expansion experiments the desired target size could be achieved, which is due to the elastic recoil of the stent cells. Deviations from the target diameter between 14-38% were determined. However, larger diameters also showed a constriction of the balloon, so that in some cases the target diameter could not be achieved at all. No strut fractures occurred even at maximum balloon diameter and pressure (5.0 mm noncompliant balloons). As a result the side branch accessibility differs depending on the individual stent designs. No particular risk for the stent was found by extensive overdilatation.

scholarly journals In vitro study of poly(ethylene carbonate) as a drug-eluting stent coating

2012 ◽  
Vol 22 (4) ◽  
pp. 295-302 ◽  
Author(s):  
Huijuan Bian ◽  
Shaoxiong Zhou ◽  
Xinjie Liang ◽  
Qiang Li ◽  
Wei Han
Keyword(s):  
Ethylene Carbonate ◽  
In Vitro Study ◽  
Vitro Study ◽  
Drug Eluting Stent ◽  
Drug Eluting ◽  
Poly Ethylene ◽  
Stent Coating

In vitro оценка содержания лекарственных веществ и кинетики их выделения из коронарных стентов с различными типами полимерных покрытий

2019 ◽  
Vol 52 (12) ◽  
pp. 50-54
Author(s):  
Анна Игоревна Простякова ◽  
Дмитрий Игоревич Зыбин ◽  
Дмитрий Валерьевич Капустин
Keyword(s):  
Drug Eluting Stent ◽  
Drug Eluting

Изучение профиля выделения лекарственного средства in vitro — необходимый этап при оптимизации полимерно-лекарственной композиции в процессе разработки стентов, выделяющих лекарственное вещество (ЛВ). В статье представлены результаты ВЭЖХ-анализа содержания ЛВ и кинетики его выделения из различных типов полимерно-лекарственного покрытия выделяющих ЛВ коронарных стентов (drug eluting stent — DES): биодеградируемого покрытия с сиролимусом и стабильного покрытия с зотаролимусом. Содержание ЛВ оценивали для кримпированных стентов на системе доставки, а также после раскрытия. Продемонстрирована связь морфологии лекарственного покрытия с кинетикой выделения ЛВ и показано, что крупные морфологические дефекты покрытия приводят к отклонению параметров выделения ЛВ.

Neointimal Coverage on Drug-Eluting Stent Struts Crossing Side-Branch Vessels Using Optical Coherence Tomography

2010 ◽  
Vol 105 (11) ◽  
pp. 1565-1569 ◽  
Author(s):  
Ae-Young Her ◽  
Byoung Kwon Lee ◽  
Jae-Min Shim ◽  
Jung-Sun Kim ◽  
Byoung-Keuk Kim ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Side Branch ◽  
Drug Eluting Stent ◽  
Optical Coherence ◽  
Drug Eluting ◽  
Neointimal Coverage

scholarly journals In vitro Remote Aspiration Embolectomy for the Treatment of Acute Ischemic Stroke

2018 ◽  
Vol 8 (1) ◽  
pp. 20-26
Author(s):  
Asim Rizvi ◽  
Sean T. Fitzgerald ◽  
Kent D. Carlson ◽  
Dan Dragomir Daescu ◽  
Waleed Brinjikji ◽  
...  
Keyword(s):  
Case Series ◽  
In Vitro Study ◽  
Side Branch ◽  
Collateral Branch ◽  
Proximal Internal Carotid Artery ◽  
Glass Model ◽  
Catheter Tip ◽  
Inner Diameter ◽  
The Impact

Background: “Remote aspiration,” using suction from the proximal internal carotid artery (ICA) to open terminus occlusions, has been reported in small case series. However, it remains unclear whether remote aspiration is feasible for middle cerebral artery occlusions in the setting of potential inflow from communicating arteries. We performed an in vitro study to assess whether suction applied at various locations proximal to an occlusion could successfully aspirate the clot. Methods: A glass model of 4 mm inner diameter (ID) with 1 mm distal narrowing and 2 mm side branch to simulate a communicating artery was constructed. A proximal side branch was placed to simulate inflow from the proximal ICA. The impact of three different-sized catheters (ID 0.088, 0.070, and 0.056 in) on histologically different (red blood cell-cell rich, fibrin-rich, and mixed) clot analogues was tested with the catheter tip placed remotely either distal or proximal to the collateral branch. Aspiration was attempted with (1) open system (flow in both the ICA and the collateral branch, (2) flow arrest with open collateral (no flow in the ICA, but flow in the collateral branch), and (3) closed system (no flow in either the ICA or the collateral branch). The outcome was success or failure of remote aspiration. Results: For the 0.088-in catheter, remote aspiration was successful in all conditions. For the 0.070-in catheter, remote aspiration was unsuccessful without proximal flow arrest, but was successful in all other scenarios. For the 0.056-in catheter, remote aspiration was successful only with complete flow arrest. Conclusions: In a noncollapsible system, remote aspiration can be successfully achieved even in the setting of prominent branch arteries by using relatively large aspiration catheters. Proximal flow arrest may facilitate successful remote aspiration for some catheter sizes.

scholarly journals Effect of topical fluoride on microshear bond strength of primary enamel to composite, microhardness of enamel and its surface morphology: An in vitro study

2019 ◽  
Vol 13 (4) ◽  
pp. 305-310
Author(s):  
Mina Biria ◽  
Sajedeh Namaei Ghasemi ◽  
Seyedeh Mahsa Sheikh-Al-Eslamian ◽  
Narges Panahandeh
Keyword(s):  
Bond Strength ◽  
Artificial Saliva ◽  
Morphological Characteristics ◽  
In Vitro Study ◽  
Vitro Study ◽  
Control Group ◽  
Modes Of Failure ◽  
Group 3 ◽  
Microshear Bond Strength

Background. This in vitro study aimed to evaluate the microshear bond strength (μSBS), microhardness and morphological characteristics of primary enamel after treating with sodium fluoride (NaF) and acidulated phosphate fluoride (APF). Methods. Forty-eight primary canines were cut into mesial and distal sections and assigned to five groups randomly: group 1 (immersed in saliva as a control), group 2 (treated with NAF and immersed in saliva for 30 minutes), group 3 (treated with APF and immersed in saliva for 30 minutes), group 4 (treated with NAF and immersed in saliva for 10 days), and group 5 (treated with APF and immersed in saliva for 10 days). Composite resin (Filtek Z250) was bonded on the specimens (n=15) for measuring the μSBS. After storage in 37°C artificial saliva for 24 hours, µSBS and Vickers hardness tests (10 readings) were performed. The data were analyzed using one-way ANOVA and Kolmogorov-Smirnov, Levene’s and Tukey HSD tests (P<0.05). Morphological analysis of enamel and modes of failure were carried out under a scanning electron microscope (SEM) on two remaining specimens. Results. Significant differences in μSBS were only noted between groups 2 and 4 (P=0.024). Group 3 showed a significant decrease in hardness after storage in artificial saliva (P<0.001), with a significantly lower hardness than the other groups (P<0.001). The SEM observations showed irregular particles in groups 3 and 5; uniform, smooth and thin coats were seen in groups 2 and 4. Conclusion. Fluoride therapy with NaF and APF gels prior to restorative treatments had no adverse effects on the microshear bond strength.

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