Association between genetic polymorphisms of MMP8 and the risk of steroid-induced osteonecrosis of the femoral head in the population of northern China

Abstract IntroductionSteroid-induced osteonecrosis of the femoral head (ONFH ) is a disease of bone metabolism, and genetic factors are generally considered to play an important role. The purpose of this study was to investigate the relationship between single nucleotide polymorphisms (SNPs) in MIR17HG and MIR155HG and the risk of steroid-induced ONFH in the population of northern China.MethodsA total of 199 steroid-induced ONFH patients and 506 healthy controls were recruited for the study. Four SNPs of MIR17HG and seven SNPs of MIR155HG were genotyped by Sequenom MassARRAY. ORs and 95% CIs were used to evaluate the relationship between these SNPs and steroid-induced ONFH.ResultsIn the codominant model, patients with the MIR17HG SNPs(rs7318578) AA genotype had an increased risk of steroid-induced ONFH (OR = 1.79, p = 0.039), in the recessive model, patients with the MIR17HG SNP(rs7318578) AA genotype had an increased risk of steroid-induced ONFH (OR = 1.78, p = 0.032). Stratified analysis showed that a MIR17HG SNP (rs7318578) and MIR155HG SNPs(rs77218221, rs11911469, rs34904192 and rs4143370) were closely related to different unornamented phenotypes of steroid-induced ONFH. Analysis of the clinical indicators revealed significant differences in high-density lipoprotein (HDL-C) levels between the ONFH group and the control group (p = 0.005). MIR17HG SNP(rs75267932) and MIR155HG SNPs(rs77699734, rs1893650 and rs34904192) were correlated with different lipid indexes.ConclusionOur results confirm that MIR17HG and MIR155HG gene mutations are associated with steroid-induced ONFH susceptibility in the population of northern China, providing new evidence for the early detection and prevention of ONFH.

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Association Between Genetic Polymorphisms of MIR3142HG and the Risk of Steroid-induced Osteonecrosis of the Femoral Head in the Population of Northern China

10.21203/rs.3.rs-90412/v1 ◽

2020 ◽

Author(s):

Tiantian Wang ◽

Huiqiang Wu ◽

Tingting Liu ◽

Mneghu Sun ◽

Feimeng An ◽

...

Keyword(s):

Femoral Head ◽

Protective Factor ◽

Genetic Model ◽

Northern China ◽

Chinese Han ◽

Aseptic Necrosis ◽

Chain Imbalance ◽

Stratified Analysis ◽

The Relationship

Abstract Background: Steroid-induced osteonecrosis of the femoral head (ONFH) is aseptic necrosis of the femoral head caused by glucocorticoid use. Once necrotic femoral head necrosis occurs, it irreversibly affects the quality of life seriously. Studies have shown that the susceptibility to steroid-induced ONFH is likely to be related to the variation of miRNA coding genes. Therefore, this study aimed was to investigate the effect of MIR3142HG on steroid-induced ONFH.Methods: Agena MassARRAY was used to genotype MIR3142HG gene rs1582417, rs2431689, rs7727155 and rs17057846 in 199 patients and 506 healthy people. A genetic model and haplotype analysis were used to evaluate the relationship between the MIR3142HG polymorphism and the risk of steroid-induced ONFH. The odds ratio (OR) and 95% confidence intervals (CIs) were obtained through logistic regression to assess the influence of gene polymorphisms on the occurrence of steroid-induced ONFH.Results: The consequences show that rs7727115(OR=0.76,p=0.036) is a protective factor, it could reduce the risk of steroid-induced ONFH, rs1582417(OR=1.28, p=0.041) could increase the risk of steroid-induced ONFH. Stratified analysis , according to each clinical index shows that MIR3142HG TC-CC genotype facilitated the risk of steroid-induced ONFH in male ( p<0.05). In addition, rs2431689 is related to HDL-C(p=0.012) and ApoA1 (p=0.010) levels, and rs17057846 (p=0.024) is related to ApoB levels.The linkage analysis indicated that three SNPs (rs2431689, rs7727115 and rs17057846) in MIR3142HG with significant chain imbalance. In addition, haplotype “GGG” of MIR3142HG was found out is harmful for steroid-induced ONFH.Conclusion: Our results firstly confirm that the genetic polymorphism of MIR3142HG is associated with steroid-induced ONFH susceptibility in Chinese Han population.

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Significant association between RETN genetic polymorphisms and alcohol‐induced osteonecrosis of femoral head

Molecular Genetics & Genomic Medicine ◽

10.1002/mgg3.822 ◽

2019 ◽

Vol 7 (8) ◽

Author(s):

Chang Liu ◽

Feimeng An ◽

Yuju Cao ◽

Jiaqi Wang ◽

Ye Tian ◽

...

Keyword(s):

Femoral Head ◽

Genetic Polymorphisms ◽

Osteonecrosis Of Femoral Head

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The effects of MIR137HG genetic polymorphisms on the susceptibility of alcohol-induced osteonecrosis of the femoral head in a chinese male population

Gene ◽

10.1016/j.gene.2021.145902 ◽

2021 ◽

pp. 145902

Author(s):

Yongchang Guo ◽

Yuju Cao ◽

Xiaoyan Feng ◽

Dapeng Zhang ◽

Liying Fan ◽

...

Keyword(s):

Femoral Head ◽

Genetic Polymorphisms ◽

Male Population ◽

Chinese Male

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Significant Associations of SOX9 Gene Polymorphism and Gene Expression with the Risk of Osteonecrosis of the Femoral Head in a Han Population in Northern China

BioMed Research International ◽

10.1155/2016/5695317 ◽

2016 ◽

Vol 2016 ◽

pp. 1-11 ◽

Cited By ~ 3

Author(s):

Yang Song ◽

Zhenwu Du ◽

Ming Ren ◽

Qiwei Yang ◽

Yujie Sui ◽

...

Keyword(s):

Gene Expression ◽

Femoral Head ◽

Gene Polymorphism ◽

Protein Expression ◽

Northern China ◽

Development Stage ◽

Control Group ◽

Cartilage Growth ◽

Increased Risk ◽

Sox9 Gene

Sex determining region Y-box 9 (SOX9) is a key transcription factor involved in cartilage formation during the embryonic development stage and cartilage growth and repair after birth. To explore the roles of polymorphism and expression of the SOX9 gene in the development of osteonecrosis of the femoral head (ONFH), we analyzed the polymorphism of rs12601701 [A/G] and rs1042667 [A/C] and the serum protein expression of the SOX9 gene in 182 patients with ONFH and 179 healthy control subjects. Results revealed that the A-A haplotype of SOX9 gene as well as the GG and AA genotypes of rs12601701 was significantly associated with increased ONFH risk (P=0.038) and the risk of bilateral hip lesions of ONFH (P=0.009), respectively. The C-A, A-A, and A-G haplotypes were also statistically associated with the decreased and increased risk of bilateral hip lesions of ONFH (P=0.03,P=0.048, andP=0.013), respectively, while the A-A haplotype closely related to the clinical stages of ONFH (P=0.041). More importantly, the serum SOX9 protein expression of the ONFH group was greatly decreased compared to control group (P=0.0001). Our results first showed that the gene polymorphism and gene expression of SOX9 were significantly associated with the risk and clinical phenotypes of ONFH and also indicate that the SOX9 gene may play a key role in the development of ONFH.

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