Comparison of the GenCut Core Biopsy System to Transbronchial Biopsy Forceps for Flexible Bronchoscopic Lung Biopsy

2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Lindsey Orr ◽  
Rebecca Krochmal ◽  
Rajiv Sonti ◽  
Pedro DeBrito ◽  
Eric D. Anderson
Keyword(s):  
Core Biopsy ◽  
Lung Biopsy ◽  
Transbronchial Biopsy ◽  
Biopsy Forceps

scholarly journals Biopince Full Core Biopsy Device for Percutaneous Lung Biopsy: A Retrospective Analysis of 184 Procedures Analyzing Complication Rates and Procedure Success

2021 ◽  
pp. 17-25
Author(s):  
Robert Bernstein ◽  
Ryan Garrow
Keyword(s):  
Core Biopsy ◽  
Lung Biopsy ◽  
Research Question ◽  
Outpatient Setting ◽  
High Rate ◽  
Complication Rates ◽  
Core Needle ◽  
Biopsy Device ◽  
Percutaneous Lung Biopsy ◽  
Full Core

Background: Unlike fine needle aspiration, core needle biopsies allow the collection of intact tissue for pathological and molecular evaluation. In outpatient clinical practice, full core needle lung biopsy may be underused because of concerns that it might be too dangerous. We describe our experience using a full core device for percutaneous lung biopsy in a large cohort of patients. Research Question: Is percutaneous full core needle lung biopsy effective and safe in the outpatient setting? Study Design and Methods: The analyzed population comprised patients with lung masses >1.1 cm who underwent percutaneous lung biopsy with a full core device. Analyzed data included core mass dimensions, distance from pleural edge to mass, lobe location, type, outcomes, and complications. Biopsy success was defined as adequate tissue acquisition for pathological evaluation that yielded a diagnosis. Biopsy procedures with incomplete data were excluded from this analysis. Results: We analyzed data from 184 lung biopsies performed on 182 patients (mean age, 70±11.7 years). Most biopsies were parenchymal (54.9%). The overall diagnostic success rate was 98.4%. No complications were reported for 77.2% of biopsies. Minor complications occurred during 39 biopsies (21.2%) and were primarily pneumothorax (16.8%). Major complications occurred during 4 biopsies (2.1%): 3 patients with pneumothorax required emergency department (ED) management and 1 patient went to the ED for severe pain. All complications resolved within 24 hours without hospitalization or transfusion. Crosstabulation analyses showed no significant differences between the lung lobe locations in terms of rates of disposition and complications, and between the lesion types in terms of rates of disposition and complications. Interpretation: Percutaneous lung biopsy performed using a full core biopsy device demonstrated a high rate of diagnostic success and a low risk of clinically significant procedural complications in an outpatient setting.

scholarly journals Lung biopsy with guillotine cutting needle and biopsy forceps though transdiaphragmatic thoracoscopy in dogs with pulmonary alterations

2018 ◽  
Vol 38 (11) ◽  
pp. 2117-2123
Author(s):  
Letícia M. Fratini ◽  
Cristiano Gomes ◽  
Luciana Queiroga ◽  
Fabiane R. Santos ◽  
Alexandra P. Fantinatti ◽  
...  
Keyword(s):  
Lung Biopsy ◽  
Histopathological Examination ◽  
Perioperative Complications ◽  
Screening Tests ◽  
Histopathological Analysis ◽  
Imaging Features ◽  
Biopsy Forceps ◽  
Pathology Laboratory ◽  
Cutting Needle ◽  
Guillotine Cutting

ABSTRACT: Lung diseases are common in small animal clinical routine. Diagnosis is usually affected due to nonspecific symptoms. Imaging features such as radiography and chest ultrasound are acceptable screening tests, although lung biopsy can provides a precise diagnosis. Thus thoracoscopy provides a minimally invasive diagnostic assessment for chest diseases and offers the benefits such as improved illumination and magnification of the image when compared with thoracotomy. In this study we evaluated the transdiaphragmatic thoracoscopic-assisted techniques of lung biopsy with a the guillotine cutting needle and biopsy forceps, in dogs presenting radiographic suspicion on pulmonary tumors. Fourteen dogs regardless of breed, gender, age and body weight admitted at the Hospital of Veterinary Clinics (HCV) of the Veterinary College (FAVET) of Universidade Federal do Rio Grande do Sul (UFRGS), were assessed. Inclusion criteria were presence of nodules on chest radiography and triage tests without changes that could hinder general anesthesia and surgical approach. The animals were positioned in dorsal recumbence and two thoracoscopic ports were established: the first port for working instruments; the second paraxyphoid port for the telescope. Three samples were collected using each sampling method from each lesion or from tumors macroscopically similar whenever their size was less than one centimeter. The samples were sent for histopathological examination in the Veterinary Pathology Laboratory of FAVET/UFRGS. Surgical time was recorded from first incision to wound closure and surgical complications were reported. The dogs were evaluated for the presence of subcutaneous emphysema, hematoma, seroma, local infection and dehiscence. No conversion to open surgery was necessary during the thoracoscopic procedure in any patient. Thoracoscopic assisted biopsy using guillotine needle and biopsy forceps was a safe and fast technique, without perioperative complications. Both devices provided good quality samples for histopathological analysis of lung abnormalities. However the cutting guillotine needle was more efficient especially in larger pulmonary nodules. The transdiaphragmatic access provided optimal approach for both hemithoraces.

Efficiency and safety of transbronchial cryobiopsy in the diagnosis of disseminated lung diseases in patients after unsuccessful transbronchial forceps lung biopsy

MedAlliance ◽  
2020 ◽  
Vol 8 (3) ◽  
pp. 66-72
Keyword(s):  
Differential Diagnosis ◽  
Pulmonary Tuberculosis ◽  
Lung Biopsy ◽  
Lung Diseases ◽  
Pleural Cavity ◽  
Pulmonary Hemorrhage ◽  
Transbronchial Biopsy ◽  
Small Airways ◽  
Safe Procedure ◽  
X Ray

Disseminated lung diseases is a group of pathologies characterized by damage to the small airways, alveo-li, interstitium of the lungs united by a common symp-tom, dissemination in the lung tissue detected by X-ray. Pathologies included in the DLD group are numerous, and differential diagnosis between them is difficult, due to the similarity of symptoms and the absence of patho-gnomonic signs. Transbronchial cryobiopsy of the lungs is a relatively new technique, currently used in diagnos-tics, along with other methods of morphological verifi-cation in disseminated lung diseases. However, there are only sporadic publications on its use in Russia. The article describes the first experience of using transbronchial cry-obiopsy in patients with disseminated lung diseases after negative transbronchial biopsy. Objective. To obtain the first cli nical experience with the TBLC method. To assess the role and efficacy of TBLC in the diagnosis of DLDs. Ma-terials and methods. Patients with oncology in medical history or with previous tuberculosis were not included into the study; a total of 15 patients were included. The process was verified in 11 (73.33%) patients. Of these, sarcoidosis of the lungs was detected in 8 (72.73%) cases, pulmonary tuberculosis in 2 (18.18%), idiopathic intersti-tial pneumonia in 1 (9.09%). Complications were record-ed in 2 patients (13.33%): apical pneumothorax, which did not require pleural cavity drainage; and pulmonary hemorrhage requiring prolonged mechanical ventilation.Conclusions. Transbronchial cryobiopsy in patients with disseminated lung disease after unsuccessful transbron-chial lung biopsy appears to be a highly informative and relatively safe procedure. Cryobiopsy through a rigid bronchoscope tube appears to be safer. TBLC from the apex of the lungs, as well as in smokers, seems to be a more difficult task to verify, but this requires further studies

Pediatric Transbronchial Lung Biopsy

1992 ◽  
Vol 101 (2) ◽  
pp. 135-137 ◽  
Author(s):  
Harlan R. Muntz ◽  
Mark Wallace ◽  
Rodney P. Lusk
Keyword(s):  
Lung Biopsy ◽  
Lung Transplant ◽  
Pediatric Patients ◽  
Immunocompromised Patient ◽  
Pulmonary Hemorrhage ◽  
Hyaline Membrane Disease ◽  
Biopsy Forceps ◽  
Hyaline Membrane ◽  
Lung Biopsies ◽  
Adequate Tissue

A retrospective review of 25 transbronchial lung biopsies in 19 pediatric patients is reported. Nineteen of these procedures used a rigid ventilating bronchoscope and a small cup biopsy forceps. The indications included diffuse pulmonary infiltrates in the immunocompromised patient, severe hyaline membrane disease, tumor, and lung transplant. In 84 % of the procedures, adequate tissue was obtained. There was a 12.5% incidence of pneumothorax and no significant pulmonary hemorrhage.

scholarly journals PBF-Guided Biopsy with a Novel Puncture Biopsy Forceps Needle—Feasibility Study

Diagnostics ◽  
2021 ◽  
Vol 11 (9) ◽  
pp. 1638
Author(s):  
Geke Litjens ◽  
Christian Gerges ◽  
Yogesh M. Shastri ◽  
Piyush Somani ◽  
Torsten Beyna ◽  
...  
Keyword(s):  
Core Biopsy ◽  
Correct Diagnosis ◽  
Needle Aspiration ◽  
Biopsy Forceps ◽  
Pancreatic Lesion ◽  
Novel Device ◽  
Guided Biopsy ◽  
Puncture Biopsy ◽  
Technical Issues ◽  
Subepithelial Lesion

Endoscopic ultrasound (EUS) with fine needle aspiration (FNA) or biopsy (FNB) to diagnose lesions in the gastrointestinal tract is common. Demand for histology sampling to identify treatment-specific targets is increasing. Various core biopsy FNB needles to obtain tissue for histology are currently available, however, with variable (37–97%) histology yields. In this multicenter study, we evaluated performance, safety, and user experience of a novel device (the puncture biopsy forceps (PBF) needle). Twenty-four procedures with the PBF needle were performed in 24 patients with a suspected pancreatic lesion (n = 10), subepithelial lesion (n = 10), lymph node (n = 3), or pararectal mass (n = 1). In 20/24 (83%) procedures, the PBF needle yielded sufficient material for interpretation (sample adequacy). In 17/24 (71%), a correct diagnosis was made with the material from the PBF needle (diagnostic accuracy). All participating endoscopists experienced a learning curve. (Per)procedural technical issues occurred in four cases (17%), but there were no adverse events. The PBF needle is a safe and potentially useful device to obtain an EUS-guided biopsy specimen. As the design of the PBF needle is different to core biopsy FNB needles, specific training will likely further improve the performance of the PBF needle. Furthermore, the design of the needle needs further improvement to make it more robust in clinical practice.

scholarly journals Pneumomediastinum after transbronchial cryobiopsy

2018 ◽  
Vol 88 (2) ◽  
Author(s):  
Emanuela Barisione ◽  
Rita Bianchi ◽  
Roberto Fiocca ◽  
Mario Salio
Keyword(s):  
Systematic Reviews ◽  
Lung Biopsy ◽  
Transbronchial Biopsy ◽  
Spontaneous Resolution ◽  
Safe Procedure ◽  
Surgical Lung Biopsy ◽  
First Case

Pneumomediastinum is defined as the presence of air or gas within the mediastinum and it rarely complicates bronchoscopy. We report, to our best knowledge, the first case of pneumomediastinum following a transbronchial cryobiopsy (TBLC). TBLC is considered a safe procedure as compared with both transbronchial biopsy and surgical lung biopsy. Systematic reviews, metanalysis and a Pubmed research, revealed that in literature no pneumomediastinum has been mentioned after TBLC. We report this case for to make it known to interventional pulmonologists the possibility that a pneumomediastinum can follow a TBLC. In our case the spontaneous resolution in few days did not require any intervention.

scholarly journals CT guided lung biopsy: Diagnostic yield and complications, using 18G coaxial semi-automatic core needle

2019 ◽  
Vol 4 (1) ◽  
pp. 20-25
Author(s):  
Ajit Thapa ◽  
Kamal Subedi ◽  
Sundar Suwal ◽  
Dinesh Chataut
Keyword(s):  
Core Biopsy ◽  
Lung Biopsy ◽  
Diagnostic Yield ◽  
Lung Nodule ◽  
Histopathological Diagnosis ◽  
Safe Procedure ◽  
Ct Guided ◽  
Biopsy Needle ◽  
Core Needle ◽  
Clinically Significant

Introduction: CT guided biopsy is essential for histopathological diagnosis of suspicious lung nodule, which are not amenable for either bronchoscopic or sonography guided sampling. Methods: Twenty eight patients with suspicious lung nodules not amenable for bronchoscopic or sonography guided sampling who underwent CT guided lung biopsy with 18 G coaxial semiautomatic core biopsy needle in one year were retrospectively studied for diagnostic yield and complications. Results: Out of 28 patients, who underwent CT guided lung nodule biopsy, 18 were male and 10 were female. The age ranged from 22 to 80 years. Lesion size ranged from one cm to four cm and depth of lesion from pleura ranged from zero cm to five cm. Diagnostic yield of our core needle biopsy was 26(92.3%). Clinically significant complication was low. Massive pneumothorax which needed intercostal drainage was 7.14% (2 patients). Pulmonary hemorrhage manifesting as hemoptysis was seen in 14.3 %( 2 patients). No hemothorax or air embolism was noted in any of the patient. Conclusion: CT guided lung lesion biopsy with 18 G coaxial semi-automatic core biopsy needle is a safe procedure with good diagnostic yield and relatively low incidence of clinically significant complications.

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